公开(公告)号：US20190008938A1

公开(公告)日：2019-01-10

申请号：US15748773

申请日：2016-07-29

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Nicholas Valiante ,  Tal Zaks

IPC: A61K39/00 ,  A61P35/00 ,  A61K47/68 ,  C12N15/62 ,  A61K9/127 ,  A61K47/54 ,  A61K47/26

Abstract: The invention relates to concatemeric peptide epitope RNAs, as well as methods and compositions thereof. mRNA vaccines are also provided according to the invention, including cancer vaccines.

公开(公告)号：US10124055B2

公开(公告)日：2018-11-13

申请号：US15674585

申请日：2017-08-11

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks

IPC: A61K39/12 ,  A61K9/00 ,  A61K9/127 ,  A61K39/39 ,  A61K39/42 ,  A61K48/00 ,  A61K9/51 ,  A61K39/015 ,  A61K39/00

Abstract: The disclosure relates to Zika virus infection and the treatment thereof. The invention includes ribonucleic acid compositions, as well as methods of using the compositions for treating and preventing Zika virus infection.

公开(公告)号：US09872900B2

公开(公告)日：2018-01-23

申请号：US15091123

申请日：2016-04-05

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Axel Bouchon ,  Eric Yi-Chun Huang

IPC: A61K39/145 ,  A61K48/00 ,  A61K39/12 ,  A61K39/39 ,  C12N7/00 ,  A61K31/7105 ,  A61K9/00 ,  A61K39/155 ,  A61K9/127 ,  A61K9/51 ,  A61K39/00

CPC classification number: A61K39/145 ,  A61K9/0019 ,  A61K9/1271 ,  A61K9/5123 ,  A61K9/5146 ,  A61K31/7105 ,  A61K39/12 ,  A61K39/155 ,  A61K39/39 ,  A61K48/00 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55555 ,  C12N7/00 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16234

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising polynucleotide molecules encoding one or more antigens.

公开(公告)号：US20170340724A1

公开(公告)日：2017-11-30

申请号：US15674585

申请日：2017-08-11

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks

IPC: A61K39/12 ,  A61K39/39 ,  A61K39/42 ,  A61K39/00

CPC classification number: A61K39/12 ,  A61K9/0019 ,  A61K9/1271 ,  A61K9/513 ,  A61K39/015 ,  A61K39/39 ,  A61K39/42 ,  A61K2039/51 ,  A61K2039/5254 ,  A61K2039/53 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/575 ,  C12N2770/24034 ,  C12N2770/24134 ,  C12N2770/36134

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.