公开(公告)号：US10518001B2

公开(公告)日：2019-12-31

申请号：US15352111

申请日：2016-11-15

申请人： Boston Scientific SciMed, Inc.

发明人： Jacob Drew Edick

IPC分类号： C22F1/06 ,  A61L31/02 ,  A61L31/14 ,  C22C23/06 ,  A61F2/86 ,  C22C23/02 ,  C22C23/04

摘要： A bioerodible endoprosthesis includes a bioerodible magnesium alloy including between 50 weight percent and 92 weight percent magnesium, at least 5.5 weight percent in sum of one or more elements selected from the group consisting of Ho, Er, Lu, Tb and Tm, and at least 2.0 weight percent in sum of one or more elements selected from the group consisting of Y, Nd and Gd. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 15 microns and second-phase precipitates and/or ceramic nanoparticles in grain boundaries between the equiaxed Mg-rich solid solution-phase grains. The secondary-phase precipitates or ceramic nanoparticles have an average longest dimension of 2.0 micron or less. The microstructure can be produced by one or more equal-channel high-strain processes.

公开(公告)号：US20190194782A1

公开(公告)日：2019-06-27

申请号：US16277173

申请日：2019-02-15

申请人： University of Florida Research Foundation, Inc.

发明人： Michele Manuel ,  Josephine Allen ,  Jordan P. Ball ,  Harpreet Singh Brar ,  Ida Svensson BERGLUND

IPC分类号： C22C23/00 ,  C22F1/06 ,  A61L27/58 ,  C22C1/04 ,  C22C23/06 ,  A61L27/30 ,  A61L27/04

CPC分类号： C22C23/00 ,  A61L27/047 ,  A61L27/306 ,  A61L27/58 ,  A61L2400/18 ,  A61L2420/02 ,  C22C1/0408 ,  C22C23/06 ,  C22F1/06

摘要： Disclosed herein is an article comprising a metal alloy; where the metal alloy comprises a base metal, a second element and a third element; where the base metal is magnesium, calcium, strontium, zinc, or a combination thereof; where the second element is chemically different from the third element; and where the second element and the third element are scandium, yttrium, gadolium, cerium, neodymium, dysporium, or a combination thereof; and a protective layer disposed upon the metal alloy and is reactively bonded to the metal alloy; where the protective layer comprises a base non-metallic derivative, a second non-metallic derivative and a third non-metallic derivative of metals present in the metal alloy; and where the base non-metallic derivative, the second non-metallic derivative and the third non-metallic derivative are all chemically different from one another.

公开(公告)号：US10077492B2

公开(公告)日：2018-09-18

申请号：US14624372

申请日：2015-02-17

申请人： Jiangyin Biodegrade Medical Technology Co., Ltd

发明人： Li Li ,  Yufeng Zheng ,  Zhen Li ,  Qingfu Chen ,  Diantao Zhang ,  Jingtao Li

IPC分类号： C22F1/06 ,  C22C23/00 ,  C22C23/02 ,  C22C23/04 ,  C22C23/06

CPC分类号： C22F1/06 ,  C22C23/00 ,  C22C23/02 ,  C22C23/04 ,  C22C23/06

摘要： The present invention provides an ultrafine-grained profile of twin-crystal wrought magnesium alloys, preparation process and use of the same. In the process, raw materials of magnesium alloys are firstly smelted and cast, and are subjected to solution treatment at 300˜500° C.; then a preform is pre-deformed, so that a great amount of twin crystal microstructure forms in the magnesium alloys and the grain size of not larger than 100 μm is achieved; subsequently continuous ECAP process is performed at 200˜350° C., and the die is replaced in according to requirement so as to obtain the desired profile. The ultrafine-grained profile of magnesium alloys prepared in the invention has the grain sizes of from 100 to 450 nm, the tensile strength of 300˜400 MPa, and the elongation of 20˜35%. The length of the profile can be more than 10 m, meeting the needs of continuous production.

公开(公告)号：US20180161144A1

公开(公告)日：2018-06-14

申请号：US15880274

申请日：2018-01-25

申请人： BIOTRONIK AG

发明人： Ullrich Bayer ,  Bernd Block ,  Baerbel Becher ,  Daniel Lootz

IPC分类号： A61F2/04 ,  C22C28/00 ,  A61L31/02 ,  B21C23/00 ,  B21C23/32 ,  C23C10/22 ,  C10M103/04 ,  C22C23/06 ,  C22C23/00 ,  B21D21/00 ,  A61F2/82 ,  A61F2/02

CPC分类号： A61F2/04 ,  A61F2/02 ,  A61F2/82 ,  A61L31/022 ,  B21C23/002 ,  B21C23/32 ,  B21D21/00 ,  C10M103/04 ,  C10M2201/053 ,  C10N2210/03 ,  C10N2210/04 ,  C10N2230/06 ,  C10N2240/404 ,  C22C23/00 ,  C22C23/06 ,  C22C28/00 ,  C23C10/22

摘要： An implant, in particular an intraluminal endoprosthesis, or a semi-finished part for an implant, having a hollow cylindrical body, wherein the body includes magnesium, and the body is enriched with gallium or a gallium alloy in a region close to a surface.

