公开(公告)号：US20050149524A1

公开(公告)日：2005-07-07

申请号：US11056200

申请日：2005-02-14

Applicant: Timothy Humphrey ,  Xin Lu ,  Afsar Parhizgar ,  Salahuddin Ahmed ,  James Wiltshire ,  John Morelock ,  Joseph Harmon ,  Spiro Collias ,  Paul Zhang

Inventor： Timothy Humphrey ,  Xin Lu ,  Afsar Parhizgar ,  Salahuddin Ahmed ,  James Wiltshire ,  John Morelock ,  Joseph Harmon ,  Spiro Collias ,  Paul Zhang

IPC: G06F17/27 ,  G06F17/30 ,  G06F7/00

CPC classification number: G06F17/30613 ,  G06F17/27 ,  G06F17/2755 ,  G06F17/30728 ,  Y10S707/917 ,  Y10S707/942 ,  Y10S707/99932 ,  Y10S707/99933 ,  Y10S707/99934 ,  Y10S707/99935 ,  Y10S707/99937

Abstract: A computer-automated system and method identify text in a first “citing” court case, near a “citing instance” (in which a second “cited” court case is cited), that indicates the reason(s) for citing (RFC). The automated method of designating text, taken from a set of citing documents, as reasons for citing (RFC) that are associated with respective citing instances of a cited document, has steps including: obtaining contexts of the citing instances in the respective citing documents (each context including text that includes the citing instance and text that is near the citing instance), analyzing the content of the contexts, and selecting (from the citing instances' context) text that constitutes the RFC, based on the analyzed content of the contexts. A related computer-automated system and method selects content words that are highly related to the reasons a particular document is cited, and gives them weights that indicate their relative relevance. Another related computer-automated system and method forms lists of morphological forms of words. Still another related computer-automated system and method scores sentences to show their relevance to the reasons a document is cited. Also, another related computer-automated system and method generates lists of content words. In a preferred embodiment, the systems and methods are applied to legal (especially case law) documents and legal (especially case law) citations.

公开(公告)号：US20050123977A1

公开(公告)日：2005-06-09

申请号：US11004749

申请日：2004-12-03

Applicant: Xin Lu

Inventor： Xin Lu

IPC: A61K38/16 ,  C07K14/47 ,  C07K16/00 ,  C12Q1/68 ,  G01N33/574 ,  G01N33/68 ,  C07H21/04 ,  C07K16/40 ,  C12N9/64

CPC classification number: C07K14/4746 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/5748 ,  G01N33/6875 ,  G01N2500/02 ,  G01N2510/00

Abstract: We describe screening methods for agents which modulate the interaction of p53 activator/inhibitor binding proteins with polymorphic p53 polypeptide variants, cells expressing combinations of said activator/inhibitor proteins and p53 variants; diagnostic assays to determine the genotype of an individual with respect to said p53 polymorphism; and therapeutic compositions for use in the treatment of conditions which would benefit from a stimulation of apoptosis.

Abstract translation: 我们描述调节p53激活物/抑制剂结合蛋白与多态性p53多肽变体，表达所述激活物/抑制蛋白和p53变体组合的细胞的相互作用的试剂的筛选方法; 用于确定个体相对于所述p53多态性的基因型的诊断测定; 以及用于治疗可受益于细胞凋亡刺激的病症的治疗组合物。

公开(公告)号：US09752196B2

公开(公告)日：2017-09-05

申请号：US13499850

申请日：2010-10-25

Applicant: Ekaterina Pestova ,  Mona Stein Legator ,  Xin Lu ,  Dimitri Semizarov

Inventor： Ekaterina Pestova ,  Mona Stein Legator ,  Xin Lu ,  Dimitri Semizarov

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q1/6841 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/178

Abstract: The methods and compositions described herein address the need for a diagnostic method that can be provided to patients with early stage lung cancer, especially non-small cell lung cancer (NSCLC), to determine whether the patient is at increased risk of poor disease outcome. The methods and compositions thus allow for more informed treatment decisions for the early stage lung cancer patient.

公开(公告)号：US09297045B2

公开(公告)日：2016-03-29

申请号：US12910892

申请日：2010-10-25

Applicant: Dimitri Semizarov ,  Xin Lu ,  Ke Zhang ,  Rick R. Lesniewski ,  John S. Coon

Inventor： Dimitri Semizarov ,  Xin Lu ,  Ke Zhang ,  Rick R. Lesniewski ,  John S. Coon

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158

Abstract: Disclosed are methods for identifying early-stage non-small-cell lung cancer (NSCLC) patients who will have an unfavorable prognosis for the recurrence of lung cancer after surgical resection. The methods are based in part on the discovery that chromosomal copy number gains at Chr19, 34.7 Mb-35.6 Mb can be used for prognostic classification. The methods preferably use fluorescence in situ hybridization with fluorescently labeled nucleic acid probes to hybridize to patient samples to quantify the chromosomal copy number of this genetic locus.

