利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

261 条记录 (耗时 0.024 秒)

    Method of making polyhydric alcohol solutions of enhanced efficacy antiperspirant actives
    51.
    发明授权
    Method of making polyhydric alcohol solutions of enhanced efficacy antiperspirant actives 失效
    制备增效功效多元醇溶液止汗活性物质的方法

    公开(公告)号：US5939057A

    公开(公告)日：1999-08-17

    申请号：US874232

    申请日：1997-06-13

    申请人： Stephen J. Provancal ,  Angel L. Carrillo ,  Thomas J. Fluhler ,  Richard Oryszczak ,  Jayant N. Sane

    发明人： Stephen J. Provancal ,  Angel L. Carrillo ,  Thomas J. Fluhler ,  Richard Oryszczak ,  Jayant N. Sane

    IPC分类号： A61K8/20 ,  A61K8/26 ,  A61K8/28 ,  A61K8/34 ,  A61K8/44 ,  A61K8/58 ,  A61K8/86 ,  A61Q15/00 ,  A61K7/34 ,  A61K7/38

    CPC分类号： A61Q15/00 ,  A61K8/26 ,  A61K8/28 ,  A61K8/345 ,  A61K8/44

    摘要： The present invention comprises a process of preparing a solution of an enhanced efficacy aluminum antiperspirant salt in a polyhydric alcohol by(a) providing an aqueous solution consisting essentially of about 5% to about 18% by weight of an enhanced efficacy aluminum antiperspirant salt in water, the enhanced efficacy aluminum antiperspirant salt having been prepared in situ without having been dried to a solid powder;(b) mixing the aqueous solution with a sufficient amount of a liquid polyhydric alcohol to provide a mixed solution which has an antiperspirant salt to polyhydric alcohol ratio of about 1:4 to about 1.2:1; and(c) rapidly evaporating the water from the mixed solution under vacuum to provide a final liquid polyhydric alcohol solution containing about 20 to 50% enhanced efficacy aluminum antiperspirant salt and about 2 to 16% water, with the balance being polyhydric alcohol.An alkaline glycinate salt, such as sodium, potassium or zinc glycinate, may be added to the polyhydric alcohol prior to the addition of the antiperspirant salt solution in order to raise the pH of the recovered product to about 4.1 to 5.0.

    摘要翻译： 本发明包括通过（a）提供基本上由约5重量％至约18重量％的增强的功效铝止汗酸盐在水中的水溶液制备增强的功效性铝止汗药盐在多元醇中的溶液的方法 已经在原位制备了不再干燥成固体粉末的增强效力的铝止汗药; （b）将水溶液与足量的液体多元醇混合以提供具有止汗剂盐与多元醇比为约1:4至约1.2:1的混合溶液; 和（c）在真空下从混合溶液中快速蒸发水，以提供含有约20至50％增强效力的铝止汗塞盐和约2至16％水的最终液体多元醇溶液，余量为多元醇。碱性 可以在添加止汗盐溶液之前将甘氨酸盐，例如甘氨酸钠，钾或锌，加入到多元醇中，以将回收产物的pH提高至约4.1至5.0。

    Basic aluminum antiperspirant active materials having enhanced activity, antiperspirant active compositions containing such materials, and methods for preparation of such materials and compositions
    55.
    发明授权
    Basic aluminum antiperspirant active materials having enhanced activity, antiperspirant active compositions containing such materials, and methods for preparation of such materials and compositions 失效
    具有增强活性的碱性铝止汗剂活性物质，含有这些材料的止汗活性组合物，以及制备这种材料和组合物的方法

    公开(公告)号：US5624665A

    公开(公告)日：1997-04-29

    申请号：US456482

    申请日：1995-06-01

    申请人： Morton L. Barr ,  Paul J. Vincenti ,  Elaine L. Vanderhoof

    发明人： Morton L. Barr ,  Paul J. Vincenti ,  Elaine L. Vanderhoof

    IPC分类号： A61K8/19 ,  A61K8/26 ,  A61K8/28 ,  A61K8/29 ,  A61K8/44 ,  A61Q15/00 ,  C01B11/14 ,  C01B11/18 ,  C01B11/22 ,  C01F7/00 ,  C01F7/48 ,  C01F7/66 ,  A61K7/38 ,  A61K7/32

    CPC分类号： C01F7/66 ,  A61K8/19 ,  A61K8/26 ,  A61K8/28 ,  A61K8/29 ,  A61K8/44 ,  A61Q15/00 ,  C01B11/14 ,  C01B11/18 ,  C01B11/22 ,  C01F7/002 ,  C01F7/48 ,  A61K2800/58 ,  C01P2002/86 ,  C01P2002/87

    摘要： Disclosed are basic aluminum antiperspirant materials having univalent complex oxoanions (e.g., nitrate); methods of making such materials; antiperspirant compositions containing such basic aluminum materials, another antiperspirant active material (e.g., a basic zirconium halide salt), and optionally a neutral amino acid: and methods of making such compositions. Size exclusion high performance liquid chromatography chromatograms of the disclosed basic aluminum materials have a peak 4 relative area of at least 25%, a peak 3 relative area of less than 60%, the sum of the peaks 3 and 4 being at least 50%; and less than 10% of the chromatographic peaks eluting at peaks 1 and 2. The disclosed basic aluminum materials have less than 25% of the aluminum in the form of Al.sup.b polyhydroxyaquoaluminum, and have a .sup.27 Al NMR spectrum in which the area of the 71.5-73.5 ppm resonance line includes more than 50% of the combined areas of the 62.5-63.5 ppm and 71.5-73.5 ppm resonance lines, and 5%-30% of the total area under the spectrum from 140 ppm to -80 ppm is contained in the resonance line at 71.5-73.5 ppm. The basic aluminum material of the present invention can be produced by adding a stoichiometric or near-stoichiometric amount of aluminum metal to a solution of an aluminum salt having a univalent complex oxoanion; the basic aluminum material can also be made by adding to such solution of the aluminum salt, aluminum metal having, in total, a relatively small surface area (large-sized particles of aluminum).

