公开(公告)号：US08764956B2

公开(公告)日：2014-07-01

申请号：US13348168

申请日：2012-01-11

申请人： Hun-joo Lee ,  Joon-ho Kim ,  Chin-sung Park ,  Jung-im Han ,  Seung-yeon Yang ,  Shin-i Yoo

发明人： Hun-joo Lee ,  Joon-ho Kim ,  Chin-sung Park ,  Jung-im Han ,  Seung-yeon Yang ,  Shin-i Yoo

IPC分类号： B01L3/00

CPC分类号： B01L3/5027 ,  B01L2200/06

摘要： A microfluidic device for electrochemically regulating the pH of a fluid includes: an ion-exchange material; an anode chamber having a surface defined by a surface of the ion-exchange material and an anode electrode disposed along an edge of the surface of the anode chamber; and a cathode chamber having a surface defined by an opposite surface of the ion-exchange material and a cathode electrode disposed along an edge of the surface of the cathode chamber.

摘要翻译： 用于电化学调节流体pH的微流体装置包括：离子交换材料; 具有由所述离子交换材料的表面限定的表面的阳极室和沿着所述阳极室的表面的边缘设置的阳极电极; 以及阴极室，其具有由离子交换材料的相对表面限定的表面和沿着阴极室的表面的边缘设置的阴极电极。

公开(公告)号：US08524059B2

公开(公告)日：2013-09-03

申请号：US13495342

申请日：2012-06-13

申请人： Hun joo Lee ,  Jin tae Kim ,  Sung-young Jeong ,  Joon-ho Kim ,  Hee-kyun Lim

发明人： Hun joo Lee ,  Jin tae Kim ,  Sung-young Jeong ,  Joon-ho Kim ,  Hee-kyun Lim

IPC分类号： G01N27/44

CPC分类号： G05D21/02

摘要： A pH adjusting apparatus includes an electrolytic chip receiving a solution, an electrolytic chip loading station receiving the electrolytic chip, an input unit inputting electrolysis conditions, a control unit receiving the electrolysis conditions and controlling electrolysis performed in the electrolytic chip, and a display unit displaying the electrolysis conditions and a progress of the electrolysis. Thus, the pH of a solution can be adjusted easily and accurately, by precisely controlling a constant current, a constant voltage, and current and voltage application times, thereby enabling useful application in various biological assays such as cell lysis. Furthermore, the pH adjusting apparatus has small size and weight and can be operated for a long time after charging once due to low power consumption.

摘要翻译： pH调节装置包括：接收溶液的电解芯片，接收电解芯片的电解芯片装载站，输入电解条件的输入单元，接收电解条件的控制单元以及控制电解芯片中进行的电解;以及显示单元， 电解条件和电解进度。 因此，通过精确地控制恒定电流，恒定电压，电流和电压施加时间，可以容易且精确地调节溶液的pH，从而可用于各种生物测定如细胞裂解中的有用应用。 此外，pH调节装置的体积小，重量轻，能够在低功耗的情况下一次充电后长时间运转。

公开(公告)号：US08663976B2

公开(公告)日：2014-03-04

申请号：US13039630

申请日：2011-03-03

申请人： Won-seok Chung ,  Kak Namkoong ,  Joon-ho Kim

发明人： Won-seok Chung ,  Kak Namkoong ,  Joon-ho Kim

IPC分类号： C12M1/34 ,  C12M3/00

CPC分类号： B01L9/527 ,  B01L3/502715 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/147 ,  B01L2300/1827

摘要： A polymerase chain reaction (“PCR”) apparatus includes a PCR chip holder which accommodates and supports a PCR chip, a housing which supports ends of the PCR chip holder, a temperature control element which moves perpendicularly with respect to the PCR chip holder in a space between the housing and the PCR chip holder in the housing, and an elastic unit which elastically biases the temperature control element toward the PCR chip holder, between the temperature control element and the housing. The temperature control element includes a top surface which is selectively contacted to a bottom surface of the PCR chip.

摘要翻译： 聚合酶链式反应（“PCR”）装置包括：一个PCR芯片保持器，其容纳和支持PCR芯片;支撑PCR芯片保持器端部的壳体;一个相对于PCR芯片保持器垂直移动的温度控制元件 壳体和壳体中的PCR芯片保持器之间的空间以及在温度控制元件和壳体之间弹性地将温度控制元件朝向PCR芯片保持器偏置的弹性单元。 温度控制元件包括选择性地接触PCR芯片的底表面的顶表面。

公开(公告)号：US08398843B2

公开(公告)日：2013-03-19

申请号：US12913044

申请日：2010-10-27

申请人： Jung-im Han ,  Joon-ho Kim

发明人： Jung-im Han ,  Joon-ho Kim

IPC分类号： G01N27/28 ,  G01N27/40

CPC分类号： B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00828 ,  B01J2219/00853 ,  B01J2219/00862 ,  B01L3/5027

摘要： Provided is a microfluidic device for electrochemically regulating the pH of a fluid comprising: a cathode substrate; an anode substrate facing the cathode substrate and forming a reaction chamber with the cathode substrate; and a nonconductor which forms a boundary between the portions of the cathode substrate and the anode substrate that are capable of contacting one another, wherein at least one of the cathode substrate and the anode substrate is a semiconductor doped with impurities and the other is a metal electrode.

