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公开(公告)号：US07512438B2
公开(公告)日：2009-03-31
申请号：US10950401
申请日：2004-09-28
IPC分类号： A61B5/0452
CPC分类号： A61N1/37235 , A61B5/0031 , A61B5/0452 , A61B5/0472 , A61B5/413 , A61N1/025 , A61N1/37247
摘要： A “tracker system” that includes electrical leads which are part of an implanted cardiotracker plus external equipment that includes external alarm and a physician's programmer. The tracker system is designed to monitor the degradation of a patient's cardiovascular condition from one or more causes, These causes include the rejection of a transplanted heart and/or the progression of a stenosis in a coronary artery. As one or more stenoses in a coronary artery become progressively more narrow thereby causing reduced blood flow to the heart muscle coronary circulation, the tracker system can alert the patient by either or both internal and/or external alarm to take the appropriate medical action. The physician's programmer can be used to display histograms of key heart signal parameters that are indicative of the patient's cardiovascular condition.
摘要翻译： “跟踪器系统”包括作为植入式心脏病治疗机的一部分的电引线，以及包括外部警报和医生程序员的外部设备。 跟踪器系统被设计成从一个或多个原因监测患者心血管病症的恶化。这些原因包括移植心脏的排斥和/或冠状动脉狭窄进展。 由于冠状动脉中的一个或多个狭窄变得越来越狭窄，从而导致血液流向心脏肌肉冠状动脉循环的减少，跟踪器系统可以通过内部和/或外部警报中的一个或两个来警告患者以采取适当的医疗行动。 医师的程序员可用于显示指示患者心血管疾病的关键心脏信号参数的直方图。
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公开(公告)号：US07037327B2
公开(公告)日：2006-05-02
申请号：US09961927
申请日：2001-09-24
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2/90 , A61F2002/9583 , A61F2250/0018 , A61F2250/0042 , A61F2250/0048
摘要： A hybrid stent that is defined as having a central section that is balloon expandable and end sections that are self-expanding. The entire stent is mounted on a balloon of a balloon angioplasty catheter. One way to retain the self-expanding portion of the stent onto a balloon onto which it has been nested is to place a cylindrical elastomer tube around each of the self-expanding end sections of the stent. Another way to retain the hybrid stent onto a stent delivery system is to use a conventional sheath that is pulled back to initiate stent deployment
摘要翻译： 被定义为具有球囊可膨胀的中心部分和自膨胀的末端部分的混合支架。 整个支架安装在球囊血管成形术导管的球囊上。 将支架的自膨胀部分保持在其已经嵌套在其上的气球上的一种方法是将圆柱形弹性体管围绕在支架的每个自扩张端部分上。 将混合支架保持在支架输送系统上的另一种方法是使用被拉回以启动支架部署的常规护套
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公开(公告)号：US07011673B2
公开(公告)日：2006-03-14
申请号：US10107221
申请日：2002-03-26
IPC分类号： A61F2/06
CPC分类号： A61F2/95 , A61F2/958 , A61M2025/0186 , A61M2025/1004
摘要： The present invention is a stent delivery system that uses a short section of a guide wire that is fixedly attached to a distal section of a balloon angioplasty catheter. By not having a guide wire that slides through the balloon of the balloon angioplasty catheter, the balloon on which the stent is mounted can have a reduced diameter. Therefore, the outside diameter of the undeployed stent mounted onto that balloon is also minimized. This provides a minimum profile, i.e., a minimum outside diameter, for the stent. A minimum profile at the distal section of the stent delivery system is highly advantageous for improving the percentage of cases that can be treated by means of direct stenting; i.e., without requiring pre-dilation of a stenosis.
