公开(公告)号：US10383944B2

公开(公告)日：2019-08-20

申请号：US15129505

申请日：2015-03-03

申请人： Dow Global Technologies LLC

发明人： Neal J. Fetner ,  David L. Malotky ,  Jin Zhao ,  Matthias Knarr ,  Michael J. Devon ,  Roland Adden

IPC分类号： A61K9/28 ,  A61K47/38 ,  A61K9/48 ,  C08B13/00 ,  C08L1/32 ,  A61J3/07

摘要： An aqueous composition useful for producing capsules shells comprises a) at least one dispersed esterified cellulose ether comprising (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and b) from 0.05 to 20 percent of at least one salt of a fatty acid, based on the weight of the dispersed esterified cellulose ether, wherein the median particle size, d50, of the dispersed esterified cellulose ether particles is up to 7 micrometers, such median particle size (d50) being the size at which 50 mass percent of the particles have a smaller equivalent diameter and 50 mass percent have a larger equivalent diameter.

公开(公告)号：US10297859B2

公开(公告)日：2019-05-21

申请号：US15272644

申请日：2016-09-22

申请人： FUJIFILM Corporation

发明人： Hiroaki Mochizuki ,  Tomonori Mimura ,  Masaomi Makino ,  Katsuhiko Meguro

IPC分类号： H01M10/056 ,  C08B3/10 ,  C08B11/16 ,  C08B3/08 ,  H01M10/0525 ,  C08B11/02 ,  H01M10/0562 ,  H01M4/04 ,  H01M4/131 ,  H01M4/133 ,  H01M4/134 ,  H01M4/1391 ,  H01M4/1393 ,  H01M4/1395 ,  H01M4/62 ,  H01M4/66 ,  H01M10/058 ,  C08B11/193 ,  C08B13/00 ,  C08B15/06 ,  C09J101/02 ,  C08L1/02 ,  C08L1/10 ,  C08L1/26 ,  C08L1/32 ,  H01M10/04

摘要： An all-solid-state secondary battery includes a positive electrode active substance layer; a negative electrode active substance layer; and an inorganic solid electrolyte layer, in which at least one of the positive electrode active substance layer, the negative electrode active substance layer, or the inorganic solid electrolyte layer contains an inorganic solid electrolyte having conductivity of ions of metal belonging to Group 1 or 2 of the periodic table and a cellulose polymer.

公开(公告)号：US20180273646A1

公开(公告)日：2018-09-27

申请号：US15761926

申请日：2016-09-21

申请人： Dow Global Technologies LLC.

发明人： Robert B. Appeil

IPC分类号： C08B13/00

CPC分类号： C08B13/00

摘要： A process for preparing an esterified cellulose ether comprises the step of esterifying a cellulose ether with (i) an aliphatic monocarboxylic acid anhydride or (ii) a dicarboxylic acid anhydride or (iii) a combination of an aliphatic monocarboxylic acid anhydride and a dicarboxylic acid anhydride in the presence of acetic acid. The esterification reaction is conducted in the presence of an alkali metal diacetate as a reaction catalyst.

公开(公告)号：US09890220B2

公开(公告)日：2018-02-13

申请号：US14766609

申请日：2014-02-28

申请人： Dow Global Technologies LLC

发明人： Oliver Petermann ,  Meinolf Brackhagen ,  Matthias Sprehe

IPC分类号： C08B13/00 ,  C08B11/20 ,  C08L1/32 ,  A61K9/48 ,  A61K9/14 ,  A61K9/28

CPC分类号： C08B13/00 ,  A61K9/146 ,  A61K9/2866 ,  A61K9/4816 ,  C08B11/20 ,  C08L1/32

摘要： Esterified cellulose ethers which comprise (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, which have a viscosity of up 50 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C., and a weight average molecular weight Mw of at least 220,000 Dalton, or which have a viscosity of up 100 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C., and a weight average molecular weight Mw of at least 310,000 Dalton are useful for preparing solid dispersions comprising drugs.