摘要翻译： 提供一种用于电化学调节流体pH的微流体装置，包括：阴极衬底; 面向阴极基板的阳极基板，并与阴极基板形成反应室; 以及形成能够彼此接触的阴极基板和阳极基板的部分之间的边界的非导体，其中阴极基板和阳极基板中的至少一个是掺杂有杂质的半导体，另一个是金属 电极。

公开(公告)号：US07510865B2

公开(公告)日：2009-03-31

申请号：US11347185

申请日：2006-02-03

申请人： Kyu-tae Yoo ,  Joon-ho Kim ,  Jun-hong Min ,  Sung-ouk Jung ,  Ji-na Namgoong ,  Kui-hyun Kim ,  Jeo-young Shim ,  Kak Namkoong

发明人： Kyu-tae Yoo ,  Joon-ho Kim ,  Jun-hong Min ,  Sung-ouk Jung ,  Ji-na Namgoong ,  Kui-hyun Kim ,  Jeo-young Shim ,  Kak Namkoong

IPC分类号： C12M1/34

CPC分类号： G01N33/54373

摘要： Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region on an upper surface of an end portion of the sensing plate; an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and a pair of switching electrodes that are separated by a predetermined distance and is connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. A target material need not be labelled, a signal processing of a fluorescent or electrical detection signal using an analysis apparatus is not required, and a signal can be directly decoded by confirming whether a current flows through the switch.

摘要翻译： 提供了一种感测开关和使用该感测开关的感测方法。 感测开关包括：基板; 底物上的支撑物; 感测板，其与所述支撑体的一侧连接并且与所述基板平行预定距离; 在感测板的端部的上表面上的受体结合区域; 当与受体结合区结合的受体选择性地结合到电或磁性活性配体时，引起感测板偏转的电场或磁场产生装置; 以及一对分离预定距离的开关电极，并且当感测板由于感测板的偏转而与基板接触时被连接。 目标材料不需要标注，不需要使用分析装置的荧光或电检测信号的信号处理，并且可以通过确认电流是否流过开关直接解码信号。

公开(公告)号：US20060284138A1

公开(公告)日：2006-12-21

申请号：US11453116

申请日：2006-06-14

申请人： Hun-joo Lee ,  Ji-na Namgoong ,  Soo-suk Lee ,  Joon-ho Kim

发明人： Hun-joo Lee ,  Ji-na Namgoong ,  Soo-suk Lee ,  Joon-ho Kim

IPC分类号： C01B31/16

CPC分类号： C08J5/2218 ,  B01J39/20 ,  B01J41/14 ,  B01J47/016 ,  B01J47/12 ,  B01L3/5027 ,  C08J5/20

摘要： An ion exchangeable mixture containing a polymeric compound consisting of an ion exchange resin, an acrylamide mixture containing at least one bisacrylamide and at least one acrylamide, and a copolymer obtained by reacting the polymeric compound with the acrylamide mixture, and a method of producing the same are provided. The ion exchangeable membrane produced by using the ion exchangeable mixture has significantly smaller electric resistance than conventional ion exchangeable membranes, and has excellent selective permeability because the ion exchangeable membrane is electrically charged. The ion exchangeable membrane can be produced under very mild production conditions, and thus can be produced very easily. Furthermore, the ion exchangeable membrane can be also formed into film during a crosslinking reaction in a solvent of water, and thus is advantageous in that the ion exchangeable membrane can be freely produced into desired sizes, shapes and forms.

公开(公告)号：US20050199917A1

公开(公告)日：2005-09-15

申请号：US11057642

申请日：2005-02-14

申请人： Kyu-tae Yoo ,  Geun-bae Lim ,  Joon-ho Kim ,  Kak Namkoong

发明人： Kyu-tae Yoo ,  Geun-bae Lim ,  Joon-ho Kim ,  Kak Namkoong

IPC分类号： G01N27/327 ,  C12Q1/68 ,  G01N27/414 ,  G01N33/487 ,  H01L29/08

CPC分类号： G01N27/4145

摘要： There is provided a biomolecule FET enhancing a sensitivity. The biomolecule FET includes a substrate, first and second impurity regions formed on both sides of the substrate, and doped with impurities of a polarity opposite to that of the substrate, a gate formed on the substrate and being in contact with the first and second impurity regions, and a probe biomolecule attached to the gate. A region of the gate adjacent to the first impurity region is wider than a region thereof adjacent to the second impurity region. A density of the probe biomolecule attached to the surface of the gate is increased, and when detecting a level of hybridization of the probe biomolecule and the target biomolecule, its sensitivity is improved.

