利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

62 条记录 (耗时 0.032 秒)

    4-Hydroxy-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxides and salts thereof
    51.
    发明授权
    4-Hydroxy-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxides and salts thereof 失效
    4-羟基-2H-萘并（{2,1-e {9-1,2-噻嗪-3-甲酰胺-1,1-二氧化物及其盐

    公开(公告)号：US3992535A

    公开(公告)日：1976-11-16

    申请号：US626623

    申请日：1975-10-29

    申请人： Gunter Trummlitz ,  Helmut Teufel ,  Wolfhard Engel ,  Ernst Seeger ,  Walter Haarmann ,  Gunther Engelhardt

    发明人： Gunter Trummlitz ,  Helmut Teufel ,  Wolfhard Engel ,  Ernst Seeger ,  Walter Haarmann ,  Gunther Engelhardt

    IPC分类号： C07D275/06 ,  C07D279/02 ,  C07D417/12 ,  C07D513/04 ,  A61K31/54

    CPC分类号： C07D275/06 ,  C07D279/02

    摘要： Compounds of the formula ##SPC1##WhereinR.sub.1 is hydrogen, methyl or ethyl, andAr is phenyl, 3-chlorophenyl, 3-bromophenyl, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 3-tolyl, 2-methoxyphenyl, 3-methoxyphenyl, 2-pyridyl, 4-methyl-2-pyridyl, 6-methyl-2-pyridyl, 3-hydroxy-2-pyridyl, 3-pyridyl, 4-pyridyl, 6-chloro-3-pyridazinyl, 2-pyrazinyl, 6-chloro-2-pyrazinyl, 6-chloro-4-pyrimidinyl, 2-thiazolyl, 4-methyl-2-thiazolyl, 4-ethyl-2-thiazolyl, 5-methyl-2-thiazolyl, 5-ethyl-2-thiazolyl, 4,5-dimethyl-2-thiazolyl, 4-ethyl-5-methyl-2-thiazolyl, 5-ethyl-4-methyl-2-thiazolyl, 2-benzothiazolyl, 4,5,6,7-tetrahydro-2-benzothiazolyl, 5,6-dihydro-7H-thiopyrano[4,3-d]thiazol-2-yl, 3-methyl-5-isothiazolyl, 1,3,4-thiadiazolyl, 5-methyl-1,3,4-thiadiazol-2-yl or 5-methyl-3-isoxazolyl,And non-toxic, pharmacologically acceptable salts thereof formed with an inorganic or organic base; the compounds as well as their salts are useful as inhibitors of platelet adhesion and aggregation.

    摘要翻译： 式WHERE R1的化合物是氢，甲基或乙基，Ar是苯基，3-氯苯基，3-溴苯基，2-氟苯基，3-氟苯基，4-氟苯基，3-甲苯基，2-甲氧基苯基，3-甲氧基苯基， 2-吡啶基，4-甲基-2-吡啶基，6-甲基-2-吡啶基，3-羟基-2-吡啶基，3-吡啶基，4-吡啶基，6-氯-3-哒嗪基，2-吡嗪基，6-吡啶基， 4-氯-2-吡嗪基，6-氯-4-嘧啶基，2-噻唑基，4-甲基-2-噻唑基，4-乙基-2-噻唑基，5-甲基-2-噻唑基，5-乙基-2-噻唑基， 4,5-二甲基-2-噻唑基，4-乙基-5-甲基-2-噻唑基，5-乙基-4-甲基-2-噻唑基，2-苯并噻唑基，4,5,6,7-四氢-2- 苯并噻唑基，5,6-二氢-7H-噻喃并[4,3-d]噻唑-2-基，3-甲基-5-异噻唑基，1,3,4-噻二唑基，5-甲基-1,3,4-噻二唑基， 噻二唑-2-基或5-甲基-3-异恶唑基，以及与无机或有机碱形成的非毒性，药理学上可接受的盐; 化合物作为它们的盐作为板材粘合和聚集的抑制剂有用。

    Derivatives of 4-(4-biphenylyl)-butyric acid
    57.
    发明授权
    Derivatives of 4-(4-biphenylyl)-butyric acid 失效
    4-（4-联苯基） - 丁酸的衍生物

