公开(公告)号：US11426707B2

公开(公告)日：2022-08-30

申请号：US15012507

申请日：2016-02-01

Applicant: Waters Technologies Corporation

Inventor： Kevin D. Wyndham ,  Nicole L. Lawrence

IPC: B01J20/288 ,  B01J20/32 ,  B01J20/28 ,  B01D15/08

Abstract: Novel porous materials comprising nanoparticles, use in chromatographic separations, processes for its preparation, and separations devices containing the chromatographic material are described by the instant invention. In particular, the disclosure describes porous inorganic/organic hybrid particles embedded with nanoparticles selected from oxides or nitrides of the following: silicon carbide, aluminum, diamond, cerium, carbon black, carbon nanotubes, zirconium, barium, cerium, cobalt, copper, europium, gadolinium, iron, nickel, samarium, silicon, silver, titanium, zinc, boron, and mixtures thereof.

公开(公告)号：US20210331138A1

公开(公告)日：2021-10-28

申请号：US17353096

申请日：2021-06-21

Applicant: Waters Technologies Corporation

Inventor： Kevin D. Wyndham ,  Michael F. Morris ,  Darryl W. Brousmiche ,  Jason F. Hill ,  Jacob N. Fairchild

IPC: B01J20/283 ,  B01J20/32 ,  C07F7/18 ,  B01J20/288 ,  B01D15/26 ,  B01J20/28 ,  B01D15/30 ,  B01D15/32 ,  B01D15/40 ,  B01D53/02 ,  B01J20/22 ,  B01J20/289 ,  B01J20/30

Abstract: In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.

公开(公告)号：US11071969B1

公开(公告)日：2021-07-27

申请号：US15407117

申请日：2017-01-16

Applicant: Waters Technologies Corporation

Inventor： Kevin D. Wyndham ,  John E. O'Gara

IPC: B01J20/285 ,  B01J20/26 ,  C08J9/28

Abstract: The present disclosure provides porous carbon-heteroatom-silicon inorganic/organic homogenous copolymeric hybrid materials, methods for their preparation, and uses thereof, e.g., as chromatographic separations materials. The present disclosure also provides methods of preparing porous inorganic/organic homogenous copolymeric hybrid materials, comprising two or more repeat units, comprising (a) preparing a polyoligomeric siloxane (POS) by partial condensation of tetraalkoxysilane, adding a heterocyclic silane, and further reacting the heterocyclic silane with the POS to thereby prepare a porous inorganic/organic homogenous copolymeric hybrid material, comprising a carbon-heteroatom-silicon functionality or (b) partially condensing an organic olefin, an alkenyl functionalized silane, an alkoxysilane, or a heterocyclic silane, or mixtures thereof, adding a heterocyclic silane, and further reacting the heterocyclic silane with the partially condensed polymer to thereby prepare a porous inorganic/organic homogenous copolymeric hybrid material comprising a carbon-heteroatom-silicon functionality.

公开(公告)号：US10974167B2

公开(公告)日：2021-04-13

申请号：US16202504

申请日：2018-11-28

Applicant: Waters Technologies Corporation

Inventor： Kevin D. Wyndham ,  Pamela C. Iraneta ,  Thomas H. Walter

IPC: B01D15/36 ,  G01N30/90 ,  B01D15/32 ,  B01D15/38 ,  B01J20/286 ,  B01J20/32 ,  B01D15/18 ,  B01J20/29

Abstract: The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are high purity chromatographic materials comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifier.

公开(公告)号：US20210023531A1

公开(公告)日：2021-01-28

申请号：US16926102

申请日：2020-07-10

Applicant: Waters Technologies Corporation

Inventor： Darryl W. Brousmiche ,  Jacob N. Fairchild ,  Jason F. Hill ,  Giorgis Isaac ,  Michael F. Morris ,  Kevin D. Wyndham

IPC: B01J20/283 ,  B01J20/32 ,  C07F7/18 ,  B01J20/288 ,  B01D15/26 ,  B01J20/28 ,  B01D15/30 ,  B01D15/32 ,  B01D15/40 ,  B01D53/02 ,  B01J20/22 ,  B01J20/289 ,  B01J20/30

Abstract: The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group. In some examples, the present disclosure can include a chromatographic system having a chromatographic column having a stationary phase with a chromatographic substrate containing silica, metal oxide, an inorganic-organic hybrid material, a group of block copolymers, or a combination thereof.

