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公开(公告)号：US5942276A
公开(公告)日：1999-08-24
申请号：US8236
申请日：1998-01-16
CPC分类号： A61N1/0568 , A61L31/082 , A61L31/18
摘要： A method of fabricating a radiopaque dissolvable covering for a member on an implantable lead, including the steps of mixing a radiopaque material with a solvent to form a paste, applying the paste to the member and allowing the paste to harden. The lead preferably is provided with a drug incorporated therein which is subject to degradation at high temperature, located adjacent to the member, and the applying step preferably takes place at about room temperature. The member to which the paste is applied may be an active fixation device such as a barb or a helix or may be a deployable member such as a tine or an electrode bearing member.
摘要翻译： 一种制造用于可植入导线上的构件的不透射线可溶解覆盖物的方法，包括以下步骤：将不透射线材料与溶剂混合以形成糊剂，将糊剂施加到构件上并使糊料硬化。 铅优选具有并入其中的药物，其在与所述部件相邻的高温下经历降解，并且所述施加步骤优选在约室温下进行。 施加糊剂的构件可以是活性固定装置，例如倒钩或螺旋，或者可以是可展开构件，例如尖齿或电极承载构件。
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2.发明授权
公开(公告)号：US5473812A
公开(公告)日：1995-12-12
申请号：US227429
申请日：1994-04-14
CPC分类号： A61N1/056 , Y10T29/49117
摘要： A medical electrical lead and method of manufacturing such a lead for use in cardiac pacing, the lead having a distal end having an active fixation device such as a helix electrode (46) having a distal end and a proximal end, the tissue securing means extending from the lead body distal end, an electrical conductor (15) extending between the proximal and distal ends of the lead, and a longitudinally extending torque indicator (35 or 36) affixed to the lead body (10) proximal to the tissue securing means, the torque indicator (35 or 36) showing rotational movement or distortion of the torque indicator (35 or 36) under fluoroscopy.
摘要翻译： 一种医疗电引线和制造用于心脏起搏的这种引线的方法，所述引线具有远端，所述远端具有主动固定装置，例如具有远端和近端的螺旋电极（46），所述组织固定装置延伸 从引线体远端引出在引线的近端和远端之间延伸的电导体（15），以及靠近组织固定装置固定到引线本体（10）的纵向延伸的扭矩指示器（35或36） 显示在透视下的转矩指示器（35或36）的旋转运动或变形的转矩指示器（35或36）。
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公开(公告)号：US08852173B2
公开(公告)日：2014-10-07
申请号：US13273521
申请日：2011-10-14
IPC分类号： A61K9/22 , A61B17/34 , A61M5/142 , A61M5/172 , A61B18/00 , A61B17/00 , A61B17/22 , A61B18/14 , A61M5/14
CPC分类号： A61M5/14276 , A61B17/00234 , A61B17/3417 , A61B17/3478 , A61B18/1492 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2017/3484 , A61B2017/3488 , A61B2017/349 , A61B2018/00291 , A61B2018/00357 , A61B2018/00392 , A61M5/1723 , A61M2005/1405 , A61M2205/3523
摘要： Methods and systems for transvenously accessing the pericardial space via the vascular system and atrial wall, particularly through the superior vena cava and right atrial wall, to deliver a pharmacologic agent, particularly a NO-donor drug, to the heart are disclosed. A proximal connector of an infusion catheter is coupled to an infusion pump, and a distal catheter segment having a distal infusion catheter lumen end opening is disposed in the pericardial space. The implantable infusion pump is operable in conjunction with an implantable ischemia monitor to monitor the ischemic state and trigger delivery or regulate the periodic delivery of the pharmacologic agent to optimally treat ischemia. The patient may operate a patient activator that the patient when feeling ischemia symptoms to transmit a signal that is received by the implantable infusion pump and triggers delivery of a bolus and/or continuous infusion.
摘要翻译： 公开了通过血管系统和心房壁，特别是通过上腔静脉和右心房壁经心脏进入心包空间的方法和系统，以向心脏递送药理学特别是NO供体药物。 输注导管的近端连接器联接到输注泵，并且具有远端输注导管腔端部开口的远侧导管段设置在心包空间中。 可植入输注泵可与可植入缺血监测器结合操作以监测缺血状态并触发递送或调节药理学剂的周期性递送以最佳地治疗缺血。 患者可以操作患者活化剂，当感觉到缺血症状时患者传递由可植入输液泵接收的信号并触发推注和/或连续输注的传递。
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公开(公告)号：US20110029056A1
公开(公告)日：2011-02-03
申请号：US12846547
申请日：2010-07-29
IPC分类号： A61N1/05
CPC分类号： A61N1/0553 , A61N1/0558
摘要： A medical system for electrical stimulation includes a first column of electrodes, a second column of electrodes, an expandable member disposed between first and second columns, and an expansion mechanism adapted to transmit an externally applied pressure to the expandable member. The pressure expands the expandable member in order to force the first column of electrodes apart from the second column of electrodes. The first and second columns, disposed side-by-side, may be inserted through a percutaneous needle and into a epidural space, alongside a spinal cord; after insertion, the first column may be forced apart from the second column by applying the pressure to the expandable member.