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公开(公告)号：US06547817B1
公开(公告)日：2003-04-15
申请号：US09596074
申请日：2000-06-16
IPC分类号： A61M2900
CPC分类号： A61F2/844 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91533 , A61F2002/9155 , A61F2210/0019
摘要： An expandable stent for delivery to a coronary artery. The stent has at least two longitudinally spaced apart circumferential rings having closed ends. Each of the circumferential rings has at least two peak segments and at least two valley segments. At least one longitudinally extending connector extends between adjacent circumferential rings. The connector has a first end portion fixedly connected to a first circumferential ring and a second end portion fixedly connected to an adjacent circumferential ring. The connector has at least one circumferentially extending turn back portion between its first and second end portions that can expand or contract in length while being passed through a curved coronary artery.
摘要翻译： 用于输送到冠状动脉的可扩张支架。 支架具有至少两个具有闭合端的纵向间隔开的周向环。 每个周向环具有至少两个峰段和至少两个谷段。 至少一个纵向延伸的连接件在相邻周向环之间延伸。 连接器具有固定地连接到第一周向环的第一端部和固定地连接到相邻周向环的第二端部。 连接器在其第一和第二端部之间具有至少一个沿圆周方向延伸的折回部分，其能够在穿过弯曲的冠状动脉的同时膨胀或收缩。
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公开(公告)号：US06315708B1
公开(公告)日：2001-11-13
申请号：US09540629
申请日：2000-03-31
IPC分类号： A61N500
CPC分类号： A61F2/958 , A61F2/90 , A61F2002/9583 , A61F2250/0018 , A61F2250/0042 , A61F2250/0048
摘要： The present invention is a hybrid stent that is defined as having a central section that is balloon expandable and end sections that are self-expanding. The entire stent is mounted on a balloon of a balloon angioplasty catheter. One way to retain the self-expanding portion of the stent onto a balloon onto which it has been nested is to place a cylindrical elastomer tube around each of the self-expanding end sections of the stent. Another way to retain the hybrid stent onto a stent delivery system is to use a conventional sheath that is pulled back to initiate stent deployment
摘要翻译： 本发明是一种混合型支架，其被定义为具有球囊可膨胀的中心部分和自膨胀的端部。 整个支架安装在球囊血管成形术导管的球囊上。 将支架的自膨胀部分保持在其已经嵌套在其上的气球上的一种方法是将圆柱形弹性体管围绕在支架的每个自扩张端部分上。 将混合支架保持在支架输送系统上的另一种方法是使用被拉回以启动支架部署的常规护套
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公开(公告)号：US06270521B1
公开(公告)日：2001-08-07
申请号：US09316843
申请日：1999-05-21
IPC分类号： A61F1100
CPC分类号： A61F2/95 , A61F2/958 , A61F2002/9583 , A61F2250/0036
摘要： An ultra-thin distal sheath section of the sheathed system uses heat shrinkable elastomer tubing with a wall thickness that is less than 0.05 mm and may be less than 0.025 mm. There are two methods for securing the ultra-thin distal sheath section over the distal tip. A first method is to employ another thin tube shrunk down over the distal end of the ultra-thin distal sheath. It is also envisioned that simply shrinking the ultra-thin distal sheath section down on the tapered section of the distal tip will hold it securely. A monorail (rapid exchange) version of this stent delivery system is also envisioned. A second version uses radioopaque elastic bands mounted over the ends of the balloon just proximal and just distal to the stent to provide a low profile for a primary stent delivery system. These radioopaque elastic bands could contain a high-density material such as tungsten to make them radioopaque and eliminate the need for radioopaque markers normally attached to the angioplasty balloon inner shaft.
