公开(公告)号：US08904016B2

公开(公告)日：2014-12-02

申请号：US12716099

申请日：2010-03-02

Applicant: Yan Fu

Inventor： Yan Fu

IPC: G06F15/16

CPC classification number: G06F15/16

Abstract: An approach is provided for selecting a network server. An apparatus comprising at least one processor, and at least one memory including computer program code, the at least one memory and the computer program code configured to, with the at least one processor, cause, at least in part, the apparatus to load from one or more network servers configuration information of one or more network servers used by a service provider network. The apparatus is also caused to select a network server in the service provider network based at least in part on at least one of network server latency and the network server load. The apparatus is further caused to set the network server as default network server used for at least one of current and future session on one or more user equipment.

Abstract translation: 提供了一种用于选择网络服务器的方法。 一种装置，包括至少一个处理器，以及包括计算机程序代码的至少一个存储器，所述至少一个存储器和所述计算机程序代码被配置为与所述至少一个处理器一起至少部分地使所述装置从 服务提供商网络使用的一个或多个网络服务器的一个或多个网络服务器配置信息。 该设备还被引导以至少部分地基于网络服务器延迟和网络服务器负载中的至少一个来在服务提供商网络中选择网络服务器。 进一步使设备将网络服务器设置为在一个或多个用户设备上用于当前和将来会话中的至少一个的默认网络服务器。

公开(公告)号：US20140147492A1

公开(公告)日：2014-05-29

申请号：US14008428

申请日：2012-03-28

Applicant: Yongzhang Luo ,  Yang Chen ,  Yan Fu ,  Lin Jia ,  Guodong Chang

Inventor： Yongzhang Luo ,  Yang Chen ,  Yan Fu ,  Lin Jia ,  Guodong Chang

IPC: A61K31/7048 ,  A61K47/48 ,  A61K31/365 ,  A61K38/17 ,  A61K31/724

CPC classification number: A61K31/7048 ,  A61K9/0019 ,  A61K9/127 ,  A61K31/065 ,  A61K31/718 ,  A61K38/1709 ,  A61K38/39 ,  A61K39/395 ,  A61K45/06 ,  A61K47/60 ,  A61K2300/00

Abstract: The present invention relates to a new use of a known medicament. Specifically, the invention relates to methods and compositions for enhancing the therapeutic efficacy of a therapeutic agent by increasing the uptake of the therapeutic agent by target cells, and in particular relates to a pharmaceutical composition comprising a regulating agent of lipid raft/caveolae-dependent endocytic pathway and some therapeutic agents, such as anti-tumor agents. The invention also relates to a method for screening a regulating agent of lipid raft/caveolae-dependent endocytic pathway capable of enhancing the therapeutic efficacy of anti-tumor agents.

Abstract translation: 本发明涉及已知药物的新用途。 具体地，本发明涉及通过增加靶细胞对治疗剂的吸收来增强治疗剂的治疗功效的方法和组合物，并且特别涉及包含脂质筏/穴ol依赖性内吞调节剂的药物组合物 途径和一些治疗剂，例如抗肿瘤剂。 本发明还涉及一种能够增强抗肿瘤剂治疗功效的脂筏/穴ol石依赖性内吞途径调节剂的方法。

公开(公告)号：US20140099270A1

公开(公告)日：2014-04-10

申请号：US14064701

申请日：2013-10-28

Applicant: Yan Fu ,  Zailin Yu

Inventor： Yan Fu ,  Zailin Yu

IPC: A61K8/64 ,  A61K8/99 ,  A61Q19/00 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q19/02

CPC classification number: A61K8/64 ,  A61K8/99 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/107 ,  A61K36/064 ,  A61K38/1808 ,  A61K38/1816 ,  A61K38/1858 ,  A61K38/193 ,  A61K38/20 ,  A61K38/217 ,  A61K38/30 ,  A61K38/38 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08 ,  C07K14/475 ,  C07K2319/00 ,  A61K2300/00

Abstract: The present invention provides a recombinant fusion protein which stimulates the rejuvenation and reactivation of skin and epidermal cells for improving skin appearance, smoothing wrinkles and freckles, and whitening skin. Particularly, the present invention provides various types of products for improving skin, which contain recombinant fusion protein of human serum albumin (HSA) with cytokine peptides (EGF, FGF, KGF, HGH, HGF, PDGF, GCSF, interferon, IL-11 or IGF) by genetic engineering technology. The fusion protein can be used independently or in a combination or combination with yeast fermentation products, or with varied emulsifiers, thickeners, moisturizer, preservatives, yeasts and ferments.