摘要翻译： 提供了提高灵敏度的生物分子FET。 生物分子FET包括基板，形成在基板两侧的第一和第二杂质区，并且掺杂极性与基板极性相反的杂质;形成在基板上并与第一和第二杂质接触的栅极 区域，以及连接到门的探针生物分子。 与第一杂质区相邻的栅极的区域比与第二杂质区相邻的区域宽。 附着在栅极表面的探针生物分子的密度增加，并且当检测到探针生物分子和靶生物分子的杂交水平时，其灵敏度得到改善。

公开(公告)号：US08519014B2

公开(公告)日：2013-08-27

申请号：US13605503

申请日：2012-09-06

申请人： Hun-joo Lee ,  Ji-na Namgoong ,  Soo-suk Lee ,  Joon-ho Kim

发明人： Hun-joo Lee ,  Ji-na Namgoong ,  Soo-suk Lee ,  Joon-ho Kim

IPC分类号： B01J49/00 ,  C08J5/20 ,  C01B31/16

CPC分类号： C08J5/2218 ,  B01J39/20 ,  B01J41/14 ,  B01J47/016 ,  B01J47/12 ,  B01L3/5027 ,  C08J5/20

摘要： An ion exchangeable mixture containing a polymeric compound consisting of an ion exchange resin, an acrylamide mixture containing at least one bisacrylamide and at least one acrylamide, and a copolymer obtained by reacting the polymeric compound with the acrylamide mixture, and a method of producing the same are provided. The ion exchangeable membrane produced by using the ion exchangeable mixture has significantly smaller electric resistance than conventional ion exchangeable membranes, and has excellent selective permeability because the ion exchangeable membrane is electrically charged. The ion exchangeable membrane can be produced under very mild production conditions, and thus can be produced very easily. Furthermore, the ion exchangeable membrane can be also formed into film during a crosslinking reaction in a solvent of water, and thus is advantageous in that the ion exchangeable membrane can be freely produced into desired sizes, shapes and forms.

摘要翻译： 含有由离子交换树脂，含有至少一种双丙烯酰胺和至少一种丙烯酰胺的丙烯酰胺混合物组成的聚合物的离子交换性混合物和通过使聚合物与丙烯酰胺混合物反应得到的共聚物及其制造方法 被提供。 通过使用离子交换性混合物制造的离子交换膜的电阻比常规的离子交换膜的电阻小得多，并且由于可离子交换膜带电而具有优异的选择性渗透性。 离子交换膜可以在非常温和的生产条件下生产，因此可以非常容易地生产。 此外，在水的溶剂中的交联反应期间，也可以将离子交换膜形成为膜，因此有利的是可离子交换膜可以自由地制成所需的尺寸，形状和形状。

公开(公告)号：US08293095B2

公开(公告)日：2012-10-23

申请号：US11472182

申请日：2006-06-21

申请人： Jung-im Han ,  Joon-ho Kim

发明人： Jung-im Han ,  Joon-ho Kim

IPC分类号： G01N27/44

CPC分类号： G05D21/02

摘要： Provided is a microfluidic device for electrically regulating the pH of a fluid comprising: a first chamber comprising a first electrode; a second chamber comprising a second electrode; a third chamber comprising a third electrode, a metal ion exchange membrane between the first and second chambers; and a hydrogen ion exchange membrane between the first or second chamber and the third chamber.

摘要翻译： 提供一种用于电流调节流体pH的微流体装置，包括：第一室，包括第一电极; 第二室，包括第二电极; 第三室，包括第三电极，在第一和第二室之间的金属离子交换膜; 以及在第一或第二室与第三室之间的氢离子交换膜。

公开(公告)号：US20110048966A1

公开(公告)日：2011-03-03

申请号：US12913044

申请日：2010-10-27

申请人： Jung-im Han ,  Joon-ho Kim

发明人： Jung-im Han ,  Joon-ho Kim

IPC分类号： C02F1/66 ,  C02F1/461

CPC分类号： B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00828 ,  B01J2219/00853 ,  B01J2219/00862 ,  B01L3/5027

摘要： Provided is a microfluidic device for electrochemically regulating the pH of a fluid comprising: a cathode substrate; an anode substrate facing the cathode substrate and forming a reaction chamber with the cathode substrate; and a nonconductor which forms a boundary between the portions of the cathode substrate and the anode substrate that are capable of contacting one another, wherein at least one of the cathode substrate and the anode substrate is a semiconductor doped with impurities and the other is a metal electrode.

摘要翻译： 提供一种用于电化学调节流体pH的微流体装置，包括：阴极衬底; 面向阴极基板的阳极基板，并与阴极基板形成反应室; 以及形成能够彼此接触的阴极基板和阳极基板的部分之间的边界的非导体，其中阴极基板和阳极基板中的至少一个是掺杂有杂质的半导体，另一个是金属 电极。