公开(公告)号：US1393714A

公开(公告)日：1921-10-11

申请号：US33336119

申请日：1919-10-25

Applicant: DU PONT

Inventor： STINE CHARLES M A ,  LAWRENCE GILSON JOHN

IPC: C07C205/24

CPC classification number: C07C201/14 ,  C07C201/16 ,  C07C205/24

公开(公告)号：US20180111956A1

公开(公告)日：2018-04-26

申请号：US15558910

申请日：2016-03-25

Applicant: President and Fellows of Harvard College

Inventor： Andrew G. Myers ,  Ziyang Zhang

IPC: C07H15/12 ,  C07H11/02 ,  C07H17/02 ,  C07C201/14 ,  C07C201/12 ,  C07H1/00

CPC classification number: C07H15/12 ,  C07B2200/07 ,  C07C201/12 ,  C07C201/14 ,  C07H1/00 ,  C07H11/02 ,  C07H15/18 ,  C07H17/02

Abstract: The present invention provides desosamine and mycaminose analogs and nitro sugars and methods for their preparation. The invention also provides methods of cyclizing a compound of Formula (A′) with glyoxal to give a nitro sugar of Formula (B). Methods for the preparation of compound of Formula (D′) are provided comprising cyclization of a nitro alcohol to give a nitro sugar and reduction and alkylation of the nitro sugar to give a desosamine, mycaminose, or an analog thereof.

公开(公告)号：US09630940B2

公开(公告)日：2017-04-25

申请号：US15148716

申请日：2016-05-06

Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

Inventor： Pandurang V. Chouthaiwale ,  Fujie Tanaka

IPC: C07D309/28 ,  C07D309/16 ,  C07C201/14 ,  C07D309/30 ,  C07D317/30 ,  C07D407/04 ,  C07D241/44 ,  C07D243/02 ,  C07D307/54 ,  C07C205/55

CPC classification number: C07D309/28 ,  C07C201/14 ,  C07C205/55 ,  C07C2601/14 ,  C07D241/44 ,  C07D243/02 ,  C07D307/54 ,  C07D309/30 ,  C07D317/30 ,  C07D407/04

Abstract: Disclosed is a process for preparing dihydro-2H-pyran derivatives of formula I: wherein R1 and R2 are defined herein. The process of the invention provides the compound of formula I in concise cascade reactions and in one pot. The compound of formulae I prepared by the process of the invention and its further transformed derivatives are useful for making pharmaceutical composition for the treatment of proliferative diseases.

公开(公告)号：US20150329472A1

公开(公告)日：2015-11-19

申请号：US14652913

申请日：2013-12-20

Applicant: NIPPON SODA CO., LTD.

Inventor： Hiroki Inoue ,  Yuzuru Sakata ,  Shinichi Kobayashi ,  Yoshikazu Ito ,  Takashi Kitayama

IPC: C07C209/74 ,  C07C209/32 ,  C07C17/00 ,  C07C201/14 ,  C07C211/52 ,  C07C205/12

CPC classification number: C07C209/74 ,  C07C17/00 ,  C07C17/06 ,  C07C17/12 ,  C07C201/08 ,  C07C201/14 ,  C07C205/12 ,  C07C209/32 ,  C07C211/52 ,  C07C25/13

Abstract: The present invention provides a halogenated aniline represented by formula (I) (wherein each of X1 and X2 independently represents a chlorine atom, a bromine atom or an iodine atom), a method for producing the halogenated aniline, and other aspects.