Abstract translation: 本发明提供了一种重组融合蛋白，其能刺激皮肤和表皮细胞的复原和再激活，以改善皮肤外观，使皱纹和雀斑平滑，以及美白皮肤。 特别地，本发明提供各种类型的用于改善皮肤的产品，其含有人血清白蛋白（HSA）与细胞因子肽（EGF，FGF，KGF，HGH，HGF，PDGF，GCSF，干扰素，IL-11或 IGF）通过基因工程技术。 融合蛋白可以独立使用或与酵母发酵产物组合使用，或与各种乳化剂，增稠剂，保湿剂，防腐剂，酵母和发酵剂组合使用。

公开(公告)号：US20140056966A1

公开(公告)日：2014-02-27

申请号：US13488932

申请日：2012-06-05

Applicant: Yongzhang LUO ,  Guodong Chang ,  Shuling Yang ,  Lei Gao ,  Yan Fu

Inventor： Yongzhang LUO ,  Guodong Chang ,  Shuling Yang ,  Lei Gao ,  Yan Fu

IPC: A61K47/48

CPC classification number: A61K47/60 ,  C12N9/6435 ,  C12Y304/21007

Abstract: The present invention provides an anti-tumor or anti-angiogenesis medicament, the combination or kit containing the medicament, and the method for producing the same. The anti-tumor or anti-angiogenesis medicament contains a conjugate comprising a modifying agent and the angiostatin or its fragments, wherein the conjugate exhibits prolonged in vivo half-life as compared to an unmodified angiostatin or its fragments. The modifying agent is selected from the group consisting of macromolecular polymers, protein molecules or fragments thereof, peptides, small molecules, or chemical substances of any other forms.

Abstract translation: 本发明提供抗肿瘤或抗血管生成药物，含有该药物的组合物或试剂盒及其制备方法。 抗肿瘤或抗血管生成药物含有包含修饰剂和血管抑素或其片段的缀合物，其中与未修饰的血管抑素或其片段相比，缀合物表现出延长的体内半衰期。 改性剂选自高分子聚合物，蛋白质分子或其片段，肽，小分子或任何其它形式的化学物质。

公开(公告)号：US08407351B2

公开(公告)日：2013-03-26

申请号：US12626418

申请日：2009-11-25

Applicant: Yan Fu

Inventor： Yan Fu

IPC: G06F15/16

CPC classification number: H04L67/02 ,  H04L67/303

Abstract: Techniques to ensure that user agent information is transported includes determining whether both a type field and a client platform information field are included in a first portion of a uniform resource locator field (URL) of a hypertext transfer protocol (HTTP) request message received from a remote client process. The first portion is different from a domain portion of the URL. The type field holds data that indicates whether the remote client inserted the client information field into a URL of an original HTTP request message. If both the type field and the client platform information field are included, then it is determined, based on data in the type field, whether to include both the type field and the client platform information field in a first portion of a URL in a link in a HTTP response message. The HTTP response message is sent to the remote client process.

Abstract translation: 确保用户代理信息被传送的技术包括确定类型字段和客户端平台信息字段是否被包括在从一个或多个客户机平台信息接收到的超文本传输​​协议（HTTP）请求消息的统一资源定位符字段（URL）的第一部分中 远程客户端进程。 第一部分与URL的域部分不同。 类型字段保存指示远程客户端是否将客户端信息字段插入到原始HTTP请求消息的URL中的数据。 如果包括类型字段和客户端平台信息字段，则基于类型字段中的数据确定是否将链接中的URL的第一部分中的类型字段和客户端平台信息字段都包括在一起 在HTTP响应消息中。 HTTP响应消息被发送到远程客户端进程。

公开(公告)号：US08370505B2

公开(公告)日：2013-02-05

申请号：US12626418

申请日：2009-11-25

Applicant: Yan Fu

Inventor： Yan Fu

IPC: G06F15/16

Abstract: Techniques to ensure that user agent information is transported includes determining whether both a type field and a client platform information field are included in a first portion of a uniform resource locator field (URL) of a hypertext transfer protocol (HTTP) request message received from a remote client process. The first portion is different from a domain portion of the URL. The type field holds data that indicates whether the remote client inserted the client information field into a URL of an original HTTP request message. If both the type field and the client platform information field are included, then it is determined, based on data in the type field, whether to include both the type field and the client platform information field in a first portion of a URL in a link in a HTTP response message. The HTTP response message is sent to the remote client process.

公开(公告)号：US08364970B2

公开(公告)日：2013-01-29

申请号：US12388326

申请日：2009-02-18

Applicant: Yan Fu

Inventor： Yan Fu

IPC: G06F21/00

CPC classification number: H04L63/08 ,  G06F21/6218 ,  H04L63/0807

Abstract: An approach is provided for authorizing one or more services from service providers in a communications network. The approach includes receiving a request from a first service provider, the request having an associated primary token and a secondary token identifier, the secondary token identifier relating to resources of a second service provider. Based, at least in part, on the secondary token identifier, a secondary token is identified; and then the secondary token is sent to the first service provider, wherein the first service provider and the second service provider belong to different trust domains and the first service provider can use the secondary token to access resources of the second service provider.

