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51.发明授权Isolated, MAGE-3 derived peptides which complex with HLA-A2 molecules and uses thereof 失效与HLA-A2分子复合的分离的MAGE-3衍生的肽及其用途
公开(公告)号：US5591430A
公开(公告)日：1997-01-07
申请号：US261160
申请日：1994-06-17
申请人： Alan Townsend , Judy Bastin , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Thomas Gajewski
发明人： Alan Townsend , Judy Bastin , Thierry Boon-Falleur , Pierre van der Bruggen , Pierre Coulie , Thomas Gajewski
CPC分类号： C07K14/4748 , A61K38/00 , Y10S530/828 , Y10S530/865
摘要： Tumor rejection antigens derived from tumor rejection precursor MAGE-3 have been identified. These "TRAS" bind to the MHC-class I molecule HLA-A2, and the resulting complexes stimulate the production of cytolytic T cell clones which lyse the presenting cells. The peptides and complexes may be used diagnostically, therapeutically, and as immunogens for the production of antibodies, or as targets for the generation of cytolytic T cell clones.
摘要翻译： 已经鉴定了源于肿瘤排斥前体MAGE-3的肿瘤排斥抗原。 这些“TRAS”与MHC-I类分子HLA-A2结合，并且所得复合物刺激裂解呈递细胞的溶细胞T细胞克隆的产生。 肽和复合物可以用于诊断，治疗和用作产生抗体的免疫原，或用作产生溶细胞T细胞克隆的靶标。
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52.发明授权Peptides which are derived from tumor rejection antigen precursor molecule MAGE-1, which complex to MHC molecule HLA-C clone 10, and uses thereof 失效衍生自与MHC分子HLA-C克隆10复合的肿瘤排斥抗原前体分子MAGE-1的肽及其用途
公开(公告)号：US5558995A
公开(公告)日：1996-09-24
申请号：US195186
申请日：1994-02-14
IPC分类号： G01N33/566 , A61K31/70 , A61K35/14 , A61K38/00 , A61K38/17 , A61K39/00 , A61K48/00 , A61K49/00 , A61P35/00 , C07K14/47 , C07K14/74 , C12N5/08 , C12N5/10 , C12N15/09 , C12Q1/02 , C12Q1/04 , C07K7/06 , C07K7/08 , G01N33/68
CPC分类号： C07K14/4748 , A61K48/00 , C07K14/70539 , G01N33/00 , A61K38/00 , A61K39/00 , Y10S530/828
摘要： The invention relates to the identification of complexes of HLA-C-clone 10 and MAGE-1 derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
摘要翻译： 本发明涉及在异常细胞表面鉴定HLA-C-clone 10和MAGE-1衍生肽的复合物。 该观察的治疗和诊断结果是本发明的主题。
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公开(公告)号：US20090203124A1
公开(公告)日：2009-08-13
申请号：US12016690
申请日：2008-01-18
CPC分类号： C07K14/4748 , A61K38/00
摘要： The invention describes HLA class II binding peptides encoded by the MAGE tumor associated genes, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of MAGE genes.
摘要翻译： 本发明描述了由MAGE肿瘤相关基因编码的HLA II类结合肽，以及编码与其有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以MAGE基因表达为特征的病症的方法和产品。
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公开(公告)号：US07351409B2
公开(公告)日：2008-04-01
申请号：US10753158
申请日：2004-01-07
申请人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catie Traversari , Vincent Stroobant , Guy R. Cornelis , Thierry Boon-Falleur , Pierre van der Bruggen , Erwin Schultz , Guy Warnier
发明人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catie Traversari , Vincent Stroobant , Guy R. Cornelis , Thierry Boon-Falleur , Pierre van der Bruggen , Erwin Schultz , Guy Warnier
CPC分类号： C07K14/4748
摘要： The present invention relates to isolation of cytotoxic T lymphocyte (CTL) clones. In particular, the present invention relates to isolated CTL clones that are specific for proteins of the MAGE family. The CTL clones of the present invention have been isolated by successive steps of stimulation and testing of lymphocytes with antigen presenting cells which present antigens derived from different expression systems, e.g., from recombinant Yersinia, recombinant Salmonella, or recombinant viruses. The present invention further relates to antigenic peptides as well as the peptide/HLA complexes which are recognized by the isolated CTL clones.
摘要翻译： 本发明涉及细胞毒性T淋巴细胞（CTL）克隆的分离。 特别地，本发明涉及对MAGE家族的蛋白质特异的分离的CTL克隆。 本发明的CTL克隆已经通过连续的步骤来刺激和测试淋巴细胞来分离，所述抗原呈递细胞提供来自不同表达系统的抗原，例如来自重组耶尔森氏菌，重组沙门氏菌或重组病毒。 本发明还涉及被分离的CTL克隆识别的抗原肽以及肽/ HLA复合物。
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公开(公告)号：US07049413B2
公开(公告)日：2006-05-23
申请号：US09860840
申请日：2001-05-18
IPC分类号： C07K14/435 , C07K7/00 , C07K14/00
CPC分类号： C07K14/4748 , A61K38/00
摘要： The invention describes HLA class II binding peptides encoded by the MAGE-A3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE-A3 gene.
