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公开(公告)号：US20200056153A1
公开(公告)日：2020-02-20
申请号：US16662033
申请日：2019-10-24
发明人： Anthony WARD , Roberto CAMPOS-GONZALEZ , Alison SKELLEY , Khushroo GANDHI , Curt CIVIN , James C. STURM , Michael GRISHAM
摘要： The present invention is directed to the use of microfluidics in the preparation of cells and compositions for therapeutic uses.
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公开(公告)号：US20200054772A1
公开(公告)日：2020-02-20
申请号：US16661067
申请日：2019-10-23
IPC分类号： A61K49/22
摘要： The invention described herein relates to colloidal particles useful for photoacoustic imaging. The particles comprise a photoacoustic imaging agent with an absorbance maximum or plateau in the range of wavelengths 700-1100 nm. The imaging agent also displays low optical absorbance at some wavelength in the range 700-1100 nm. This combination of high and low optical absorbance enables background subtraction in photoacoustic imaging applications. The imaging agent is an organic compound having low aqueous solubility so that it is stably encapsulated in the hydrophobic core of the particle. The particle is stabilized by a polymeric surface coating, and the polymeric stabilizing layer on the surface of the particle may contain targeting ligands for targeted diagnostics or therapeutic delivery. The particle core may also contain therapeutic agents or other imaging agents.
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公开(公告)号：US10564084B2
公开(公告)日：2020-02-18
申请号：US14764719
申请日：2014-01-30
申请人： The Trustees of Princeton University , CNRS-Centre National De La Recherche Scientifique , Universite De Rennes I , The Chancellor, Masters and Scholars of the University of Oxford
发明人： Matthieu Roche , Howard A. Stone , Isabelle Cantat , Arnaud Saint-Jalmes , Ian Griffiths , Sebastien Le Roux , Zhen Zhen Li
摘要： Disclosed is a process and device allowing for fast measurements of the physicochemical properties of amphiphiles (lipids, surfactants, soaps, . . . ). A Marangoni flow is created and characterized using amphiphiles to be characterized. The observed flow is characterized, and using the disclosed process, one can deduce from this measurement many important physicochemical parameters of the amphiphiles such as their critical micellar concentration. Compared to existing techniques, the disclosed process offers the advantage that it requires a single experiment to deduce the parameters, when other techniques (pendant drop method, conductometry, etc . . . ) require the measurement of a quantity (interfacial tension, conductometry) against a systematically varied parameter (amphiphile concentration, . . . ). The disclosed process and devices are ideal to characterize and/or screen rapidly amphiphiles molecules based on their interaction with a solvent.
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公开(公告)号：US10450259B2
公开(公告)日：2019-10-22
申请号：US16119125
申请日：2018-08-31
IPC分类号： C07C67/035 , B01J19/24 , C10L1/02 , C07C69/63 , C07C29/147 , C07C19/03 , C07C19/043 , C07C17/00 , C07C19/00 , C07C69/14 , C07C29/00 , C07C29/03 , C07C29/48
摘要： Embodiments of the present disclosure provide for methods of hydrocarbon functionalization, methods and systems for converting a hydrocarbon into a compound including at least one group ((e.g., hydroxyl group) (e.g., methane to methanol)), functionalized hydrocarbons, and the like. Systems and methods as described herein can utilize photocatalysis.
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55.发明申请公开(公告)号：US20190256355A1
公开(公告)日：2019-08-22
申请号：US16400277
申请日：2019-05-01
发明人： John T. Groves , Roy Xiao
摘要： Methods, kits, cartridges, and compounds related to generating chlorine dioxide by exposing ClO2− to at least one of an iron porphyrin catalyst or an iron porphyrazine catalyst are described.
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公开(公告)号：US10347238B2
公开(公告)日：2019-07-09
申请号：US15796292
申请日：2017-10-27
发明人： Zeyu Jin , Gautham J. Mysore , Stephen DiVerdi , Jingwan Lu , Adam Finkelstein
摘要： Systems and techniques are disclosed for synthesizing a new word or short phrase such that it blends seamlessly in the context of insertion or replacement in an existing narration. In one such embodiment, a text-to-speech synthesizer is utilized to say the word or phrase in a generic voice. Voice conversion is then performed on the generic voice to convert it into a voice that matches the narration. An editor and interface are described that support fully automatic synthesis, selection among a candidate set of alternative pronunciations, fine control over edit placements and pitch profiles, and guidance by the editors own voice.
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公开(公告)号：US10345548B2
公开(公告)日：2019-07-09
申请号：US14499026
申请日：2014-09-26
发明人： Nezih Dural , Michael V Romalis
摘要： The disclosure provides an optical apparatus including at least one optical element including glass, at least one support including silicon and a housing including glass. Furthermore, the at least one optical element and the at least one support can be anodically bonded together, and the at least one support and the housing can be anodically bonded together. The disclosure further provides a method for fabricating optical components with durable bonds and incorporates active alignment.
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公开(公告)号：US10344064B2
公开(公告)日：2019-07-09
申请号：US15265321
申请日：2016-09-14
发明人： A. James Link , Siyan Zhang
IPC分类号： A61K38/10 , A61K38/12 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C07K14/47 , C07K7/08 , A61K38/00 , A61K38/17 , A61K31/635 , G01N33/50 , G01N33/68
摘要： Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided.
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公开(公告)号：US10300410B2
公开(公告)日：2019-05-28
申请号：US14635701
申请日：2015-03-02
发明人： Hantao Ji , Adam Cohen , Phil Efthimion , Eric Edlund , Erik Gilson
摘要： Provided is an advanced liquid centrifuge using differentially rotating cylinders moveable rings at the ends thereof, as well as methods for the separation of fluids, preferably liquids.
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公开(公告)号：US10300130B2
公开(公告)日：2019-05-28
申请号：US15223980
申请日：2016-07-29
发明人： Thomas Shenk , Dai Wang
IPC分类号： C07K14/11 , A61K39/245 , A61K39/12 , C12N7/00 , A61K39/145 , A61K39/00
摘要： Methods of increasing diversity in cytomegalovirus vaccines through the selection of cell type in which the virus is propagated, and the use of cytomegalovirus produced by those methods in the development of vaccine compositions, are disclosed. Vaccine compositions comprising CMV isolated from epithelial cells are also disclosed.
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