公开(公告)号：US20090011037A1

公开(公告)日：2009-01-08

申请号：US12108228

申请日：2008-04-23

申请人： JAMES D. PIPKIN ,  GEROLD L. MOSHER ,  DOUGLAS B. HECKER

发明人： JAMES D. PIPKIN ,  GEROLD L. MOSHER ,  DOUGLAS B. HECKER

IPC分类号： A61K9/14 ,  A61K47/40

CPC分类号： C08B37/0012 ,  A61K9/0056 ,  A61K9/0075 ,  A61K9/0095 ,  A61K9/1652 ,  A61K9/205 ,  A61K9/2054 ,  A61K31/519 ,  A61K31/53 ,  A61K31/5415 ,  A61K31/573 ,  A61K31/715 ,  A61K31/724 ,  A61K45/06 ,  A61K47/40 ,  B01D1/18 ,  Y10T428/2982

摘要： A particulate SAE-CD composition is provided. The SAE-CD composition has an advantageous combination of physical properties not found in known solid forms of SAE-CD. In particular, the SAE-CD composition possesses an advantageous physicochemical and morphological property profile such that it can be tailored to particular uses. The SAE-CD composition of the invention has improved flow and dissolution performance as compared to known compositions of SAE-CD.

摘要翻译： 提供颗粒SAE-CD组合物。 SAE-CD组合物具有在已知固体形式的SAE-CD中未发现的物理性质的有利组合。 特别地，SAE-CD组合物具有有利的物理化学和形态特征，使得其可以针对特定用途进行调整。 与已知SAE-CD组合物相比，本发明的SAE-CD组合物具有改善的流动性和溶解性能。

公开(公告)号：US20080206349A1

公开(公告)日：2008-08-28

申请号：US11883215

申请日：2005-12-20

申请人： Stephen George Barnwell ,  Adrew Ian Cooper ,  David John Duncalf ,  Alison Jayne Foster ,  Steven Paul Rannard

发明人： Stephen George Barnwell ,  Adrew Ian Cooper ,  David John Duncalf ,  Alison Jayne Foster ,  Steven Paul Rannard

IPC分类号： A61K9/14

CPC分类号： C08J3/215 ,  A61K8/06 ,  A61K8/062 ,  A61K9/1611 ,  A61Q9/00 ,  B01D1/18 ,  B01D17/047 ,  C08J3/122 ,  C08J2329/04

摘要： The invention provides a method comprising the steps of: (i) providing an emulsion of: a) an aqueous solvent, such as water, b) a carrier material dispersible or soluble in (a), said carrier material being solid at ambient temperature, and preferably being a polymer and inorganic salt or a surfactant, c) a volatile second liquid phase (for example, chloroform) which is not miscible with (a), and d) a material which is dispersible or soluble in (c) but not in (a), and, (ii) Drying the emulsion at above ambient temperature (preferably by spray drying) to simultaneously remove (a) and (c) and thereby obtain the material (b) in solid form with (d) dispersed therein.

摘要翻译： 本发明提供了一种方法，其包括以下步骤：（i）提供以下物质的乳液：a）水性溶剂如水，b）在（a）中可分散或可溶的载体材料，所述载体材料在环境温度下为固体， 优选为聚合物和无机盐或表面活性剂，c）与（a）不混溶的挥发性第二液相（例如氯仿），和d）在（c）中不分散或可溶的材料 在（a）中，和（ii）在高于环境温度（优选通过喷雾干燥）下干燥乳液以同时除去（a）和（c），从而获得固体形式的物质（b），其中（d）分散在其中 。

公开(公告)号：US20080048364A1

公开(公告)日：2008-02-28

申请号：US11632196

申请日：2005-07-22

申请人： Constantine Armeniades ,  Enrique Barrera ,  Jong Kim

发明人： Constantine Armeniades ,  Enrique Barrera ,  Jong Kim

IPC分类号： C08K3/04 ,  B05D1/12 ,  B29C45/00

CPC分类号： B82Y30/00 ,  B01D1/18 ,  C01P2004/03 ,  C01P2004/13 ,  C01P2004/50 ,  C08J3/215 ,  C09C1/48 ,  C09C1/56 ,  C09D5/033

