公开(公告)号：US20090008310A1

公开(公告)日：2009-01-08

申请号：US10595546

申请日：2004-11-05

申请人： Jurgen Dannenmaier ,  Hermann Goehl ,  Thomas Ertl ,  Jacques Chevallet ,  Francesco Ribolzi ,  Bjorn Frederik Seidler ,  Lennart Jonsson ,  Eddie Nilsson

发明人： Jurgen Dannenmaier ,  Hermann Goehl ,  Thomas Ertl ,  Jacques Chevallet ,  Francesco Ribolzi ,  Bjorn Frederik Seidler ,  Lennart Jonsson ,  Eddie Nilsson

IPC分类号： A61M1/16 ,  B01D61/30

CPC分类号： A61M1/3627 ,  A61M1/1008 ,  A61M1/1039 ,  A61M1/1086 ,  A61M1/16 ,  A61M1/3639 ,  A61M1/3641 ,  A61M2205/12 ,  B01D61/30 ,  B01D63/02

摘要： An integrated blood treatment module comprises a blood treatment device (1) having a housing (2) and a first end-cap (4) and a second end-cap (5) closing both ends of the housing (2). A pump hose (17) for a peristaltic pump has a first end (18) that is secured to the housing (2) and a second end (16) that is connected to a blood inlet port (15) of the first end-cap (4) so as to form a loop. A degassing device (30) is connected to the second end-cap (5). The degassing device (30), which, in use, is full of liquid, comprises a hydrophobic membrane through which bubbles and micro-bubbles escape the degassing device.

摘要翻译： 集成血液处理模块包括具有壳体（2）和第一端盖（4）的血液处理装置（1）和封闭壳体（2）的两端的第二端盖（5）。 用于蠕动泵的泵管（17）具有固定到壳体（2）的第一端（18）和连接到第一端盖（16）的血液入口（15）的第二端（16） （4）以形成环路。 脱气装置（30）连接到第二端帽（5）。 在使用中充满液体的脱气装置（30）包括疏水膜，气泡和微气泡通过该疏水膜逸出脱气装置。

公开(公告)号：US07223336B2

公开(公告)日：2007-05-29

申请号：US10771427

申请日：2004-02-05

申请人： Claudio Tonelli ,  Vincenzo Baraldi ,  Massimo Zaccarelli ,  Annalisa Delnevo ,  Francesco Ribolzi ,  Jacques Chevallet ,  Jacques Duchamp ,  Aziz Aberkane ,  Gabriel Meyssonnier ,  Dominique Pouchoulin

发明人： Claudio Tonelli ,  Vincenzo Baraldi ,  Massimo Zaccarelli ,  Annalisa Delnevo ,  Francesco Ribolzi ,  Jacques Chevallet ,  Jacques Duchamp ,  Aziz Aberkane ,  Gabriel Meyssonnier ,  Dominique Pouchoulin

IPC分类号： B01D61/00 ,  A61M1/00 ,  A61M37/00

CPC分类号： A61M1/3621 ,  A61M2205/126 ,  A61M2205/128

摘要： The invention relates to an integrated blood treatment module (1) comprising a support element (4) and a fluid distribution circuitry associated thereto; the distribution circuitry comprises at least a blood line (44), a portion of which is secured to the support element and defines with the latter at least a U-shaped tube length (44a) designed to cooperate, when in use, with a respective pump (3a). There are then further fluid lines (45, 48, 50, 51) fastened to the support element and defining each at least a U-shaped tube length (45a, 48a, 50a, 51a) with respect to said element and each designed to cooperate, when in use, with a respective pump (3b, 3c, 3d, 3e). The support element has a first zone (274) in which the portion of the blood line is secured, and at least a second zone (275) opposite said first zone, to which all the corresponding further tube lengths are fastened.