公开(公告)号：US09790351B2

公开(公告)日：2017-10-17

申请号：US13046762

申请日：2011-03-13

申请人： Lajos Szente

发明人： Lajos Szente

IPC分类号： C08B3/00 ,  C08B5/00 ,  C08B7/00 ,  C08B13/00 ,  C08B9/00 ,  C08B31/00 ,  C08B33/00 ,  C08B30/18 ,  C08B37/16 ,  C08B35/00 ,  C08L5/16 ,  A23L29/30 ,  A23L27/00 ,  A23L33/10 ,  A23L33/20

CPC分类号： C08L5/16 ,  A23L27/75 ,  A23L29/35 ,  A23L33/10 ,  A23L33/20 ,  A23V2002/00 ,  C08B37/0015 ,  A23V2250/5114 ,  A23V2200/332 ,  A23V2250/0612 ,  A23V2250/0644 ,  A23V2250/306

摘要： A fat-binding composition contains an inclusion complex with a host molecule and a guest molecule. The guest molecule includes one or more amino acids, vitamins, flavorants or related compounds, rutin, betanin, derivatives thereof, and mixtures thereof. The fat-binding composition may be in the form of a tablet or powder, for example, and may be incorporated into a food or beverage product. If in the form of a powder or tablet, the composition may optionally contain a carbonation-forming component and may be dissolved in carbonated or non-carbonated water. The fat-binding composition may also be employed in a method for binding fat ingested by an animal which includes having the animal ingest the composition, or a food or beverage product containing the same.

公开(公告)号：US09708415B2

公开(公告)日：2017-07-18

申请号：US13497171

申请日：2010-09-21

申请人： Kevin J. Edgar ,  Nilanjana Kar

发明人： Kevin J. Edgar ,  Nilanjana Kar

IPC分类号： C08B3/16 ,  C08B3/12 ,  C08B13/00 ,  C08B15/00

CPC分类号： C08B3/16 ,  C08B3/12 ,  C08B13/00 ,  C08B15/005

摘要： The present invention relates to esters of diacids and cellulosic materials and methods for making thereof. The ester has the chemical composition of Formula (I) Formula I where R1, R2, and R3 can be the same or different, and each of which is selected from —H, —COR′, —R′″, or —COR″ COOH, with the proviso that at least one of the R1, R2, or R3 is —COR″ COOH; R′ is an alkyl, alkenyl, alkynyl, or aromatic group; R″ is an alkyl, alkenyl, or alkynyl group having 4 or more carbon atoms (≧C4); and R′″ is an alkyl, alkenyl, alkynyl, polyol, or aromatic group.

公开(公告)号：US20160347866A1

公开(公告)日：2016-12-01

申请号：US15113921

申请日：2015-01-27

申请人： DOW GLOBAL TECHNOLOGIES LLC

发明人： Oliver Petermann ,  Matthias Sprehe ,  Meinolf Brackhagen

IPC分类号： C08B13/00 ,  A61K9/10 ,  A61K9/48 ,  A61K47/38

CPC分类号： C08B13/00 ,  A61K9/10 ,  A61K9/146 ,  A61K9/2866 ,  A61K9/4816 ,  A61K47/38 ,  C08B11/20

摘要： Esterified cellulose ethers which have i) as ester groups aliphatic monovalent acyl groups or a combination of aliphatic monovalent acyl groups and groups of the formula ——C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, ii) a weight average molecular weight Mw of from 80,000 Dalton to 220,000 Dalton, iii) a Polydispersity Mw/Mn of from 1.3 to 4.0, and iv) an Mz/Mn of not more than 18.5, when the weight average molecular weight Mw, the number average molecular weight Mn and the z-average molecular weight Mz are measured by SEC-MALLS using as mobile phase a mixture produced from 40 parts by volume of acetonitrile and 60 parts by volume of aqueous buffer containing 50 mM NaH2—PO4 and 0.1 M NaNO3. are useful as enteric polymers for pharmaceutical dosage forms.

摘要翻译： 酯化纤维素醚，其具有i）酯基脂族一价酰基或脂族一价酰基的组合和式-C（O）-R-COOA的基团，其中R是二价脂族或芳族烃基，A是 氢或阳离子，ii）重均分子量Mw为80,000道尔顿至220,000道尔顿，iii）多分散性Mw / Mn为1.3至4.0，以及iv）Mz / Mn不大于18.5，当重量 平均分子量Mw，数均分子量Mn和z平均分子量Mz通过SEC-MALLS使用由40体积份乙腈和60体积份含有50mM NaH2-PO4和0.1M NaNO3。 可用作药物剂型的肠溶性聚合物。

公开(公告)号：US20150202301A1

公开(公告)日：2015-07-23

申请号：US14421064

申请日：2013-08-15

申请人： Dow Global Technologies LLC

发明人： Oliver Petermann ,  Matthias Sprehe ,  Meinolf Brackhagen ,  Steven J. Guillaudeu

IPC分类号： A61K47/38 ,  C08B13/00 ,  A61K9/10

CPC分类号： A61K47/38 ,  A61K9/10 ,  C08B11/20 ,  C08B13/00

摘要： Esterified cellulose ethers which have i) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, ii) a weight average molecular weight Mw of from 80,000 Dalton to 350,000 Dalton, iii) a Polydispersity Mw/Mn of from 1.3 to 4.1, and iv) a viscosity of up to 4.0 mPa s, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C., are useful as enteric polymers for pharmaceutical dosage forms.