摘要： The present invention is directed to new methods for combining, processing, and modifying existing materials, resulting in novel products with enhanced mechanical, electrical and electronic properties. The present invention provides for polymer/carbon nanotube composites with increased strength and toughness; beneficial for lighter and/or stronger structural components for terrestrial and aerospace applications, electrically and thermally conductive polymer composites, and electrostatic dissipative materials. Such composites rely on a molecular interpenetration between entangled single-wall carbon nanotubes (SWNTs) and cross-linked polymers to a degree not possible with previous processes.

摘要翻译： 本发明涉及用于组合，加工和修饰现有材料的新方法，从而产生具有增强的机械，电气和电子性能的新型产品。 本发明提供了具有增强的强度和韧性的聚合物/碳纳米管复合材料; 有利于用于陆地和航空航天应用的轻和/或强结构部件，导电和导热聚合物复合材料以及静电耗散材料。 这种复合材料依赖于缠结的单壁碳纳米管（SWNT）和交联聚合物之间的分子相互渗透，达到以前工艺不可能的程度。

公开(公告)号：US07322124B2

公开(公告)日：2008-01-29

申请号：US10539124

申请日：2003-12-05

申请人： Antonius Johannes Maria Bouman

发明人： Antonius Johannes Maria Bouman

IPC分类号： F26B19/00

CPC分类号： B01D1/18

摘要： The invention relates to a spray-drying device (1) having a vertical drying chamber (2), material-atomization means (4) and drying-gas feed (6) means. Filter elements (11) are present in order to filter the fine particles out of the flow of drying gas (7). The fine particles are periodically removed from the filter elements (11) and collected in fine-particle collection means (10) in such a manner that they remain separate from the main flow of spray-dried material. In this way, it is possible to successfully control the properties of the spray-dried (main) material without it being undesirably influenced by the fine particles.

摘要翻译： 本发明涉及具有垂直干燥室（2），材料雾化装置（4）和干燥气体进料（6）装置的喷雾干燥装置（1）。 存在过滤器元件（11）以便从干燥气体（7）的流动中过滤细颗粒。 周期性地从过滤器元件（11）移除细颗粒并将其收集在微粒收集装置（10）中，使得它们与喷雾干燥材料的主流分离。 以这种方式，可以成功地控制喷雾干燥（主）材料的性质，而不会不利地受到细颗粒的影响。

公开(公告)号：US20070152361A1

公开(公告)日：2007-07-05

申请号：US10584070

申请日：2004-09-16

申请人： Ove Hansen ,  Trevor Page

发明人： Ove Hansen ,  Trevor Page

IPC分类号： B29B9/00 ,  B29C31/10

CPC分类号： B01D1/18 ,  B01J2/04 ,  B29C43/34 ,  B29C2043/3494

摘要： The invention relates to a method and apparatus for producing substantially monodisperse micro particles mainly of heat sensible material using a carrier gas and a drying gas. Relatively dense micro particles with diameters in the range 1-120 μm with a very narrow span can be obtained.

摘要翻译： 本发明涉及使用载气和干燥气体主要生产主要为热敏材料的单分散微粒子的方法和装置。 可以获得具有非常窄跨度的直径在1-120μm范围内的相对致密的微粒子。

公开(公告)号：US20070045099A1

公开(公告)日：2007-03-01

申请号：US11283438

申请日：2005-11-18

申请人： Robert Wright

发明人： Robert Wright

IPC分类号： B01D3/34

CPC分类号： B01D1/16 ,  B01D1/18 ,  B01D1/20 ,  B01D1/26 ,  C02F1/10 ,  Y02W10/37

摘要： A method and system for treating feedwater includes producing a stream of hot air in an evaporation chamber having an upper section and a lower section and dispersing droplets of feedwater into the stream of hot air. The droplets evaporate and solids in the feedwater precipitate. The precipitated solids are collected in the lower section of the evaporation chamber. Water vapor is discharged from the evaporation chamber and treated in a cyclone separator to remove residual solids therefrom. The water vapor output from the cyclone separator is condensed. In this case, dry solids can be discharged from the evaporation chamber and the cyclone separator for recovery. Treated water can be recovered from the condenser.

