公开(公告)号：US20100249139A1

公开(公告)日：2010-09-30

申请号：US12727269

申请日：2010-03-19

Applicant: Daniel Hunziker ,  Christian Lerner ,  Werner Mueller ,  Ulrike Obst Sander ,  Philippe Pflieger ,  Pius Waldmeier

Inventor： Daniel Hunziker ,  Christian Lerner ,  Werner Mueller ,  Ulrike Obst Sander ,  Philippe Pflieger ,  Pius Waldmeier

IPC: C07D241/16 ,  A61K31/498 ,  A61K31/501 ,  A61K31/4965 ,  A61K31/506 ,  A61K31/44 ,  C07D471/04 ,  A61K31/47 ,  C07D401/12 ,  A61K31/444 ,  A61K31/437 ,  A61K31/381 ,  C07D241/36 ,  C07D217/04 ,  C07D215/14 ,  C07D413/12 ,  C07D213/63 ,  C07D213/55 ,  C07D333/22 ,  A61P3/00 ,  A61P3/10

CPC classification number: C07D241/12 ,  C07D207/34 ,  C07D213/30 ,  C07D213/61 ,  C07D213/64 ,  C07D215/14 ,  C07D217/16 ,  C07D241/42 ,  C07D333/38 ,  C07D401/12 ,  C07D413/12 ,  C07D471/02

Abstract: The present invention relates to compounds of formula I wherein R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.

Abstract translation: 本发明涉及式I化合物，其中R 1a至R 1d和R 2至R 5如在说明书和权利要求书中所定义，及其药学上可接受的盐。 该化合物是可用于治疗和/或预防糖尿病，血脂异常，肥胖，高血压，心血管疾病，肾上腺不平衡或抑郁症等疾病的糖皮质激素受体拮抗剂。

公开(公告)号：US20100157242A1

公开(公告)日：2010-06-24

申请号：US12524302

申请日：2008-01-25

Applicant: Gregor Esser ,  Helmut Altheimer ,  Wolfgang Becken ,  Robert Bichler ,  Anne Seidemann ,  Martin Zimmerman ,  Werner Mueller ,  Jochen Brosig ,  Dietmar Uttenweiler

Inventor： Gregor Esser ,  Helmut Altheimer ,  Wolfgang Becken ,  Robert Bichler ,  Anne Seidemann ,  Martin Zimmerman ,  Werner Mueller ,  Jochen Brosig ,  Dietmar Uttenweiler

IPC: G02C7/02

CPC classification number: G02C7/061 ,  G02C7/027 ,  G02C13/005

Abstract: The invention relates to a method for producing a progressive spectacle lens and to a corresponding apparatus, a computer program product, a storage medium and to the use of a progressive spectacle lens. The invention also relates to a method for producing a progressive spectacle lens for correcting defective vision of a spectacle wearer, comprising the following steps: the vertical and/or the horizontal spatial position of a distance reference point and/or a near reference point is specified or determined in accordance with individual data of the spectacle wearer; the spectacle lens is optimized or calculated such that the required dioptric effect of the spectacle lens is obtained in the individually determined distance reference point and/or the near reference point.

Abstract translation: 本发明涉及一种渐进式眼镜镜片的制造方法以及相应的装置，计算机程序产品，存储介质以及逐行眼镜镜片的使用。 本发明还涉及一种用于制造用于矫正眼镜佩戴者的缺陷视力的渐进式眼镜镜片的方法，包括以下步骤：指定距离参考点和/或近参考点的垂直和/或水平空间位置 或根据眼镜佩戴者的个人数据确定; 优化或计算眼镜镜片，使得在单独确定的距离参考点和/或近参考点中获得眼镜镜片的所需度数效果。

公开(公告)号：US07678818B2

公开(公告)日：2010-03-16

申请号：US11655538

申请日：2007-01-19

Applicant: Aurelia Conte ,  Holger Kuehne ,  Thomas Luebbers ,  Patrizio Mattei ,  Cyrille Maugeais ,  Werner Mueller ,  Philippe Pflieger

Inventor： Aurelia Conte ,  Holger Kuehne ,  Thomas Luebbers ,  Patrizio Mattei ,  Cyrille Maugeais ,  Werner Mueller ,  Philippe Pflieger

IPC: A61K31/44 ,  C07D213/02

CPC classification number: C07D213/82 ,  C07C237/30 ,  C07C237/32 ,  C07C255/25 ,  C07C255/54 ,  C07C271/28 ,  C07C309/66 ,  C07C311/08 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/06 ,  C07D231/14 ,  C07D261/18 ,  C07D275/03 ,  C07D333/38 ,  C07D401/12 ,  C07D403/12 ,  C07F7/081