Abstract translation: 公开了鉴定早期非小细胞肺癌（NSCLC）患者手术切除术后肺癌复发预后不良的方法。 这些方法部分基于发现Chr19,34.7Mb-35.6Mb的染色体拷贝数增加可用于预后分类。 所述方法优选使用与荧光标记的核酸探针的荧光原位杂交以与患者样品杂交以定量该遗传基因座的染色体拷贝数。

公开(公告)号：US09291625B2

公开(公告)日：2016-03-22

申请号：US12910891

申请日：2010-10-25

Applicant: Dimitri Semizarov ,  Xin Lu ,  Ke Zhang ,  Rick R. Lesniewski ,  John S. Coon

Inventor： Dimitri Semizarov ,  Xin Lu ,  Ke Zhang ,  Rick R. Lesniewski ,  John S. Coon

IPC: C12Q1/68 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/178 ,  G01N33/57423 ,  G01N2800/52 ,  G01N2800/54 ,  G01N2800/56 ,  G01N2800/60

Abstract: The present disclosure provides methods for identifying early stage non-small-cell lung cancer (NSCLC) patients who will have an unfavorable prognosis for the recurrence of lung cancer after surgical resection. The methods are based in part on the discovery of chromosomal copy number abnormalities that can be used for prognostic classification. The methods preferably use fluorescence in situ hybridization with fluorescently labeled nucleic acid probes to hybridize to patient samples to quantify the chromosomal copy number of these genetic loci.

Abstract translation: 本公开提供了用于鉴定在手术切除后对肺癌复发有不利预后的早期非小细胞肺癌（NSCLC）患者的方法。 这些方法部分基于可用于预后分类的染色体拷贝数异常的发现。 方法优选使用与荧光标记的核酸探针的荧光原位杂交与患者样品杂交以定量这些遗传基因座的染色体拷贝数。

公开(公告)号：US20150133538A1

公开(公告)日：2015-05-14

申请号：US14401600

申请日：2012-08-10

Applicant: Yanmei Zhang ,  John Jeffrey Talley ,  Mark G. Obukowicz ,  Zhengchao Tu ,  Micky Tortorella ,  Yican Wang ,  Jianqi Liu ,  Yan Chen ,  Xiaorong Liu ,  Xin Lu

Inventor： Yanmei Zhang ,  John Jeffrey Talley ,  Mark G. Obukowicz ,  Zhengchao Tu ,  Micky Tortorella ,  Yican Wang ,  Jianqi Liu ,  Yan Chen ,  Xiaorong Liu ,  Xin Lu

IPC: C07D311/58

CPC classification number: A61K31/353 ,  A61K31/382 ,  A61K31/47 ,  C07D311/58

Abstract: The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.

Abstract translation: 本发明公开了具有式（I）所示结构特征的氘代苯并吡喃化合物或其药学上可接受的盐或立体异构体或其前药分子。 具有优异的抗炎和镇痛作用和抑制肿瘤细胞生长的能力，这些化合物是新型的COX-2选择性抑制剂。 本申请公开的化合物及其药学上可接受的盐可用于制备用于治疗或预防肿瘤的抗炎和镇痛药物和药物。

公开(公告)号：US09002653B2

公开(公告)日：2015-04-07

申请号：US12607077

申请日：2009-10-28

Applicant: Dimitri Semizarov ,  Xin Lu ,  Ke Zhang ,  Rick R. Lesniewski

Inventor： Dimitri Semizarov ,  Xin Lu ,  Ke Zhang ,  Rick R. Lesniewski

IPC: G01N33/48 ,  G01N33/50 ,  G01N31/00 ,  G06F19/24 ,  G06F19/12 ,  G06F19/00 ,  G06F17/15 ,  G06F17/17 ,  G06F17/16 ,  G06F17/11 ,  G06F17/10 ,  G06F19/18

CPC classification number: G06F19/24 ,  G06F17/10 ,  G06F17/11 ,  G06F17/15 ,  G06F17/16 ,  G06F17/17 ,  G06F19/12 ,  G06F19/18 ,  G16H50/50 ,  G16H50/70

Abstract: The present invention relates to algorithms for use in defining genomic subgroups of tumors and cancer cell lines. The present invention also relates to methods for assembling panels of tumors and cancer cell lines according to genomic subgroups for use in testing the efficacy of one or more pharmaceutical compounds in the treatment of subjects suffering from at least one cancer.