摘要翻译： 本发明涉及一种集成血液处理模块（1），其包括支撑元件（4）和与其相关联的流体分配电路; 分配电路包括至少一条血液线（44），其一部分固定在支撑元件上，并且与血管线固定在至少一个U形管长度（44a）上，U形管长度（44a）在使用时与 相应的泵（3a）。 然后将另外的流体管线（45,48,50,51）固定到支撑元件并且限定每个至少U形管长度（45a，48a，50a，51a）相对于所述元件和 每个设计用于在使用时与相应的泵（3b，3c，3d，3e）配合。 所述支撑元件具有第一区域（274），其中所述血液线的所述部分被固定，以及至少第二区域（275），所述第二区域与所述第一区域相对，所有相应的另外的管段被紧固到所述第二区域。

公开(公告)号：US20050011823A1

公开(公告)日：2005-01-20

申请号：US10771377

申请日：2004-02-05

申请人： Annalisa Delnevo ,  Francesco Ribolzi ,  Claudio Tonelli ,  Vincenzo Baraldi ,  Massimo Zaccarelli ,  Jacques Chevallet ,  Jacques Duchamp ,  Aziz Aberkane ,  Gabriel Meyssonnier ,  Dominique Pouchoulin

发明人： Annalisa Delnevo ,  Francesco Ribolzi ,  Claudio Tonelli ,  Vincenzo Baraldi ,  Massimo Zaccarelli ,  Jacques Chevallet ,  Jacques Duchamp ,  Aziz Aberkane ,  Gabriel Meyssonnier ,  Dominique Pouchoulin

IPC分类号： A61M1/16 ,  A61M1/34 ,  B01D61/00

CPC分类号： A61M1/16 ,  A61M1/1605 ,  A61M1/342 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3451 ,  A61M2205/12 ,  A61M2205/128 ,  A61M2205/3393 ,  A61M2205/50 ,  A61M2230/30

摘要： The invention relates to an extracorporeal blood treatment machine in which a blood circuit (3) is equipped with an inlet line leading to a filtration unit (2) and with an outlet line (3b) from the filtration unit; a fluid circuit comprises an inlet line (4a) leading to the filtration unit and an outlet line (4b) from the filtration unit so as to allow a fluid taken from a primary container (5) to circulate within the filtration unit, thus enabling the treatment of the patient's blood. There is further an infusion line (6) acting on the outlet line of the blood circuit, which is supplied by an auxiliary fluid container (7). The inlet line of the fluid circuit is equipped with at least an infusion branch (8) acting on the outlet line of the blood circuit so as to enable the intensive therapy machine to manage therapies with large exchange of fluids.

摘要翻译： 本发明涉及一种体外血液处理机，其中血液回路（3）配备有通向过滤单元（2）的入口管线和来自过滤单元的出口管线（3b）; 流体回路包括通向过滤单元的入口管线（4a）和来自过滤单元的出口管线（4b），以便允许从主容器（5）中取出的流体在过滤单元内循环，从而使得 治疗患者的血液。 还有一个输入管线（6）作用在血液回路的出口管线上，该输液管线由辅助流体容器（7）供应。 流体回路的入口管线配备有至少一个作用在血液回路出口管路上的输液支路（8），以使得强化治疗机器能够以大量的流体交换来管理治疗。

公开(公告)号：US06579494B1

公开(公告)日：2003-06-17

申请号：US09537307

申请日：2000-03-29

申请人： Jacques Chevallet ,  Thierry Court ,  Michael John Dunkley ,  Alain Frugier ,  Lennart Jonsson ,  Nicholas John Kerry ,  Hiram Rada ,  Jean-Louis Romarie

发明人： Jacques Chevallet ,  Thierry Court ,  Michael John Dunkley ,  Alain Frugier ,  Lennart Jonsson ,  Nicholas John Kerry ,  Hiram Rada ,  Jean-Louis Romarie

IPC分类号： G05B2300

CPC分类号： A61L2/28 ,  A61L2/0023 ,  A61L2/04

摘要： A device for preparing a sterile liquid includes structure for validating a sterilization treatment applied to the liquid. The validating structure includes structure for calculating, from at least one operating parameter of the device, a parameter representing a sterilizing value for the sterilization treatment, and structure for comparing the calculated parameter to a threshold value corresponding to the sterility of the liquid.

