公开(公告)号：US20140350100A1

公开(公告)日：2014-11-27

申请号：US14287833

申请日：2014-05-27

Applicant: Chi-Ming Liang ,  Academia Sinica

Inventor： Klim King ,  Rong-Jie Chein

IPC: C07C69/96 ,  C07C69/757 ,  C07C69/007 ,  C07C49/757 ,  C07C62/32 ,  C07C47/36 ,  C07C35/37

CPC classification number: C07C69/96 ,  C07C22/02 ,  C07C29/15 ,  C07C33/16 ,  C07C33/44 ,  C07C35/37 ,  C07C45/00 ,  C07C45/41 ,  C07C47/36 ,  C07C47/46 ,  C07C49/757 ,  C07C62/32 ,  C07C67/30 ,  C07C69/007 ,  C07C69/24 ,  C07C69/33 ,  C07C69/587 ,  C07C69/757 ,  C07C211/31 ,  C07C215/42 ,  C07C225/14 ,  C07C253/00 ,  C07C253/30 ,  C07C259/06 ,  C07C271/24 ,  C07C275/28 ,  C07C321/20 ,  C07C323/15 ,  C07C323/22 ,  C07C323/28 ,  C07C327/06 ,  C07C327/16 ,  C07C2603/30 ,  C07D303/46 ,  C07F9/117

Abstract: The present disclosure provides novel glucagon-like peptide-1 (GLP-1) receptor modulators such as compounds of Formula (I) or (II), and pharmaceutically acceptable salts thereof. The present disclosure also provides pharmaceutical compositions, kits, and uses that involve the GLP-1 receptor modulators for regulating blood glucose levels and/or treating diabetes via, e.g., modulating the endogenous signaling pathways mediated by the GLP-1 receptor.

Abstract translation: 本公开提供了新型胰高血糖素样肽-1（GLP-1）受体调节剂，例如式（I）或（II）的化合物及其药学上可接受的盐。 本公开还提供了涉及用于调节血糖水平和/或通过例如调节由GLP-1受体介导的内源性信号传导途径治疗糖尿病的GLP-1受体调节剂的药物组合物，试剂盒和用途。

公开(公告)号：US20140206645A1

公开(公告)日：2014-07-24

申请号：US14160515

申请日：2014-01-21

Applicant: National Taiwan University ,  Academia Sinica

Inventor： Jung-Hsin LIN ,  Ching-Chow CHEN ,  Jim-Min FANG ,  Jhih-Bin CHEN ,  Ting-Rong CHERN ,  Tzu-Tang WEI

IPC: C07D405/12 ,  C07D309/30 ,  C07F7/08

CPC classification number: C07D405/12 ,  C07D309/30 ,  C07F7/1804

Abstract: Disclosed herein are novel compounds of formula (I), and uses thereof. The compounds of Formula (I) are inhibitors of histone deacetylases (HDACs) and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR). Also provided are methods of using the compounds of Formula (I) for inhibiting the activity of HDACs and HMGR, treating diseases associated with HDACs or HMGR (e.g., cancer, hypercholesterolemia, an acute or chronic inflammatory disease, autoimmune disease, allergic disease, pathogen infection, neurodegenerative disease, or a disease associated with oxidative stress,

Abstract translation: 本文公开了新的式（I）化合物及其用途。 式（I）的化合物是组蛋白脱乙酰酶（HDAC）和3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶（HMGR）的抑制剂。 还提供了使用式（I）化合物抑制HDAC和HMGR活性的方法，治疗与HDAC或HMGR相关的疾病（例如，癌症，高胆固醇血症，急性或慢性炎性疾病，自身免疫性疾病，过敏性疾病，病原体 感染，神经变性疾病或与氧化应激相关的疾病，

公开(公告)号：US08785402B2

公开(公告)日：2014-07-22

申请号：US12806084

申请日：2010-08-02

Applicant: Chun-Hung Lin ,  Ta-Wei Liu

Inventor： Chun-Hung Lin ,  Ta-Wei Liu

IPC: A01N43/04 ,  A61K31/70 ,  A01N43/40 ,  A61K31/445 ,  C07D211/00 ,  C12N9/99

CPC classification number: G01N33/56922 ,  A61K31/4412 ,  C12Q1/34 ,  G01N2333/924

Abstract: Methods of diagnosing Helicobacter pylori infection or associated conditions are based in part on the correlation of the presence of a α-L-fucosidase 2 marker with the infection. Methods and compositions for treating or preventing Helicobacter pylori infection or associated conditions are based in part on administering an α-L-fucosidase 2 inhibitor to an infected subject or a subject at risk of developing the infection.

