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    Manufacturing method of 3D shape structure having hydrophobic inner surface
    1.
    发明授权
    Manufacturing method of 3D shape structure having hydrophobic inner surface 有权
    具有疏水性内表面的三维形状结构的制造方法

    公开(公告)号：US08241481B2

    公开(公告)日：2012-08-14

    申请号：US12452873

    申请日：2008-03-12

    Applicant: Dong-Seob Kim ,  Dong-Hyun Kim ,  Woon-Bong Hwang ,  Hyun-Chul Park ,  Kun-Hong Lee ,  Geun-Bae Lim ,  Sang-Min Lee ,  Joon-Won Kim

    Inventor： Dong-Seob Kim ,  Dong-Hyun Kim ,  Woon-Bong Hwang ,  Hyun-Chul Park ,  Kun-Hong Lee ,  Geun-Bae Lim ,  Sang-Min Lee ,  Joon-Won Kim

    IPC: C23C28/00

    CPC classification number: C23C28/00 ,  C23C28/04 ,  C25D11/045 ,  C25D11/16 ,  C25D11/24

    Abstract: The present invention relates to a manufacturing method of a three dimensional structure having a hydrophobic inner surface. The manufacturing method includes anodizing a three dimensional metal member and forming fine holes on an external surface of the metal member, forming a replica by coating a non-wetting polymer material on the outer surface of the metal member and forming the non-wetting polymer material to be a replication structure corresponding to the fine holes of the metal member, forming an exterior by surrounding the replication structure with an exterior forming material, and etching the metal member and eliminating the metal member from the replication structure and the exterior forming material.

    Abstract translation: 本发明涉及具有疏水性内表面的三维结构体的制造方法。 该制造方法包括阳极氧化三维金属构件并在金属构件的外表面上形成细孔，通过在金属构件的外表面上涂覆非润湿聚合物材料并形成非湿润聚合物材料形成复制品 作为与金属构件的细孔对应的复制结构，通过用外部形成材料围绕复制结构形成外部，并且蚀刻金属构件并从复制结构和外部形成材料中除去金属构件。

    Method and apparatus for amplifying nucleic acids
    2.
    发明授权
    Method and apparatus for amplifying nucleic acids 有权
    扩增核酸的方法和装置

    公开(公告)号：US07943348B2

    公开(公告)日：2011-05-17

    申请号：US12504271

    申请日：2009-07-16

    Applicant: Yoon-kyoung Cho ,  Joon-ho Kim ,  Kak Namkoong ,  Geun-bae Lim ,  Jun-hong Min

    Inventor： Yoon-kyoung Cho ,  Joon-ho Kim ,  Kak Namkoong ,  Geun-bae Lim ,  Jun-hong Min

    IPC: C12Q1/68 ,  C12P19/34

    CPC classification number: G01N35/08 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/0654 ,  B01F13/0071 ,  B01F2015/0221 ,  B01J2219/00783 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2300/0809 ,  B01L2300/0861 ,  B01L2300/0883 ,  G01N2035/00366 ,  G01N2035/00514

    Abstract: A method and apparatus for amplifying nucleic acids. The method includes introducing into a reaction vessel via different inlet channels a reactant aqueous solution containing reactants for nucleic acid amplification and a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction, creating a plurality of reactant aqueous solution droplets surrounded by the fluid by contacting the reactant aqueous solution with the fluid in the reaction vessel, and amplifying the nucleic acids in the reactant aqueous solution droplets. The apparatus includes a substrate, a reaction vessel formed inside of the substrate, at least one first inlet channel formed inside the substrate, connected to an end of the reaction vessel, and allowing introduction of a reactant aqueous solution containing reactants for nucleic acid amplification into the reaction vessel, a second inlet channel formed inside the substrate, connected to the end of the reaction vessel, and allowing introduction of a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction into the reaction vessel, and a heating unit installed on the substrate in such a way to thermally contact with the substrate and heating the substrate.

