公开(公告)号：US08987274B2

公开(公告)日：2015-03-24

申请号：US14354303

申请日：2012-10-23

申请人： Latha G. Nair ,  Stephane L. Bogen ,  Ronald J. Doll ,  Yao Ma ,  Yuan Tian

发明人： Latha G. Nair ,  Stephane L. Bogen ,  Ronald J. Doll ,  Yao Ma ,  Yuan Tian

IPC分类号： A61K31/497 ,  C07D498/14 ,  C07D409/14

CPC分类号： C07D498/14 ,  C07D409/14

摘要： The present invention provides a compound of Formula (1): as described herein or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.

摘要翻译： 本发明提供式（1）的化合物：如本文所述或其药学上可接受的盐或溶剂化物。 该化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的潜在方法。

公开(公告)号：US20110143954A2

公开(公告)日：2011-06-16

申请号：US12776141

申请日：2010-05-07

申请人： Christopher Shelton ,  Yuan Tian ,  Yueming Li

发明人： Christopher Shelton ,  Yuan Tian ,  Yueming Li

IPC分类号： G01N33/573 ,  C12Q1/37 ,  C12P21/06 ,  C12N9/99 ,  C12N5/02 ,  C40B30/04 ,  C07K14/47 ,  C07K7/06 ,  C07H21/04

CPC分类号： G01N33/573 ,  C07K14/4711 ,  G01N33/542 ,  G01N2333/4709 ,  G01N2333/948 ,  G01N2500/02 ,  G01N2800/2814 ,  G01N2800/2821

摘要： Polypeptide substrates based on modifications or fragments of the various APP isoforms, assay methods based on the use of these substrates, and screening methods directed toward identifying inhibitors of γ-secretase activity. The assay methods and the screening methods are adapted for use in high throughput multi-well plate assay apparatuses. In many embodiments the substrate polypeptides are labeled for ease of detection, and/or may bind specific ligands that themselves are labeled. Generally the labels promote high specificity as well as high sensitivity of detection. These features render the assay and screening methods that employ the labeled substrates especially suited for use in high throughput assay formats. This disclosure further identifies small polypeptides based on a subsequence motif of Aβ that are shown herein to be potent inhibitors of the activity of γ-secretase.

摘要翻译： 基于各种APP同种型的修饰或片段的多肽底物，基于这些底物的使用的测定方法以及用于鉴定γ-分泌酶活性抑制剂的筛选方法。 测定方法和筛选方法适用于高通量多孔板测定装置。 在许多实施方案中，底物多肽被标记以便于检测，和/或可以结合其本身被标记的特异性配体。 通常，标记物具有高度的特异性和高灵敏度的检测。 这些特征使得使用标记底物的测定和筛选方法特别适用于高通量测定形式。 本公开进一步基于A＆bgr的亚序列基序识别小多肽; 这在本文中显示为γ-分泌酶活性的有效抑制剂。

公开(公告)号：US07941123B2

公开(公告)日：2011-05-10

申请号：US11502845

申请日：2006-08-11

申请人： Pengliang Yang ,  Yuan Tian ,  Yongsheng Zhu ,  Hui Zhao

发明人： Pengliang Yang ,  Yuan Tian ,  Yongsheng Zhu ,  Hui Zhao

IPC分类号： H04L12/58 ,  H04B5/00 ,  G01R31/08 ,  H04L12/28 ,  H04J3/06 ,  G06F15/16 ,  H04M1/66

CPC分类号： H04L67/06 ,  H04L67/04 ,  H04L67/104 ,  H04L67/1044 ,  H04L67/1074 ,  H04W8/20

摘要： The invention discloses a method and system for downloading data to mobile terminals, a mobile terminal that utilizes the method, and a method and a system for implementing data sharing between mobile terminals. The method for data downloading includes: dividing data to be downloaded into multiple data task segments by a master mobile terminal, and allocating the data task segments to one or more mobile terminals; downloading the data by the mobile terminals in accordance with the allocated data task segments; judging by the master mobile terminal whether there are any data task segments that have not been downloaded; and if yes, allocating the data task segments to at least one mobile terminal that has finished downloading data task segment; and if no, terminating the download procedure. The system for data downloading includes: a server, at least a master mobile terminal, and at least a slave mobile terminal.

