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    Growth arrest specific gene 6 peptides, antibodies, compositions, methods and uses
    52.
    发明授权
    Growth arrest specific gene 6 peptides, antibodies, compositions, methods and uses 有权
    生长停滞特异性基因6肽，抗体，组合物，方法和用途

    公开(公告)号：US07547767B2

    公开(公告)日：2009-06-16

    申请号：US11602865

    申请日：2006-11-21

    申请人： Jing Yang ,  George Heavner ,  Robert Jordan ,  Jill Giles-Komar ,  Ray Sweet

    发明人： Jing Yang ,  George Heavner ,  Robert Jordan ,  Jill Giles-Komar ,  Ray Sweet

    IPC分类号： C07K16/46

    CPC分类号： C07K14/745 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/76

    摘要： The present invention provides novel proteins and peptides from the receptor binding region of human Growth Arrest Specific Gene 6 (Gas6) and antibodies, including specified portions or variants, specific for at least one such Gas6 peptide or fragment thereof. The aforesaid peptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-Gas6 antibodies. The invention also provides for the nucleic acids encoding such peptides and anti-Gas6 antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, including therapeutic formulations, administration and devices. Fifteen novel peptide sequences from the Gas6 G domain that are implicated in Gas6 interactions with its receptors are identified, isolated, and synthesized so as to allow generation of anti-Gas6 antibodies. The peptide sequences include three ESTs that encompass regions predicted to contribute to receptor binding or that can raise anti-Gas6 antibodies. This invention provides for such antibodies to be used in modulating or treating at least one Gas6-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, thromboembolic disease, ischemic disease, venous thromboembolism, arterial or venous thrombosis, pulmonary embolism, restenosis, diabetic angiopathy and allograft atherosclerosis.

    摘要翻译： 本发明提供了来自人生长抑制特异性基因6（Gas6）的受体结合区的新型蛋白质和肽，以及对至少一种这样的Gas6肽或其片段特异的包括特定部分或变体的抗体。 上述肽可用于产生人，灵长类动物，啮齿动物，哺乳动物，嵌合，人源化和/或CDR移植的抗Gas6抗体。 本发明还提供了编码这些肽和抗Gas6抗体的核酸，互补核酸，载体，宿主细胞，以及制备和使用它们的方法，包括治疗制剂，给药和装置。 鉴定，分离和合成来自Gas6G结构域的15个新的肽序列，其与其受体相关的Gas6相互作用，以便产生抗Gas6抗体。 肽序列包括三个EST，其包含预期有助于受体结合的区域或可产生抗Gas6抗体。 本发明提供这样的抗体用于调节或治疗细胞，组织，器官，动物或患者中的至少一种Gas6相关疾病。 这些疾病可以包括但不限于血栓栓塞性疾病，缺血性疾病，静脉血栓栓塞，动脉或静脉血栓形成，肺栓塞，再狭窄，糖尿病性血管病和同种异体移植动脉粥样硬化。

    Data processing system for a multi-function device
    53.
    发明授权
    Data processing system for a multi-function device 有权
    用于多功能设备的数据处理系统

    公开(公告)号：US07336972B2

    公开(公告)日：2008-02-26

    申请号：US10809411

    申请日：2004-03-26

    申请人： Hiroshi Morisaki ,  Jing Yang

    发明人： Hiroshi Morisaki ,  Jing Yang

    IPC分类号： H04B1/38

    CPC分类号： H04N1/00204 ,  H04N2201/001 ,  H04N2201/0067

    摘要： To enable a main terminal device to implement specific functions in cooperation with a sub terminal device, when a fax machine serving as the main terminal device stores conversion request data in a shared area of its RAM (S130), a personal computer serving as the sub terminal device generates converted image data based on the conversion request data stored on the fax machine end and stores the resulting data on the fax machine end. Subsequently, the fax machine reads the converted image data stored by the personal computer and transmits this image data. In this way, the fax machine can direct the personal computer to execute part of the process simply by storing request data in a shared area of the RAM, thereby transmitting converted image data in cooperation with the personal computer.