Abstract translation: 诊断幽门螺杆菌感染或相关病症的方法部分基于α-L-岩藻糖苷酶2标记物与感染的相关性。 用于治疗或预防幽门螺杆菌感染或相关病症的方法和组合物部分地基于向被感染的受试者或患有发展感染风险的受试者施用α-L-岩藻糖苷酶2抑制剂。

公开(公告)号：US20140166880A1

公开(公告)日：2014-06-19

申请号：US14107162

申请日：2013-12-16

Applicant: ACADEMIA SINICA

Inventor： YUNN-SHIN SHIUE ,  PAI-CHIA KUO ,  CHIH-TING CHEN ,  YUH-LIN WANG ,  YONG-FEN HSIEH

IPC: H01J37/26

CPC classification number: H01J37/26 ,  H01J37/295 ,  H01J2237/2614 ,  Y10S977/881

Abstract: The present invention provides an on-chip thin film phase plate for a releasing charging, comprising a chip substrate having one or more apertures; and a thin film layer attached to the top surface of the chip substrate. The present invention also provides a method for observing organic material by TEM, which uses the above-mentioned on-chip thin film phase plate in a TEM system.

Abstract translation: 本发明提供了一种用于释放充电的片上薄膜相位板，包括具有一个或多个孔的芯片基板; 以及附着到芯片基板的顶表面的薄膜层。 本发明还提供了一种通过TEM观察有机材料的方法，其在TEM系统中使用上述片上薄膜相位板。

公开(公告)号：US08741311B2

公开(公告)日：2014-06-03

申请号：US12748265

申请日：2010-03-26

Applicant: Chi-Huey Wong ,  Che Ma ,  Cheng-Chi Wang ,  Juine-Ruey Chen

Inventor： Chi-Huey Wong ,  Che Ma ,  Cheng-Chi Wang ,  Juine-Ruey Chen

IPC: A61K39/145

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/55505 ,  C07K16/1018 ,  C07K2317/76 ,  C12N7/00 ,  C12N2740/11034 ,  C12N2740/16034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16171 ,  C12N2770/24134 ,  Y02A50/386

Abstract: Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

Abstract translation: 提供了包含部分糖基化的病毒糖蛋白的免疫原性组合物，其用作抗病毒疫苗。 使用单糖，二糖或三糖基化的病毒表面糖蛋白和多肽配制的疫苗甚至可以跨毒株提供有效和广泛的防病毒保护。 公开了包含单糖基化血凝素多肽和由其产生的疫苗的药物组合物及其用于预防或治疗病毒感染的方法。 公开了用于流感病毒HA，NA和M2，RSV蛋白F，G和SH，登革病毒糖蛋白M或E，丙型肝炎病毒糖蛋白E1或E2和HIV糖蛋白gp120和gp41的方法和组合物。

公开(公告)号：US08728787B2

公开(公告)日：2014-05-20

申请号：US13923816

申请日：2013-06-21

Applicant: Academia Sinica

Inventor： Lie-Fen Shyur

IPC: C12N9/02 ,  C12Q1/26 ,  C07K14/00 ,  C12P21/00

CPC classification number: C12N9/0061 ,  C12Y110/03002

Abstract: Novel laccases from Cerrena sp. WR1 and Lentinus sp. and uses thereof.

Abstract translation: Cerrena sp。的新型漆酶 WR1和香菇属 及其用途。

公开(公告)号：US20140124740A1

公开(公告)日：2014-05-08

申请号：US13668334

申请日：2012-11-05

Applicant: ACADEMIA SINICA

Inventor： Ta-Hsin Chow ,  Motonori Watanabe

IPC: C07C49/617 ,  H01L51/30 ,  H01L51/40 ,  C07C1/22 ,  C07C49/665

CPC classification number: H01L51/0026 ,  C07C1/2076 ,  C07C2603/54 ,  H01L51/0056 ,  H01L51/0558 ,  C07C15/20

Abstract: A hexacene derivative is described, being expressed by formula (1): wherein X1-X6 denote the presence or absence of a carbonyl bridge [—C(═O)—], with a proviso that at least one of X1-X6 is a carbonyl bridge while any six-member ring absent of a carbonyl bridge is aromatic. A method for forming hexacene is also described, including: thermally treating the hexacene derivative to expel volatile units of CO from the hexacene derivative.

Abstract translation: 描述了通过式（1）表示的并六苯衍生物：其中X1-X6表示羰基桥[-C（= O） - ]的存在或不存在，条件是X 1 -X 6中的至少一个为 羰基桥，而没有羰基桥的任何六元环是芳香族的。 还描述了形成并六苯的方法，包括：热处理并六苯衍生物以从己烯衍生物中排出CO的挥发性单元。

公开(公告)号：US08703474B2

公开(公告)日：2014-04-22

申请号：US13210637

申请日：2011-08-16

Applicant: Jui-Jen Chang ,  Cheng-Yu Ho ,  Chieh-Chen Huang ,  Ming-Che Shih ,  Wen-Hsiung Li

Inventor： Jui-Jen Chang ,  Cheng-Yu Ho ,  Chieh-Chen Huang ,  Ming-Che Shih ,  Wen-Hsiung Li

IPC: C12N1/16 ,  A61K38/00

CPC classification number: C12R1/645 ,  C12P7/22 ,  C12P7/62 ,  C12P7/6436

Abstract: Disclosed are a novel flavor compound-producing yeast strain and methods of using the strain to produce flavor compounds.