公开(公告)号：US20180100219A1

公开(公告)日：2018-04-12

申请号：US15835538

申请日：2017-12-08

申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： PRASHANT N. KUMTA ,  DA-TREN CHOU ,  DAEHO HONG ,  PARTHA SAHA

IPC分类号： C22C23/06 ,  A61L31/14 ,  C22C1/02 ,  B22D21/00 ,  A61F2/02 ,  A61L27/04 ,  A61L31/02 ,  A61K31/7036 ,  C22C23/00 ,  C22C23/04 ,  A61L27/58 ,  A61K31/397 ,  C22C1/06

CPC分类号： C22C23/06 ,  A61F2/02 ,  A61K31/397 ,  A61K31/7036 ,  A61L27/047 ,  A61L27/58 ,  A61L31/022 ,  A61L31/148 ,  B22D21/007 ,  C22C1/02 ,  C22C1/06 ,  C22C23/00 ,  C22C23/04

摘要： The invention relates to biodegradable, metal alloy-containing compositions, methods for their preparation and applications for their use. The compositions include magnesium and other components, such as yttrium, calcium, silver, cerium, and zirconium; or zinc, silver, cerium, and zirconium; or aluminum, zinc, calcium, manganese, silver, yttrium; or strontium, calcium, zinc. The compositions are prepared by vacuum induction/crucible melting together the components and casting the melted mixture in a preheated mild steel/copper mold. In certain embodiments, the compositions of the invention are particularly useful for forming medical devices for implantation into a body of a patient.

公开(公告)号：US09863020B2

公开(公告)日：2018-01-09

申请号：US15337444

申请日：2016-10-28

申请人： UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Prashant N. Kumta ,  Da-Tren Chou ,  Daeho Hong ,  Partha Saha

IPC分类号： A61F2/02 ,  C22C23/00 ,  C22C23/04 ,  C22C23/06 ,  C22C1/02 ,  C22C1/06 ,  A61L27/04 ,  A61L27/58 ,  A61K31/397 ,  A61K31/7036 ,  B22D21/00 ,  A61L31/02 ,  A61L31/14

CPC分类号： C22C23/06 ,  A61F2/02 ,  A61K31/397 ,  A61K31/7036 ,  A61L27/047 ,  A61L27/58 ,  A61L31/022 ,  A61L31/148 ,  B22D21/007 ,  C22C1/02 ,  C22C1/06 ,  C22C23/00 ,  C22C23/04

摘要： The invention relates to biodegradable, metal alloy-containing compositions, methods for their preparation and applications for their use. The compositions include magnesium and other components, such as yttrium, calcium, silver, cerium, and zirconium; or zinc, silver, cerium, and zirconium; or aluminum, zinc, calcium, manganese, silver, yttrium; or strontium, calcium, zinc. The compositions are prepared by vacuum induction/crucible melting together the components and casting the melted mixture in a preheated mild steel/copper mold. In certain embodiments, the compositions of the invention are particularly useful for forming medical devices for implantation into a body of a patient.

公开(公告)号：US09775647B2

公开(公告)日：2017-10-03

申请号：US13700858

申请日：2011-06-15

申请人： Andreas Schiffl ,  Bernhard Mingler

发明人： Andreas Schiffl ,  Bernhard Mingler

IPC分类号： A61B17/72 ,  A61B17/68 ,  C22C23/04 ,  C22F1/06 ,  A61F2/00 ,  C22C23/02 ,  C22C23/06 ,  A61L31/02 ,  A61L31/14

CPC分类号： A61B17/68 ,  A61F2/00 ,  A61L31/022 ,  A61L31/148 ,  C22C23/02 ,  C22C23/04 ,  C22C23/06 ,  C22F1/06

摘要： The invention relates to a magnesium alloy containing (in % by weight) more than 0.0 to 7.0% zinc, optionally more than 0.0 to 1.0% zirconium, optionally more than 0.0 to 1.0% calcium, optionally more than 0.0 to 1.0% manganese, optionally more than 0.0 to 0.5% silicon, optionally more than 0.0 to 1.0% silver, a max. up to 0.5% aluminum and at least one element selected from the group comprising more than 0.05 to 0.6% yttrium, more than 0.05 to 4.0% ytterbium, more than 0.05 to 4.0% gadolinium, with the residue being magnesium and impurities due to production. The invention also relates to a use of a magnesium alloy of this type and an implant therefrom and a method for producing a body of a magnesium alloy according to the invention.

公开(公告)号：US09522220B2

公开(公告)日：2016-12-20

申请号：US14527317

申请日：2014-10-29

申请人： Boston Scientific Scimed, Inc.

