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公开(公告)号：US20220235262A1
公开(公告)日：2022-07-28
申请号：US17603653
申请日：2020-04-14
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Rafal KLAJN , Zonglin CHU
Abstract: This invention relates to materials and to films comprising molecular photoswitches. The films exhibit excellent photoswitchable properties in the dry state. This invention is also related to processes of making the materials and the films and to uses of the films. The invention also relates to devices and systems comprising the films of this invention.
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公开(公告)号：US20220155305A1
公开(公告)日：2022-05-19
申请号：US17586870
申请日：2022-01-28
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Yifat MERBL , Aaron JAVITT , Assaf KACEN , Avital EISENBERG-LERNER , Merav SHMUELI
IPC: G01N33/574 , A61K39/395
Abstract: A method of treating lung cancer is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent that downregulates an amount or activity of a polypeptide selected from the group consisting of CASC5, MYOF, CTNS, FCGR2B, PCDHGC5, POMGNT2, ACSL1, CTAGE5, TECPR2, WDR48, MCPH1, PPP2R3C, ADRB1, JAG2, GEMIN7, PTPRB, PRMT9, PSME4, Ube2L3, TP53RK and PSME3.
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公开(公告)号：US11273178B2
公开(公告)日：2022-03-15
申请号：US16055241
申请日：2018-08-06
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Rachel Lea Eisenbach , Yosi Gozlan , Esther Tzehoval
IPC: A61K35/17 , C07K14/725 , C12N15/10 , C12N15/63 , C12N15/85 , C12N5/0783 , C12N5/10 , C07K14/705
Abstract: The present invention relates to methods and systems for increasing the affinity of a T cell receptor (TCR) to its ligand by subjecting the TCR gene to somatic hypermutation. The present invention further relates to use of affinity maturated TCRs to create T cells reactive against a selected antigen.
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654.发明申请公开(公告)号：US20220024758A1
公开(公告)日：2022-01-27
申请号：US17427929
申请日：2020-02-06
Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
Inventor： David MILSTEIN , Yinjun XIE
IPC: C01B3/00
Abstract: The present invention provides a system, a process and a method of storing hydrogen (H2) and releasing it on demand, comprising and making use of N-heterocycles as liquid organic hydrogen carriers (LOHCs).
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655.发明授权公开(公告)号：US11230578B2
公开(公告)日：2022-01-25
申请号：US16074086
申请日：2017-02-03
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Varda Rotter , Moshe Oren , Perry Tal , Shay Eizenberger , Avi Ben-Shimon
Abstract: An isolated peptide is provided. The peptide comprises an amino acid sequence arranged in a space and configuration that allow interaction of the peptide with the DNA Binding Domain (DBD) of p53 through at least one residue of the DBD by which pCAP 250 (SEQ ID NO: 1) binds the DBD, wherein the peptide at least partially reactivates a mutant p53 protein, with the proviso that the peptide is not SEQ ID NO: 59-382.
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Patent Agency Ranking
公开(公告)号：US20210403854A1
公开(公告)日：2021-12-30
申请号：US17474208
申请日：2021-09-14
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Ilan KOREN , Assaf VARDI , Yinon RUDICH , Adi VOLPERT , Joseph BOLLESS
Abstract: A method for monitoring species of algae for stress comprises growing a test set of algae of a given species, applying a stress of a predetermined kind to some of the algae, and irradiating the algae at a predetermined first set of wavelengths. The algae are then monitored at a predetermined second set of wavelengths to detect fluorescence and/or absorbance carried out on the first set of wavelengths by the stressed algae. The detected fluorescence and/or absorbance is compared for each irradiation wavelength between the stressed algae and unstressed algae to find signs indicating the applied stress. There is then a stage of searching through combinations of respective irradiation wavelengths and detected wavelengths to find a minimal set of irradiating and detected wavelengths that detects the stress. The smallest size set is then used in irradiating further sets of algae of the tested species to detect the given stress.
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公开(公告)号：US20210403518A1
公开(公告)日：2021-12-30
申请号：US17478926
申请日：2021-09-19
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Ofer YIZHAR , Mathias MAHN
Abstract: Bistable type II opsins are provided. Accordingly, there is provided a polypeptide comprising a bistable type II opsin and a heterologous ER export signal and/or membrane trafficking signal. Also provided are polynucleotides encoding same, cells expressing same and methods of use thereof.
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公开(公告)号：US11179437B2
公开(公告)日：2021-11-23
申请号：US16899647
申请日：2020-06-12
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Michal Sharon , Maria Gabriella Fuzesi-Levi
IPC: A61K38/10 , C12N15/113
Abstract: A method of treating a condition associated with aberrant protein degradation is disclosed. The method comprises administering to a subject in need thereof a therapeutically effective amount of an agent, which reduces the amount of CSN Acidic Protein (CSNAP) which is incorporated into the COP9 signalosome complex (CSN) of the cell.
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公开(公告)号：US20210353611A1
公开(公告)日：2021-11-18
申请号：US17277441
申请日：2019-09-19
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Eran ELINAV , Eran SEGAL
IPC: A61K31/455 , A61K35/74 , A61P25/28
Abstract: A method of treating ALS in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount at least two metabolites.
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公开(公告)号：US20210330792A1
公开(公告)日：2021-10-28
申请号：US17370743
申请日：2021-07-08
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Avigdor SCHERZ , Yoram SALOMON , Arie MARCOVICH , Alexander BRANDIS , Daniel WAGNER
IPC: A61K41/00 , A61K31/407 , A61K31/555 , A61K9/00 , A61K31/519 , A61K47/36 , A61N5/06
Abstract: An ophthalmic composition is provided, comprising chlorophyll or bacteriochlorophyll compounds for photodynamic treatment (PDT) of diseases, disorders and conditions associated with corneal or scleral anomalies, such as corneal thinning and scleral stretching.
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