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51.发明申请公开(公告)号：US20110135859A1
公开(公告)日：2011-06-09
申请号：US12878383
申请日：2010-09-09
申请人： Francois-Genes TOURNILHAC , Ludwik Leibler , Philippe Cordier , Corinne Soulie-Ziakovic , Annett Linemann , Manuel Hidalgo
发明人： Francois-Genes TOURNILHAC , Ludwik Leibler , Philippe Cordier , Corinne Soulie-Ziakovic , Annett Linemann , Manuel Hidalgo
CPC分类号： C08F8/30 , C08F8/32 , C08F8/34 , C08G69/48 , Y10T428/1352 , Y10T428/139 , C08F220/14 , C08F210/02
摘要： The invention concerns a polymer material consisting of macromolecular chains bound by hydrogen bonds, wherein: the macromolecular chains consist of a polymer skeleton whereon is fixed by at least one covalent bond a modifying agent, the modifying agent comprising, assembled in a common molecule, one or more associative groups capable of being bound by hydrogen bonds and one or more reactive groups capable of forming covalent bonds with the polymer skeleton, at least one of the associative groups of the modifying agent is an imidazolidone heterocycle, the macromolecular chains bear on average, 1 to 10 imidazolidone groups per chain. The average number of imidazolidone groups to be introduced into the macromolecular chains depends both on the average mass of said chains and the final properties desired for the material.
摘要翻译： 本发明涉及由氢键结合的大分子链组成的聚合物材料，其中：大分子链由其中通过至少一个共价键固定的聚合物骨架修饰剂组成，改性剂包含组装在共同分子中的一种，一种 或更多的能够被氢键结合的缔合基团和一个或多个能够与聚合物骨架形成共价键的反应性基团，改性剂的至少一个缔合基团是咪唑啉酮杂环，大分子链平均负载， 每链1至10个咪唑烷酮基。 引入大分子链中的咪唑烷酮基团的平均数量取决于所述链的平均质量和材料所需的最终性能。
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公开(公告)号：US20110059280A1
公开(公告)日：2011-03-10
申请号：US12991181
申请日：2009-05-05
CPC分类号： C08G83/008 , C08G69/26 , C08G69/28 , C08G69/34
摘要： The present invention relates to a method for synthesizing a supramolecular material comprising: 1—the reaction of at least one carboxylic diacid, or ester or chloride of such a diacid, with, on the one hand, at least one modifier compound bearing both reactive functional groups capable of reacting with the carboxylic acid, ester or acid chloride functional groups and associative groups capable of associating with one another by hydrogen bonds, in a molar ratio of the reactive functional groups to the carboxylic acid, ester or acid chloride functional groups of between 0.10 and 0.50, and, on the other hand, at least one polyamine, said reactions being carried out successively or simultaneously, and 2—the reaction of the polyamide obtained at the end of step 1 with urea. The present invention also relates to the resulting material, and also to the uses thereof.
摘要翻译： 本发明涉及一种合成超分子材料的方法，其包括：1-至少一种羧酸二酸或这种二酸的酯或氯化物与至少一种具有反应性官能团 能够与羧酸，酯或酰氯官能团和能够通过氢键彼此结合的缔合基团反应的基团，反应性官能团与羧酸，酯或酰氯官能团的摩尔比在 0.10和0.50，另一方面是至少一种多胺，所述反应相继或同时进行，和2-步骤1结束时得到的聚酰胺与尿素的反应。 本发明还涉及所得到的材料，以及其用途。
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53.发明申请公开(公告)号：US20090221522A1
公开(公告)日：2009-09-03
申请号：US12372373
申请日：2009-02-17
申请人： Manuel Hidalgo , Antonio Jimeno , Aik Choon Tan
发明人： Manuel Hidalgo , Antonio Jimeno , Aik Choon Tan
IPC分类号： A61K31/7068 , C12Q1/68 , C40B30/00 , A61K31/337 , A61K31/4353 , A61P35/00
CPC分类号： C12Q1/6809
摘要： The present invention comprises a treatment approach based on gene set-expression signatures that systematically connects a sample to a profile from a reference database to extrapolate the most effective therapeutic agent. Further disclosed are methods to optimize combination treatments.