发明人： Jacob Drew Edick

IPC分类号： A61F2/06 ,  A61L31/02 ,  A61L31/14 ,  C22C23/06 ,  A61F2/86 ,  C22C23/02 ,  C22C23/04 ,  C22F1/06

CPC分类号： A61L31/022 ,  A61F2/86 ,  A61F2210/0004 ,  A61L31/026 ,  A61L31/148 ,  A61L2400/12 ,  C22C23/02 ,  C22C23/04 ,  C22C23/06 ,  C22F1/06 ,  Y10T428/12993

摘要： A bioerodible endoprosthesis includes a bioerodible magnesium alloy including between 50 weight percent and 92 weight percent magnesium, at least 5.5 weight percent in sum of one or more elements selected from the group consisting of Ho, Er, Lu, Tb and Tm, and at least 2.0 weight percent in sum of one or more elements selected from the group consisting of Y, Nd and Gd. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 15 microns and second-phase precipitates and/or ceramic nanoparticles in grain boundaries between the equiaxed Mg-rich solid solution-phase grains. The secondary-phase precipitates or ceramic nanoparticles have an average longest dimension of 2.0 micron or less. The microstructure can be produced by one or more equal-channel high-strain processes.

摘要翻译： 生物腐蚀性内用假体包括生物腐蚀性镁合金，其包含50重量％至92重量％的镁，至少5.5重量％以上的一种或多种选自Ho，Er，Lu，Tb和Tm的元素，并且至少 2.0重量％以上的一种或多种选自Y，Nd和Gd的元素。 生物腐蚀性镁合金具有包括平均晶粒直径小于或等于15微米的等轴Mg富集固相晶粒的微结构，并且等轴富镁固体之间的晶界中的第二相析出物和/或陶瓷纳米颗粒 溶液相晶粒。 二次相析出物或陶瓷纳米颗粒的平均最长尺寸为2.0微米或更小。 微结构可通过一个或多个等通道高应变过程产生。

公开(公告)号：US20160168666A1

公开(公告)日：2016-06-16

申请号：US14784095

申请日：2014-04-14

申请人： NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY

发明人： Yoshihito KAWAMURA ,  Jonghyun KIM

IPC分类号： C22C23/06 ,  B22D21/04 ,  B22D21/00 ,  C22C1/02

CPC分类号： C22C23/06 ,  B22D21/007 ,  B22D21/04 ,  B22D27/04 ,  C22C1/02 ,  C22C23/04

摘要： A method of manufacturing a flame-retardant magnesium alloy having mechanical properties of a long period stacking ordered magnesium alloy and having an ignition temperature of 800° C. or more is provided. In the method of manufacturing a flame-retardant magnesium alloy, a flame-retardant magnesium alloy which contains a atomic % of Zn, b atomic % of at least one element selected from a group consisting of Gd, Tb, Tm and Lu, and x atomic % of Ca and in which a remaining part is formed of Mg and a, b and x satisfy Formulae 1 to 4 below is melted. 0.2≦a≦5.0  (Formula 1) 0.5≦b≦5.0  (Formula 2) 0.5a−0.5≦b  (Formula 3) 0

摘要翻译： 提供了具有长周期堆积有序镁合金的机械性能并且具有800℃以上的点火温度的阻燃镁合金的制造方法。 在制造阻燃镁合金的方法中，含有原子％的Zn，b原子％的选自Gd，Tb，Tm和Lu中的至少一种元素的阻燃镁合金和x Ca的原子％，其余部分由Mg形成，a，b和x满足下述式1〜4。 （式3）0.5（n = 1）0.5＆nlE; b＆nlE; 5.0（式2）0.5a-0.5＆

公开(公告)号：US20150064054A1

公开(公告)日：2015-03-05

申请号：US14535826

申请日：2014-11-07

申请人： BIOTRONIK VI Patent AG

发明人： Bodo Gerold

IPC分类号： A61L31/02 ,  C22C23/06 ,  A61L31/14

CPC分类号： A61L31/022 ,  A61L31/148 ,  C22C23/06 ,  C22F1/06

摘要： An implant made in total or in parts of a biodegradable magnesium alloy consisting of Y: 2.0-6.0% by weight, Nd: 1.5-4.5% by weight, Gd: 0-4.0% by weight, Dy: 0-4.0% by weight, Er: 0-4.0% by weight, Zr: 0.1-1.0% by weight, Li: 0-0.2% by weight, Al: 0-0.3% by weight, under the condition that a) a total content of Er, Gd and Dy is in the range of 0.5-4.0% by weight and b) a total content of Nd, Er, Gd and Dy is in the range of 2.0-5.5% by weight, the balance being magnesium and incidental impurities up to a total of 0.3% by weight.

摘要翻译： 由Y：2.0-6.0重量％，Nd：1.5-4.5重量％，Gd：0-4.0重量％，Dy：0-4.0重量％组成的可生物降解镁合金的全部或部分制造的植入物 ，Er：0-4.0重量％，Zr：0.1-1.0重量％，Li：0-0.2重量％，Al：0-0.3重量％，条件是：a）Er，Gd的总含量 Dy为0.5-4.0重量％，b）Nd，Er，Gd和Dy的总含量在2.0-5.5重量％的范围内，其余为镁和附带杂质直到总量 为0.3重量％。