Abstract translation: 本发明涉及用于定义肿瘤和癌细胞系的基因组亚组的算法。 本发明还涉及根据基因组亚组装配肿瘤和癌细胞系的组的方法，用于测试一种或多种药物化合物治疗患有至少一种癌症的受试者的功效。

公开(公告)号：US08909525B2

公开(公告)日：2014-12-09

申请号：US13205627

申请日：2011-08-09

Applicant: Yu-Kai Xiong ,  Xin Lu ,  Shih-Fang Wong ,  Dong-Sheng Lv ,  Xin-Hua Li ,  Yu-Yong Zhang ,  Jian-Jian Zhu

Inventor： Yu-Kai Xiong ,  Xin Lu ,  Shih-Fang Wong ,  Dong-Sheng Lv ,  Xin-Hua Li ,  Yu-Yong Zhang ,  Jian-Jian Zhu

IPC: G10L15/26 ,  G10L15/08

CPC classification number: G10L15/08 ,  G10L15/26

Abstract: An interactive voice recognition electronic device converts a received voice signal to a text, and searches a voice databases to find a matched voice text of the converted text. The matched voice text is taken as a recognized voice text of the voice signal if the matched voice text exists in the voice database. The electronic device obtains a predetermined number of similar voice texts if no matched voice text exists in the voice database. The electronic device converts the predetermined number of similar voice texts to the voice signals, outputs the converted voice signals in turn, and selects one of the similar voice texts as the recognized voice text according to the selection of the user. The electronic device obtains the associated answer text of the recognized voice text in the voice database and converts the answer text to voice signals.

Abstract translation: 交互式语音识别电子设备将接收的语音信号转换为文本，并且搜索语音数据库以找到经转换的文本的匹配的语音文本。 如果语音数据库中存在匹配的语音文本，则将匹配的语音文本作为语音信号的识别语音文本。 如果语音数据库中没有匹配的语音文本，则电子设备获得预定数量的类似语音文本。 电子设备将预定数量的类似语音文本转换为语音信号，依次输出转换的语音信号，并根据用户的选择选择与所识别的语音文本相似的语音文本之一。 电子设备获取语音数据库中识别的语音文本的相关应答文本，并将答案文本转换为语音信号。

公开(公告)号：US08742083B1

公开(公告)日：2014-06-03

申请号：US12978086

申请日：2010-12-23

Applicant: Dimitri Semizarov ,  Xin Lu ,  Lloyd T. Lam

Inventor： Dimitri Semizarov ,  Xin Lu ,  Lloyd T. Lam

IPC: C12Q1/68 ,  C07H21/02 ,  C07H21/04

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: MicroRNAs (miRNAs) that sensitize cancer cells to Bcl-2 family protein inhibitors are identified and described. Oligonucleotide panels, arrays and methods using the sensitizing miRNAs are also disclosed.

Abstract translation: 鉴定并描述了使癌细胞对Bcl-2家族蛋白抑制剂敏感的微小RNA（miRNA）。 还公开了使用敏化miRNA的寡核苷酸片段，阵列和方法。

公开(公告)号：US08660343B2

公开(公告)日：2014-02-25

申请号：US13483063

申请日：2012-05-30

Applicant: Yi-Hua Chung ,  Shih-Fang Wong ,  Xin Lu ,  Yu-Yong Zhang

Inventor： Yi-Hua Chung ,  Shih-Fang Wong ,  Xin Lu ,  Yu-Yong Zhang

IPC: G06K9/46

CPC classification number: G06K9/00765

Abstract: A system and a method of detecting abnormal or security-significant segments of a video are provided. The video is divided into several segments. A set of features of each segment of the video is extracted in order to calculate a set of factors corresponding to each segment. A value deemed abnormal of each segment is calculated according to the set of factors corresponding to each segment. One or more abnormal segments are determined from the segments based on the abnormal values. The set of features includes a color variable feature, a movement variable feature, a movement variable ratio feature and a background variable feature.

Abstract translation: 提供了一种检测视频的异常或安全重要段的系统和方法。 视频分为几段。 提取视频的每个片段的一组特征，以便计算与每个片段对应的一组因子。 根据与每个段相对应的因子集合，计算每个段的异常值。 基于异常值从段中确定一个或多个异常段。 特征集包括颜色变量特征，运动变量特征，运动变量比特征和背景变量特征。