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    NOVEL UBIQUTIN PROTEASES
    53.
    发明申请
    NOVEL UBIQUTIN PROTEASES 失效
    新的UBIQUTIN蛋糕

    公开(公告)号：US20070292845A1

    公开(公告)日：2007-12-20

    申请号：US10165231

    申请日：2002-06-06

    申请人： Rosana Kapeller-Libermann

    发明人： Rosana Kapeller-Libermann

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/12

    CPC分类号： C12N9/6472

    摘要： The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the invention has been introduced or disrupted. The invention still further provides isolated proteins, fusion proteins, antigenic peptides and antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供编码新多肽的分离的核酸分子。 本发明还提供了反义核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及本发明的序列已被引入或破坏的非人类转基因动物。 本发明还进一步提供分离的蛋白质，融合蛋白质，抗原肽和抗体。 还提供了利用本发明组合物的诊断方法。

    Human protein kinase, phosphatase, and protease family members and uses thereof
    54.
    发明授权
    Human protein kinase, phosphatase, and protease family members and uses thereof 失效
    新型人类蛋白激酶，磷酸酶和蛋白酶家族成员及其用途

    公开(公告)号：US07282360B2

    公开(公告)日：2007-10-16

    申请号：US11636948

    申请日：2006-12-11

    申请人： Rachel E. Meyers ,  Peter J. Olandt ,  Rosana Kapeller-Libermann ,  Rory A. J. Curtis ,  Mark Williamson ,  Nadine Weich

    发明人： Rachel E. Meyers ,  Peter J. Olandt ,  Rosana Kapeller-Libermann ,  Rory A. J. Curtis ,  Mark Williamson ,  Nadine Weich

    IPC分类号： C12N9/20 ,  C12N15/00 ,  C12N1/20 ,  C12Q1/68 ,  C07H21/04

    CPC分类号： C12N9/1205 ,  A61K38/00 ,  C07K16/40 ,  C12N9/12 ,  C12N9/16 ,  C12N9/48 ,  C12N9/6424 ,  C12N9/6427 ,  C12N9/6472 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156

    摘要： The invention provides isolated nucleic acids molecules, designated 53070, 15985, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53070, 15985, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53070, 15985, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 53070, 15985, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-53070, 15985, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为53070,15985,26583,21953，m32404,14089和23436核酸分子，其编码新的人类蛋白激酶家族成员，丝氨酸/苏氨酸蛋白激酶家族成员，丝氨酸/苏氨酸磷酸酶家族成员 ，脯氨酰寡肽酶家族成员，胰蛋白酶家族成员，胰蛋白酶丝氨酸蛋白酶家族成员和泛素蛋白酶家族成员。 本发明还提供反义核酸分子，含有53070,15985,26583,21953，m32404,14089或23436核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中53070 ，15985,26583,21953，m32404,14089或23436基因已被引入或破坏。 本发明还进一步提供了分离的53070,15985,26583,21953，m32404,14089或23436蛋白，融合蛋白，抗原肽和抗-53070,15985,26583,21953，m32404,14089或23436抗体。 还提供了利用本发明组合物的诊断方法。

    Human protein kinase, phosphatase, and protease family members and uses thereof
    55.
    发明授权
    Human protein kinase, phosphatase, and protease family members and uses thereof 有权
    人蛋白激酶，磷酸酶和蛋白酶家族成员及其用途

    公开(公告)号：US07198930B2

    公开(公告)日：2007-04-03

    申请号：US11151601

    申请日：2005-06-13

    申请人： Rosana Kapeller-Libermann

    发明人： Rosana Kapeller-Libermann

    IPC分类号： C12N9/20 ,  C07K1/00

    CPC分类号： C12N9/1205 ,  A61K38/00 ,  C07K16/40 ,  C12N9/12 ,  C12N9/16 ,  C12N9/48 ,  C12N9/6424 ,  C12N9/6427 ,  C12N9/6472 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156

