公开(公告)号：US20050256083A1

公开(公告)日：2005-11-17

申请号：US10844647

申请日：2004-05-12

Applicant: Chin-Ming Chang ,  James Chang ,  Robert Lyons

Inventor： Chin-Ming Chang ,  James Chang ,  Robert Lyons

IPC: A61K31/573 ,  A61K31/724

CPC classification number: A61K31/573 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/19 ,  A61K31/724 ,  A61K47/12 ,  A61K47/18 ,  A61K47/6951 ,  B82Y5/00 ,  Y02A50/473 ,  Y10S514/912 ,  Y10S514/914 ,  Y10S514/97 ,  A61K2300/00

Abstract: A composition comprising a cyclodextrin, a guanidine-based cationic compound, and sorbic acid is disclosed herein. Preservatives and methods related thereto, and experimental results suggesting certain advantages related to these compositions, preservatives, and methods are also presented herein.

Abstract translation: 本文公开了包含环糊精，基于胍的阳离子化合物和山梨酸的组合物。 与此相关的防腐剂和方法以及提示与这些组合物，防腐剂和方法相关的某些优点的实验结果也在本文中给出。

公开(公告)号：US06958880B2

公开(公告)日：2005-10-25

申请号：US10679523

申请日：2003-10-06

Applicant: Lucas Lee ,  YuNang Zai ,  James Chang ,  JiaHong Shu ,  PeiKoh Lee

Inventor： Lucas Lee ,  YuNang Zai ,  James Chang ,  JiaHong Shu ,  PeiKoh Lee

IPC: G11B21/02 ,  G11B21/22

CPC classification number: G11B21/22

Abstract: A device for detecting an actuator assembly parking error when a disc drive is powered on includes a magnetic latch attached to the actuator assembly and a latch pin assembly electrically connected to a base plate in the disc drive, where the latch pin assembly is positioned to contact the magnetic latch only when the actuator's read/write head is positioned over a parking zone on the disc. A detection module is electrically connected to the magnetic latch and thus is able to detect whether or not the magnetic latch is contacting the latch pin assembly when the disc drive is powered on. A method for detecting an actuator assembly parking error includes powering on the disc drive, determining whether the magnetic latch has electrical contact with the latch pin assembly, and reporting a parking error if the magnetic latch does not have electrical contact with the latch pin assembly.

Abstract translation: 一种用于在盘驱动器通电时检测致动器组件停车误差的装置包括附接到致动器组件的磁性闩锁和电连接到盘驱动器中的基板的闩锁销组件，其中闩锁销组件定位成接触 只有当执行器的读/写头位于光盘上的停放区域上时，磁锁才能使用。 检测模块电连接到磁性闩锁，因此当磁盘驱动器通电时，能够检测磁性闩锁是否接触闩锁销组件。 用于检测致动器组件停车误差的方法包括对磁盘驱动器供电，确定磁性闩锁是否与闩锁销组件电接触，以及如果磁性闩锁没有与闩锁销组件电接触则报告停车误差。

公开(公告)号：US20050234018A1

公开(公告)日：2005-10-20

申请号：US10826843

申请日：2004-04-15

Applicant: Robert Lyons ,  Chin-Ming Chang ,  Joan-En Chang-Lin ,  James Chang ,  Orest Olejnik

Inventor： Robert Lyons ,  Chin-Ming Chang ,  Joan-En Chang-Lin ,  James Chang ,  Orest Olejnik

IPC: A61K9/00 ,  A61K31/00 ,  A61K31/57 ,  A61K31/573 ,  A61K31/724 ,  A61K47/38 ,  A61K47/40

CPC classification number: A61K9/0014 ,  A61K9/0048 ,  A61K31/57 ,  A61K31/573 ,  A61K31/724 ,  A61K47/38 ,  A61K47/40

Abstract: Disclosed herein are methods of delivering drugs or therapeutically active agents to the back of the eye via topical administration of compositions comprising cyclodextrin derivatives. Compositions related thereto are also disclosed herein.