摘要翻译： 用于处理给水的方法和系统包括在具有上部和下部的蒸发室中产生热空气流，并将给水的小滴分散到热空气流中。 液滴蒸发，给水中的固体沉淀。 沉淀的固体被收集在蒸发室的下部。 水蒸汽从蒸发室排出，并在旋风分离器中处理以从其中除去残留的固体。 从旋风分离器输出的水蒸气冷凝。 在这种情况下，可以从蒸发室和旋风分离器中排出干燥的固体以进行回收。 处理水可以从冷凝器回收。

公开(公告)号：US20060093677A1

公开(公告)日：2006-05-04

申请号：US11305461

申请日：2005-12-16

申请人： Donald Chickering ,  Shaina Reese ,  Sridhar Narasimhan ,  Julie Straub ,  Howard Bernstein ,  David Altreuter ,  Eric Huang

发明人： Donald Chickering ,  Shaina Reese ,  Sridhar Narasimhan ,  Julie Straub ,  Howard Bernstein ,  David Altreuter ,  Eric Huang

IPC分类号： A61K9/14

CPC分类号： B01D1/18 ,  A61K9/0075 ,  A61K9/145 ,  A61K9/1647 ,  A61K9/1694 ,  B01J2/04

摘要： Methods are provided for making a dry powder blend pharmaceutical formulation comprising (i) forming microparticles which comprise a pharmaceutical agent; (ii) providing at least one excipient in the form of particles having a volume average diameter that is greater than the volume average diameter of the microparticles; (iii) blending the microparticles with the excipient to form a powder blend; and (iv) jet milling the powder blend to deagglomerate at least a portion of any of the microparticles which have agglomerated, while substantially maintaining the size and morphology of the individual microparticles. Jet milling advantageously can eliminate the need for more complicated wet deagglomeration processes, can lower residual moisture and solvent levels in the microparticles (which leads to better stability and handling properties for dry powder formulations), and can improve wettability, suspendability, and content uniformity of dry powder blend formulations.

公开(公告)号：US06921458B2

公开(公告)日：2005-07-26

申请号：US10752861

申请日：2004-01-07

申请人： Donald E. Chickering, III ,  Sridhar Narasimhan ,  David Altreuter ,  Paul Kopesky ,  Mark Keegan ,  Julie A. Straub ,  Howard Bernstein

发明人： Donald E. Chickering, III ,  Sridhar Narasimhan ,  David Altreuter ,  Paul Kopesky ,  Mark Keegan ,  Julie A. Straub ,  Howard Bernstein

IPC分类号： A61K9/16 ,  B01D1/18 ,  B01J2/04 ,  F26B3/12 ,  F26B17/10 ,  B01D1/16

CPC分类号： F26B17/102 ,  A61K9/1647 ,  A61K9/1688 ,  B01D1/18 ,  B01J2/04 ,  F26B3/12

摘要： Methods and apparatus are provided for making particles comprising: (a) spraying an emulsion, solution, or suspension, which comprises a solvent and a bulk material (e.g., a pharmaceutical agent), through an atomizer and into a primary drying chamber, having a drying gas flowing therethrough, to form droplets comprising the solvent and bulk material dispersed in the drying gas; (b) evaporating, in the primary drying chamber, at least a portion of the solvent into the drying gas to solidify the droplets and form particles dispersed in drying gas; and (c) flowing the particles and at least a portion of the drying gas through a jet mill to deagglomerate or grind the particles. By coupling spray drying with “in-line” jet milling, a single step process is created from two separate unit operations, and an additional collection step is advantageously eliminated. The one-step, in-line process has further advantages in time and cost of processing.