公开(公告)号：US10800799B2

公开(公告)日：2020-10-13

申请号：US15941338

申请日：2018-03-30

Applicant: Waters Technologies Corporation

Inventor： Pamela C. Iraneta ,  Thomas H. Walter ,  Xin Zhang ,  Daniel P. Walsh ,  Kevin D. Wyndham ,  Raymond P. Fisk

IPC: B01D15/00 ,  B01J20/00 ,  G01N1/00 ,  C07F9/10 ,  B01D15/32 ,  B01J20/28 ,  B01J20/287 ,  B01J20/32 ,  B01J20/10 ,  B01D15/22 ,  B01L3/00 ,  C07K1/30 ,  G01N30/88

Abstract: Methods, kits and devices for separating phospholipids and proteins from small molecules in biochemical samples can feature an apparatus having a wetting barrier, at least one frit and a separation media. For example, an apparatus can include at least one wall defining a chamber having an exit and an entrance; a wetting barrier disposed between the exit and entrance, so as to define a separation media space located between the wetting barrier and the exit and a sample receiving area located between the wetting barrier and the entrance; and a separation media disposed adjacent to the wetting barrier and having a specific affinity for phospholipids.

公开(公告)号：US20190321759A1

公开(公告)日：2019-10-24

申请号：US16375908

申请日：2019-04-05

Applicant: Waters Technologies Corporation

Inventor： Kevin D. Wyndham ,  Moon Chul Jung ,  Abhijit Tarafder ,  Wade P. Leveille, SR.

IPC: B01D29/96 ,  B01D29/05 ,  B01D29/50 ,  B01D29/66 ,  B01D15/12 ,  B01D35/143

Abstract: A liquid chromatography system, includes a fluidic flow path, a chromatography column located in the fluidic flow path, a filtration device located in the fluidic flow path before the chromatography column, the filtration device including a housing having a fluidic inlet, a fluidic outlet, wherein at least a portion of the fluidic flow path is located between the fluidic inlet and the fluidic outlet and at least one filter disposed in the portion of the fluidic flow path, wherein the at least one filter is made of a micromachined material. Liquid chromatography filtration methods are further disclosed.

公开(公告)号：US10265679B2

公开(公告)日：2019-04-23

申请号：US15911630

申请日：2018-03-05

Applicant: Waters Technologies Corporation

Inventor： Kevin D. Wyndham ,  Michael F. Morris ,  Darryl W. Brousmiche ,  Jason F. Hill ,  Jacob N. Fairchild

IPC: B01J20/28 ,  B01J20/283 ,  C07F7/18 ,  B01D15/26 ,  B01J20/288 ,  B01J20/32 ,  B01D15/30 ,  B01D15/32 ,  B01D15/40 ,  B01D53/02 ,  B01J20/22 ,  B01J20/289 ,  B01J20/30 ,  B01J20/285 ,  B01J20/284 ,  B01J20/282

Abstract: In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.

公开(公告)号：US20190091606A1

公开(公告)日：2019-03-28

申请号：US16202504

申请日：2018-11-28

Applicant: Waters Technologies Corporation

Inventor： Kevin D. Wyndham ,  Pamela C. Iraneta ,  Thomas H. Walter

IPC: B01D15/36 ,  B01D15/32 ,  B01J20/32 ,  B01D15/38 ,  B01J20/286 ,  B01J20/29 ,  G01N30/90 ,  B01D15/18

Abstract: The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are high purity chromatographic materials comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifier.

公开(公告)号：US20180353934A1

公开(公告)日：2018-12-13

申请号：US16101779

申请日：2018-08-13

Applicant: Waters Technologies Corporation

Inventor： Kevin D. Wyndham ,  Beatrice W. Muriithi

IPC: B01J20/283 ,  B01J20/32 ,  B01J20/285 ,  B01J20/28 ,  B01J20/286

CPC classification number: B01J20/283 ,  B01J20/28004 ,  B01J20/28057 ,  B01J20/28071 ,  B01J20/285 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3236 ,  B01J20/3257 ,  B01J20/3289 ,  B01J20/3293 ,  Y10T428/2991

Abstract: The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are chromatographic materials comprising having a narrow particle size distribution.