摘要翻译： 本发明描述了由MAGE-A3肿瘤相关基因编码的HLA II类结合肽，以及编码这样的肽和与之有关的抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以MAGE-A3基因表达为特征的病症的方法和产品。
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56.发明授权Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-6 and uses thereof 失效编码肿瘤排斥抗原前体MAGE-6的分离的核酸分子及其用途公开(公告)号：US06946289B1
公开(公告)日：2005-09-20
申请号：US09583848
申请日：2000-05-31
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K16/30
摘要： The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-6. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic acid molecule, and optionally, molecules coding for human leukocyte antigen HLA-A1. Use of these materials in therapeutic and diagnostic contexts are also a part of the invention.
摘要翻译： 本发明涉及编码肿瘤排斥抗原前体MAGE-6的核酸分子。 还公开了利用核酸分子和任选的编码人白细胞抗原HLA-A1的分子的载体，细胞系等。 在治疗和诊断环境中使用这些材料也是本发明的一部分。
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57.发明授权METHOD FOR IDENTIFYING INDIVIDUALS SUFFERING FROM A CELLULAR ABNORMALITY SOME OF WHOSE ABNORMAL CELLS PRESENT COMPLEXES OF HLA-CW 1601/MAGE-1 DERIVED PEPTIDES, AND METHODS FOR TREATING SAID INDIVIDUALS 有权鉴定HLA-CW 1601 / MAGE-1衍生肽复合物异常细胞的一些细胞异常的个体识别方法，以及治疗上述个体的方法公开(公告)号：US06680056B1
公开(公告)日：2004-01-20
申请号：US09633994
申请日：2000-08-08
申请人： Pierre van der Bruggen , Jean-Pierre Szikora , Pierre Coulie , Claude Wildmann , Pascale Boël , Thierry Boon-Falleur
发明人： Pierre van der Bruggen , Jean-Pierre Szikora , Pierre Coulie , Claude Wildmann , Pascale Boël , Thierry Boon-Falleur
IPC分类号： A61K3900
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/70539
摘要： Peptides which satisfy the formula of SEQ ID NO: 10 bind to HLA-Cw*1601 molecules, and stimulate proliferation of cytolytic T cells. Examples of such peptides are those set forth in SEQ ID NOS: 4 and 5.
摘要翻译： 满足SEQ ID NO：10的式的肽与HLA-Cw * 1601分子结合，并刺激溶细胞T细胞的增殖。 这些肽的实例是SEQ ID NO：4和5所示的那些。
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公开(公告)号：US06291430B1
公开(公告)日：2001-09-18
申请号：US09166448
申请日：1998-10-05
申请人： Pascal Chaux , Vincent Stroobant , Thierry Boon-Falleur , Pierre van der Bruggen , Kris Thielemans , Jurgen Kurthals
发明人： Pascal Chaux , Vincent Stroobant , Thierry Boon-Falleur , Pierre van der Bruggen , Kris Thielemans , Jurgen Kurthals
IPC分类号： A61K3804
CPC分类号： C07K14/4748 , A61K39/00 , C07K2319/00
摘要： The invention describes HLA class II binding peptides encoded by the MAGE-3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE-3 gene.
摘要翻译： 本发明描述了由MAGE-3肿瘤相关基因编码的HLA II类结合肽，以及编码这样的肽和与之有关的抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以MAGE-3基因表达为特征的病症的方法和产品。
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公开(公告)号：US06265215B1
公开(公告)日：2001-07-24
申请号：US08713354
申请日：1996-09-13
IPC分类号： C12N508
CPC分类号： C07K14/4748 , A61K38/00
摘要： This invention involves the identification of peptides which complex with HLA-Cw*16 molecules, and which may then provoke lysis of the cells to which they bind, by cytolytic T cells. Diagnostic and therapeutic uses are described.
摘要翻译： 本发明涉及鉴定与HLA-Cw * 16分子复合的肽，然后可以通过溶细胞T细胞引起它们结合的细胞的裂解。 描述诊断和治疗用途。
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60.发明授权Tumor rejection antigens presented by HLA-B44 molecules, and uses thereof 失效由HLA-B44分子呈递的肿瘤排斥抗原及其用途
公开(公告)号：US6060257A
公开(公告)日：2000-05-09
申请号：US602506
申请日：1996-02-20
申请人： Jean Herman , Pierre Coulie , Thierry Boon-Falleur , Pierre van der Bruggen , Immanuel Luescher
发明人： Jean Herman , Pierre Coulie , Thierry Boon-Falleur , Pierre van der Bruggen , Immanuel Luescher
IPC分类号： C12N15/09 , A61K35/14 , A61K39/00 , C07K7/06 , C07K14/47 , C07K14/74 , C12N1/02 , C12N5/08 , C12N5/10 , C12Q1/68 , G01N33/569 , G01N33/574 , G01N33/68
CPC分类号： C12Q1/6881 , C07K14/4748 , C07K14/70539 , C12Q1/6886 , G01N33/56977 , G01N33/57492 , A61K39/00 , C12Q2600/136
摘要： Tumor rejection antigens presented by HLA-244 molecules are described. These peptides are useful in diagnostic and therapeutic methodologies. The tumor rejection antigens are derived from MAGE tumor rejection antigen precursors.
摘要翻译： 描述了由HLA-244分子呈递的肿瘤排斥抗原。 这些肽可用于诊断和治疗方法。 肿瘤排斥抗原来自MAGE肿瘤排斥抗原前体。
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