摘要翻译： 本发明包括一种基于基因设定表达特征的处理方法，该方法将样品系统地连接到参考数据库中的分布图，以外推最有效的治疗剂。 进一步公开的是优化组合治疗的方法。
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54.发明申请SYNTHESIS OF NOVEL TUBULIN POLYMERIZATION INHIBITORS: BENZOYLPHENYLUREA (BPU) SULFUR ANALOGS 审中-公开新型管状体聚合抑制剂的合成：苯甲酰基苯酚（BPU）硫化物类似物公开(公告)号：US20090099218A1
公开(公告)日：2009-04-16
申请号：US12211492
申请日：2008-09-16
IPC分类号： A61K31/505 , C07D239/38 , A61K31/513 , C07D239/34 , A61P35/00
CPC分类号： C07D239/34 , C07D239/38
摘要： This invention provides a series of BPU analogues; their synthesis and evaluated biological activity. BPU sulfur analogues were found to possess up to 20 fold increased potency, when compared to compound 1, in various cancerous cell lines.
摘要翻译： 本发明提供了一系列BPU类似物; 其合成和评估生物活性。 与各种癌细胞系中的化合物1相比，发现BPU硫类似物具有高达20倍的效力。
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公开(公告)号：US06458896B1
公开(公告)日：2002-10-01
申请号：US09180524
申请日：1999-05-21
IPC分类号： C08F400
CPC分类号： C08J3/12 , C08J2333/02 , C08L33/02
摘要： Certain mixtures of two superabsorbent powders having very different capillary suctions exhibit a resulting capillary suction which approaches the higher value. The resulting mixtures simultaneously exhibit a high capillary suction and a high intrinsic absorption capacity.
摘要翻译： 具有非常不同毛细管吸力的两种超吸收性粉末的某些混合物表现出接近较高值的所得毛细吸力。 所得混合物同时表现出高毛细吸力和高固有吸收能力。
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公开(公告)号：US5976696A
公开(公告)日：1999-11-02
申请号：US796730
申请日：1997-02-07
CPC分类号： C08J3/245 , C08J2300/14 , Y10T428/2998
摘要： Shell/core distortion-resistant particulates of a partially crosslinked superabsorbent polymer, the gradient of partial crosslinking of which being to such extent that the shells are harder and less flexible than the cores thereof, have a capacity to absorb 0.9% saline water of at least 50 g/g and the modulus of which is at least 35,000 Pa; a bed of a saline water gel of the subject particulates has a saline water absorption of at least 20 g/g and a porosity of at least 500 g.
摘要翻译： 部分交联的超吸收聚合物的壳/芯抗变形颗粒，其部分交联的梯度在这样的程度上使得壳比其芯更硬并且柔韧性更小，具有至少吸收0.9％盐水的能力 50g / g，模量为35,000Pa以上; 本发明颗粒的盐水凝胶床具有至少20g / g的盐水吸收和至少500g的孔隙率。
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57.发明授权公开(公告)号：US09562183B2
公开(公告)日：2017-02-07
申请号：US13404388
申请日：2012-02-24
CPC分类号： C09K5/063 , F28D20/021 , Y02E60/145 , Y02E70/30
摘要： A compound consisting of a linear saturated C8-C24 hydrocarbon-based chain bearing at each end a nitrogen-containing functional group, other than —NH2, is used for the storage of thermal energy.A process for the storage and optionally for the release of thermal energy comprises the contacting of a wall to be cooled with a first heat transfer fluid then of said first heat transfer fluid with a material comprising said compound and optionally the contacting of said material with a second heat transfer fluid then of said second heat transfer fluid with a wall to be heated.