    公开(公告)号：US4021479A

    公开(公告)日：1977-05-03

    申请号：US406196

    申请日：1973-10-15

    申请人： Ernst Seeger ,  Wolfhard Engel ,  Josef Nickl ,  Helmut Teufel

    发明人： Ernst Seeger ,  Wolfhard Engel ,  Josef Nickl ,  Helmut Teufel

    IPC分类号： C07C57/58 ,  C07C63/333 ,  C07C65/14

    CPC分类号： C07C205/56 ,  C07C57/58 ,  Y10S514/916

    摘要： Compounds of the formulas ##STR1## and ##STR2## wherein A is --CH.sub.2 -- or --CH(OH)--,R.sub.1 is hydrogen, halogen or, when R.sub.2 and R.sub.3 are other than both hydrogen, also methyl,R.sub.2 is hydrogen, halogen, cyano, nitro, amino or (alkanoyl of 1 to 4 carbon atoms)-amino,R.sub.3 is hydrogen or halogen,Provided, however, that at least one of R.sub.1, R.sub.2 and R.sub.3 is other than hydrogen, andR.sub.4 is hydrogen or alkyl of 1 to 4 carbon atoms, and non-toxic salts of the free acids (R.sub.4 = H) formed with inorganic or organic bases; the compounds as well as their salts are useful as antiphlogistics and antiproliferatives.

    摘要翻译： 其中A是-CH 2 - 或-CH（OH） - ，R 1是氢，卤素，或者当R 2和R 3不同于氢时，也是甲基，R 2是氢，卤素 ，氰基，硝基，氨基或（1至4个碳原子的烷酰基） - 氨基，R3是氢或卤素，提供，然而，至少一个R 1，R 2和R 3不是氢，并且R 4是氢或烷基 1至4个碳原子的无毒盐和无机或有机碱形成的游离酸（R4 = H）的无毒盐; 化合物及其盐可用作消炎剂和抗增殖剂。

    2-[(Amino)-aryl-methylene]-benzo[b]thiophen-3(2H)-ones
    60.
    发明授权
    2-[(Amino)-aryl-methylene]-benzo[b]thiophen-3(2H)-ones 失效
    2 - [（氨基） - 芳基 - 亚甲基] - 苯并[b]噻吩-3（2H） - 酮

    公开(公告)号：US4288437A

    公开(公告)日：1981-09-08

    申请号：US173173

    申请日：1980-07-28

    申请人： Wolfhard Engel ,  Gunter Trummlitz ,  Ernst Seeger ,  Joachim Kahling

    发明人： Wolfhard Engel ,  Gunter Trummlitz ,  Ernst Seeger ,  Joachim Kahling

    IPC分类号： A61K31/38 ,  A61K31/381 ,  A61K31/44 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P25/08 ,  C07D333/62 ,  C07D333/64 ,  C07D409/06

    CPC分类号： C07D333/62 ,  C07D333/64

    摘要： Compounds of the formula ##STR1## wherein Ar is phenyl; mono- or di-substituted phenyl, where the substituents are one to two halogens, one to two alkyls of 1 to 3 carbon atoms, or one amino, nitro, cyano or trifluoromethyl; or pyridinyl;R is hydrogen, chlorine, methyl or methoxy;R.sub.1 is hydrogen or methyl;R.sub.2 is hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, methyl-(cycloalkyl of 3 to 8 carbon atoms) or --A--R.sub.4,where A is alkylene of 2 to 3 carbon atoms, and R.sub.4 is hydroxyl, methylamino, dimethylamino, N-methyl-ethylamino, diethylamino, pyrrolidino, piperidino, hexamethyleneimino, morpholino or 4-methyl-1-piperazinyl; orR.sub.1 and R.sub.2, together with each other and the nitrogen atom to which they are attached, form a 4- to 7-membered, saturated or mono-unsaturated, unsubstituted or substituted heterocycle which may contain nitrogen, oxygen, sulfur, sulfinyl or sulfonyl as additional ring members, where the substituents are alkyls of 1 to 3 carbon atoms.The compounds are useful as anticonvulsants.

    摘要翻译： 其中Ar是苯基的式IMAMA的化合物; 单取代或二取代的苯基，其中取代基是一至两个卤素，一至二个碳原子数为1至2个的烷基，或一个氨基，硝基，氰基或三氟甲基; 或吡啶基; R是氢，氯，甲基或甲氧基; R1是氢或甲基; R2是氢，1至6个碳原子的烷基，2至6个碳原子的烯基，2至6个碳原子的炔基，3至8个碳原子的环烷基，甲基 - 3至8个碳原子的环烷基或-A -R4，其中A为2至3个碳原子的亚烷基，R4为羟基，甲基氨基，二甲基氨基，N-甲基 - 乙基氨基，二乙基氨基，吡咯烷子基，哌啶子基，六亚甲基亚氨基，吗啉代或4-甲基-1-哌嗪基; 或R 1和R 2彼此连接并与它们相连的氮原子形成可含有氮，氧，硫，亚磺酰基或磺酰基的4-至7-元饱和或单不饱和的未被取代或取代的杂环 作为另外的环成员，其中取代基是1至3个碳原子的烷基。 该化合物可用作抗惊厥药。