摘要翻译： 用于电刺激的医疗系统包括第一列电极，第二电极列，设置在第一和第二列之间的可扩张构件以及适于将外部施加的压力传递到可扩张构件的膨胀机构。 压力使可膨胀构件膨胀，以迫使第一列电极与第二列电极分开。 并排设置的第一和第二列可以穿过经皮针插入到与脊髓一起的硬膜外腔中; 在插入之后，通过向可膨胀构件施加压力，第一柱可以被迫离开第二柱。
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公开(公告)号：US07833157B2
公开(公告)日：2010-11-16
申请号：US12121647
申请日：2008-05-15
申请人： Rebecca Gottlieb , Rajiv Shah , Mary M. Morris , Victor Giron , Michael E. Miller , Bradley J. Enegren
发明人： Rebecca Gottlieb , Rajiv Shah , Mary M. Morris , Victor Giron , Michael E. Miller , Bradley J. Enegren
CPC分类号： A61M25/0032 , A61B5/028 , A61B5/14532 , A61B5/1486 , A61B5/415 , A61M5/14244 , A61M5/1723 , A61M25/0017 , A61M25/0023 , A61M2025/0003 , A61M2025/0046 , A61M2230/201 , Y10T29/49826
摘要： A multilumen catheter having tubings extending into lumens within the catheter. The lumens may be used for blood, drugs or other medicants. The lumens may also be used for sensors. The junction element, external to the patient, connects the tubings to the lumens. The tubings, also external to the patient, connect to infusion members, to which one or more infusion systems may be connected to deliver blood, drugs and other medicants to the patient. A sensor having a sensing element may extend through the sensor lumen and be positioned internal to the patient for physiological parameter sensing. An external portion of the sensor may be connected to associated electronics to provide automatic monitoring of the physiological parameters and automatic delivery and control of the infusants. Also, a central line catheter for delivering fluids directly into a main artery or vein near the heart, which contains a first lumen to deliver a fluid through the central line catheter and a second lumen containing a sensor capable indicating a characteristic level in blood. The first lumen delivers the fluid downstream of the sensor to prevent any interference between the fluid delivery and the sensor readings. In other versions, the central line catheter can have additional lumens for additional purposes. In addition, the central line catheter can further include a flush sleeve to remove debris around the sensor.
摘要翻译： 一种多管导管，其具有延伸到导管内腔内的管道。 流明可用于血液，药物或其他药物。 流明也可用于传感器。 患者外部的连接元件将管道连接到管腔。 也在患者外部的管连接到输注构件，一个或多个输注系统可以连接到输注构件，以向患者输送血液，药物和其他药剂。 具有感测元件的传感器可以延伸穿过传感器内腔并且位于患者的内部以用于生理参数感测。 传感器的外部部分可以连接到相关联的电子设备，以提供对生理参数的自动监测以及对输入的自动传送和控制。 另外，一种用于将流体直接输送到心脏附近的主动脉或静脉的中心线导管，其包含用于通过中心线导管输送流体的第一内腔和包含能够指示血液中的特征水平的传感器的第二腔。 第一个内腔在传感器的下游传送流体，以防止流体输送和传感器读数之间的任何干扰。 在其他版本中，中心线导管可以具有另外的流明用于其他目的。 此外，中心线导管还可以包括冲洗套筒以去除传感器周围的碎屑。
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公开(公告)号：US20100226903A1
公开(公告)日：2010-09-09
申请号：US12400059
申请日：2009-03-09
IPC分类号： A61K35/12
CPC分类号： A61K35/28 , A61B5/06 , A61B5/7285 , A61B6/12 , A61B6/481 , A61B6/487 , A61B6/541 , A61K35/39 , A61K49/0017 , A61K49/06
摘要： A method of delivering therapy to a target site. The method includes (a) obtaining a base image of the target site, (b) injecting a dose of a mix of a therapeutic agent and a contrast agent into a first injection location at the target site via a needle passing through a catheter, (c) collecting sequential fluoroscopic images of a contrast agent dispersion cloud at the first injection location, (d) determining a contrast agent dispersion area from the sequential fluoroscopic images, (e) determining a therapeutic agent dispersion area from the contrast agent dispersion area, (f) marking the therapeutic agent dispersion area on the base image of the target site, and (g) repeating (b) through (f) until the target site is substantially covered with overlapping therapeutic agent dispersion areas corresponding to a plurality of injections at a plurality of injection locations at the target site.
