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223 条记录 (耗时 0.032 秒)

    Dielectrophoretic process for retaining polarizable target-particles and device for performing that process
    52.
    发明授权
    Dielectrophoretic process for retaining polarizable target-particles and device for performing that process 有权
    用于保持极化目标颗粒的介电泳工艺和用于执行该过程的装置

    公开(公告)号：US08329015B2

    公开(公告)日：2012-12-11

    申请号：US11629895

    申请日：2005-06-14

    申请人： Thierry Chappuis ,  Damien Voisard

    发明人： Thierry Chappuis ,  Damien Voisard

    IPC分类号： G01N27/26 ,  G01N27/447 ,  B03C5/02 ,  B03C5/00

    CPC分类号： B03C5/028

    摘要： A process and a device for retaining polarizable target-particles from a fluid suspension of polarizable target-particles comprising the steps of pumping that suspension into a vertical or inclined channel and applying an alternating electric field inducing a negative dielectrophoretic force on the target-particles, the force being sufficient to push them a distance of at least or about 25 m from the surface of an electrode-bearing wall, thereby creating an upward-moving clarified fluid zone in the vicinity of that wall and a downward-moving target-particle containing fluid zone at a distance from that wall.

    摘要翻译： 一种用于从可极化目标颗粒的流体悬浮液中保持可极化目标颗粒的方法和装置，包括以下步骤：将该悬浮液泵送到垂直或倾斜通道中，并且对目标颗粒施加引起负介电电泳力的交变电场， 该力足以将它们从电极轴承壁的表面推出至少或约25μm的距离，从而在该壁附近产生向上移动的澄清流体区域和包含 流体区距离该墙一定距离。

    Oral pharmaceutical composition of anilinopyrimidine, preparation and use thereof
    53.
    发明授权
    Oral pharmaceutical composition of anilinopyrimidine, preparation and use thereof 失效
    苯胺嘧啶的口服药物组合物，其制备及用途

    公开(公告)号：US08277839B2

    公开(公告)日：2012-10-02

    申请号：US12307605

    申请日：2007-07-05

    申请人： Santa Fabiano ,  Mario Maio

    发明人： Santa Fabiano ,  Mario Maio

    IPC分类号： A61K9/66 ,  A61K31/497 ,  A61P35/04

    CPC分类号： A61K9/4858 ,  A61K9/14 ,  A61K9/1652 ,  A61K9/4866 ,  A61K31/506 ,  A61K47/6951 ,  B82Y5/00

    摘要： An oral pharmaceutical composition comprising a capsule dosage form containing a liquid fill composition including an anilinopyrimidine derivative of Formula (I) and a pharmaceutically acceptable excipient selected from the group consisting of polyethylene glycol, a glyceryl ester of capric acid or a mixture thereof. The liquid fill composition is formulated in a hard gelatin capsules and can be used for the preparation of a medicament for the treatment of cancer in particular AML.

    摘要翻译： 一种口服药物组合物，其包含含有液体填充组合物的胶囊剂型，所述液体填充组合物包含式（I）的苯胺基嘧啶衍生物和选自聚乙二醇，癸酸的甘油酯或其混合物的药学上可接受的赋形剂。 液体填充组合物配制成硬明胶胶囊，可用于制备用于治疗特别是AML的癌症的药物。

    Treatment of cartilage disorders with FGF-18
    54.
    发明授权
    Treatment of cartilage disorders with FGF-18 有权
    用FGF-18处理软骨疾病

    公开(公告)号：US08207115B2

    公开(公告)日：2012-06-26

    申请号：US12374488

    申请日：2007-08-24

    申请人： Alberto Gimona ,  Christoph H. Ladel ,  Elmar Vom Baur

    发明人： Alberto Gimona ,  Christoph H. Ladel ,  Elmar Vom Baur

    IPC分类号： A61K38/18

    CPC分类号： A61K38/1825

    摘要： This invention concerns the treatment of cartilage disorder and osteoarthritis in particular. More specifically, it relates to the use of FGF-18 in treatment regimens of patients having a cartilage disorder such as osteoarthritis, such as for example knee osteoarthritis or secondary hip osteoarthritis. Specifically provided is a preferred treatment scheme comprising once weekly administration of an FGF-18 compound per treatment cycle.

    摘要翻译： 本发明特别涉及软骨障碍和骨关节炎的治疗。 更具体地说，本发明涉及FGF-18在患有软骨疾病如骨关节炎（例如膝关节骨性关节炎或继发性髋关节骨性关节炎）的患者的治疗方案中的用途。 具体提供的是优选的治疗方案，每个治疗周期每周一次给予FGF-18化合物。

    Multiple dose aromatase inhibitor for treating infertility
    59.
    发明授权
    Multiple dose aromatase inhibitor for treating infertility 失效
    多剂量芳香酶抑制剂治疗不育症

    公开(公告)号：US07820706B2

    公开(公告)日：2010-10-26

    申请号：US10475175

    申请日：2001-04-17

    申请人： Robert F. Casper ,  Mohamed F. M. Mitwally

    发明人： Robert F. Casper ,  Mohamed F. M. Mitwally

    IPC分类号： A01N43/64 ,  A61K31/41

    CPC分类号： A61K31/5685 ,  A61K31/00 ,  A61K31/4196 ,  A61K38/24 ,  A61K2300/00

    摘要： A method of inducing ovulation in a female suffering from anovulatory infertility which comprises administering to said female two or more daily doses of at least one aromatase inhibitor. A method for augmenting ovulation in an ovulating female suffering from unexplained infertility or another type of ovulatory infertility which comprises administering to said female two or more daily doses of at least one aromatase inhibitor early in one or more menstrual cycles. A method of substantially reducing dosage levels of follicle stimulating hormone (FSH) for administration to a female undergoing infertility treatment which comprises administering a combination of two or more daily doses of at least one aromatase inhibitor (AI) with a plurality of daily doses of follicle stimulating hormone (FSH). A method of increasing response to a follicle stimulating hormone from a female who is a poor responder to follicle stimulation, which comprises administering a combination of two or more daily doses or at least one aromatase inhibitor (AI) with a plurality of daily doses of follicle stimulating hormone (FSH). Also disclosed are related pharmaceutical preparations and uses.

    摘要翻译： 一种诱导患有排卵不孕症的女性排卵的方法，其包括向所述女性施用两次或更多次日剂量的至少一种芳香酶抑制剂。 一种用于增加排卵女性排卵的方法，所述排卵女性患有不明原因的不育症或另一种类型的排卵不育症，其包括在一个或多个月经周期早期向所述雌性两剂或更多剂量的至少一种芳香酶抑制剂施用。 一种用于施用于不孕不育治疗的女性的促卵泡激素（FSH）的剂量水平的方法，其包括将两种或更多日剂量的至少一种芳香酶抑制剂（AI）的组合与多个日剂量的卵泡 刺激激素（FSH）。 增加对来自卵泡刺激的不良反应者的女性的促卵泡激素的反应的方法，其包括将两种或更多种每日剂量的组合或至少一种芳香酶抑制剂（AI）与多个每日剂量的卵泡 刺激激素（FSH）。 还公开了相关的药物制剂和用途。