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51.发明授权公开(公告)号：US08420368B2
公开(公告)日：2013-04-16
申请号：US13371082
申请日：2012-02-10
申请人： Erno Pungor , Charles Hague , Zhi Chen
发明人： Erno Pungor , Charles Hague , Zhi Chen
IPC分类号： C12N9/14
CPC分类号： C12N9/16 , A01K2217/075 , A01K2267/035 , A61K38/00 , C12Q1/34 , C12Q1/44 , C12Y301/06014 , G01N33/6893 , G01N2333/924 , G01N2400/40 , G01N2500/04 , G01N2800/04
摘要： This invention provides compositions of active highly phosphorylated lysosomal sulfatase enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal sulfatase enzymes and compositions and their use in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly lysosomal storage diseases that are caused by, or associated with, a deficiency in the lysosomal sulfatase enzyme.
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公开(公告)号：US08101381B2
公开(公告)日：2012-01-24
申请号：US12832882
申请日：2010-07-08
申请人： Scott R. Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen , Steven D. Hughes
发明人： Scott R. Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen , Steven D. Hughes
CPC分类号： C07K14/715 , A61K38/00
摘要： Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides polynucleotides, vectors, cells, and methods of production related to a new human cytokine receptor designated as “Zcytor16.”
摘要翻译： 细胞因子及其受体已被证明在基础研究和治疗方面都是有用的。 本发明提供与称为“Zcytor16”的新的人类细胞因子受体相关的多核苷酸，载体，细胞和生产方法。
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公开(公告)号：US20100292151A1
公开(公告)日：2010-11-18
申请号：US12620059
申请日：2009-11-17
申请人： Scott R. Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen
发明人： Scott R. Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/00
摘要： Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16” and uses thereof.
摘要翻译： 细胞因子及其受体已被证明在基础研究和治疗方面都是有用的。 本发明提供了称为“Zcytor16”的新的人细胞因子受体及其应用。
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公开(公告)号：US07790851B2
公开(公告)日：2010-09-07
申请号：US12435218
申请日：2009-05-04
申请人： Scott R. Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen , Steven D. Hughes
发明人： Scott R. Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen , Steven D. Hughes
IPC分类号： C07K14/52
CPC分类号： C07K14/715 , A61K38/00
摘要： Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”
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55.发明申请SUBSTITUTED PYRIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS 审中-公开用于治疗癌症和其他疾病的替代吡啶衍生物公开(公告)号：US20100075971A1
公开(公告)日：2010-03-25
申请号：US12628735
申请日：2009-12-01
申请人： Jacques DUMAS , Wendy Lee , Yuanwei Chen , Lila Adnane , William J. Scott , Sharad Verma , Jianqing Chen , Zhi Chen , Lin Yi
发明人： Jacques DUMAS , Wendy Lee , Yuanwei Chen , Lila Adnane , William J. Scott , Sharad Verma , Jianqing Chen , Zhi Chen , Lin Yi
IPC分类号： A61K31/4412 , C07D211/74 , C07D405/12 , C07D401/12 , C07D413/14 , C07D401/04 , C07D417/14 , A61K31/4433 , A61K31/4709 , A61K31/4439 , A61K31/4545 , A61K31/5377
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译： 本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。
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公开(公告)号：US07667000B2
公开(公告)日：2010-02-23
申请号：US11670118
申请日：2007-02-01
申请人： Scott R. Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen
发明人： Scott R. Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen
IPC分类号： C07K16/00
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/00
摘要： Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”
摘要翻译： 细胞因子及其受体已被证明在基础研究和治疗方面都是有用的。 本发明提供了称为“Zcytor16”的新的人细胞因子受体。
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57.发明授权Fused tricyclic heterocycles useful for treating hyper-proliferative disorders 失效用于治疗高增殖性疾病的融合的三环杂环公开(公告)号：US07384947B2
公开(公告)日：2008-06-10
申请号：US11512032
申请日：2006-08-28
申请人： Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott M. Wilhelm , Qian Zhao
发明人： Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin D. Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott M. Wilhelm , Qian Zhao
IPC分类号： A61K31/497 , A61K31/4355 , A61K31/4436 , A61K31/443 , A61K31/427
CPC分类号： C07D407/06 , C07D307/92 , C07D307/93 , C07D333/74 , C07D405/06 , C07D409/06 , C07D413/06 , C07D491/04 , C07D493/04
摘要： This invention relates to a novel fused tricyclic heterocycle of the formula and its use for the treatment of hyper-proliferative disorders.
摘要翻译： 本发明涉及下式的新型稠合三环杂环及其用于治疗高增殖性疾病的用途。
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公开(公告)号：US20070299247A1
公开(公告)日：2007-12-27
申请号：US11829011
申请日：2007-07-26
申请人： Scott Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen , Steven Hughes
发明人： Scott Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen , Steven Hughes
IPC分类号： C07K14/715
CPC分类号： C07K14/715 , A61K38/00
摘要： Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”
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公开(公告)号：US20070134237A1
公开(公告)日：2007-06-14
申请号：US11670118
申请日：2007-02-01
申请人： Scott Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen
发明人： Scott Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/00
摘要： Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”
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60.发明申请Fused tricyclic heterocycles useful for treating hyper-proliferative disorders 失效用于治疗高增殖性疾病的融合的三环杂环公开(公告)号：US20060287387A1
公开(公告)日：2006-12-21
申请号：US11512032
申请日：2006-08-28
申请人： Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott Wilhelm , Qian Zhao
发明人： Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott Wilhelm , Qian Zhao
IPC分类号： A61K31/381 , A61K31/343
CPC分类号： C07D407/06 , C07D307/92 , C07D307/93 , C07D333/74 , C07D405/06 , C07D409/06 , C07D413/06 , C07D491/04 , C07D493/04
摘要： This invention relates to a novel fused tricyclic heterocycle of the formula and its use for the treatment of hyper-proliferative disorders.
摘要翻译： 本发明涉及下式的新型稠合三环杂环及其用于治疗高增殖性疾病的用途。
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