摘要翻译： 本发明公开了一种向移动终端下载数据的方法和系统，利用该方法的移动终端，以及用于实现移动终端之间的数据共享的方法和系统。 用于数据下载的方法包括：由主移动终端将要下载的数据划分为多个数据任务段，并将数据任务段分配给一个或多个移动终端; 根据分配的数据任务段，由移动终端下载数据; 由主移动终端判断是否存在尚未下载的任何数据任务段; 如果是，则将数据任务段分配给已完成下载数据任务段的至少一个移动终端; 如果否，终止下载过程。 用于数据下载的系统包括：服务器，至少主移动终端和至少从属移动终端。

公开(公告)号：US20100158243A1

公开(公告)日：2010-06-24

申请号：US12339537

申请日：2008-12-19

申请人： Yuan Tian ,  Abtin Keshavarzian

发明人： Yuan Tian ,  Abtin Keshavarzian

IPC分类号： H04K1/00 ,  H04K1/04

CPC分类号： H04L9/0637 ,  H04L9/12 ,  H04L2209/08 ,  H04L2209/80

摘要： A data encryption method includes providing a sender node having information to transmit. The information is divided into a sequence of frames. A respective one of a plurality of frame numbers is assigned to each of the frames. At least one nonce and at least one security key are used to perform block cipher encryption and produce within the sender node a respective block cipher encryption output for each of the frames. The information is converted from a sequence of plaintext frames to a sequence of ciphertext frames by use of the block cipher encryption outputs produced within the sender node. The converting is performed within the sender node and after the block cipher encryption outputs have been produced within the sender node. A receiver node is used to ascertain the frame numbers. The at least one nonce is transmitted from the sender node to the receiver node. The at least one nonce and the at least one security key are used to perform block cipher encryption and produce within the receiver node a respective block cipher encryption output for each of the frames. The ciphertext frames are transmitted from the sender node to the receiver node. The ciphertext frames are transmitted after the block cipher encryption outputs have been produced within the receiver node. The transmitted ciphertext is converted back into the plaintext frames by use of the block cipher encryption outputs produced within the receiver node. The converting is performed within the receiver node and after the block cipher encryption outputs have been produced within the receiver node.

摘要翻译： 数据加密方法包括提供具有要发送的信息的发送者节点。 信息被分成一系列帧。 将多个帧号中的相应一个分配给每个帧。 使用至少一个随机数和至少一个安全密钥来执行块密码加密，并且在发送器节点内产生用于每个帧的相应块密码加密输出。 信息通过使用发送方节点内产生的块密码加密输出，从明文帧序列转换成密文序列。 转换在发送方节点内执行，并且在发送方节点内产生了块密码加密输出。 接收机节点用于确定帧号。 至少一个随机数从发送方节点发送到接收方节点。 所述至少一个随机数和所述至少一个安全密钥用于执行块密码加密，并且在所述接收器节点内产生用于每个帧的相应块密码加密输出。 密文帧从发送方节点发送到接收方节点。 在接收器节点中产生块密码加密输出之后，发送密文帧。 通过使用在接收器节点内产生的块密码加密输出将所传输的密文转换回明文帧。 转换在接收器节点内执行，并且在接收器节点中已经产生块加密输出之后。

公开(公告)号：US20090067449A1

公开(公告)日：2009-03-12

申请号：US11900085

申请日：2007-09-10

申请人： Yuan Tian

发明人： Yuan Tian

IPC分类号： H04L12/28

CPC分类号： G08G1/0962 ,  H04L12/40019 ,  H04L2012/40273

摘要： An integrated system for interactive communication and multimedia support in a vehicle. The system includes a plurality of peripheral devices and a central control unit. Each of the peripheral devices is configured to be installed in the vehicle. The central control unit is also configured to be installed in the vehicle and has a communication interface. The communication interface includes first and second communication platforms and communicates with the plurality of peripheral devices via at least one of the first and second communication platforms. Each communication platform is configured to support bi-directional and selective communication between each of the peripheral devices.