摘要翻译： 护套系统的超薄远端护套部分使用壁厚小于0.05mm且可能小于0.025mm的热收缩弹性体管。 有两种方法用于将超薄远端鞘部分固定在远端上。 第一种方法是使用在超薄远侧鞘的远端下方收缩的另一条细管。 还可以想到，将超薄远端鞘部分简单地收缩在远侧尖端的锥形部分上将牢固地保持。 还设想了该支架输送系统的单轨（快速交换）版本。 第二个版本使用放射性弹性带，其安装在球囊的端部的刚好在支架的近侧并且仅在支架的远端处，以为主支架输送系统提供低轮廓。 这些不透射线的弹性带可以含有诸如钨的高密度材料，使其不透射线，并且不需要通常附着于血管成形术球囊内轴的不透射线标记。
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公开(公告)号：US6086604A
公开(公告)日：2000-07-11
申请号：US263518
申请日：1999-03-05
CPC分类号： A61F2/844 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91533 , A61F2002/9155 , A61F2210/0019
摘要： The present invention provides for an expandable stent (10 or 20) for use in an artery or other vessel of a human body. The stent structure (10 or 20) maintains the patency of the vessel within which the stent (10 or 20) is expanded radially outward. One embodiment of the present invention is a stent (10) having a multiplicity of frames (12) joined together by at least two undulating longitudinal structures (14L and 14R) which can readily change their length in the longitudinal direction so as to provide increased longitudinal flexibility for the stent (10) for easy passage through and placement within a curved vessel such as a coronary artery. The stent (20) is an embodiment of the present invention having frames (22) joined with longitudinal structures (24B, 24T and 24R) and formed from a single, thin-walled piece of metal by laser cutting or chemical etching. Because the stent (20) is fabricated from a single piece of metal, it provides a multiplicity of closed perimeter cells that are formed as a continuous metal structure.
摘要翻译： 本发明提供一种用于人体动脉或其他血管的可扩张支架（10或20）。 支架结构（10或20）保持支架（10或20）径向向外扩张的容器的通畅性。 本发明的一个实施例是具有通过至少两个起伏的纵向结构（14L和14R）连接在一起的多个框架（12）的支架（10），其可以容易地改变其在纵向上的长度，从而提供增加的纵向 支架（10）的灵活性容易通过并放置在诸如冠状动脉的弯曲容器内。 支架（20）是本发明的实施例，其具有通过激光切割或化学蚀刻由单个薄壁金属片形成的具有纵向结构（24B，24T和24R）的框架（22）。 因为支架（20）由单块金属制成，所以它提供了多个形成为连续金属结构的封闭周边细胞。
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公开(公告)号：US6016449A
公开(公告)日：2000-01-18
申请号：US957869
申请日：1997-10-27
IPC分类号： A61N1/36
CPC分类号： A61B5/0476 , A61B5/4094 , A61B5/6814 , A61N1/3605 , A61N1/36025 , A61N1/36082 , A61N1/37211
摘要： Disclosed is a multiple electrode, closed-loop, responsive system for the treatment of certain neurological diseases such as epilepsy, migraine headaches and Parkinson's disease. Brain electrodes would be placed in close proximity to the brain or deep within brain tissue. When a neurological event such as the onset of an epileptic seizure occurs, EEG signals from the electrodes are processed by signal conditioning means in a control module that can be placed beneath the patient's scalp, within the patient's chest, or situated externally on the patient. Neurological event detection means in the control module will then cause a response to be generated for stopping the neurological event. The response could be an electrical signal to brain electrodes or to electrodes located remotely in the patient's body. The response could also be the release of medication or the application of a sensory input such as sound, light or mechanical vibration or electrical stimulation of the skin. The response to the neurological event can originate from devices either internal or external to the patient. The system also has the capability for multi-channel recording of EEG related signals that occur both before and after the detection of a neurological event. Programmability of many different operating parameters of the system by means of external equipment provides adaptability for treating patients who manifest different symptoms and who respond differently to the response generated by the system.