Abstract translation: 本发明提供由式（I）表示的卤代苯胺（其中X1和X2各自独立地表示氯原子，溴原子或碘原子），卤代苯胺的制造方法等。

公开(公告)号：US20130204043A1

公开(公告)日：2013-08-08

申请号：US13812690

申请日：2011-07-26

Applicant: Thomas Knauf ,  Michael Merkel ,  Andreas Karl Rausch ,  Peter Lehner ,  Jürgen Münnig

Inventor： Thomas Knauf ,  Michael Merkel ,  Andreas Karl Rausch ,  Peter Lehner ,  Jürgen Münnig

IPC: C07C201/14

CPC classification number: C07C201/14 ,  C07C201/08 ,  C07C201/16 ,  C07C209/36 ,  C07C205/06 ,  C07C211/46

Abstract: The present invention relates to a continuous process for the production of nitrobenzene by nitration of benzene with nitric acid or mixtures of nitric acid and sulfuric acid to give a crude nitrobenzene, washing of the crude nitrobenzene by means of at least one of each of an acid, alkaline and neutral washing, there being obtained a pre-purified nitrobenzene which, as well as containing nitrobenzene, at least contains also low boilers, optionally middle boilers as well as high boilers and salts, wherein the pre-purified nitrobenzene is purified further by separating off low boilers in a distillation apparatus by evaporation of the low boilers, and separation of nitrobenzene from the resulting further purified nitrobenzene in a distillation apparatus by partial evaporation of nitrobenzene, wherein pure nitrobenzene is removed from the distillation apparatus in gaseous form and is subsequently condensed, and wherein the non-evaporated portion of the further purified nitrobenzene is fed back into the washing at any desired point.

Abstract translation: 本发明涉及通过用硝酸或硝酸和硫酸的混合物硝化硝酸生产硝基苯的连续方法，得到粗硝基苯，通过以下各项中的至少一种酸洗粗硝基苯 碱性和中性洗涤，得到预纯化的硝基苯以及含有硝基苯，至少还含有低锅炉，任选的中间锅炉以及高锅炉和盐，其中预纯化的硝基苯进一步通过 通过蒸发低沸点锅炉将蒸馏装置中的低锅炉分离出来，并通过硝基苯的部分蒸发在蒸馏装置中将硝基苯与所得到的进一步纯化的硝基苯分离，其中将纯硝基苯以气态从蒸馏装置中除去，随后 冷凝，并且其中进一步纯化的硝基苯的未蒸发部分进料 回到任何想要的点的洗涤。

公开(公告)号：US20130184504A1

公开(公告)日：2013-07-18

申请号：US13823831

申请日：2011-09-05

Applicant: Shengjian Zhang ,  Yingxian Zhao ,  Hong Zhang

Inventor： Shengjian Zhang ,  Yingxian Zhao ,  Hong Zhang

IPC: C07C201/14

CPC classification number: C07C201/14 ,  C07C201/06 ,  C07C205/02

Abstract: The present invention relates to a method for preparing 2,3-dimethyl-2,3-dinitrobutane (DMNB), which includes the following steps: (1) making titanium-silicate molecular sieve catalyst, acetone, hydrogen peroxide and ammonia contact and react at 65-80° C. to obtain a modified titanium-silicate molecular sieve catalyst; and (2-1) making acetone oxime and hydrogen peroxide contact and react in the presence of the modified titanium-silicate molecular sieve catalyst and water under the conditions of temperature of 60-90° C. and pH of 8-10, and separating DMNB from the reaction products thereof; or (2-2) making acetone, ammonia and hydrogen peroxide contact and react in the presence of the modified titanium-silicate molecular sieve catalyst and water under the conditions of temperature of 60-90° C. and pH of 8-10, and separating DMNB from the reaction products thereof. By the method provided by the present invention, DMNB can be prepared without having to use dangerous chemicals, such as 2-nitropropane, NaH and the like.

Abstract translation: 本发明涉及一种制备2,3-二甲基-2,3-二硝基丁烷（DMNB）的方法，其包括以下步骤：（1）使钛硅酸盐分子筛催化剂，丙酮，过氧化氢和氨接触并反应 在65-80℃下，得到改性钛酸酯分子筛催化剂; 和（2-1）使丙酮肟和过氧化氢接触并在改性的钛酸硅酸盐分子筛催化剂和水的存在下在60-90℃的温度和pH为8-10的条件下反应，并分离 DMNB反应产物; 或（2-2）使丙酮，氨和过氧化氢接触并在改性钛硅酸盐分子筛催化剂和水的存在下在60-90℃的温度和pH为8-10的条件下反应，和 从其反应产物中分离DMNB。 通过本发明提供的方法，可以制备DMNB，而不必使用危险化学品，例如2-硝基丙烷，NaH等。