摘要翻译： 用于存储和任选地释放热能的方法包括使待冷却的壁与第一传热流体接触，然后使所述第一传热流体与包含所述化合物的材料接触，并且任选地使所述材料与 所述第二传热流体与所述第二传热流体之间具有待加热的壁。
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公开(公告)号：US09315868B2
公开(公告)日：2016-04-19
申请号：US13254610
申请日：2010-03-05
申请人： Bert Vogelstein , Kenneth W. Kinzler , D. Williams Parsons , Sian Jones , Scott Kern , Ralph Hruban , James R. Eshleman , Michael Goggins , Alison Klein , Manuel Hidalgo , Victor E. Velculescu
发明人： Bert Vogelstein , Kenneth W. Kinzler , D. Williams Parsons , Sian Jones , Scott Kern , Ralph Hruban , James R. Eshleman , Michael Goggins , Alison Klein , Manuel Hidalgo , Victor E. Velculescu
IPC分类号： C12Q1/68 , C12P19/34 , A61P35/00 , G01N33/574 , C07H21/04
CPC分类号： C12Q1/6886 , A61K31/407 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/57438 , G01N2333/47
摘要： The present invention provides a method for detecting mutations in the PALB2 gene in pancreatic cancer patients and in individuals having a family history of pancreatic cancer. Methods are also provided for diagnosing a predisposition to pancreatic cancer, for predicting a patient's response to pancreatic cancer therapies, and for treating pancreatic cancer, based on presence of a PALB2 mutation or abberant PALB2 gene expression in a patient.
摘要翻译： 本发明提供了一种检测胰腺癌患者和具有胰腺癌家族史的个体中PALB2基因突变的方法。 还提供了用于诊断患有胰腺癌的倾向，用于预测患者对胰腺癌治疗的反应以及用于治疗患者胰腺癌的方法，其基于在患者体内PALB2突变或异常PALB2基因表达的存在。
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公开(公告)号：US09157877B2
公开(公告)日：2015-10-13
申请号：US14117416
申请日：2012-03-02
申请人： Manuel Hidalgo , Franck Medlege
发明人： Manuel Hidalgo , Franck Medlege
CPC分类号： G01N25/48 , G01N25/20 , G01N25/4866 , Y10T436/200833 , Y10T436/216
摘要： A process for characterizing a copolymer of ethylene and vinyl acetate (EVA) using a differential calorimetry analysis technique. This process is determining one or more values of characteristic(s) of a sample of EVA copolymer, one of which is a level of crosslinking of the sample. The process makes it possible to determine not only the degree of crosslinking, but also the vinyl acetate content and the molecular mass of an EVA sample, in a simple, rapid, easy and precise manner.
摘要翻译： 使用差示量热分析技术表征乙烯和乙酸乙烯酯（EVA）的共聚物的方法。 该方法确定了EVA共聚物样品的一个或多个特征值，其中之一是样品的交联水平。 该方法不但能够以简单，快速，简单和精确的方式测定EVA样品的交联度，而且还测定乙酸乙烯酯含量和分子量。
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公开(公告)号：US09045432B2
公开(公告)日：2015-06-02
申请号：US13809795
申请日：2011-07-12
IPC分类号： C07D233/34 , C07D233/36
CPC分类号： C07D233/34 , C07D233/36
摘要： A compound includes at least one group Q and at least one group A linked together by at least one “spacer” group Sp, in which: group Q includes a dipole containing at least one nitrogen atom, preferably a nitrile oxide, nitrone, or nitrile imine function; group A contains at least one nitrogen atom, and is preferably an imidazolidinyl, ureyl, bis-ureyl, ureido-pyrimidyl, and triazolyl group; and Sp is an atom or a group of atoms forming a link between Q and A, preferably, a linear, branched or cyclic hydrocarbon-based optionally substituted chain, and may contain one or more aromatic radicals and/or heteroatoms. The compound may react with an unsaturated polymer forming a covalent bond with the polymer. The compound is useful for providing good interaction between fillers and polymers by establishing labile, non-covalent bonds between the polymer chains and the filler, thereby limiting processing problems.
摘要翻译： 化合物包括至少一个基团Q和至少一个通过至少一个“间隔基”基团Sp连接在一起的基团A，其中：基团Q包括含有至少一个氮原子的偶极子，优选氧化腈，硝酮或腈 亚胺功能; A组含有至少一个氮原子，优选为咪唑烷基，脲基，双ureyl，脲基 - 嘧啶基和三唑基; 并且Sp是在Q和A之间形成连接的原子或一组原子，优选直链，支链或环状烃基任选取代的链，并且可以含有一个或多个芳族基团和/或杂原子。 该化合物可与与聚合物形成共价键的不饱和聚合物反应。 该化合物可用于通过在聚合物链和填料之间建立不稳定的非共价键来提供填料和聚合物之间的良好相互作用，从而限制了加工问题。
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