    摘要翻译： 公开了具有单价复合氧代阴离子（例如硝酸盐）的碱性止汗剂材料; 制作这种材料的方法; 含有这种碱性铝材料的止汗组合物，另一种止汗剂活性物质（例如碱性卤化锆盐）和任选的中性氨基酸：以及制备这种组合物的方法。 所公开的碱性铝材料的尺寸排阻高效液相色谱色谱图具有至少25％的峰4相对面积，峰3相对面积小于60％，峰3和4的总和至少为50％; 并且在峰1和2处洗脱的色谱峰小于10％。所公开的碱性铝材料具有少于25％的Alb聚羟基铝形式的铝，并且具有27Al NMR谱，其中71.5- 73.5ppm共振线包括62.5-63.5ppm和71.5-73.5ppm共振线的组合面积的50％以上，并且在140ppm至-80ppm的光谱范围内的总面积的5％-30％包含在 共振线为71.5-73.5ppm。 本发明的碱性铝材料可以通过将化学计量或近化学计量的铝金属加入到具有一价复合氧阴离子的铝盐溶液中来制备; 碱性铝材料也可以通过向铝盐，总共具有相对小的表面积（大尺寸的铝颗粒）的铝金属溶液中加入来制备。

    Clear antiperspirant gel stick and method for making same
    57.
    发明授权
    Clear antiperspirant gel stick and method for making same 失效
    透明止汗凝胶棒及其制作方法

    公开(公告)号：US5463098A

    公开(公告)日：1995-10-31

    申请号：US110086

    申请日：1993-08-20

    申请人： Rocco Giovanniello ,  Nelson P. Ayala

    发明人： Rocco Giovanniello ,  Nelson P. Ayala

    IPC分类号： A61K8/28 ,  A61K8/34 ,  A61K8/44 ,  A61Q15/00 ,  C07F9/00 ,  A61K7/32 ,  A61K7/36 ,  A61K7/38

    CPC分类号： A61Q15/00 ,  A61K8/0229 ,  A61K8/042 ,  A61K8/28 ,  A61K8/345 ,  A61K8/44 ,  A61K2800/262

    摘要： A residue free, antiperspirant gel stick composition is disclosed which comprises an antiperspirant compound which is soluble in a diol, a normally liquid, water soluble diol, a gelling agent and a zinc glycinate in amount sufficient to control the pH of the gel stick at about 4.1 to about 5.0, the glycine to zinc mole ratio of the zinc glycinate added being about 2.0/1 to about 3.0/1. The process for preparing a diol soluble antiperspirant active useful in preparing the residue free gel stick is also disclosed and comprises reacting an antiperspirant compound with a water soluble, normally liquid diol in a water solution by heating for about 1 to about 100 hours at a temperature of about 50.degree. C. to about 110.degree. C.; adding a zinc glycinate to the reaction mixture and removing the water to recover a powdered antiperspirant active.

    摘要翻译： 公开了一种无残留的止汗凝胶棒组合物，其包含可溶于二醇的止汗化合物，常规液体，水溶性二醇，胶凝剂和甘氨酸锌，其量足以控制凝胶棒的pH在约 4.1至约5.0，加入的甘氨酸锌的甘氨酸与锌的摩尔比为约2.0 / 1至约3.0 / 1。 还公开了可用于制备无残留凝胶棒的二醇可溶性止汗剂活性剂的制备方法，包括使止汗化合物与水溶液通常为液体的二醇在水溶液中反应，在温度下加热约1至约100小时 约50℃至约110℃。 向反应混合物中加入甘氨酸锌，除去水以回收粉末状止汗剂活性物质。

    Non-whitening antiperspirant composition
    59.
    发明授权
    Non-whitening antiperspirant composition 失效
    非美白止汗组合物

    公开(公告)号：US5449511A

    公开(公告)日：1995-09-12

    申请号：US090368

    申请日：1993-07-12

    申请人： Craig M. Coe

    发明人： Craig M. Coe

    IPC分类号： A61K8/58 ,  A61K8/894 ,  A61Q15/00 ,  A61K7/32 ,  A61K7/34 ,  A61K7/38

    CPC分类号： A61Q15/00 ,  A61K8/585 ,  A61K8/894 ,  A61K2800/31 ,  A61K2800/412 ,  Y10S424/05

    摘要： An anhydrous antiperspirant product includes an anhydrous carrier vehicle; an antiperspirant active salt suspended in particle form in the vehicle; and a nonvolatile water soluble liquid masking agent that is interactive with the antiperspirant active salt to essentially eliminate discernible whitening without substantially inhibiting the antiperspirant activity of the salt when the product is applied to the skin.

    摘要翻译： 无水止汗产品包括无水载体载体; 在车辆中以颗粒形式悬浮的止汗活性盐; 以及与止汗剂活性盐相互作用的非挥发性水溶性液体掩蔽剂，以在产品施用于皮肤时基本上消除可辨别的增白，而基本上不会抑制盐的止汗活性。