公开(公告)号：US09770537B2

公开(公告)日：2017-09-26

申请号：US14303309

申请日：2014-06-12

Applicant: SurModics, Inc.

Inventor： Joram Slager ,  Aleksey V. Kurdyumov ,  Toni M. Heyer

IPC: A61F2/00 ,  A61L29/16 ,  C07D498/18 ,  A61K9/14 ,  A61K31/436 ,  A61K9/00

CPC classification number: A61L29/16 ,  A61K9/0019 ,  A61K9/14 ,  A61K31/436 ,  A61L2300/416 ,  C07D498/18 ,  Y10T428/2982

Abstract: The invention provides therapeutic particulates including a macrolide, such as rapamycin, in solid state crystalline form, having a size of 20μm or less, or 10μm or less. The particulates are formed in one method by preparing a composition with a macrolide and first (e.g., xylene) and second (e.g., an alcohol, acetone, or acetonitrile) solvents. In the composition a maximum solubility for the macrolide that is greater than a maximum solubility of the macrolide dissolved in either the first or second solvent individually. The first and second solvents are then evaporated from the composition to provide the macrolide particulates. In another method, the particulates can be formed by a method including sonication and stirring/evaporation steps, and the particulates can be obtained from a supersaturated solution, formed during the process. Particulates display desirable low polydispersity, and can be used in therapeutic compositions, or can be associated with an implantable or insertable medical device for the treatment of a subject.

公开(公告)号：US20170112973A1

公开(公告)日：2017-04-27

申请号：US15385112

申请日：2016-12-20

Applicant: Surmodics, Inc.

Inventor： Joram Slager ,  Toni M. Heyer ,  David E. Babcock

IPC: A61L29/16 ,  C12N15/113 ,  A61M25/10 ,  A61K31/713 ,  A61K47/34 ,  A61L29/08 ,  A61K31/337

CPC classification number: A61L29/085 ,  A61K9/5031 ,  A61K31/337 ,  A61K31/713 ,  A61K47/34 ,  A61L29/14 ,  A61L29/16 ,  A61L2300/258 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2300/62 ,  A61L2300/802 ,  A61L2420/06 ,  A61L2420/08 ,  A61M25/10 ,  A61M2025/105 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/32 ,  C08L39/06 ,  C08L33/26

Abstract: Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.

公开(公告)号：US09555119B2

公开(公告)日：2017-01-31

申请号：US14072520

申请日：2013-11-05

Applicant: SurModics, Inc.

Inventor： Joseph Ventura ,  Shannon Wadman ,  Joram Slager ,  Joseph Schmidt McGonigle ,  Robert W. Hergenrother

IPC: A61K31/337 ,  A61K47/34 ,  A61L27/18 ,  A61L27/54 ,  A61K9/00

CPC classification number: A61K47/34 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/337 ,  A61L27/18 ,  A61L27/54 ,  A61L2300/416 ,  A61L2300/63 ,  A61L2400/06 ,  C08L79/02

Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In a more specific embodiment, the cationic delivery agent includes branched PEI. Methods of making the delivery composition, as well as kits and methods of use are also disclosed.

Abstract translation: 本文公开了用于施用疏水性活性剂的递送组合物。 在一个实施方案中，公开了用于向患者的组织或器官局部施用疏水性活性剂的递送组合物。 在一个实施方案中，递送组合物包括阳离子递送剂，治疗有效量的疏水活性剂和药学上可接受的水性载体。 在一个实施方案中，阳离子递送剂包括聚乙烯亚胺（PEI）。 在更具体的实施方案中，阳离子递送剂包括支链PEI。 还公开了制备递送组合物的方法，以及试剂盒和使用方法。

公开(公告)号：US20160022502A1

公开(公告)日：2016-01-28

申请号：US14819955

申请日：2015-08-06

Applicant: SurModics, Inc.

Inventor： Shawn Fuller ,  Bryan A. Claseman ,  Joram Slager ,  Jeffrey J. Missling ,  Gary Maharaj ,  Gary W. Opperman ,  Nathan A. Lockwood ,  Robert W. Hergenrother ,  Charles Olson

IPC: A61F13/00

CPC classification number: A61F13/00068 ,  A61F13/00021 ,  A61F13/00029 ,  A61F13/8405 ,  A61F2013/00153 ,  A61F2013/00327 ,  A61F2013/00331 ,  A61F2013/00357 ,  A61F2013/00557 ,  A61L15/22 ,  A61L15/44 ,  A61L15/60 ,  A61L2300/102 ,  A61L2300/208

Abstract: Embodiments of the invention include wound packing devices and methods of making and using the same. In an embodiment, the invention includes a wound packing device including a plurality of spacing elements capable of absorbing exudate, wherein the surface of the spacing elements resist colonization by microorganisms. The wound packing device can also include a connector connecting the plurality of spacing elements to one another. Other embodiments are also included herein.

Abstract translation: 本发明的实施例包括伤口包装装置及其制造和使用方法。 在一个实施方案中，本发明包括包含能够吸收渗出物的多个间隔元件的伤口包装装置，其中间隔元件的表面抵抗微生物的定居。 卷绕包装装置还可以包括将多个间隔元件彼此连接的连接器。 本文还包括其它实施例。

公开(公告)号：US20150140107A1

公开(公告)日：2015-05-21

申请号：US14609270

申请日：2015-01-29

Applicant: SurModics, Inc.

Inventor： Joram Slager ,  Toni M. Heyer ,  David E. Babcock

IPC: A61L29/08 ,  A61L29/16

CPC classification number: A61L29/085 ,  A61K9/5031 ,  A61K31/337 ,  A61K31/713 ,  A61K47/34 ,  A61L29/14 ,  A61L29/16 ,  A61L2300/258 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2300/62 ,  A61L2300/802 ,  A61L2420/06 ,  A61L2420/08 ,  A61M25/10 ,  A61M2025/105 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/32 ,  C08L39/06 ,  C08L33/26

Abstract: Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.

Abstract translation: 本发明的实施方案包括药物递送涂层和包括其的装置。 在一个实施方案中，本发明包括包含聚合物层的药物递送涂层。 聚合物层可包括亲水性外表面。 涂层还可以包括接触亲水性外表面的基体。 基质可以包括颗粒疏水性治疗剂和阳离子剂。 聚合物层还可以包括具有侧基光反应性基团的亲水聚合物和包含两个芳基酮官能团的光交联剂。 本文还包括其它实施例。

公开(公告)号：US20130190689A1

公开(公告)日：2013-07-25

申请号：US13793390

申请日：2013-03-11

Applicant: SURMODICS, INC.

Inventor： Joram Slager

IPC: A61L29/16

CPC classification number: A61L29/16 ,  A61K9/5031 ,  A61K31/337 ,  A61L29/085 ,  A61L29/14 ,  A61L2300/258 ,  A61L2300/416 ,  A61L2300/62 ,  A61L2400/18 ,  A61L2420/08 ,  C08L39/06 ,  C08L33/26

Abstract: Embodiments of the invention include devices and coatings for devices including coated hydrophobic active agent particles. In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a cationic agent in contact with the particulate hydrophobic therapeutic agent. Other embodiments are also included herein.

Abstract translation: 本发明的实施方案包括用于包括涂覆的疏水活性剂颗粒的装置的装置和涂层。 在一个实施方案中，本发明包括药物递送装置，其包括基底; 以及设置在基材上的被覆治疗剂颗粒，所述涂敷的治疗剂颗粒包含颗粒状疏水性治疗剂; 和与颗粒疏水治疗剂接触的阳离子剂。 本文还包括其它实施例。