摘要:
An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; R1 and R2 are H or alkyl; R3 and R4 are halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R5 is halogen atom, H, OH, alkoxy, aryloxy, alkyl or aryl. Each group can be substituted.
摘要翻译:本发明的目的是产生一种可用作药物的新型吲唑衍生物,并找到该衍生物的新药理作用。 本发明的化合物由式[I]表示,具有优异的Rho激酶抑制作用。 在该式中,环X为苯环或吡啶环; R 1和R 2均为H或烷基; R 3和R 4是卤素,H,OH,烷氧基,烯氧基,炔氧基,环烷氧基,环烯氧基,芳氧基,烷基,烯基,炔基,环烷基,环烯基,芳基, 羧基,烃基,烷基羰基等; R 5是卤素原子,H,OH,烷氧基,芳氧基,烷基或芳基。 每组可以替代。
摘要:
Shock-absorbing material made from a mixture of solid particles and viscous elastic material is arranged at the periphery of an information storage and retrieval device. When an external shock is applied to the device, the shock-absorbing material is greatly deformed and dissipates the shock energy by inner friction sufficiently to prevent damage to the inner mechanism of the device. The deformed shock-absorbing material can be restored to the original shape so that it is repeatedly usable. Furthermore, by comparing the deformed shape and the quick reference table provided with the device, the amount shock acceleration can be roughly determined. The device conforms to one of a series of dimensional standards for information storage and retrieval devices.
摘要:
A dielectric waveguide designed to avoid the influence of reflection of electromagnetic waves at connected portions of dielectric strips and to have an improved characteristic. The distance L between connection planes between pairs of dielectric strips adjacent in the direction of propagation of an electromagnetic wave is set to an odd number multiple of ¼ of the guide wavelength. Reflected waves are thereby superposed in phase opposition to each other to cancel out. In this manner, propagation of a reflected signal to ports is limited.
摘要:
A deformable conductive elastomer excellent in reliability, linearity, and mechanical characteristics, and a manufacturing method thereof are provided. Elastomer particles with a particle size of 10 through 300 &mgr;m and conductive particles with a particle size of 10 through 40 &mgr;m are almost uniformly dispersed in a non-conductive elastomer. Ceramic particles with a particle size of 1000 nm or less are also almost uniformly dispersed in the non-conductive elastomer. At least the non-conductive elastomer uncrosslinked, the elastomer particles, and the conductive particles are added to the dispersion medium, and the mixture is vibrated, mixed, and dried to crosslink the uncrosslinked non-conductive elastomer. At least the non-conductive elastomer, the elastomer particles, and the conductive particles are added to the dispersion medium, and the mixture is vibrated, mixed, and dried.
摘要:
A current-limiting resistor is connected between a power-supply line and a heater provided near the oxygen-detecting element of limiting-current type oxygen sensor. A power MOSFET is connected between the heater and a ground line. The resistor and the heater have such resistances that a current I2 flowing through the resistor and the heater when the heater has a resistance R2 is about I1{square root over ((R1/R2))}, where I1 is a current flowing through the resistor and the heater when the heater has a resistance R1.
摘要:
A rotary shaft is rotatably supported by a hydrodynamic fluid radial bearing and a hydrodynamic fluid thrust bearing which are excellent in shock resistance, an bearing arrangement in which vibration in a translation mode of the shaft, among vibration components caused by unbalance force exerted to the rotary shaft, is supported by the radial bearing, and vibration in conical mode is supported by the thrust bearing, magnetic fluid is used as lubrication oil, and a permanent magnet is located between the radial bearing and the thrust bearing so as to apply a magnetic attracting force between the rotary shaft and the thrust bearing so as to carry out axial positioning in order to use the magnetic disc device in an arbitrary attaching posture. With this arrangement, the magnetic disc device using such a bearing arrangement can enhance portability, thinning and antishock ability, and reduce noise and power consumption, thereby it is possible to provide a note-type personal computer with a high degree of reliability.
摘要:
A dielectric waveguide designed to avoid the influence of reflection of electromagnetic waves at connected portions of dielectric strips and to have an improved characteristic. A third dielectric strip is inserted in a part of a connection section at which a first dielectric strip and a second dielectric strip are connected to each other, and the distances between the three connection planes in said connection section are determined so that a wave reflected at the connection plane between the first and third dielectric strips, a wave reflected at the connection plane between the first and second dielectric strips, and a wave reflected at the connection plane between the second and third dielectric strips are superposed with a phase difference of 2&pgr;/3 from each other. Alternatively or in addition, the distance between the first-second dielectric strip connection plane and the first-third dielectric strip connection plane is set to ⅙ of the guide wavelength of an electromagnetic wave propagating through the dielectric strips, and the distance between the first-second dielectric strip connection plane and the second-third dielectric strip connection plane is set to ⅙ of the guide wavelength. Reflected waves are thereby superposed in phase opposition to each other to cancel out. In this manner, propagation of a reflected signal to ports is limited.
摘要:
An ATM exchange system which handles fixed-length cells, such as an ATM exchange, is designed in such a manner that even when a failure occurs particularly in an interface unit or an ATM switch section, downstream stations can be informed of the failure reliably and that when some failure is detected, counting of a charge counter is disabled to always ensure proper charging. For a method of matching between software and hardware in the ATM exchange system including the ATM switch section having a plurality of line associated sections and firmwares associated with those line associated sections, and a call control processor for controlling the ATM switch section, identifiers of an SVC (Switched Virtual Channel) call and a PVC (Permanent Virtual Channel) call are given to connection information of software on the call control processor, connection data affixed with the identifier of the SVC call is released only on the software on the call control processor during a restarting process of the call control processor, and a request to release the SVC call to all the line associated sections in the hardware of the ATM switch section, whereby matching of path information between the software on the call control processor and the hardware of the ATM switch section is performed.
摘要:
A disk drive unit includes a rotary member, which has a spindle, and has an information-recording disk fixedly mounted thereon, and a bearing unit rotatably supporting the spindle. The bearing unit includes a radial bearing device, provided in opposed relation to an outer peripheral surface of the spindle, and a thrust bearing device provided in opposed relation to a distal end surface of the spindle. The radial bearing device has a concentric arc-shaped bearing surface, which is concentric with the circular outer periphery of the spindle, and a non-concentric arc-shaped bearing surface which is non-concentric with the circular outer periphery of the spindle. The disk drive unit further includes a motor for imparting a rotational force to the spindle, and a lubricating fluid filled in the bearing unit.
摘要:
In a millimeter wave module or the like having both a normal NRD guide and a hyper NRD guide, a conversion portion structure for non, radiative dielectric waveguides of different types has excellent conversion characteristics at the connection between the two types of NRD guides. In a first conversion portion, the width of a dielectric strip is changed from the width of a dielectric strip in the hyper NRD guide portion to the width of a dielectric strip in the normal NRD guide portion, grooves of approximately the same depth as grooves in the hyper NRD guide are provided extending as far as the second conversion portion, and in a third conversion portion, the width of these grooves widens perpendicular to the propagation direction of electromagnetic waves and parallel to the face of conductive plates. According to this structure, guide conversion can be achieved with low radiation in a predetermined frequency band.