摘要翻译： 用于制备无菌液体的装置包括用于验证施加到液体的灭菌处理的结构。 验证结构包括从装置的至少一个操作参数计算表示灭菌处理的消毒值的参数的结构，以及用于将所计算的参数与对应于液体的无菌性的阈值进行比较的结构。

公开(公告)号：US5722399A

公开(公告)日：1998-03-03

申请号：US465047

申请日：1995-06-06

申请人： Jacques Chevallet ,  Alain Frugier ,  Eric Louvet

发明人： Jacques Chevallet ,  Alain Frugier ,  Eric Louvet

IPC分类号： G01L7/00 ,  A61M1/14 ,  A61M1/16 ,  A61M1/36 ,  G01L11/00 ,  A61B5/00

CPC分类号： G01L11/006 ,  A61M1/3639 ,  A61M1/16 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355

摘要： A liquid treatment apparatus includes a sensor which is sensitive to a variation in gas pressure and which generates signals indicative of sensed pressures. The apparatus also included a casing divided into a first compartment and a second compartment by a flexible membrane, the first compartment having at least one orifice for the introduction of the liquid, and the second compartment being connectable in a leaktight manner to the pressure sensor. A pump is provided to vary a quantity of gas in the second compartment, and a controller is provided to regulate the pump as a function of variations in pressure generated in the second compartment. The controller is configured to receive signals from the sensor and to cause, through the pump, at least two successive pressure variations, having opposite directions, in the second compartment so as to adjust said position of the membrane between a wall of the casing bounding the first compartment and a wall of the casing bounding the second compartment.

摘要翻译： 液体处理装置包括对气体压力变化敏感的并且产生指示感测压力的信号的传感器。 该装置还包括通过柔性膜分成第一隔室和第二隔室的壳体，第一隔室具有用于引入液体的至少一个孔，并且第二隔室以密封方式连接到压力传感器。 提供泵以改变第二隔室中的气体量，并且提供控制器以根据在第二隔室中产生的压力变化来调节泵。 控制器被配置为从传感器接收信号并且通过泵在第二隔室中引起具有相反方向的至少两个连续的压力变化，以便调节膜的位于封套的壳体的壁之间的位置 第一隔室和围绕第二隔室的壳体的壁。

公开(公告)号：US5318511A

公开(公告)日：1994-06-07

申请号：US831536

申请日：1992-02-05

申请人： Jean-Claude Riquier ,  Jacques Chevallet

发明人： Jean-Claude Riquier ,  Jacques Chevallet

IPC分类号： A61M1/14 ,  A61M1/30 ,  A61M1/36 ,  A61M1/03

CPC分类号： A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/306 ,  A61M1/3639 ,  A61M2205/3382 ,  A61M2205/3386

摘要： A single needle extracorporeal blood circuit for connection to a blood treatment device includes an arterial portion having an arterial reservoir, an end for connection to the needle, an end for connection to the blood treatment device, and a first valve for flow communicating the needle with the arterial reservoir. The blood circuit also includes a venous portion having a venous reservoir, an end for connection to the blood treatment device, an end for connection to the needle, and a second valve for flow communicating the needle with the venous reservoir. Detectors monitor quantities of liquid in the arterial and venous reservoirs so that the first valve is opened in response to the presence of a first predetermined quantity of liquid in the arterial reservoir or a second predetermined quantity of liquid in the venous reservoir. Similarly, the second valve is opened in response to the presence of either a third predetermined quantity of liquid in the arterial reservoir or a fourth predetermined quantity of liquid in the venous reservoir.