Abstract: Compounds of formula I processes for their preparation, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

Abstract translation: 式I化合物的制备方法，它们作为药物的用途以及包含它们的药物组合物。

公开(公告)号：US07600872B2

公开(公告)日：2009-10-13

申请号：US11794056

申请日：2005-10-07

Applicant: Gregor Esser ,  Helmut Altheimer ,  Edda Wehner ,  Werner Mueller ,  Jochen Brosig ,  Dietmar Uttenweiler

Inventor： Gregor Esser ,  Helmut Altheimer ,  Edda Wehner ,  Werner Mueller ,  Jochen Brosig ,  Dietmar Uttenweiler

IPC: G02C7/02

CPC classification number: G02C7/085 ,  G02C7/083

Abstract: The invention relates to a spectacle lens device comprising at least one electrically adaptive area, wherein optical properties of the spectacle lens device can be controlled in an electric manner. The spectacle lens device is configured in such a manner that the optical properties of a predetermined or predeterminable control area can be controlled in an electrical manner which is essentially independent from the optical properties in a surrounding area. The invention also relates to the control area and to the surrounding area, respectively, about a partial area of the electrically adaptive area. The control area and the surrounding area do not a common area. The invention further relates to a pair of spectacles comprising a spectacle lens device, to the use of the inventive spectacle lens device and also to a method for operating an electrically adaptive area.

Abstract translation: 本发明涉及一种眼镜镜片装置，其包括至少一个电适应区域，其中可以以电方式控制眼镜镜装置的光学特性。 眼镜透镜装置以这样的方式构造，使得可以以基本上独立于周围区域的光学性质的电气方式来控制预定或可预定的控制区域的光学特性。 本发明还分别涉及电适配区域的部分区域的控制区域和周边区域。 控制区域和周边区域不是公共区域。 本发明还涉及一种眼镜，其包括眼镜镜装置，使用本发明的眼镜镜装置，还涉及一种用于操作电适应区域的方法。

公开(公告)号：US20080054119A1

公开(公告)日：2008-03-06

申请号：US11889993

申请日：2007-08-17

Applicant: Werner Mueller

Inventor： Werner Mueller

IPC: B65H35/08

CPC classification number: B65H19/2215 ,  B65H2301/41362 ,  B65H2301/4148 ,  B65H2405/44 ,  B65H2408/23152

Abstract: Winding machine for winding a web of material divided into strips by longitudinal cuts, in particular a web of paper, plastic of metal foil, having two winding shafts that extend transversely across the machine width, which are positioned at one side of the machine in a pivotable turning device for moving from a winding position to a discharge position and back, whereby at the machine side opposite the turning device, a support device having a support element is arranged, which can be vertically moved by a drive, and which supports the end of a winding shaft on its way from the winding position to the discharge position.

Abstract translation: 用于通过纵向切口（特别是纸幅，金属箔的塑料）卷绕被分成条带的材料卷绕机的卷绕机，具有横跨机器宽度延伸的两个卷绕轴，其位于机器的一侧 可枢转的转动装置用于从卷绕位置移动到排放位置和后部，由此在与转向装置相对的机器侧设置有具有支撑元件的支撑装置，其可以通过驱动器垂直移动，并且支撑端部 在从卷绕位置到排出位置的途中，卷轴的轴线。

公开(公告)号：US20070219261A1

公开(公告)日：2007-09-20

申请号：US11655538

申请日：2007-01-19

Applicant: Aurelia Conte ,  Holger Kuehne ,  Thomas Luebbers ,  Patrizio Mattei ,  Cyrille Maugeais ,  Werner Mueller ,  Philippe Pflieger

Inventor： Aurelia Conte ,  Holger Kuehne ,  Thomas Luebbers ,  Patrizio Mattei ,  Cyrille Maugeais ,  Werner Mueller ,  Philippe Pflieger

IPC: A61K31/425 ,  A61K31/42

CPC classification number: C07D213/82 ,  C07C237/30 ,  C07C237/32 ,  C07C255/25 ,  C07C255/54 ,  C07C271/28 ,  C07C309/66 ,  C07C311/08 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/06 ,  C07D231/14 ,  C07D261/18 ,  C07D275/03 ,  C07D333/38 ,  C07D401/12 ,  C07D403/12 ,  C07F7/081

Abstract: Compounds of formula I processes for their preparation, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

Abstract translation: 式I化合物的制备方法，它们作为药物的用途以及包含它们的药物组合物。

公开(公告)号：US07259183B2

公开(公告)日：2007-08-21

申请号：US11197688

申请日：2005-08-04

Applicant: Aurelia Conte-Mayweg ,  Holger Kuehne ,  Thomas Luebbers ,  Cyrille Maugeais ,  Werner Mueller ,  Philippe Pflieger

Inventor： Aurelia Conte-Mayweg ,  Holger Kuehne ,  Thomas Luebbers ,  Cyrille Maugeais ,  Werner Mueller ,  Philippe Pflieger

IPC: A61K31/4045 ,  A61K31/416 ,  C07D231/56 ,  C07D209/08

CPC classification number: C07D209/30

Abstract: The present invention relates to compounds of formula (I): wherein —X—Y—, R1 to R11 and n are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are mediated by CETP inhibitors.

