Biologic device for regulation of gene expression and method therefor
    53.
    发明申请
    Biologic device for regulation of gene expression and method therefor 审中-公开
    用于调节基因表达的生物装置及其方法

    公开(公告)号:US20070036770A1

    公开(公告)日:2007-02-15

    申请号:US11272432

    申请日:2005-11-10

    IPC分类号: A61K48/00 G06F19/00 C12N15/86

    摘要: A system and device are provided which include a gene regulatory system controlling expression of one or more expression cassettes present in or released by the device, by emitting one or more stimulations. An expression cassette includes a regulatable transcription control element that is responsive to the emitted stimulations linked to an open reading frame of interest. The system optionally includes a sensor to sense a parameter indicative of a need, a telemetry module to receive an external command, or a programmable device, for regulating gene expression of the open reading frame.

    摘要翻译: 提供了一种系统和装置,其包括通过发射一种或多种刺激来控制存在于或释放的装置中的一种或多种表达盒的表达的基因调控系统。 表达盒包括可调节的转录控制元件,其响应于与感兴趣的开放阅读框架相关联的发射刺激。 该系统可选地包括用于感测指示需要的参数的传感器,用于接收外部命令的遥测模块或用于调节开放阅读框的基因表达的可编程设备。

    Method and apparatus to modulate cellular regeneration post myocardial infarct
    56.
    发明申请
    Method and apparatus to modulate cellular regeneration post myocardial infarct 失效
    调节心肌梗塞后细胞再生的方法和装置

    公开(公告)号:US20050288721A1

    公开(公告)日:2005-12-29

    申请号:US10862716

    申请日:2004-06-07

    摘要: A system delivers cardiac pacing therapy and chemical and/or biological therapy to modulate myocardial tissue growth in a heart after myocardial infarction (MI). The system includes an agent delivery device to release one or more agents to an MI region to modulate myocardial tissue growth in that region, and a cardiac rhythm management (CRM) device to deliver pacing pulses to enhance the effects of the one or more agents by altering myocardial wall stress and cardiac workload. In one embodiment, the system is an implantable system including an implantable agent delivery device and an implantable CRM device.

    摘要翻译: 系统提供心脏起搏治疗和化学和/或生物治疗以调节心肌梗塞(MI)后心脏中的心肌组织生长。 该系统包括用于将一个或多个药剂释放到MI区域以调节该区域中的心肌组织生长的药剂递送装置,以及心律管理(CRM)装置,以递送起搏脉冲以增强一种或多种药剂的作用 改变心肌壁压力和心脏工作量。 在一个实施例中,该系统是包括可植入剂递​​送装置和可植入CRM装置的可植入系统。

    Diagnosing and treating cancer
    57.
    发明申请
    Diagnosing and treating cancer 审中-公开
    诊断和治疗癌症

    公开(公告)号:US20050202020A1

    公开(公告)日:2005-09-15

    申请号:US11027954

    申请日:2004-12-30

    摘要: Methods for treating or diagnosing cancers of the female reproductive tract and childhood cancers are disclosed. The methods described herein use binding agents, e.g., antibodies, specific for the extracellular domain of human prostate specific membrane antigen (PSMA).

    摘要翻译: 公开了治疗或诊断女性生殖道和儿童期癌症的方法。 本文描述的方法使用对人前列腺特异性膜抗原(PSMA)的细胞外结构域特异的结合剂,例如抗体。

    c-myc coding region determinant-binding protein (CRD-BP) and its nucleic acid sequence
    58.
    发明授权
    c-myc coding region determinant-binding protein (CRD-BP) and its nucleic acid sequence 失效
    c-myc编码区决定簇结合蛋白(CRD-BP)及其核酸序列

    公开(公告)号:US06794151B2

    公开(公告)日:2004-09-21

    申请号:US09873637

    申请日:2001-06-04

    申请人: Jeffrey Ross

    发明人: Jeffrey Ross

    IPC分类号: G01N33574

    摘要: A method of diagnosing the presence or absence of cancer in a human patient is disclosed. In one embodiment, this method comprises the steps of examining patient tissue for the CRD-BP expression levels and comparing that expression level with control levels. The present invention is also a method of inhibiting cancer cell growth comprising the step of eliminating or lowering the level of functional CRD-BP in the cancerous tissues.

    摘要翻译: 公开了一种在人类患者中诊断癌症存在或不存在的方法。 在一个实施方案中,该方法包括检查患者组织的CRD-BP表达水平并将该表达水平与对照水平进行比较的步骤。 本发明也是抑制癌细胞生长的方法,包括消除或降低癌组织中功能性CRD-BP水平的步骤。