摘要翻译： 酯化纤维素醚，其具有i）脂族一价酰基和式-C（O）-R-COOA基团的组合，其中R是二价脂族或芳族烃基，A是氢或阳离子，ii）重量 平均分子量Mw为80,000道尔顿至350,000道尔顿，iii）多分散性Mw / Mn为1.3至4.1，以及iv）粘度高达4.0mPa·s，以2.0wt％的酯化纤维素醚溶液 在20℃下0.43重量％的NaOH水溶液可用作药物剂型的肠溶性聚合物。

公开(公告)号：US20150065547A1

公开(公告)日：2015-03-05

申请号：US14390041

申请日：2012-10-24

申请人： Dow Global Technologies LLC

发明人： Robert L. Schmitt ,  Robert L. Sammler ,  Meinolf Brackhagen ,  Oliver Petermann ,  Roland Adden ,  Nicholas S. Grasman ,  Steven J. Guillaudeu

IPC分类号： A61K47/38 ,  A61K47/10 ,  A61K9/48 ,  A61K31/4166 ,  A61K9/14 ,  C08B13/00 ,  A61K31/343

CPC分类号： A61K47/38 ,  A61K9/08 ,  A61K9/145 ,  A61K9/146 ,  A61K9/4816 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/343 ,  A61K31/4166 ,  A61K47/10 ,  C08B11/193 ,  C08B13/00

摘要： An esterified cellulose ether comprises (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein the cellulose ether has anhydroglucose units joined by 1-4 linkages and has methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl as substituents such that the esterified cellulose ether has an MS (hydroxyalkyl) of 0.05 to 1.00, and hydroxyl groups of anhydroglucose units are substituted with methyl groups such that [s23/s26−0.2*MS(hydroxyalkyl)] is 0.36 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group. The esterified cellulose ether is useful as an excipient for poorly water-soluble drugs.

摘要翻译： 酯化的纤维素醚包括（i）脂族一价酰基或（ii）式-C（O）-R-COOA的基团，其中R是二价脂族或芳族烃基，A是氢或阳离子或（iii） 脂族一价酰基和式-C（O）-R-COOA基团的组合，其中纤维素醚具有通过1-4键连接并具有甲基，羟基烷基和任选的烷基的脱水葡萄糖单元， 甲基作为取代基使得酯化纤维素醚具有0.05至1.00的MS（羟烷基），脱水葡萄糖单元的羟基被甲基取代，使得[s23 / s26-0.2 * MS（羟烷基）]为0.36以下， 其中s23是脱水葡萄糖单元的摩尔分数，其中只有脱水葡萄糖单元的2-和3-位上的两个羟基被甲基取代，其中s26是脱水葡萄糖单元的摩尔分数，其中仅th 脱水葡萄糖单元的2-和6-位上的两个羟基被甲基取代。 酯化纤维素醚可用作水溶性差的药物的赋形剂。

公开(公告)号：US20150031873A1

公开(公告)日：2015-01-29

申请号：US14384220

申请日：2013-03-12

申请人： Dow Global Technologies LLC

发明人： Matthias Sprehe ,  Oliver Petermann ,  Robert Bruce Appell

IPC分类号： C08B13/00

CPC分类号： C08B13/00 ,  C08B11/20

摘要： A reaction product mixture is obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid anhydride or with a di- or tricarboxylic acid anhydride or with a combination of an aliphatic mono-carboxylic acid anhydride and a di- or tri-carboxylic acid anhydride in the presence of (c) an aliphatic carboxylic acid. A process for precipitating an esterified cellulose ether from this reaction product mixture comprises the step of contacting the reaction product mixture with water and subjecting the combination of water and the reaction product mixture to a shear rate of at least 800 s−1. The precipitated esterified cellulose ether can be recovered as a non-tacky product.

摘要翻译： 反应产物混合物由（a）纤维素醚与（b）脂肪族单羧酸酐或二 - 或三羧酸酐的反应或与脂肪族单羧酸酐和二 - 或三羧酸酐在（c）脂族羧酸存在下反应。 从该反应产物混合物中沉淀酯化纤维素醚的方法包括使反应产物混合物与水接触并使水和反应产物混合物的组合经受至少800s -1的剪切速率的步骤。 沉淀的酯化纤维素醚可以作为非粘性产物回收。