Abstract translation: 本文公开了通过局部施用包含环糊精衍生物的组合物将药物或治疗活性剂递送至眼睛后部的方法。 本文还公开了与其相关的组合物。

公开(公告)号：US20050101582A1

公开(公告)日：2005-05-12

申请号：US10966764

申请日：2004-10-14

Applicant: Robert Lyons ,  James Chang ,  John Trogden ,  Scott Whitcup

Inventor： Robert Lyons ,  James Chang ,  John Trogden ,  Scott Whitcup

IPC: A61K9/00 ,  A61K31/573 ,  A61K47/36

CPC classification number: A61K31/58 ,  A61K9/0048 ,  A61K31/573 ,  A61K47/36

Abstract: Compositions, and methods of using such compositions, useful for injection into the posterior segments of human or animal eyes are provided. Such compositions include corticosteroid component-containing particles present in a therapeutically effective amount, a viscosity inducing component, and an aqueous carrier component. The compositions have viscosities of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity is in the range of from about 140,000 cps to about 300,000 cps. The compositions advantageously suspend the particles for prolonged periods of time.

Abstract translation: 提供了组合物和使用这种组合物的方法，其可用于注射到人或动物眼睛的后段中。 这样的组合物包括以治疗有效量存在的含皮质类固醇成分的颗粒，粘度诱导组分和水性载体组分。 组合物在0.1 /秒的剪切速率下具有至少约10cps或约100cps的粘度。 在优选的实施方案中，粘度在约140,000cps至约300,000cps的范围内。 组合物有利地将颗粒悬浮长时间。

公开(公告)号：US06568981B1

公开(公告)日：2003-05-27

申请号：US09499792

申请日：2000-02-08

Applicant: James Chang

Inventor： James Chang

IPC: A63H3304

CPC classification number: A63H33/048 ,  Y10S446/901 ,  Y10T24/27 ,  Y10T24/2708

Abstract: A construction piece covered at least partially with display loop fabric and having one or more double sided hook-surfaced tabs removably affixed to said fabric so as to permit the attachment of one construction piece to another.

Abstract translation: 至少部分地用显示环织物覆盖的结构件，并且具有一个或多个可移除地固定到所述织物上的双面钩表面突起，以允许将一个结构件附接到另一个。

公开(公告)号：US07942654B2

公开(公告)日：2011-05-17

申请号：US11833493

申请日：2007-08-03

Applicant: James Chang

Inventor： James Chang

IPC: F04B43/08 ,  F04B43/12 ,  F04B45/06

CPC classification number: F04B43/1292 ,  F04B43/0072 ,  F04B43/0081

Abstract: The present invention provides an addressable multi-channel peristaltic pump. According to the invention, this pump design allows for selection and operation of one or more pump heads on a drive shaft, while locking other non-selected pump heads in a stationary position. It is possible to operate the multi-channel pump using a limited number of motors, preferably two motors: a selector motor and a dispense motor. Thus, the pump provides for pumping or dispensing of one or more fluids without the need for multiple pumps. Likewise, compared with typical single motor multi-channel systems, where all pump heads on the drive shaft must rotate at the same time, the present invention provides for selective dispensing of one or more fluids. The pumps of the present invention are suitable for any multiple fluid transfer application, including in automated multi-channel reagent dispensing systems, such as nucleic acid purification systems.

Abstract translation: 本发明提供一种可寻址的多通道蠕动泵。 根据本发明，该泵设计允许在驱动轴上选择和操作一个或多个泵头，同时将其它未选择的泵头锁定在静止位置。 可以使用有限数量的电动机，优选两个电动机来操作多通道泵：选择器电动机和分配电动机。 因此，泵提供一个或多个流体的泵送或分配，而不需要多个泵。 同样，与典型的单电动机多通道系统相比，驱动轴上的所有泵头必须同时旋转，本发明提供了一种或多种流体的选择性分配。 本发明的泵适用于任何多种流体转移应用，包括在自动多通道试剂分配系统中，例如核酸纯化系统。

公开(公告)号：US20070299004A1

公开(公告)日：2007-12-27

申请号：US11897177

申请日：2007-08-28

Applicant: Andrew Acheampong ,  Diane Tang-Liu ,  James Chang ,  David Power

Inventor： Andrew Acheampong ,  Diane Tang-Liu ,  James Chang ,  David Power

IPC: A61K38/13 ,  A61P27/02

CPC classification number: A61K38/13 ,  A61K9/0048 ,  A61K9/107 ,  A61K47/02 ,  A61K47/10 ,  A61K47/22 ,  A61K47/32 ,  A61K47/44

Abstract: Methods of treating an eye of a human or animal include administering to an eye of a human or animal a composition in the form of an emulsion including water, a hydrophobic component and a cyclosporin component in a therapeutically effective amount of less than 0.1% by weight of the composition. The weight ratio of the cyclosporin component to the hydrophobic component is less than 0.8.