摘要翻译： 公开了一种用于治疗某些神经系统疾病如癫痫，偏头痛和帕金森病的多重电极闭环应答系统。 脑电极将放置在靠近脑部或脑组织深处。 当出现诸如癫痫发作的神经系统事件时，来自电极的EEG信号由控制模块中的信号调节装置处理，该控制模块可以放置在患者的头皮之下，患者的胸部内，或者位于病人的外部。 然后，控制模块中的神经事件检测装置将产生用于停止神经系统事件的响应。 响应可以是对脑电极或位于病人身体远端的电极的电信号。 该反应也可以是药物的释放或者诸如声音，光或机械振动或电刺激皮肤的感觉输入的应用。 对神经系统事件的反应可以来自患者内部或外部的装置。 该系统还具有在检测神经系统事件之前和之后发生的EEG相关信号的多通道记录的能力。 通过外部设备对系统的许多不同操作参数的可编程性提供了适应性，用于治疗表现不同症状的患者，并且对系统产生的反应有不同的反应。
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公开(公告)号：US5749825A
公开(公告)日：1998-05-12
申请号：US714315
申请日：1996-09-18
CPC分类号： A61F2/90 , A61F2/954 , A61F2/958 , A61F2/856 , A61F2/91 , A61F2002/065 , A61F2002/067 , A61F2210/0095 , A61F2250/006
摘要： A stent delivery catheter system for the treatment of stenoses at an arterial bifurcation consists of a main guide wire, a side branch guide wire, a unique design balloon angioplasty catheter which includes a side branch tube and a stent that can be deployed to a larger diameter in the main artery leading to the arterial bifurcation, and deployed to a smaller diameter within one of the branch arteries at an arterial bifurcation. The balloon angioplasty catheter used to deploy the dual diameter stent has a proximal section that has a larger diameter as compared to the diameter of a distal section which distal section is designed to be placed in a branch artery of the bifurcation. An opening in the wall of the stent allows for the passage of the side branch tube that provides angular orientation of the pre-deployed stent relative to the two branches of the bifurcation. The side branch tube is also used to help assure proper longitudinal placement of the stent relative to the saddle point of the bifurcation. After the stent is deployed, the opening in the stent wall allows unobstructed blood flow into that side branch artery that is not initially stented.
摘要翻译： 用于治疗动脉分叉狭窄的支架输送导管系统包括主导丝，侧分支引导线，独特的设计球囊血管成形术导管，其包括侧分支管和可以展开到更大直径的支架 在导致动脉分叉的主动脉中，并且在动脉分叉处部署到一个分支动脉内的较小直径。 用于展开双直径支架的球囊血管成形术导管具有与远端部分的直径相比具有较大直径的近端部分，其远端部分被设计成放置在分叉的分支动脉中。 支架壁上的开口允许侧分支管的通过，其提供相对于分叉的两个分支的预先展开的支架的角度定向。 侧支管还用于帮助确保支架相对于分叉的鞍点的适当纵向放置。 在展开支架之后，支架壁中的开口允许无阻塞的血液流入最初不支架的侧支支动脉。
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60.发明授权
公开(公告)号：US5735859A
公开(公告)日：1998-04-07
申请号：US800613
申请日：1997-02-14
摘要： The present invention is a device and method for securing and releasing the distal end of a thin-walled sheath to and from a distal section of a stent delivery catheter. The invention comprises a stent delivery catheter system which includes a sheath which is releasably attached to a distal section of a stent delivery catheter. When the stent delivery system has been advanced into the body so that the stent (which is situated coaxially within the sheath) is placed at the site of an arterial stenosis where it is to be deployed, the sheath is released from the stent delivery catheter and then the sheath is pulled back in a proximal direction thereby uncovering the stent. Self-deploying stents will automatically deploy when the sheath is pulled back. Balloon expandable stents can be deployed by balloon inflation after the sheath has been pulled back. One embodiment of the distally attachable and releasable sheath utilizes a guide wire that passes through the stent delivery catheter first to hold and then to release the distal end of the sheath from a distal section of the stent delivery catheter.
摘要翻译： 本发明是一种用于将薄壁护套的远端固定并释放到支架输送导管的远端部分的装置和方法。 本发明包括支架递送导管系统，其包括可释放地附接到支架递送导管的远端部分的护套。 当支架输送系统已经进入体内，使得支架（其位于鞘内同轴位置）被放置在其将要部署的动脉狭窄部位时，护套从支架输送导管释放，并且 然后将护套沿近侧方向拉回，从而露出支架。 当护套被拉回时，自动部署支架将自动部署。 护套被拉回之后，球囊扩张支架可以通过球囊膨胀进行部署。 远端可附接和可释放的护套的一个实施例使用导线首先穿过支架输送导管以保持，然后从支架输送导管的远端部分释放护套的远端。
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