Abstract translation: 公开了一种新颖的产生风味化合物的酵母菌株和使用该菌株产生风味化合物的方法。

公开(公告)号：US20140099667A1

公开(公告)日：2014-04-10

申请号：US14041493

申请日：2013-09-30

Applicant: Academia Sinica

Inventor： Andrew H.-J. WANG ,  Min-Feng` Hsu ,  Chii-Shen Yang ,  Hsu-Yuang Fu

IPC: C07K14/215

CPC classification number: C07K14/215 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/50

Abstract: An expression vector is disclosed, which comprises: a) a polynucleotide sequence encoding a bacteriorhodopsin or a mutant bacteriorhodopsin; b) a multiple cloning site; c) a T7 promoter, d) a polyhistidine tag; e) a first protease cleavage site; f) optionally a second protease cleavage site; and g) optionally a linker; wherein the mutant bacteriorhodopsin comprises the residue corresponding to Asn94 of SEQ ID NO: 1. Also disclosed is a fusion membrane protein expression system, which comprises: a) a polynucleotide sequence encoding a mutant Haloarcula marismortui bacteriorhodopsin/D94N (HmBRI/D94N) or a Haloquadratum walsbyi bacteriorhodopsin (HwBR); b) a target membrane protein; and c) a T7 promoter, operably linked to the mutant HmBRI/D94N or HwBR and the target membrane protein. Host cells comprising the expression vector or the fusion membrane protein expression system and methods of using the same are also disclosed.

Abstract translation: 公开了一种表达载体，其包括：a）编码细菌视紫红质或突变型细菌视紫红质的多核苷酸序列; b）多克隆位点; c）T7启动子，d）多组氨酸标签; e）第一个蛋白酶切割位点; f）任选的第二蛋白酶切割位点; 和g）任选的接头; 其中所述突变型细菌视紫红质包含对应于SEQ ID NO：1的Asn94的残基。还公开了融合膜蛋白表达系统，其包含：a）编码突变型Haloarcula marismortui细菌视紫红质/ D94N（HmBRI / D94N）或 Haloquadratum walsbyi细菌视紫红质（HwBR）; b）靶膜蛋白; 和c）与突变体HmBRI / D94N或HwBR和靶膜蛋白可操作地连接的T7启动子。 还公开了包含表达载体或融合膜蛋白表达系统的宿主细胞及其使用方法。

公开(公告)号：US08680020B2

公开(公告)日：2014-03-25

申请号：US12503797

申请日：2009-07-15

Applicant: Chi-Huey Wong ,  Chung-Yi Wu ,  Susan Y. Tseng

Inventor： Chi-Huey Wong ,  Chung-Yi Wu ,  Susan Y. Tseng

IPC: C40B40/12 ,  C40B20/04

CPC classification number: G01N33/553 ,  C40B40/12 ,  C40B50/14 ,  G01N33/582 ,  G01N2333/942 ,  G01N2400/10 ,  H01J49/40

Abstract: Aluminum coated glass slides provide a novel glycan array platform. Specifically, aluminum coated glass slides increase sensitivity of fluorescent based assay methods. Additionally, aluminum coated glass slides allows for mass spectroscopic analysis of carbohydrates and provide a platform for examining activity of cellulases. The unique properties of ACG slides include: 1) the metal oxide layer on the surface can be activated for grafting organic compounds such as modified oligosaccharides; 2) the surface remains electrically conductive, and the grafted oligosaccharides can be simultaneously characterized by mass spectrometry and carbohydrate-binding assay; and 3) the slides are more sensitive than transparent glass slides in binding analysis.

Abstract translation: 镀铝玻璃片提供了一种新的聚糖阵列平台。 具体来说，铝涂层玻璃片增加了基于荧光的测定方法的灵敏度。 另外，铝涂层玻璃载玻片允许碳水化合物的质谱分析，并提供一个检查纤维素酶活性的平台。 ACG载玻片的独特性质包括：1）表面上的金属氧化物层可以活化，用于接枝有机化合物如改性寡糖; 2）表面保持导电，并且接枝的寡糖可以通过质谱法和碳水化合物结合测定同时表征; 和3）在结合分析中，载玻片比透明玻片更敏感。