Abstract translation: 提供了一种用于从通信网络中的服务提供商授权一个或多个服务的方法。 该方法包括从第一服务提供商接收请求，所述请求具有相关联的主令牌和次令牌标识符，次要令牌标识符与第二服务提供商的资源相关。 至少部分地基于次要令牌标识符，识别次要令牌; 然后将次要令牌发送到第一服务提供商，其中第一服务提供商和第二服务提供商属于不同的信任域，并且第一服务提供商可以使用辅助令牌来访问第二服务提供商的资源。

公开(公告)号：US20120209575A1

公开(公告)日：2012-08-16

申请号：US13025497

申请日：2011-02-11

Applicant: Saeed David Barbat ,  Yan Fu ,  Xiaomo Jiang ,  Parakrama Valentine Weerappuli ,  Ren-Jye Yang ,  Guosong Li

Inventor： Saeed David Barbat ,  Yan Fu ,  Xiaomo Jiang ,  Parakrama Valentine Weerappuli ,  Ren-Jye Yang ,  Guosong Li

IPC: G06F17/10

CPC classification number: G06F17/5009 ,  G06F17/5095 ,  G06F2217/16

Abstract: A method and system for assessing the accuracy and validity of a computer model constructed to simulate a multivariate complex dynamic system. The method and system exploit a probabilistic principal component analysis method along with Bayesian statistics, thereby taking into account the uncertainty and the multivariate correlation in multiple response quantities. It enables a system analyst to objectively quantify the confidence of computer models/simulations, thus providing rational, objective decision-making support for model assessment. The validation methodology has broad applications for models of any type of dynamic system. In a disclosed example, it is used in a vehicle safety application.

Abstract translation: 一种用于评估构建为模拟多变量复杂动态系统的计算机模型的准确性和有效性的方法和系统。 该方法和系统利用贝叶斯统计学的概率主成分分析方法，从而考虑到多个响应量的不确定性和多变量相关性。 它使系统分析师能够客观地量化计算机模型/模拟的置信度，从而为模型评估提供合理，客观的决策支持。 验证方法对于任何类型的动态系统的模型都有广泛的应用。 在公开的示例中，其用于车辆安全应用中。

公开(公告)号：US20120165510A1

公开(公告)日：2012-06-28

申请号：US13254987

申请日：2010-03-05

Applicant: Luo Yongzhang ,  Huadong Tang ,  Yan Fu

Inventor： Luo Yongzhang ,  Huadong Tang ,  Yan Fu

IPC: C07K14/75

CPC classification number: C07K14/75 ,  A61K38/363

Abstract: The invention discloses a novel application of fibrinogen-420 and its active domain (alpha EC domain), and a separate alpha EC domain protein has the same or similar function with fibrinogen-420. Fibrinogen-420 and its active domain can be widely used in inhibiting protein aggregation, helping protein refolding, drugs which can prevent and/or treat protein conformation disease, detecting denatured protein in quality control and protect protein from denaturation.

Abstract translation: 本发明公开了一种纤维蛋白原420及其活性结构域（αEC结构域）的新应用，单独的αEC结构域蛋白与纤维蛋白原-F4具有相同或相似的功能。 纤维蛋白原420及其活性结构域可广泛用于抑制蛋白质聚集，有助于蛋白质重折叠，可预防和/或治疗蛋白质构象疾病的药物，检测质量控制中的变性蛋白质，保护蛋白质免于变性。

公开(公告)号：US20110161961A1

公开(公告)日：2011-06-30

申请号：US12648825

申请日：2009-12-29

Applicant: Yan Fu

Inventor： Yan Fu

IPC: G06F9/46 ,  G06F15/16

CPC classification number: G06F9/5027 ,  G06F2209/5011 ,  G06F2209/5018

Abstract: An approach is provided for optimized information transmission using dedicated threads. A thread manager receives a request from a device for content information. The thread manager assigns the request to a worker thread for processing to generate the content information. The thread manager further determines whether the worker thread has completed the processing of the content information. The thread manager delegates the processed content information to a transmission thread based, at least in part, on the determination, wherein the transmission thread causes, at least in part, transfer of the processed content information. The thread manager releases the worker thread from the assigned request.

Abstract translation: 提供了一种使用专用线程优化信息传输的方法。 线程管理器从设备接收内容信息的请求。 线程管理器将请求分配给工作线程进行处理以生成内容信息。 线程管理器还确定工作线程是否已经完成了内容信息的处理。 所述线程管理器至少部分地基于所述确定将所处理的内容信息委托给传输线程，其中所述传输线程至少部分地导致所处理的内容信息的传送。 线程管理器从分配的请求中释放工作线程。