公开(公告)号：US07517983B2

公开(公告)日：2009-04-14

申请号：US10595943

申请日：2004-11-25

Applicant: Cláudio Cerqueira Lopes ,  Rosângela Sabattini Capella Lopes ,  Jarí Nobrega Cardoso ,  Jacqueline Alves da Silva ,  Letícia Gomes Ferreira

Inventor： Cláudio Cerqueira Lopes ,  Rosângela Sabattini Capella Lopes ,  Jarí Nobrega Cardoso ,  Jacqueline Alves da Silva ,  Letícia Gomes Ferreira

IPC: C07D237/32 ,  C07D237/04 ,  C07D231/28

CPC classification number: C07C201/14 ,  C07D237/28 ,  C07C205/57

Abstract: The present invention describes a process to form hydrazides from the reaction of a hydrazine and a dicarboxylic, using a Lewis acid as a main reagent of the reaction. The reaction occurs in a safe reactional environment, utilizing smooth conditions, neither involving high temperatures nor high pressures, producing the desired products with high yields, between 90-95%. The invention also describes a kit for utilization of chemiluminescent substances, comprised of two solutions.

Abstract translation: 本发明描述了使用路易斯酸作为反应的主要试剂从肼和二羧酸的反应形成酰肼的方法。 该反应发生在安全的反应环境中，使用平稳的条件，既不涉及高温也不高压，以高产率生产所需产物，在90-95％之间。 本发明还描述了一种用于利用由两种溶液组成的化学发光物质的试剂盒。

公开(公告)号：US20080242900A1

公开(公告)日：2008-10-02

申请号：US10586683

申请日：2005-02-02

Applicant: Johannes Buttner ,  Wolfgang Mackenroth ,  Heinrich Hermann ,  Peter Konieczny ,  Jurgen Gebauer

Inventor： Johannes Buttner ,  Wolfgang Mackenroth ,  Heinrich Hermann ,  Peter Konieczny ,  Jurgen Gebauer

IPC: C07C205/06

CPC classification number: C07C201/08 ,  C07C201/14 ,  C07C205/06

Abstract: The invention relates to a method for producing dinitrotoluene, comprising the steps of a) reacting toluene with nitric acid in the presence of sulphuric acid to give mononitrotoluene, b) separating the reaction product of step a) into a mononitrotoluene-containing organic phase and a sulphuric acid-containing aqueous phase, c) reacting the mononitrotoluene-containing organic phase with nitric acid in the presence of sulphuric acid to give dinitrotoluene, d) separating the reaction product of step c) into a dinitrotoluene-containing organic phase and a sulphuric-acid containing aqueous phase, whereby the reaction product of step a) contains 3.0 to 8 wt % of toluene, in relation to the organic phase, and 0.1 to 1.2 wt. % of nitric acid, in relation to the aqueous phase and the phase separation of step b) is carried out in such a manner that further reaction of toluene with nitric acid is prevented.

Abstract translation: 本发明涉及二硝基甲苯的制备方法，包括以下步骤：a）在硫酸存在下使甲苯与硝酸反应得到单硝基甲苯，b）将步骤a）的反应产物分离成含有单硝基甲苯的有机相和 含硫酸的水相，c）在硫酸存在下使含有单硝基甲苯的有机相与硝酸反应，得到二硝基甲苯，d）将步骤c）的反应产物分离成含有二硝基甲苯的有机相和含硫酸的有机相， 含有酸的水相，其中步骤a）的反应产物相对于有机相含有3.0-8wt％的甲苯，和0.1-1.2wt。 相对于水相和步骤b）的相分离，硝酸的百分比以防止甲苯与硝酸的进一步反应的方式进行。

