公开(公告)号：US20110202102A1

公开(公告)日：2011-08-18

申请号：US13119992

申请日：2008-09-23

申请人： Andreas Blomqvist

发明人： Andreas Blomqvist

IPC分类号： A61N1/36

CPC分类号： A61N1/36585 ,  A61N1/3682 ,  A61N1/3702

摘要： An implantable medical device measures an AV delay in connection with measurement of N physiological patient parameters. The parameters are used for identifying a sub-space of an N-dimensional parameter space. An expected AV delay is assigned to the identified sub-space based on the measured AV delay, where the parameter space with expected AV delays constitute decision support information to be used by the device for performing a selective heart pacing. This selective pacing is performed based on a priori probability determined using the support information and a measured set of N parameters. The a priori probability represents the probability of successful AV conduction at a current patient condition determined based on the measured parameters.

摘要翻译： 可植入医疗装置测量与N个生理学患者参数的测量相关的AV延迟。 这些参数用于识别N维参数空间的子空间。 基于所测量的AV延迟，将预期的AV延迟分配给所识别的子空间，其中具有预期AV延迟的参数空间构成要由设备用于执行选择性心脏起搏的决策支持信息。 基于使用支持信息确定的先验概率和N个参数的测量集来执行该选择性起搏。 先验概率表示在基于测量的参数确定的当前患者状况下AV传导成功的概率。

公开(公告)号：US20110046691A1

公开(公告)日：2011-02-24

申请号：US12990136

申请日：2008-06-18

申请人： Anders Björling ,  Andreas Blomqvist ,  Karin Järverud

发明人： Anders Björling ,  Andreas Blomqvist ,  Karin Järverud

IPC分类号： A61N1/36

CPC分类号： A61B5/0215 ,  A61B5/053 ,  A61N1/36521

摘要： An implantable heart stimulator has an impedance measurement a cardiogenic impedance waveform using an impedance configuration arranged to measure myocardial contractility of the heart. The heart stimulator further has a calculating unit that calculates an estimate value being related to at least two impedance values of the waveform, or of an average waveform of several consecutive waveforms, during a predetermined time period of the waveform, or average waveform, the calculated estimate value being an estimate of the left ventricular (LV) systolic pressure.

摘要翻译： 可植入心脏刺激器具有使用布置成测量心脏的心肌收缩力的阻抗配置的心源阻抗波形的阻抗测量。 心脏刺激器还具有计算单元，该计算单元在波形的预定时间段期间，计算与波形的至少两个阻抗值或几个连续波形的平均波形有关的估计值，或者计算出平均波形 估计值是左心室（LV）收缩压的估计值。

公开(公告)号：US20110028855A1

公开(公告)日：2011-02-03

申请号：US12933612

申请日：2008-04-29

申请人： Andreas Blomqvist

发明人： Andreas Blomqvist

IPC分类号： A61B5/02 ,  A61B5/0452

CPC分类号： A61N1/3702 ,  A61B5/0031 ,  A61B5/0452 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/7239 ,  A61B5/7275 ,  A61N1/36521 ,  G06F19/00

摘要： An implantable medical device has an event detector that detects a predetermined cardiac event during a heart cycle of a subject. A reference time is assigned to this detected cardiac event. An onset detector detects the onset of ventricular filling of the heart during the heart cycle. The relative time of the detected filling onset is determined based on the assigned time reference. An increased risk of heart failure of the subject is automatically determined based on the determined relative time for the filling onset. Generally, a reduction in the relative time, as determined at different points in time, indicates an increased heart failure risk or the presence of a heart failure condition.