摘要翻译： 用于连接到血液处理装置的单针体外血液回路包括具有动脉储存器的动脉部分，用于连接到针的端部，用于连接到血液处理装置的端部，以及用于使针与第 动脉血管。 血液循环还包括具有静脉储存器的静脉部分，用于连接到血液处理装置的端部，用于连接到针头的端部以及用于使针与静脉储存器连通的第二阀。 检测器监测动脉和静脉储存器中的液体的量，使得响应于在动脉储存器中存在第一预定量的液体或在静脉储存器中存在第二预定量的液体来打开第一阀。 类似地，响应于在动脉储存器中存在第三预定量的液体或静脉储存器中的第四预定量的液体，第二阀打开。

公开(公告)号：US4923613A

公开(公告)日：1990-05-08

申请号：US192657

申请日：1988-05-11

申请人： Jacques Chevallet

发明人： Jacques Chevallet

IPC分类号： A61M1/14 ,  A61M1/16

CPC分类号： A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/1617

摘要： A method for determining the blood sodium level of a patient whose blood circulates through one compartment of an exchanger separated from a dialysis fluid by a semipermeable membrane, wherein the conductivity of the dialysis fluid of equilibrium with the plasma is determined by: changing in a selected manner the conductivity of the dialysis fluid at inflow the exchanger, measuring the conductivity of the dialysis fluid at outflow from the exchanger, determining a lag time t.sub.L of the change in conductivity of dialysis fluid between inflow to and outflow from the exchanger, and determining an equilibrium conductivity value of the dialysis fluid for which the conductivity at outflow from the exchanger at an instant t is equal to the conductivity at inflow at an instant t-t.sub.L. The invention also relates to an artificial kidney incorporating means for carrying out this method.

摘要翻译： 一种用于确定血液通过半透膜从透析液分隔开的交换器的一个隔室循环的患者的血液钠水平的方法，其中与血浆的平衡的透析液的电导率通​​过以下方式确定： 测量透析液在从交换器流出时的电导率，确定透析流体在从交换器流入和流出之间的电导率变化的滞后时间t L，并确定透析流体在流过交换器时的电导率; 在时刻t从交换器流出的电导率等于在瞬间t-tL流入时的电导率的透析液的平衡电导率值。 本发明还涉及一种包含用于实施该方法的装置的人造肾。

公开(公告)号：US4889635A

公开(公告)日：1989-12-26

申请号：US42878

申请日：1987-04-24

申请人： Jacques Chevallet

发明人： Jacques Chevallet

IPC分类号： A61M1/14 ,  A61M1/16

CPC分类号： A61M1/16 ,  A61M1/165

摘要： The invention relates to an artificial kidney for controlling and maintaining parity of the entering and emerging quantities in the dialysis liquid circuit. The artificial kidney comprises a dialysis liquid circuit having on either side of the haemodialyser a sensor capable of measuring the quantity of the circulating liquid and a pump for displacing the said dialysis liquid. A microprocessor controller for comparing the quantities of liquid circulating in the upline sensor with the quantities of liquid circulating in the downline sensor, the controller is used for maintaining the quantities of liquid circulating in the upline sensor equal to the quantities of liquid circulating in the downline sensor, during the same period, by subjecting the operation of the pump for displacing the dialysis liquid to the result of the comparison determined by the controller.

摘要翻译： 本发明涉及一种人造肾，用于控制和维持透析液体回路中进入和出现量的奇偶性。 人造肾包括透析液回路，其在血液透析器的任一侧具有能够测量循环液体的量的传感器和用于移动所述透析液体的泵。 一个微处理器控制器，用于将在上行传感器中循环的液体量与在下行传感器中循环的液体量进行比较，该控制器用于保持在上行传感器中循环的液体量等于在下行线中循环的液体量 传感器，在同一时期，通过使泵的操作使透析液移动到由控制器确定的比较结果。