    Abstract translation: 用于扩增核酸的方法和装置。 该方法包括通过不同的入口通道将含有用于核酸扩增的反应物的反应物水溶液和与反应物水溶液相分离并且不参与扩增反应的流体引入反应容器，形成多个反应物水溶液 通过使反应物水溶液与反应容器中的流体接触，并且扩增反应物水溶液液滴中的核酸，由流体包围的液滴。 该装置包括基板，形成在基板内部的反应容器，形成在基板内部的至少一个第一入口通道，与反应容器的端部连接，并且允许将含有用于核酸扩增的反应物的反应物水溶液引入到 反应容器，形成在基板内部的第二入口通道，连接到反应容器的端部，并且允许引入与反应物水溶液相分离并且不参与扩增反应的流体进入反应容器， 以及加热单元，其以与基板热接触并加热基板的方式安装在基板上。

    METHOD AND APPARATUS FOR AMPLIFYING NUCLEIC ACIDS
    4.
    发明申请
    METHOD AND APPARATUS FOR AMPLIFYING NUCLEIC ACIDS 有权
    用于放大核酸的方法和装置

    公开(公告)号：US20100021972A1

    公开(公告)日：2010-01-28

    申请号：US12504271

    申请日：2009-07-16

    Applicant: Yoon-kyoung Cho ,  Joon-ho Kim ,  Kak Namkoong ,  Geun-bae Lim ,  Jun-hong Min

    Inventor： Yoon-kyoung Cho ,  Joon-ho Kim ,  Kak Namkoong ,  Geun-bae Lim ,  Jun-hong Min

    IPC: C12P19/34

    CPC classification number: G01N35/08 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/0654 ,  B01F13/0071 ,  B01F2015/0221 ,  B01J2219/00783 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2300/0809 ,  B01L2300/0861 ,  B01L2300/0883 ,  G01N2035/00366 ,  G01N2035/00514

    Abstract: A method and apparatus for amplifying nucleic acids. The method includes introducing into a reaction vessel via different inlet channels a reactant aqueous solution containing reactants for nucleic acid amplification and a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction, creating a plurality of reactant aqueous solution droplets surrounded by the fluid by contacting the reactant aqueous solution with the fluid in the reaction vessel, and amplifying the nucleic acids in the reactant aqueous solution droplets. The apparatus includes a substrate, a reaction vessel formed inside of the substrate, at least one first inlet channel formed inside the substrate, connected to an end of the reaction vessel, and allowing introduction of a reactant aqueous solution containing reactants for nucleic acid amplification into the reaction vessel, a second inlet channel formed inside the substrate, connected to the end of the reaction vessel, and allowing introduction of a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction into the reaction vessel, and a heating unit installed on the substrate in such a way to thermally contact with the substrate and heating the substrate.

    Abstract translation: 用于扩增核酸的方法和装置。 该方法包括通过不同的入口通道将含有用于核酸扩增的反应物的反应物水溶液和与反应物水溶液相分离并且不参与扩增反应的流体引入反应容器，形成多个反应物水溶液 通过使反应物水溶液与反应容器中的流体接触，并且扩增反应物水溶液液滴中的核酸，由流体包围的液滴。 该装置包括基板，形成在基板内部的反应容器，形成在基板内部的至少一个第一入口通道，与反应容器的端部连接，并且允许将含有用于核酸扩增的反应物的反应物水溶液引入到 反应容器，形成在基板内部的第二入口通道，连接到反应容器的端部，并且允许引入与反应物水溶液相分离并且不参与扩增反应的流体进入反应容器， 以及加热单元，其以与基板热接触并加热基板的方式安装在基板上。

    METHOD OF TREATING SURFACE OF SUBSTRATE USED IN BIOLOGICAL REACTION SYSTEM
    5.
    发明申请
    METHOD OF TREATING SURFACE OF SUBSTRATE USED IN BIOLOGICAL REACTION SYSTEM 审中-公开
    处理生物反应体系中使用的底物表面的方法

    公开(公告)号：US20090018032A1

    公开(公告)日：2009-01-15

    申请号：US12238165

    申请日：2008-09-25

    Applicant: Sun-hee Kim ,  Soo-suk Lee ,  Geun-bae Lim ,  Young-sun Lee

    Inventor： Sun-hee Kim ,  Soo-suk Lee ,  Geun-bae Lim ,  Young-sun Lee

    IPC: C40B40/06

    CPC classification number: B01L3/508 ,  B01L7/52 ,  B01L2300/163 ,  B05D1/62 ,  B05D2203/35 ,  C03C17/30

    Abstract: Provided is a method of treating a surface of a substrate used in a biochemical reaction system, the method including forming a polymer film on the surface by vapor deposition of a compound of formula (1) below and a compound of formula (2) below: (RO)3—Si—(CH2)n1—X  (1) (RO)3—Si—(CH2)n2—(CF2)m—X  (2) wherein R is one of a methyl group and an ethyl group, X is one of a methyl group and a trifluoromethyl group, n1 is an integer from 1 to 3, n2 is an integer from 1 to 10, and m is an integer from 1 to 10.