摘要翻译： 可植入医疗装置具有事件检测器，其在对象的心脏周期期间检测预定的心脏事件。 参考时间被分配给该检测到的心脏事件。 发作检测器检测在心脏周期期间心脏心脏充盈的发作。 根据分配的时间参考确定检测到的填充开始的相对时间。 基于所确定的填充开始的相对时间自动确定受试者心脏衰竭的风险增加。 通常，在不同时间点确定的相对时间的减少表示心力衰竭风险增加或心力衰竭状况的存在。

公开(公告)号：US20090281584A1

公开(公告)日：2009-11-12

申请号：US12519416

申请日：2006-12-20

申请人： Andreas Blomqvist ,  Anders Bjorling ,  Göran Budgivars ,  Dominic Rivas ,  Maria Torpo

发明人： Andreas Blomqvist ,  Anders Bjorling ,  Göran Budgivars ,  Dominic Rivas ,  Maria Torpo

IPC分类号： A61N1/362 ,  A61B5/04 ,  A61N1/39 ,  H01R43/00

CPC分类号： A61N1/056 ,  A61B5/0422 ,  A61B5/416 ,  A61B5/418 ,  A61N1/365 ,  Y10T29/49002

摘要： An implantable medical sensor arrangement has a sensor body configured for implantation in a subject, to which at least one sensor head is connected through at least one connective wire. The sensor head(s) and at least a portion of the connective wire(s) are tightly packed and enclosed by a protective sensor shell. This sensor shell is composed of a dissolvable material that will dissolve or can be triggered to dissolve following introduction of the sensor arrangement into a subject.

摘要翻译： 可植入医疗传感器装置具有构造成用于植入受试者的传感器主体，至少一个传感器头通过至少一个连接线连接到该主体上。 传感头和至少一部分连接线被一个保护传感器外壳紧密地包住并包围。 该传感器外壳由可溶解的材料组成，其可以在将传感器装置引入被摄体之后溶解或者被触发以溶解。

公开(公告)号：US09522275B2

公开(公告)日：2016-12-20

申请号：US13884934

申请日：2010-11-30

申请人： Andreas Blomqvist ,  Torbjorn Persson ,  Rolf Hill

发明人： Andreas Blomqvist ,  Torbjorn Persson ,  Rolf Hill

IPC分类号： A61N1/365 ,  A61N1/362 ,  A61N1/368

CPC分类号： A61N1/365 ,  A61N1/3627 ,  A61N1/36585 ,  A61N1/3682 ,  A61N1/3684

摘要： Methods and systems for optimizing stimulation of a heart of a patient are disclosed. The method comprises: determining recommended pacing settings including recommended AV delays and/or recommended VV delays based on IEGM data. Further, at least one hemodynamical parameter is determined based on measured at least one hemodynamical signal. Reference pacing settings are determined including reference AV delays and/or reference VV delays based on said hemodynamical parameters. An AV delay correction value and a VV delay correction value are calculated as a difference between recommended AV and/or VV delays and reference AV and/or VV delays, respectively. The correction values are used for updating recommended AV and/or VV delays, respectively.

摘要翻译： 公开了用于优化患者心脏刺激的方法和系统。 该方法包括：根据IEGM数据确定推荐的起搏设置，包括推荐的AV延迟和/或推荐的VV延迟。 此外，基于测量的至少一个血液动力学信号来确定至少一个血液动力学参数。 基于所述血液动力学参数确定参考起搏设置，包括参考AV延迟和/或参考VV延迟。 AV延迟校正值和VV延迟校正值被分别计算为推荐的AV和/或VV延迟与参考AV和/或VV延迟之间的差。 校正值分别用于更新推荐的AV和/或VV延迟。

公开(公告)号：US09108064B2

公开(公告)日：2015-08-18

申请号：US13131527

申请日：2008-11-28

申请人： Andreas Blomqvist ,  Karin Järverud

发明人： Andreas Blomqvist ,  Karin Järverud

IPC分类号： A61B5/02 ,  A61N1/368 ,  A61N1/362 ,  A61N1/365 ,  A61N1/37

CPC分类号： A61B5/686 ,  A61B5/02028 ,  A61B5/04012 ,  A61B5/042 ,  A61B5/0432 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/368 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3702

摘要： An implantable medical device has an impedance processor that determines impedance data reflective of the transvalvular impedance of a heart valve of a heart during a heart cycle. The determined impedance data are processed by a representation processor that estimates diastolic and systolic transvalvular impedance representations. A condition processor determines the presence of any heart valve malfunction, such as valve regurgitation andor stenosis, of the heart valve based on the estimated diastolic and systolic transvalvular impedance representations.