    摘要： The invention provides isolated nucleic acids molecules, designated 53070, 15985, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53070, 15985, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53070, 15985, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 53070, 15985, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-53070, 15985, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为53070,15985,26583,21953，m32404,14089和23436核酸分子，其编码新的人蛋白激酶家族成员，丝氨酸/苏氨酸蛋白激酶家族成员，丝氨酸/苏氨酸磷酸酶家族成员 ，脯氨酰寡肽酶家族成员，胰蛋白酶家族成员，胰蛋白酶丝氨酸蛋白酶家族成员和泛素蛋白酶家族成员。 本发明还提供反义核酸分子，含有53070,15985,26583,21953，m32404,14089或23436核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中53070 ，15985,26583,21953，m32404,14089或23436基因已被引入或破坏。 本发明还进一步提供了分离的53070,15985,26583,21953，m32404,14089或23436蛋白，融合蛋白，抗原肽和抗-53070,15985,26583,21953，m32404,14089或23436抗体。 还提供了利用本发明组合物的诊断方法。

    17867, a novel human aminopeptidase
    56.
    发明授权
    17867, a novel human aminopeptidase 失效

    公开(公告)号：US07034111B2

    公开(公告)日：2006-04-25

    申请号：US10039073

    申请日：2001-12-31

    申请人： Rosana Kapeller-Libermann ,  Mark Williamson

    发明人： Rosana Kapeller-Libermann ,  Mark Williamson

    IPC分类号： C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C07K2/00 ,  C07K5/00

    CPC分类号： C12Q1/37 ,  A61K38/00 ,  C12N9/48 ,  G01N2500/00 ,  Y02A50/475

    摘要： The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.

    13245, a novel human myotonic dystrophy type protein kinase and uses therefor
    59.
    发明授权
    13245, a novel human myotonic dystrophy type protein kinase and uses therefor 失效
    13245，一种新型人类强直性营养不良型蛋白激酶，并用于此

    公开(公告)号：US06946274B2

    公开(公告)日：2005-09-20

    申请号：US10017216

    申请日：2001-10-23

    申请人： Rosana Kapeller-Libermann

    发明人： Rosana Kapeller-Libermann

    IPC分类号： A61K38/00 ,  C12N9/12 ,  C12N1/20 ,  C07H21/04 ,  C12N9/20 ,  C12N15/00 ,  C12Q1/68

    CPC分类号： C12N9/1205 ,  A01K2217/05 ,  A61K38/00 ,  C12N9/12

    摘要： The invention provides isolated nucleic acids molecules, designated 13245 nucleic acid molecules, which encode a novel myotonic dystrophy type protein kinase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 13245 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 13245 gene has been introduced or disrupted. The invention still further provides isolated 13245 proteins, fusion proteins, antigenic peptides and anti-13245 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供编码新型强直性营养不良型蛋白激酶的分离的核酸分子，命名为13245核酸分子。 本发明还提供了反义核酸分子，含有13245个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏13245基因的非人转基因动物。 本发明还进一步提供分离的13245蛋白，融合蛋白，抗原肽和抗-13245抗体。 还提供了利用本发明组合物的诊断方法。

    18036, a novel calpain-like protease and uses thereof
    60.
    发明授权
    18036, a novel calpain-like protease and uses thereof 失效
    18036，一种新型钙蛋白酶样蛋白酶及其用途

    公开(公告)号：US06620592B2

    公开(公告)日：2003-09-16

    申请号：US09794960

    申请日：2001-02-26

    申请人： Rosana Kapeller-Libermann

    发明人： Rosana Kapeller-Libermann

    IPC分类号： C12N950

    CPC分类号： C12N9/6472

    摘要： Novel calpain-like protease polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length calpain-like protease proteins, the invention further provides isolated calpain-like protease fusion proteins, antigenic peptides, and anti-calpain-like protease antibodies. The invention also provides calpain-like protease nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a calpain-like protease gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 公开了新的钙蛋白酶样蛋白酶多肽，蛋白质和核酸分子。 除了分离的全长钙蛋白酶样蛋白酶蛋白，本发明还提供了分离的钙蛋白酶样蛋白酶融合蛋白，抗原肽和抗钙蛋白酶样蛋白酶抗体。 本发明还提供了钙蛋白酶样蛋白酶核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中已经引入了钙蛋白酶样蛋白酶基因的非人类转基因动物 或中断。 还提供了利用本发明组合物的诊断，筛选和治疗方法。