公开(公告)号：US20050106553A1

公开(公告)日：2005-05-19

申请号：US10877047

申请日：2004-06-25

申请人： Felix Franks ,  Ross Hatley ,  Sheila Mathias

发明人： Felix Franks ,  Ross Hatley ,  Sheila Mathias

IPC分类号： A61K9/14 ,  A61K35/12 ,  A61K35/32 ,  A61K38/17 ,  B01D1/18 ,  B01J2/04 ,  C07K1/00 ,  C07K17/02 ,  C12N1/04 ,  C12N5/02 ,  C12N5/06 ,  C12N9/96 ,  C12N9/98 ,  C12N11/00 ,  C12N11/02 ,  A01N1/02 ,  B29B9/00

CPC分类号： C12N11/02 ,  A61K35/12 ,  B01D1/18 ,  B01J2/04 ,  C07K17/02 ,  C12N1/04 ,  C12N9/96 ,  Y10S159/01 ,  A61K2300/00

摘要： Materials which are not themselves storage-stable at room temperature are made suitable for storage by mixing them with a carrier substance and spray drying the resulting mixture so as to form particles containing both the material and the carrier substance in which the carrier substance is in an amorphous, i.e. glassy or rubbery, state. Formation of such a composition greatly enhances stability. The material stored may be a biological material such as an enzyme, the components of a chemical reaction such as reagents for carrying out an assay, or even viable biological cells.

摘要翻译： 在室温下本身不具有储存稳定性的材料通过将其与载体物质混合而适于储存并喷雾干燥所得混合物，以便形成含有载体物质的物质和载体物质的颗粒 无定形，即玻璃状或橡胶状态。 这种组合物的形成大大提高了稳定性。 存储的材料可以是生物材料，例如酶，化学反应的成分，例如用于进行测定的试剂，或甚至活的生物细胞。

公开(公告)号：US20050079138A1

公开(公告)日：2005-04-14

申请号：US10955261

申请日：2004-09-30

申请人： Donald Chickering ,  Shaina Reese ,  Sridhar Narasimhan ,  Julie Straub ,  Howard Bernstein ,  David Altreuter ,  Eric Huang ,  Luis Brito ,  Rajeev Jain

发明人： Donald Chickering ,  Shaina Reese ,  Sridhar Narasimhan ,  Julie Straub ,  Howard Bernstein ,  David Altreuter ,  Eric Huang ,  Luis Brito ,  Rajeev Jain

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K9/16 ,  B01D1/18 ,  B01J2/04 ,  A61L9/04

CPC分类号： B01D1/18 ,  A61K9/0075 ,  A61K9/145 ,  A61K9/1647 ,  A61K9/1694 ,  B01J2/04

摘要： Methods are provided for making a dry powder blend pharmaceutical formulation, comprising the steps of: (a) providing microparticles which comprise a pharmaceutical agent; (b) blending the microparticles with at least one excipient in the form of particles to form a powder blend; and (c) jet milling the powder blend to form a dry powder blend pharmaceutical formulation having improved dispersibility, suspendability, or wettability as compared to the microparticles of step (a) or the powder blend of step (b). The method can further include dispersing the dry powder blend pharmaceutical formulation in a liquid pharmaceutically acceptable vehicle to make an formulation suitable for injection. Alternatively, the method can further include processing the dry powder blend pharmaceutical formulation into a solid oral dosage form. In one embodiment, the microparticles of step (a) are formed by a solvent precipitation or crystallization process.

摘要翻译： 提供用于制备干粉混合药物制剂的方法，包括以下步骤：（a）提供包含药剂的微粒; （b）将微粒与颗粒形式的至少一种赋形剂混合以形成粉末混合物; 和（c）与步骤（a）的微粒或步骤（b）的粉末混合物相比，喷粉研磨粉末混合物以形成具有改善的分散性，悬浮性或润湿性的干粉混合物药物制剂。 该方法还可以包括将干粉混合物药物制剂分散在液体药学上可接受的载体中以制备适于注射的制剂。 或者，该方法还可以包括将干粉混合药物制剂加工成固体口服剂型。 在一个实施方案中，步骤（a）的微粒通过溶剂沉淀或结晶过程形成。