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51.发明授权Techniques for placing medical leads for electrical stimulation of nerve tissue 有权放置用于电刺激神经组织的医疗线的技术公开(公告)号：US08532793B2
公开(公告)日：2013-09-10
申请号：US12433809
申请日：2009-04-30
IPC分类号： A61N1/00
CPC分类号： A61N1/36053 , A61M25/09 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/057 , A61N1/36085 , A61N1/36114 , A61N1/36125 , A61N1/36128
摘要： This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient.
摘要翻译： 本公开涉及用于在患者体内靠近神经组织布置医疗引线和电刺激和/或感测电极的额外的，内部的和经血管内的医疗引线放置技术。
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公开(公告)号：US08323248B2
公开(公告)日：2012-12-04
申请号：US12822009
申请日：2010-06-23
IPC分类号： A61M5/178
CPC分类号： A61M5/158 , A61M25/0084
摘要： A medical fluid delivery system is provided including a steerable, guide catheter, a delivery catheter adapted for deployment at a targeted tissue site using the steerable guide catheter, the delivery catheter including a proximal port, a distal port, and a lumen extending between the proximal and distal ports; a distal fixation element coupled to the delivery catheter so as to position the distal port adjacent the targeted tissue site; and a flexible hollow needle adapted to be advanced through the delivery catheter lumen, the flexible needle including a tissue-piercing distal tip for extending from the distal port of the delivery catheter for advancement into the targeted tissue site and a proximal end for extending from the proximal port of the delivery catheter through which a medical fluid is delivered.
摘要翻译： 提供了一种医疗流体输送系统，其包括可转向的导向导管，适于使用可转向引导导管在目标组织部位展开的输送导管，所述输送导管包括近端口，远端口和在近端 和远端口; 远端固定元件，其联接到所述输送导管，以便将所述远端口邻近所述目标组织部位定位; 以及柔性中空针，其适于前进穿过输送导管腔，所述柔性针包括组织穿刺远侧末端，用于从输送导管的远端延伸进入目标组织部位，并且近端从 输送导管的近端口，通过该端口传送医用流体。
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公开(公告)号：US20100274221A1
公开(公告)日：2010-10-28
申请号：US12767224
申请日：2010-04-26
CPC分类号： A61B5/036 , A61B5/0031 , A61B5/0215 , A61B5/4839 , A61M5/14276 , A61M5/16854 , A61M5/1723 , A61M2005/1726 , A61M2205/3331 , A61M2205/3334
摘要： A method for adjusting delivery of a therapeutic fluid to a patient suffering from or at risk of pulmonary arterial hypertension includes introducing the therapeutic fluid to a patient via a catheter at a predetermined rate. The catheter is positioned to deliver the fluid to the right ventricle or the pulmonary artery. The catheter a one-way valve configured to allow the fluid to flow from the catheter to the target location. The method further includes monitoring pressure of the target location by monitoring internal catheter pressure, and adjusting the rate at which the therapeutic fluid is introduced to the catheter based on the monitored pressure. The rate at which the fluid is introduced to the catheter is increased if internal catheter pressure increases, and the rate at which the fluid is introduced to the catheter is decreased if the internal catheter pressure decreases.
摘要翻译： 用于调节对患有或具有肺动脉高压的风险的患者的治疗流体的递送的方法包括以预定的速率经由导管将治疗流体引入患者体内。 定位导管以将流体输送到右心室或肺动脉。 导管是单向阀，其构造成允许流体从导管流到目标位置。 该方法还包括通过监测内部导管压力来监测目标位置的压力，并且基于所监测的压力来调节治疗流体被引入导管的速率。 如果内部导管压力增加，流体被引入导管的速率增加，并且如果内部导管压力降低，则将流体引入导管的速率降低。
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公开(公告)号：US20100262001A1
公开(公告)日：2010-10-14
申请号：US12822009
申请日：2010-06-23
CPC分类号： A61M5/158 , A61M25/0084
摘要： A medical fluid delivery system is provided including a steerable, guide catheter, a delivery catheter adapted for deployment at a targeted tissue site using the steerable guide catheter, the delivery catheter including a proximal port, a distal port, and a lumen extending between the proximal and distal ports; a distal fixation element coupled to the delivery catheter so as to position the distal port adjacent the targeted tissue site; and a flexible hollow needle adapted to be advanced through the delivery catheter lumen, the flexible needle including a tissue-piercing distal tip for extending from the distal port of the delivery catheter for advancement into the targeted tissue site and a proximal end for extending from the proximal port of the delivery catheter through which a medical fluid is delivered.