Abstract translation: 治疗人或动物眼睛的方法包括向人或动物眼睛施用包含水，疏水组分和环孢菌素组分的乳液形式的组合物，其治疗有效量小于0.1重量％ 的组成。 环孢菌素组分与疏水组分的重量比小于0.8。

公开(公告)号：US20070087962A1

公开(公告)日：2007-04-19

申请号：US11470923

申请日：2006-09-07

Applicant: Walter Tien ,  Richard Graham ,  James Chang

Inventor： Walter Tien ,  Richard Graham ,  James Chang

IPC: A61K38/13 ,  A61K31/355

CPC classification number: A61K38/13 ,  A61K31/355

Abstract: A liquid comprising a therapeutically effective concentration of a cyclosporin and a vitamin E tocopherol polyethylene glycol succinate, wherein said liquid is an emulsion. is disclosed herein. Methods of treating diseases or conditions using said compositions, and medicaments related thereto, are also disclosed herein.

Abstract translation: 包含治疗有效浓度的环孢菌素和维生素E生育酚聚乙二醇琥珀酸酯的液体，其中所述液体是乳液。 在此公开。 使用所述组合物治疗疾病或病症的方法及其相关药物也在本文中公开。

公开(公告)号：US20070077908A1

公开(公告)日：2007-04-05

申请号：US11393899

申请日：2006-03-31

Applicant: Pieter Vorenkamp ,  Klaas Bult ,  Frank Carr ,  Christopher Ward ,  Ralph Duncan ,  Tom Kwan ,  James Chang ,  Haideh Khorramabadi

Inventor： Pieter Vorenkamp ,  Klaas Bult ,  Frank Carr ,  Christopher Ward ,  Ralph Duncan ,  Tom Kwan ,  James Chang ,  Haideh Khorramabadi

IPC: H04B1/10 ,  H04B1/26 ,  H04N5/455

CPC classification number: H03D3/18 ,  H01F17/0006 ,  H01F17/0013 ,  H01F27/34 ,  H01F27/40 ,  H01F27/42 ,  H01F2017/0053 ,  H01F2021/125 ,  H01L23/5227 ,  H01L27/0248 ,  H01L27/0251 ,  H01L27/08 ,  H01L2924/0002 ,  H01L2924/3011 ,  H03B5/04 ,  H03B5/364 ,  H03D7/161 ,  H03D7/18 ,  H03F1/26 ,  H03F1/3211 ,  H03F3/195 ,  H03F3/45183 ,  H03F3/45188 ,  H03F3/68 ,  H03F3/72 ,  H03F2200/111 ,  H03F2200/294 ,  H03F2200/372 ,  H03F2200/447 ,  H03F2200/63 ,  H03F2203/45264 ,  H03F2203/45286 ,  H03G1/0023 ,  H03G1/0029 ,  H03G3/3052 ,  H03H7/25 ,  H03H11/04 ,  H03H11/1291 ,  H03H11/53 ,  H03H11/54 ,  H03H19/004 ,  H03J1/0075 ,  H03J3/04 ,  H03J3/08 ,  H03J3/185 ,  H03J2200/10 ,  H03L7/10 ,  H03L7/183 ,  H03L7/23 ,  H03L2207/06 ,  H01L2924/00

Abstract: An integrated receiver with channel selection and image rejection substantially implemented on a single CMOS integrated circuit is described. A receiver front end provides programable attenuation and a programable gain low noise amplifier. Frequency conversion circuitry advantageously uses LC filters integrated onto the substrate in conjunction with image reject mixers to provide sufficient image frequency rejection. Filter tuning and inductor Q compensation over temperature are performed on chip. The filters utilize multi track spiral inductors. The filters are tuned using local oscillators to tune a substitute filter, and frequency scaling during filter component values to those of the filter being tuned. In conjunction with filtering, frequency planning provides additional image rejection. The advantageous choice of local oscillator signal generation methods on chip is by PLL out of band local oscillation and by direct synthesis for in band local oscillator. The VCOs in the PLLs are centered using a control circuit to center the tuning capacitance range. A differential crystal oscillator is advantageously used as a frequency reference. Differential signal transmission is advantageously used throughout the receiver.