Abstract translation: 本发明涉及式（I）化合物：其中-XY-，R 1至R 11和n如说明书和权利要求中所定义，并且药学上可接受的 的盐。 该化合物可用于治疗和/或预防由CETP抑制剂介导的疾病。

公开(公告)号：US20070101446A1

公开(公告)日：2007-05-03

申请号：US11546539

申请日：2006-10-10

Applicant: Klaus Rajewsky ,  Werner Mueller ,  Juergen Roes

Inventor： Klaus Rajewsky ,  Werner Mueller ,  Juergen Roes

IPC: A01K67/027 ,  C12P21/04

CPC classification number: C12N15/8509 ,  A01K67/0276 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/01 ,  A61K38/00 ,  C07K16/00 ,  C07K16/2803 ,  C07K16/4283 ,  C07K2317/20 ,  G01N33/56966

Abstract: This invention provides novel methods of obtaining autologous monoclonal antibodies (AMABs) to self-antigens or homologs thereof. The method involves obtaining a genetically engineered host animal that does not biosynthesize at least one epitope of the antigen and utilizes the lack of self-tolerance of the host to the epitope to produce antibodies specific to the antigen. The invention also encompasses the AMABs produced by the methods. The invention further encompasses methods of isolating cells comprising the use of such AMABs that have specificity for a cell surface antigen.

Abstract translation: 本发明提供了获得自身抗原或其同系物的自体单克隆抗体（AMAB）的新方法。 该方法包括获得不生物合成抗原的至少一个表位的遗传工程宿主动物，并利用宿主对表位的自身耐受性不足以产生抗原特异性抗体。 本发明还包括通过这些方法生产的AMAB。 本发明还包括分离细胞的方法，所述方法包括使用对细胞表面抗原具有特异性的这种AMAB。

公开(公告)号：US07166589B2

公开(公告)日：2007-01-23

申请号：US11376976

申请日：2006-03-16

Applicant: Michael G. Klug ,  Patrizio Mattei ,  Werner Mueller ,  Werner Neidhart ,  Matthias Heinrich Nettekoven ,  Philippe Pflieger ,  Jean-Marc Plancher

Inventor： Michael G. Klug ,  Patrizio Mattei ,  Werner Mueller ,  Werner Neidhart ,  Matthias Heinrich Nettekoven ,  Philippe Pflieger ,  Jean-Marc Plancher

IPC: C07D403/04 ,  C07D403/14 ,  A61K31/551 ,  A61P3/04

CPC classification number: C07D401/04 ,  C04B35/632 ,  C07D215/42 ,  C07D401/12 ,  C07D405/14

Abstract: Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3, A1 and A2 have the significance given in claim 1, can be used in the form of pharmaceutical preparations for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.

Abstract translation: 式I化合物及其药学上可接受的盐和酯，其中R 1，R 2，R 3，A 1， 具有权利要求1给出的意义的化合物可以以用于治疗或预防关节炎，心血管疾病，糖尿病，肾功能衰竭，饮食失调的药物制剂的形式使用， 肥胖。

公开(公告)号：US07064134B2

公开(公告)日：2006-06-20

申请号：US11272207

申请日：2005-11-10

Applicant: Michael G. Klug ,  Patrizio Mattei ,  Werner Mueller ,  Werner Neidhart ,  Matthias Heinrich Nettekoven ,  Philippe Pflieger ,  Jean-Marc Plancher

Inventor： Michael G. Klug ,  Patrizio Mattei ,  Werner Mueller ,  Werner Neidhart ,  Matthias Heinrich Nettekoven ,  Philippe Pflieger ,  Jean-Marc Plancher

IPC: C07D401/04 ,  C07D401/14 ,  A61K31/4709 ,  A61P3/04

CPC classification number: C07D401/04 ,  C04B35/632 ,  C07D215/42 ,  C07D401/12 ,  C07D405/14

Abstract: Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3, A1 and A2 have the significance given in claim 1, can be used in the form of pharmaceutical preparations for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.