摘要翻译： 提供了一种医疗流体输送系统，其包括可转向的导向导管，适于使用可转向引导导管在目标组织部位展开的输送导管，所述输送导管包括近端口，远端口和在近端 和远端口; 远端固定元件，其联接到所述输送导管，以便将所述远端口邻近所述目标组织部位定位; 以及柔性中空针，其适于前进穿过输送导管腔，所述柔性针包括组织穿刺远侧末端，用于从输送导管的远端延伸进入目标组织部位，以及近端从 输送导管的近端口，通过该端口传送医用流体。
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公开(公告)号：US20090276023A1
公开(公告)日：2009-11-05
申请号：US12433809
申请日：2009-04-30
IPC分类号： A61N1/05
CPC分类号： A61N1/36053 , A61M25/09 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/057 , A61N1/36085 , A61N1/36114 , A61N1/36125 , A61N1/36128
摘要： This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient.
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公开(公告)号：US07270650B2
公开(公告)日：2007-09-18
申请号：US11017336
申请日：2004-12-20
CPC分类号： A61M25/02 , A61M5/1418 , A61M5/14276 , A61M2005/1416 , A61M2025/0213 , A61M2025/024 , A61M2025/028 , A61M2025/0286 , A61M2039/025 , A61M2210/0687 , A61M2210/0693
摘要： A catheter system and method for intracranial infusion of therapeutic substances to a patient. An anchor formed of generally flexible, elastomeric material is used to mount the catheter to the outer surface of the skull of the patient. The anchor has a through hole for receiving the catheter, a channel, extending substantially from the through hole, into which a portion of the catheter may be inserted to retain the portion substantially parallel to the surface of the skull, and at least one flange for engaging the outer surface of the skull. An anchor clip may be provided to engage the anchor adjacent the through hole to further stabilize the catheter.
摘要翻译： 用于向患者颅内输注治疗物质的导管系统和方法。 由通常柔性的弹性体材料形成的锚固件用于将导管安装到患者颅骨的外表面。 锚固体具有用于接收导管的通孔，基本上从通孔延伸的通道，导管的一部分可以插入该通道中以保持基本上平行于颅骨表面的部分，以及至少一个凸缘 接合颅骨的外表面。 可以设置锚固夹以使邻近通孔的锚固件接合以进一步稳定导管。
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公开(公告)号：US07022116B2
公开(公告)日：2006-04-04
申请号：US10691814
申请日：2003-10-23
申请人： Mary M. Morris
发明人： Mary M. Morris
IPC分类号： A61M31/00
CPC分类号： A61M5/14276 , A61M5/16859
摘要： A method for monitoring a bolus delivered to a pressure-responsive valve of a fluid infusion catheter includes delivering the bolus through the infusion catheter over a period of time lasting between approximately one minute and approximately 60 minutes and observing a measured pressure versus time during the bolus delivery.
摘要翻译： 用于监测递送到流体输注导管的压力响应阀的推注的方法包括在约1分钟至约60分钟之间的时间段内输送推注通过输注导管，并观察推注期间的测量压力与时间的关系 交货。
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公开(公告)号：US06551290B1
公开(公告)日：2003-04-22
申请号：US09540444
申请日：2000-03-31
申请人： Dennis D. Elsberry , Chris Christiansen , Mary M. Morris , Douglas Owen Hankner , Robert Cushing Hamlen
发明人： Dennis D. Elsberry , Chris Christiansen , Mary M. Morris , Douglas Owen Hankner , Robert Cushing Hamlen
IPC分类号： A61M2500
CPC分类号： A61M25/0069 , A61M5/14276 , A61M27/006 , A61M2025/0057
摘要： A medical catheter comprising a proximal end having an opening for fluid containing a therapeutic drug, a distal end, the distal end defining at least one opening, and a porous portion covering the opening defined by the distal end. In one embodiment, the medical catheter comprises a proximal end having an opening for fluid containing a therapeutic drug, at least two distal ends. the proximal end connected to the two distal ends with a connector, the distal ends each defining at least, one opening, a diffuser covering the opening of each distal end, and a separate restrictor downstream of the connector and upstream of each distal end to provide substantially equal flow through each distal end. An additional restrictor can also be placed upstream of the connector. In another embodiment, a combination diffuser and restrictor covers the opening of each distal end.