Abstract translation: 描述了基本上在单个CMOS集成电路上实现的具有信道选择和图像抑制的集成接收机。 接收机前端提供可编程衰减和可编程增益低噪声放大器。 频率转换电路有利地使用集成到衬底上的LC滤波器与图像抑制混合器结合，以提供足够的图像频率抑制。 过滤器调谐和电感Q补偿温度在芯片上执行。 滤波器采用多轨螺旋电感。 使用本地振荡器调整滤波器以调整替代滤波器，以及滤波器组件值期间的频率缩放与被调谐的滤波器的频率缩放。 结合滤波，频率规划提供了额外的镜像抑制。 片上本地振荡器信号产生方法的有利选择是通过PLL带外本地振荡和通过频带本地振荡器的直接合成。 PLL中的VCO使用控制电路居中，使调谐电容范围居中。 差分晶体振荡器有利地用作频率参考。 差分信号传输有利地用于整个接收机。

公开(公告)号：US20070015694A1

公开(公告)日：2007-01-18

申请号：US11255821

申请日：2005-10-19

Applicant: James Chang ,  Orest Olejnik ,  Bruce Firestone

Inventor： James Chang ,  Orest Olejnik ,  Bruce Firestone

IPC: A61K38/13 ,  A61K36/47

CPC classification number: A61K38/13 ,  A61K9/0048 ,  A61K9/1075 ,  A61K36/00 ,  A61K47/44 ,  Y10S514/912 ,  Y10S514/975 ,  A61K2300/00

Abstract: A composition is disclosed herein comprising from about 0.001% to about 0.4% cyclosporin A, castor oil, and a surfactant selected from the group consisting of alcohol ethoxylates, alcohols, alkyl glycosides, alkyl polyglycosides, alkylphenol ethoxylates, amine oxides, block polymers, carboxylated alcohol or alkylphenol ethoxylates, carboxylic adds/fatty acids, cellulose derivatives, ethoxylated alcohols, ethoxylated alkylphenols, ethoxylated aryl phenols, ethoxylated fatty acids, ethoxylated fatty acids, ethoxylated fatty esters and oils, fatty alcohols, fatty esters, glycol esters, lanolin-based derivatives, lecithin and lecithin derivatives, lignin and lignin derivatives, methyl esters, monoglycerides and derivatives, phosphalipids, polyacrylic acids, polyethylene glycols, polyethylene oxide-polypropylene oxide copolymers, polyethylene oxides, polymeric surfactants, polypropylene oxides, propoxylated alcohols, propoxylated alkyl phenols, propoxylated fatty acids, protein-based surfactants, sarcosine derivatives, silicone-based surfactants, sorbitan derivatives, stearates, sucrose and glucose esters and derivatives, and combinations thereof.

Abstract translation: 本文公开了一种组合物，其包含约0.001％至约0.4％的环孢菌素A，蓖麻油和选自醇乙氧基化物，醇，烷基糖苷，烷基多糖苷，烷基酚乙氧基化物，氧化胺，嵌段聚合物，羧化的 醇或烷基酚乙氧基化物，羧酸添加物/脂肪酸，纤维素衍生物，乙氧基化醇，乙氧基化烷基酚，乙氧基化芳基酚，乙氧基化脂肪酸，乙氧基化脂肪酸，乙氧基化脂肪酯和油，脂肪醇，脂肪酯，二醇酯，羊毛脂基 衍生物，卵磷脂和卵磷脂衍生物，木质素和木质素衍生物，甲酯，单酸甘油酯和衍生物，磷脂，聚丙烯酸，聚乙二醇，聚环氧乙烷 - 聚氧丙烯共聚物，聚环氧乙烷，聚合物表面活性剂，聚环氧丙烷，丙氧基化醇，丙氧基化烷基酚， 丙氧基化脂肪酸，蛋白质类表面活性剂 鞣剂，肌氨酸衍生物，硅氧烷基表面活性剂，脱水山梨糖醇衍生物，硬脂酸盐，蔗糖和葡萄糖酯及其衍生物及其组合。