摘要翻译： 可植入医疗装置具有阻抗处理器，其确定在心脏周期期间反映心脏心脏瓣膜的跨瓣阻抗的阻抗数据。 所确定的阻抗数据由估计舒张期和收缩期跨瓣阻抗表示的表示处理器处理。 状态处理器基于估计的舒张和收缩的跨瓣阻抗表示来确定心脏瓣膜的任何心脏瓣膜故障的存在，例如瓣膜反流和/或狭窄。

公开(公告)号：US20140257070A1

公开(公告)日：2014-09-11

申请号：US13517009

申请日：2011-06-20

申请人： Andreas Blomqvist ,  Kjell Noren

发明人： Andreas Blomqvist ,  Kjell Noren

IPC分类号： A61B5/02 ,  A61B5/04 ,  A61B5/042 ,  A61B5/0215 ,  A61B5/0472

CPC分类号： A61B5/02028 ,  A61B5/0215 ,  A61B5/04012 ,  A61B5/0422 ,  A61B5/0472 ,  A61B5/7239 ,  A61N1/36514 ,  A61N1/36564

摘要： Cardiac valve events are monitored by recording a left atrial pressure (LAP) representing signal using an implantable pressure sensor (50). The LAP signal is processed in order to generate a derivative LAP signal representative of the first time derivative of the LAP signal. The opening of the aortic valve of the heart is then identified to coincide in time with a minimum in the derivative LAP signal following ventricular depolarization in a cardiac cycle.

摘要翻译： 通过使用可植入压力传感器（50）记录表示信号的左心房压力（LAP）来监测心脏瓣膜事件。 处理LAP信号以产生代表LAP信号的第一时间导数的导数LAP信号。 然后心脏的主动脉瓣的开口在心脏周期的心室去极化之后被确定为在时间上与导数LAP信号中的最小值一致。

公开(公告)号：US08761871B2

公开(公告)日：2014-06-24

申请号：US12442744

申请日：2006-09-25

申请人： Andreas Blomqvist

发明人： Andreas Blomqvist

IPC分类号： A61B5/053 ,  A61N1/365

CPC分类号： A61N1/36521 ,  A61B5/0537 ,  A61B5/0538 ,  A61N1/37258

摘要： A medical device having an impedance measurement circuit connected to at least two intracorporeal measurement electrodes arranged to measure the impedance of tissue inside the body of a patient. The impedance measurement circuit is adapted to apply a measurement current/voltage signal to the electrodes to measure and calculate the impedance of the measurement tissue, and to apply the calculated impedance value to a storage unit. The stored impedance values are used, by an analysis unit, to measure the amount of visceral fat of the tissue object inside the body of the patient.

摘要翻译： 一种具有阻抗测量电路的医疗装置，该阻抗测量电路连接至至少两个体内测量电极，其布置成测量患者体内组织的阻抗。 阻抗测量电路适于向电极施加测量电流/电压信号，以测量和计算测量组织的阻抗，并将计算的阻抗值应用于存储单元。 存储的阻抗值由分析单元用于测量患者体内的组织物体的内脏脂肪的量。