摘要翻译： 一种医疗导管，其包括具有用于含有治疗药物的流体的开口的近端，远端，限定至少一个开口的远端以及覆盖由远端限定的开口的多孔部分。 在一个实施例中，医疗导管包括近端，其具有用于含有治疗药物的流体的开口，至少两个远端。 所述近端与连接器连接到所述两个远端，所述远端各限定至少一个开口，覆盖每个远端的开口的扩散器，以及在所述连接器的下游和每个远端上游的单独限制器，以提供 基本相等的流经每个远端。 另外还可以在连接器的上游设置一个限流器。 在另一个实施例中，组合扩散器和限流器覆盖每个远端的开口。
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公开(公告)号：US5942276A
公开(公告)日：1999-08-24
申请号：US8236
申请日：1998-01-16
CPC分类号： A61N1/0568 , A61L31/082 , A61L31/18
摘要： A method of fabricating a radiopaque dissolvable covering for a member on an implantable lead, including the steps of mixing a radiopaque material with a solvent to form a paste, applying the paste to the member and allowing the paste to harden. The lead preferably is provided with a drug incorporated therein which is subject to degradation at high temperature, located adjacent to the member, and the applying step preferably takes place at about room temperature. The member to which the paste is applied may be an active fixation device such as a barb or a helix or may be a deployable member such as a tine or an electrode bearing member.
摘要翻译： 一种制造用于可植入导线上的构件的不透射线可溶解覆盖物的方法，包括以下步骤：将不透射线材料与溶剂混合以形成糊剂，将糊剂施加到构件上并使糊料硬化。 铅优选具有并入其中的药物，其在与所述部件相邻的高温下经历降解，并且所述施加步骤优选在约室温下进行。 施加糊剂的构件可以是活性固定装置，例如倒钩或螺旋，或者可以是可展开构件，例如尖齿或电极承载构件。
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公开(公告)号：US5827296A
公开(公告)日：1998-10-27
申请号：US706623
申请日：1996-09-06
申请人： Mary M. Morris , Peter M. J. Mulier
发明人： Mary M. Morris , Peter M. J. Mulier
CPC分类号： A61N1/056 , A61M25/0662
摘要： A medical electrical lead system featuring a medical electrical lead which features an improved anchoring sleeve. The medical electrical lead and anchoring sleeve cooperate with an introducer sheath to minimize the flow of blood through the introducer sheath during the introduction of the lead into the blood vessel. Specifically, the lead has a connector assembly, a conductor attached thereto and an electrode electrically coupled to the conductor. An insulative sleeve covers the conductor and an annular anchoring sleeve is movably positioned over the insulative sleeve. The anchoring sleeve has a distal end and a proximal end and further has an annular or circumferential seal within the inner lumen at the distal end. The distal end is further tapered along its exterior portion. The taper of the distal end cooperates with an introducer sheath to provide a seal between the outer portion of the anchoring sleeve and the introducer sheath. The circumferential seal on the same distal end cooperates with the medical electrical lead to create a seal between the anchoring sleeve and the medical electrical lead. In such a manner, a hemostatic seal is accomplished such that blood will not flow through the introducer sheath while the lead is within the introducer sheath and being positioned into the body.
摘要翻译： 一种医用电气导线系统，其特征在于具有改进的锚定套筒的医用电线。 医疗电引线和锚定套管与引导器护套配合，以在导线引入血管期间最小化血液通过导引器护套的流动。 具体地，引线具有连接器组件，连接到其上的导体和电连接到导体的电极。 绝缘套管覆盖导体，环形锚定套可移动地定位在绝缘套上。 锚定套筒具有远端和近端，并且在远端处的内腔内还具有环形或周向密封。 远端沿其外部部分进一步变细。 远端的锥度与导引器护套配合以在锚定套筒的外部部分和导引器护套之间提供密封。 同一远端的圆周密封与医用电引线配合，以在锚定套管和医用电线之间产生密封。 以这种方式，实现止血密封，使得当引线位于导引器鞘内并且定位在体内时，血液将不会流过导引鞘。
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