摘要翻译： 将治疗递送到目标部位的方法。 该方法包括（a）获得目标部位的基础图像，（b）通过穿过导管的针将目标部位的剂量的治疗剂和造影剂的剂量注射到目标部位的第一注射位置（ c）在第一注射位置处收集造影剂分散云的顺序透视图像，（d）从顺序透视图像确定造影剂分散区域，（e）从造影剂分散区域确定治疗剂分散区域（ f）在目标部位的基础图像上标记治疗剂分散区域，和（g）重复（b）到（f）直到目标部位基本上覆盖有与多个注射相对应的重叠治疗剂分散区域 在目标地点的多个注射位置。
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公开(公告)号：US20090276022A1
公开(公告)日：2009-11-05
申请号：US12433773
申请日：2009-04-30
申请人： John E. Burnes , Kenneth C. Gardeski , Ruth N. Klepfer , Patrick E. Macaulay , Mary M. Morris , Avram Scheiner
发明人： John E. Burnes , Kenneth C. Gardeski , Ruth N. Klepfer , Patrick E. Macaulay , Mary M. Morris , Avram Scheiner
IPC分类号： A61N1/05
CPC分类号： A61N1/36053 , A61M25/09 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/057 , A61N1/36085 , A61N1/36114 , A61N1/36125 , A61N1/36128
摘要： This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient.
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8.发明授权Radiopague marking of lead electrode zone in a continuous conductor construction 失效连续导体结构中铅电极区的不透射线标记公开(公告)号：US07277762B2
公开(公告)日：2007-10-02
申请号：US10280276
申请日：2002-10-25
IPC分类号： A61N1/06
CPC分类号： A61N1/0563
摘要： A cardiac transvenous defibrillation lead has a continuous coil conductor within a layer of insulation. A portion of the coil conductor is exposed as a defibrillation electrode. In order to enhance fluoroscopic visualization of the exposed electrode during implant, the end of the exposed electrode is marked with a radiopaque element. The element may be in the form of an adhesive filled with radiopaque material that is used to backfill under the layer of insulation. Alternatively, a tube made of radiopaque material may be installed between the layer of insulation and the coil conductor.
摘要翻译： 心脏静脉除颤引线在绝缘层内具有连续的线圈导体。 线圈导体的一部分作为除颤电极露出。 为了在植入期间增强暴露电极的荧光透视可视化，暴露电极的端部用不透射线的元件标记。 元件可以是填充有不透射线材料的粘合剂的形式，其用于在绝缘层下方回填。 或者，由不透射线材料制成的管可以安装在绝缘层和线圈导体之间。
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公开(公告)号：US07235067B2
公开(公告)日：2007-06-26
申请号：US10382757
申请日：2003-03-06
申请人： Mary M. Morris , Timothy G. Laske , Kenneth T. Heruth , Michael R. Ujhelyi , Jesus W. Casas-Bejar , David S. Olson
发明人： Mary M. Morris , Timothy G. Laske , Kenneth T. Heruth , Michael R. Ujhelyi , Jesus W. Casas-Bejar , David S. Olson
IPC分类号： A61M25/16
CPC分类号： A61M25/0075
摘要： A catheter body includes an exit port over which a pressure responsive sleeve is formed that allows material to exit a lumen of the catheter body at a given pressure. In one embodiment, a surface of the sleeve is approximately flush with a surface of the catheter body. In another embodiment the sleeve includes a tapered edge.
摘要翻译： 导管主体包括出口，在该出口处形成压力响应套筒，其允许材料在给定压力下离开导管体的内腔。 在一个实施例中，套筒的表面与导管主体的表面大致齐平。 在另一个实施例中，套筒包括锥形边缘。
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10.发明授权Radiopaque marking of lead electrode zone in a continuous conductor construction 失效连续导体结构中铅电极区的不透射线标记公开(公告)号：US06501992B1
公开(公告)日：2002-12-31
申请号：US09690163
申请日：2000-10-17
IPC分类号： A61N105
CPC分类号： A61N1/0563
摘要： A cardiac transvenous defibrillation lead has a continuous coil conductor within a layer of insulation. A portion of the coil conductor is exposed as a defibrillation electrode. In order to enhance fluoroscopic visualization of the exposed electrode during implant, the end of the exposed electrode is marked with a radiopaque element. The element may be in the form of an adhesive filled with radiopaque material that is used to backfill under the layer of insulation. Alternatively, a tube made of radiopaque material may be installed between the layer of insulation and the coil conductor.
摘要翻译： 心脏静脉除颤引线在绝缘层内具有连续的线圈导体。 线圈导体的一部分作为除颤电极露出。 为了在植入期间增强暴露电极的荧光透视可视化，暴露电极的端部用不透射线的元件标记。 元件可以是填充有不透射线材料的粘合剂的形式，其用于在绝缘层下方回填。 或者，由不透射线材料制成的管可以安装在绝缘层和线圈导体之间。
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