公开(公告)号：US06881871B1

公开(公告)日：2005-04-19

申请号：US10911761

申请日：2004-07-29

Applicant: Matthew C. Davis

Inventor： Matthew C. Davis

IPC: C07C205/06 ,  C07C205/00

CPC classification number: C07C201/14 ,  C07C205/06

Abstract: An environmentally friendly methods for making 2,4,6-trinitrotoluene (TNT) compounds comprising, providing nitromalondialdehydes, providing dinitro-compounds, reacting the nitromalondialdehydes with the dinitro-compounds to produce aldol-intermediate compounds, and subjecting the intermediate compounds to a cyclodehydrative mechanism to produce 2,4,6-trinitrotoluene (TNT) compounds in an environmentally friendly manner. Another embodiment includes an environmentally friendly method for making 2,4,6-trinitrotoluene (TNT) compounds comprising, providing nitromethylamino-hexafluorophosphates, providing dinitro-compounds, reacting the trimethinium hexafluorophosphates with the dinitro-compounds to produce aldol-intermediate compounds, and subjecting the intermediate compounds to a cyclodehydrative mechanism to produce environmentally friendly 2,4,6-trinitrotoluene (TNT) compounds. Embodiments of the present invention include the 2,4,6-trinitrotoluene (TNT) compounds produced by the methods of described above.

Abstract translation: 制备2,4,6-三硝基甲苯（TNT）化合物的环保方法包括提供硝基醛，提供二硝基化合物，使硝基醛与二硝基化合物反应以产生醛醇 - 中间体化合物，以及使中间体化合物经历环状 机制以环保的方式生产2,4,6-三硝基甲苯（TNT）化合物。 另一个实施方案包括用于制备2,4,6-三硝基甲苯（TNT）化合物的环境友好的方法，其包括提供硝基甲基氨基六氟磷酸盐，提供二硝基化合物，使三硝基六氟磷酸盐与二硝基化合物反应以产生醛醇 - 中间体化合物， 将中间体化合物转化为环状脱水机制，生成环保的2,4,6-三硝基甲苯（TNT）化合物。 本发明的实施方案包括通过上述方法制备的2,4,6-三硝基甲苯（TNT）化合物。

公开(公告)号：US5364989A

公开(公告)日：1994-11-15

申请号：US908725

申请日：1992-07-06

Applicant: Isao Aoki ,  Takanori Tabuchi ,  Isao Minamida

Inventor： Isao Aoki ,  Takanori Tabuchi ,  Isao Minamida

IPC: A01N35/08 ,  A01N37/52 ,  A01N43/40 ,  A01N43/42 ,  A01N43/78 ,  C07C205/08 ,  C07C205/09 ,  C07C211/27 ,  C07D213/38 ,  C07D213/61 ,  C07D213/64 ,  C07D213/70 ,  C07D213/74 ,  C07D215/12 ,  C07D239/26 ,  C07D277/28 ,  C07D277/32 ,  C07D277/42 ,  C07C205/02 ,  C07C201/06

CPC classification number: C07D213/64 ,  A01N35/08 ,  A01N37/52 ,  A01N43/40 ,  A01N43/42 ,  A01N43/78 ,  C07C201/12 ,  C07C201/14 ,  C07C211/27 ,  C07D213/38 ,  C07D213/61 ,  C07D213/70 ,  C07D213/74 ,  C07D215/12 ,  C07D239/26 ,  C07D277/28 ,  C07D277/32 ,  C07D277/42

Abstract: Methods for the production of 1,1,1-trihalogeno-2-nitroethanes from 1,1-dihalogenoethylene by using nitric acid or its salt and hydrogen chloride or hydrogen bromide or its salt, and for the production of .alpha.-unsaturated amines from the 1,1,1-trihalogeno-2-nitroethanes which are useful as insecticides.

Abstract translation: 通过使用硝酸或其盐和氯化氢或溴化氢或其盐从1,1-二卤代乙烯生产1,1,1-三卤代-2-硝基乙烷的方法，以及用于从 可用作杀虫剂的1,1,1-三卤代-2-硝基乙基铵。