公开(公告)号：US20200121824A1

公开(公告)日：2020-04-23

申请号：US16717965

申请日：2019-12-17

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Steve Plotkin ,  Xinping Wu

IPC: A61L24/06 ,  A61L24/00 ,  C08F222/38

Abstract: Embolic particles are described. The particles are reaction products of a prepolymer solution including at least one polyether macromer and an appropriate monomer.

公开(公告)号：US10588923B2

公开(公告)日：2020-03-17

申请号：US16232929

申请日：2018-12-26

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael J. Constant ,  Joshua Garretson

IPC: A61K31/785 ,  A61L24/00 ,  A61K9/00 ,  A61L24/04 ,  A61K31/78 ,  A61K47/32

Abstract: Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

公开(公告)号：US20190192726A1

公开(公告)日：2019-06-27

申请号：US16287797

申请日：2019-02-27

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael J. Constant ,  Edward Michael Keeley ,  Rob Greene ,  Clayton Harris

IPC: A61L24/06 ,  A61L24/00 ,  A61K49/04 ,  A61K49/12

Abstract: Polymeric compositions are described comprising a biocompatible polymer including a biodegradable linkage to a visualization agent and a non-physiological solution; wherein the biocompatible polymer is soluble in the non-physiological solution and insoluble in a physiological solution. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

公开(公告)号：US10328458B2

公开(公告)日：2019-06-25

申请号：US13781385

申请日：2013-02-28

Applicant: MicroVention, Inc.

Inventor： Joshua Garretson ,  John Belletto ,  Gregory M. Cruise

IPC: B05D5/00 ,  C09D171/08 ,  B05D3/14 ,  C08G18/48 ,  C08G18/78 ,  C09D175/08 ,  A61L29/08 ,  A61L31/10

Abstract: Described herein are methods of coating both metallic and polymeric surfaces adding hydrophilicity comprising the steps mixing a coating composition comprising at least one polyol, at least one compound having at least two isocyanate groups, and an organic solvent; introducing nucleophilic functional groups on the surface thereby creating an active surface; subjecting the active surface to the coating composition thereby forming a coated surface; and curing the coated surface. Medical devices, for example, implantable medical devices can be coated by the methods described herein.

公开(公告)号：US10328175B2

公开(公告)日：2019-06-25

申请号：US15719197

申请日：2017-09-28

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Xinping Wu ,  Gloria Hincapie ,  Yue Wu

IPC: A61L24/00 ,  A61K47/69 ,  A61K31/4745 ,  A61K31/555 ,  A61L24/06 ,  C08F220/56 ,  A61L31/04 ,  A61L31/14 ,  C08F236/20 ,  A61L26/00 ,  A61B17/12 ,  A61B17/00

Abstract: Described are polymers and methods of forming and using same.

公开(公告)号：US20190134078A1

公开(公告)日：2019-05-09

申请号：US16232929

申请日：2018-12-26

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael J. Constant ,  Joshua Garretson

IPC: A61K31/785 ,  A61L24/00 ,  A61K9/00 ,  A61L24/04 ,  A61K31/78

CPC classification number: A61K31/785 ,  A61K9/0024 ,  A61K31/78 ,  A61K47/32 ,  A61L24/0089 ,  A61L24/046 ,  A61L2430/36

Abstract: Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

公开(公告)号：US10226533B2

公开(公告)日：2019-03-12

申请号：US14678514

申请日：2015-04-03

Applicant: MIcroVention, Inc.

Inventor： Gregory M. Cruise ,  Clayton G. Harris ,  Michael J. Constant

IPC: A61K47/32 ,  A61K31/7068 ,  A61K31/787 ,  C07H19/06 ,  C07F15/00 ,  A61K9/00 ,  A61K49/04 ,  A61L31/14 ,  A61L31/16 ,  A61L31/18 ,  A61K47/58

Abstract: Polymers are described herein comprising: a reaction product of a prepolymer solution including at least one macromer and at least one visualization agent; and an active agent electrostatically bound to the polymer filament or chemically bound to the at least one monomer; wherein the polymer filament does not include metallic support members.

公开(公告)号：US20180325649A1

公开(公告)日：2018-11-15

申请号：US15977967

申请日：2018-05-11

Applicant: MicroVention, Inc.

Inventor： Xinping Wu ,  Jodi Hong ,  Gregory M. Cruise

IPC: A61F2/06 ,  A61L31/14 ,  A61F2/00

CPC classification number: A61F2/06 ,  A61F2/0077 ,  A61F2/82 ,  A61L31/08 ,  A61L31/14

Abstract: Described are medical devices including expandable tubular bodies configured to be implanted into a lumen, wherein the outer surface of the expandable tubular bodies are coupled to a polymer(s).

公开(公告)号：US09937201B2

公开(公告)日：2018-04-10

申请号：US15142395

申请日：2016-04-29

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael J. Constant ,  Joshua Garretson

IPC: A61K31/785 ,  A61K9/00 ,  A61K31/78 ,  A61L24/00 ,  A61L24/04 ,  A61K47/32

CPC classification number: A61K31/785 ,  A61K9/0024 ,  A61K31/78 ,  A61K47/32 ,  A61L24/0089 ,  A61L24/046 ,  A61L2430/36

Abstract: Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

公开(公告)号：US20180036155A1

公开(公告)日：2018-02-08

申请号：US15784052

申请日：2017-10-13

Applicant: MicroVention, Inc.

Inventor： Tai D. Tieu ,  Gregory M. Cruise ,  Heather Griffin ,  Helen Nguyen ,  Minh Nguyen ,  Ponaka Pung ,  Shirley Vong

IPC: A61F2/945 ,  A61F2/90 ,  D04C1/06 ,  A61F2/852 ,  D04C3/48 ,  A61F2/966 ,  A61F2/91 ,  A61F2/82

CPC classification number: A61F2/945 ,  A61F2/852 ,  A61F2/90 ,  A61F2/91 ,  A61F2/966 ,  A61F2002/823 ,  A61F2002/826 ,  A61F2002/828 ,  A61F2210/0076 ,  A61F2230/0021 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0058 ,  A61F2230/0067 ,  A61F2240/001 ,  A61F2250/0023 ,  A61F2250/0036 ,  A61F2250/0098 ,  D04C1/06 ,  D04C3/48 ,  D10B2509/06

Abstract: In one embodiment according to the present invention, a stent is described having a generally cylindrical body formed from a single woven nitinol wire. The distal and proximal ends of the stent include a plurality of loops, some of which include marker members used for visualizing the position of the stent. In another embodiment, the previously described stent includes an inner flow diverting layer.