公开(公告)号：US08690787B2

公开(公告)日：2014-04-08

申请号：US13265722

申请日：2009-04-29

申请人： Andreas Blomqvist ,  Karin Järverud ,  Michael Broomè

发明人： Andreas Blomqvist ,  Karin Järverud ,  Michael Broomè

IPC分类号： A61B5/02

CPC分类号： A61B5/02158 ,  A61B5/02007 ,  A61B5/02028 ,  A61B5/02125 ,  A61B5/0295 ,  A61B5/053

摘要： An implantable coronary perfusion monitoring device for in-vivo determination of a coronary perfusion index (CPI) indicative of the coronary perfusion of a heart has a time measurement unit to determine a blood pressure reflection wave measure t indicating the timely position in the heart cycle of the maximum of a reflected blood pressure wave and in a time period starting at a preset point of time in systole and ending at a local maximum of blood pressure following aortic valve closure and, a diastolic peak pressure measurement unit adapted to determine a diastolic peak blood pressure measure DPP related to diastolic aortic peak pressure and a systolic arterial pressure measurement unit adapted to determine a systolic arterial blood pressure measure SAP related to systolic arterial pressure, and a coronary perfusion index calculating unit adapted to determine said coronary perfusion index CPI as (t·DPP)/SAP.

摘要翻译： 用于体内确定指示心脏冠状动脉灌注的冠状动脉灌注指数（CPI）的可植入冠状动脉灌注监测装置具有时间测量单元，以确定表示心脏周期中及时位置的血压反射波测量值 反射血压波的最大值和在收缩期的预设时间点开始并且在主动脉瓣关闭后结束于局部最大血压的时间段内，以及适于确定舒张峰血液的舒张峰值压力测量单元 压力测量与舒张性主动脉​​峰值压力相关的DPP和适于确定与收缩期动脉压相关的收缩期动脉血压测量SAP的收缩期动脉压测量单元，以及适于将所述冠状动脉灌注指数CPI确定为（t）的冠状动脉灌注指数计算单元 ·DPP）/ SAP。

公开(公告)号：US20120035493A1

公开(公告)日：2012-02-09

申请号：US12853130

申请日：2010-08-09

申请人： Dan E. Gutfinger ,  Fujian Qu ,  Alex Soriano ,  Ryan Rooke ,  Yelena Nabutovsky ,  Riddhi Shah ,  Andreas Blomqvist

发明人： Dan E. Gutfinger ,  Fujian Qu ,  Alex Soriano ,  Ryan Rooke ,  Yelena Nabutovsky ,  Riddhi Shah ,  Andreas Blomqvist

IPC分类号： A61B5/053

CPC分类号： A61B5/0538 ,  A61B5/02028 ,  A61B5/029 ,  A61B5/4878 ,  A61B5/686 ,  A61B7/00 ,  A61B2562/0219

摘要： A new model is provided for understanding and exploiting impedance or admittance values measured by implantable medical devices, such as pacemakers or cardiac resynchronization devices (CRTs.) The device measures impedance along vectors extending through tissues of the patient between various pairs of electrodes. The device then converts the vector-based impedance measurements into near-field individual electrode-based impedance values. This is accomplished, in at least some examples, by converting the vector-based impedance measurements into a set of linear equations to be solved while ignoring far-field contributions to the impedance measurements. The device solves the linear equations to determine the near-field impedance values for the individual electrodes, which are representative of the impedance of tissues in the vicinity of the electrodes. The device then performs or controls various device functions based on the near-field values, such as analyzing selected near-field values to detect heart failure or pulmonary edema.

摘要翻译： 提供了一种新型号，用于了解和利用可植入医疗设备（例如起搏器或心脏再同步装置（CRT））测量的阻抗或导纳值。该装置测量沿着延伸穿过患者组织的不同对电极之间的阻力。 然后，器件将基于矢量的阻抗测量值转换为近场单独的基于电极的阻抗值。 这在至少一些示例中是通过将基于矢量的阻抗测量值转换成待解决的一组线性方程而实现的，同时忽略对阻抗测量的远场贡献。 该装置解决了线性方程来确定各个电极的近场阻抗值，其代表电极附近的组织的阻抗。 然后，设备基于近场值执行或控制各种设备功能，例如分析所选的近场值以检测心脏衰竭或肺水肿。