    摘要翻译： 为了使主终端装置与子终端装置协同实现特定的功能，当用作主终端装置的传真机将转换请求数据存储在其RAM的共享区域中时（S130），作为 子终端设备基于存储在传真机端的转换请求数据生成转换的图像数据，并将结果数据存储在传真机端。 随后，传真机读取由个人计算机存储的转换的图像数据并发送该图像数据。 以这种方式，传真机可以通过将请求数据存储在RAM的共享区域中来指导个人计算机执行部分处理，从而与个人计算机协作传送转换的图像数据。

    Trajectory estimation apparatus, method, and medium for estimating two-dimensional trajectory of gesture
    54.
    发明申请
    Trajectory estimation apparatus, method, and medium for estimating two-dimensional trajectory of gesture 审中-公开
    用于估计手势二维轨迹的轨迹估计装置，方法和介质

    公开(公告)号：US20070171202A1

    公开(公告)日：2007-07-26

    申请号：US11651531

    申请日：2007-01-10

    申请人： Jing Yang ,  Dong-yoon Kim ,  Won-chul Bang

    发明人： Jing Yang ,  Dong-yoon Kim ,  Won-chul Bang

    IPC分类号： G09G5/08

    CPC分类号： G06F3/0346

    摘要： A trajectory estimation apparatus, method, and medium using a triaxial accelerometer are provided. The trajectory estimation apparatus includes a motion sensing module which measures an acceleration component for each of three axes from the input 3D gesture using a triaxial accelerometer, a gravitational component removal module which calculates a gravitational acceleration component and removes the gravitational acceleration component from the acceleration component, a gesture determination module which identifies gesture type represented by an acceleration component obtained as the result of the removal performed by the gravitational component removal module, and a compensation module which compensates for the acceleration component obtained as the result of the removal performed by the gravitational component removal module by using different compensation methods for different gesture types.

    摘要翻译： 提供了使用三轴加速度计的轨迹估计装置，方法和介质。 轨迹估计装置包括运动感测模块，该运动感测模块使用三轴加速度计从输入3D手势测量三个轴中的每一个的加速度分量，重力分量去除模块，其计算重力加速度分量并从加速分量中去除重力加速度分量 手势确定模块，其识别由作为由重力分量去除模块执行的去除结果而获得的加速度分量表示的手势类型;以及补偿模块，其补偿作为重力结果执行的结果获得的加速度分量 通过使用不同的手势类型的不同的补偿方法来实现元件移除模块。

    Growth arrest specific gene 6 peptides, antibodies, compositions, methods and uses
    56.
    发明申请
    Growth arrest specific gene 6 peptides, antibodies, compositions, methods and uses 有权
    生长停滞特异性基因6肽，抗体，组合物，方法和用途

    公开(公告)号：US20070128200A1

    公开(公告)日：2007-06-07

    申请号：US11602865

    申请日：2006-11-21

    申请人： Jing Yang ,  George Heavner ,  Robert Jordan ,  Jill Giles-Komar ,  Ray Sweet

    发明人： Jing Yang ,  George Heavner ,  Robert Jordan ,  Jill Giles-Komar ,  Ray Sweet

    IPC分类号： A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C12N5/06 ,  C12N1/21

    CPC分类号： C07K14/745 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/76

    摘要： The present invention provides novel proteins and peptides from the receptor binding region of human Growth Arrest Specific Gene 6 (Gas6) and antibodies, including specified portions or variants, specific for at least one such Gas6 peptide or fragment thereof. The aforesaid peptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-Gas6 antibodies. The invention also provides for the nucleic acids encoding such peptides and anti-Gas6 antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, including therapeutic formulations, administration and devices. Fifteen novel peptide sequences from the Gas6 G domain that are implicated in Gas6 interactions with its receptors are identified, isolated, and synthesized so as to allow generation of anti-Gas6 antibodies. The peptide sequences include three ESTs that encompass regions predicted to contribute to receptor binding or that can raise anti-Gas6 antibodies. This invention provides for such antibodies to be used in modulating or treating at least one Gas6-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, thromboembolic disease, ischemic disease, venous thromboembolism, arterial or venous thrombosis, pulmonary embolism, restenosis, diabetic angiopathy and allograft atherosclerosis.