摘要翻译： 一种用于车辆中交互式通信和多媒体支持的集成系统。 该系统包括多个外围设备和中央控制单元。 每个外围设备被配置为安装在车辆中。 中央控制单元还被配置为安装在车辆中并且具有通信接口。 通信接口包括第一和第二通信平台，并且经由第一和第二通信平台中的至少一个与多个外围设备进行通信。 每个通信平台被配置为支持每个外围设备之间的双向和选择性通信。

公开(公告)号：US20060276111A1

公开(公告)日：2006-12-07

申请号：US11142918

申请日：2005-06-02

申请人： Yuan Tian ,  Alpay Yilmaz ,  Gerald Alonzo ,  Martin Wohlert ,  Yongqi Hu ,  Stan Tsai ,  Robert Ewald ,  Shou-Sung Chang

发明人： Yuan Tian ,  Alpay Yilmaz ,  Gerald Alonzo ,  Martin Wohlert ,  Yongqi Hu ,  Stan Tsai ,  Robert Ewald ,  Shou-Sung Chang

IPC分类号： B24B1/00 ,  B24B33/00

CPC分类号： B24B53/017 ,  B24B53/12

摘要： Embodiments of a conditioning element for conditioning a processing pad are provided herein. In one embodiment, a conditioning element for conditioning a processing pad includes a body having a face. A plurality of diamond particles are disposed on the face and define a conditioning surface. The diamond particles are of a type selected from the group consisting of very blocky (4D), blocky (3D), and irregular (2D), and have a shape ratio less than or equal to 1.2. In one embodiment, the diamond particles have an average size of between about 85 and about 115 μm. In one embodiment, the size of the diamond particles may have a standard of deviation that is less than about 5 μm. In one embodiment, the diamond particles may have a spacing of greater than 400 μm.

摘要翻译： 本文提供了用于调节加工垫的调节元件的实施例。 在一个实施例中，用于调节处理垫的调节元件包括具有面的主体。 多个金刚石颗粒设置在面上并限定调理表面。 金刚石颗粒是选自非常块状（4D），块状（3D）和不规则（2D）的类型，并且具有小于或等于1.2的形状比。 在一个实施方案中，金刚石颗粒的平均尺寸为约85至约115μm。 在一个实施方案中，金刚石颗粒的尺寸可以具有小于约5μm的偏差标准。 在一个实施例中，金刚石颗粒可以具有大于400μm的间隔。

公开(公告)号：US20050133363A1

公开(公告)日：2005-06-23

申请号：US11031545

申请日：2005-01-08

申请人： Yongqi Hu ,  Yan Wang ,  Alain Duboust ,  Feng Liu ,  Antoine Manens ,  Siew Neo ,  Stan Tsai ,  Liang-Yuh Chen ,  Paul Butterfield ,  Yuan Tian ,  Sen-Hou Ko

发明人： Yongqi Hu ,  Yan Wang ,  Alain Duboust ,  Feng Liu ,  Antoine Manens ,  Siew Neo ,  Stan Tsai ,  Liang-Yuh Chen ,  Paul Butterfield ,  Yuan Tian ,  Sen-Hou Ko

IPC分类号： B23H5/08 ,  B23H5/10 ,  B24B37/04 ,  B24B53/007 ,  B24D13/14 ,  H01L21/321 ,  C25D17/00

CPC分类号： B82Y30/00 ,  B23H5/08 ,  B23H5/10 ,  B24B37/046 ,  B24B37/14 ,  B24B37/16 ,  B24B37/205 ,  B24B37/22 ,  B24B37/24 ,  B24B37/26 ,  B24B53/017 ,  H01L21/32125 ,  Y10T428/249924

摘要： Embodiments of a polishing article for processing a substrate are provided. In one embodiment, a polishing article for processing a substrate comprises a fabric layer having a conductive layer disposed thereover. The conductive layer has an exposed surface adapted to polish a substrate. The fabric layer may be woven or non-woven. The conductive layer may be comprised of a soft metal and, in one embodiment, the exposed surface may be planar.

摘要翻译： 提供了用于处理基板的抛光制品的实施例。 在一个实施例中，用于处理衬底的抛光制品包括其上设置有导电层的织物层。 导电层具有适于抛光衬底的暴露表面。 织物层可以是编织的或非织造的。 导电层可以由软金属构成，并且在一个实施例中，暴露的表面可以是平面的。