Antibodies to &agr;v&bgr;3 integrin
    52.
    发明授权
    Antibodies to &agr;v&bgr;3 integrin 失效
    抗体为alphavbeta3整合素

    公开(公告)号:US06359126B1

    公开(公告)日:2002-03-19

    申请号:US08874837

    申请日:1997-06-13

    IPC分类号: C07H2104

    摘要: The invention relates to monoclonal antibodies to the &agr;v&bgr;3 integrin receptor known to be expressed in large amounts on the surface of osteoclasts and accordingly, associated with bone resorption. The disclosed monoclonal antibodies recognize unique epitopes on &agr;v&bgr;3 and are useful in the treatment of conditions associated with excessive bone resorption and/or in the inhibition of tumor cell growth.

    摘要翻译: 本发明涉及已知在破骨细胞表面上大量表达的α受体α整联蛋白受体的单克隆抗体,因此与骨吸收有关。 所公开的单克隆抗体识别出在alphavbeta3上的独特表位,并且可用于治疗与过量骨吸收和/或抑制肿瘤细胞生长相关的病症。

    Nucleic acid encoding monoclonal antibodies to leukemia inhibitory factor
    55.
    发明授权
    Nucleic acid encoding monoclonal antibodies to leukemia inhibitory factor 失效
    核酸编码白血病抑制因子的单克隆抗体

    公开(公告)号:US5668003A

    公开(公告)日:1997-09-16

    申请号:US438455

    申请日:1995-05-10

    申请人: Kyung Jin Kim

    发明人: Kyung Jin Kim

    摘要: The invention relates to nucelic acids encoding monoclonal antibodies to human leukemia inhibitory factor. The disclosed monoclonal antibodies are believed to recognize unique epitopes on hLIF and are useful in the treatment of conditions wherein the presence of hLIF causes or contributes to undesirable pathological effects, such as cachexia, dysregulated calcium metabolism, or excessive bone cell proliferation, and in the detection of hLIF, for example, in clinical samples or specimens.

    摘要翻译: 本发明涉及编码人白血病抑制因子单克隆抗体的营养酸。 所公开的单克隆抗体被认为在hLIF上识别出独特的表位,并且可用于治疗其中hLIF的存在引起或有助于不期望的病理学作用,例如恶病质,调节钙代谢或过度骨细胞增殖的病症,并且在 检测hLIF,例如临床样本或标本。