    摘要翻译： 本发明提供了来自人生长抑制特异性基因6（Gas6）的受体结合区的新型蛋白质和肽，以及对至少一种这样的Gas6肽或其片段特异的包括特定部分或变体的抗体。 上述肽可用于产生人，灵长类动物，啮齿动物，哺乳动物，嵌合，人源化和/或CDR移植的抗Gas6抗体。 本发明还提供了编码这些肽和抗Gas6抗体的核酸，互补核酸，载体，宿主细胞，以及制备和使用它们的方法，包括治疗制剂，给药和装置。 鉴定，分离和合成来自Gas6G结构域的15个新的肽序列，其与其受体相关的Gas6相互作用，以便产生抗Gas6抗体。 肽序列包括三个EST，其包含预期有助于受体结合的区域或可产生抗Gas6抗体。 本发明提供这样的抗体用于调节或治疗细胞，组织，器官，动物或患者中的至少一种Gas6相关疾病。 这些疾病可以包括但不限于血栓栓塞性疾病，缺血性疾病，静脉血栓栓塞，动脉或静脉血栓形成，肺栓塞，再狭窄，糖尿病性血管病和同种异体移植动脉粥样硬化。

    User interface method, medium, and apparatus with gesture-recognition
    58.
    发明申请
    User interface method, medium, and apparatus with gesture-recognition 有权
    用户界面方法，媒体和手势识别装置

    公开(公告)号：US20060177112A1

    公开(公告)日：2006-08-10

    申请号：US11342968

    申请日：2006-01-31

    申请人： Jing Yang ,  Dongyoon Kim

    发明人： Jing Yang ,  Dongyoon Kim

    IPC分类号： G06K9/00 ,  G09G5/00

    CPC分类号： G06F3/017 ,  G06F3/0346

    摘要： A user interface method, medium, and apparatus with gesture-recognition. The user interface method may include measuring acceleration of a gesture-recognition based input device while a writing gesture is performed, e.g., in the air, using the gesture-recognition based input device to generate acceleration signals, and determining whether the gesture-recognition based input device is operated in a predetermined gesture range from a time period when the writing gesture is made, or the acceleration signals, to generate warnings when the gesture-recognition based input device deviates the predetermined gesture range.

    摘要翻译： 具有手势识别的用户界面方法，媒介和装置。 用户界面方法可以包括在执行写入手势时测量基于手势识别的输入装置的加速度，例如在空中，使用基于手势识别的输入装置来产生加速度信号，以及确定基于姿势识别的 输入装置在从作出写入手势的时间段的预定手势范围或加速度信号中进行操作，以在基于手势识别的输入装置偏离预定手势范围时产生警告。

    Methods of diagnosing, preventing and treating cancer metastasis
    60.
    发明授权
    Methods of diagnosing, preventing and treating cancer metastasis 失效
    诊断，预防和治疗癌症转移的方法

    公开(公告)号：US08568998B2

    公开(公告)日：2013-10-29

    申请号：US13309067

    申请日：2011-12-01

    申请人： Sendurai Mani ,  Jing Yang ,  Robert A. Weinberg

    发明人： Sendurai Mani ,  Jing Yang ,  Robert A. Weinberg

    IPC分类号： G01N33/574 ,  A61K49/00

    CPC分类号： G01N33/57492 ,  C12N2799/027 ,  C12N2799/06 ,  G01N33/5011

    摘要： The invention relates to methods and compositions for inhibiting metastasis, such as by inhibiting FOXC2 expression or activity. The invention further relates to methods of prognosticating, diagnosing, and assisting in the diagnosis of metastasis in an individual, or of determining the metastatic potential of a tumor. The invention further relates to methods of identifying agents which inhibit metastasis.

    摘要翻译： 本发明涉及抑制转移的方法和组合物，例如通过抑制FOXC2表达或活性。 本发明还涉及预测，诊断和辅助个体中转移的诊断或确定肿瘤的转移潜力的方法。 本发明还涉及鉴定抑制转移的药物的方法。