    Abstract translation: 本发明提供一种处理生物化学反应体系中使用的基板的表面的方法，该方法包括通过以下式（1）的化合物和下述式（2）的化合物的气相沉积在表面上形成聚合物膜： （RO）3-Si-（CH2）n1-X（1）<？in-line-formula description =“In-line-formula description =”In-line-formula“ （RO）3-Si-（CH2）n2-（CF2）mX（2）式（“R”） ）<？in-line-formula description =“In-line formula”end =“tail”？>其中R是甲基和乙基之一，X是甲基和三氟甲基之一，n1是 1〜3的整数，n2为1〜10的整数，m为1〜10的整数。

    Sensitivity enhanced biomolecule field effect transistor
    7.
    发明授权
    Sensitivity enhanced biomolecule field effect transistor 有权
    灵敏度增强的生物分子场效应晶体管

    公开(公告)号：US07151301B2

    公开(公告)日：2006-12-19

    申请号：US11057642

    申请日：2005-02-14

    Applicant: Kyu-tae Yoo ,  Geun-bae Lim ,  Joon-ho Kim ,  Kak Namkoong

    Inventor： Kyu-tae Yoo ,  Geun-bae Lim ,  Joon-ho Kim ,  Kak Namkoong

    IPC: H01L29/76

    CPC classification number: G01N27/4145

    Abstract: There is provided a biomolecule FET enhancing a sensitivity. The biomolecule FET includes a substrate, first and second impurity regions formed on both sides of the substrate, and doped with impurities of a polarity opposite to that of the substrate, a gate formed on the substrate and being in contact with the first and second impurity regions, and a probe biomolecule attached to the gate. A region of the gate adjacent to the first impurity region is wider than a region thereof adjacent to the second impurity region. A density of the probe biomolecule attached to the surface of the gate is increased, and when detecting a level of hybridization of the probe biomolecule and the target biomolecule, its sensitivity is improved.

    Abstract translation: 提供了提高灵敏度的生物分子FET。 生物分子FET包括基板，形成在基板两侧的第一和第二杂质区，并且掺杂极性与基板极性相反的杂质;形成在基板上并与第一和第二杂质接触的栅极 区域，以及连接到门的探针生物分子。 与第一杂质区相邻的栅极的区域比与第二杂质区相邻的区域宽。 附着在栅极表面的探针生物分子的密度增加，并且当检测到探针生物分子和靶生物分子的杂交水平时，其灵敏度得到改善。

    Biomolecule sensing method using Field Effect Transistor with controllable Debye length
    9.
    发明申请
    Biomolecule sensing method using Field Effect Transistor with controllable Debye length 审中-公开
    使用可控德拜长度的场效应晶体管的生物分子感测方法

    公开(公告)号：US20050191683A1

    公开(公告)日：2005-09-01

    申请号：US11063214

    申请日：2005-02-22

    Applicant: Kyu-tae Yoo ,  Geun-bae Lim

    Inventor： Kyu-tae Yoo ,  Geun-bae Lim

    IPC: G01N27/327 ,  C12Q1/68 ,  G01N33/543

    CPC classification number: G01N33/54373

    Abstract: A method of sensing biomolecules in an electrolyte solution by using a bio FET. When it is sensed that probe biomolecules are immobilized to a gate surface of the bio FET or that the probe biomolecules are hybridized with target biomolecules, a Debye length from the biomolecules having charges attached to the gate surface is controlled.

    Abstract translation: 通过使用生物FET感测电解质溶液中的生物分子的方法。 当感测到探针生物分子被固定在生物FET的栅极表面上或者探针生物分子与靶生物分子杂交时，来自具有连接到栅极表面的电荷的生物分子的德拜长度受到控制。

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