公开(公告)号：US6165515A

公开(公告)日：2000-12-26

申请号：US99334

申请日：1998-06-18

申请人： Toshikatsu Matsuyama ,  Jin-emon Konishi

发明人： Toshikatsu Matsuyama ,  Jin-emon Konishi

IPC分类号： A61K35/12 ,  A61K35/36 ,  A61P19/10 ,  A61P43/00 ,  A61K35/00 ,  A61K35/34

CPC分类号： A61K35/766 ,  A61K35/36 ,  A61K2300/00

摘要： A therapeutic agent for osteoporosis brought about by a decrease in estrogen comprises an extract from inflammatory rabbit skin inoculated with vaccinia virus as an effective component. In ovariectomized rats, a model animal for osteoporosis brought about by a decrease in estrogen, the extract from inflammatory rabbit skin inoculated with vaccinia virus has an excellent action for maintaining bone volume and bone strength. The therapeutic agent containing the extract as an active component is very useful for treatment and prevention of osteoporosis brought about by a decrease in estrogen which is frequently caused by menopause or ovariectomy in women. The extract from inflammatory rabbit skin inoculated with vaccinia virus has a high safety profile even when administered for a long term.

摘要翻译： 由雌激素降低引起的骨质疏松症治疗剂包括用痘苗病毒接种的炎性兔皮肤的提取物作为有效成分。 在卵巢切除的大鼠中，由雌激素降低引起的骨质疏松症模型动物，用痘苗病毒接种的炎性兔皮的提取物具有保持骨量和骨强度的优异作用。 含有提取物作为活性成分的治疗剂对于治疗和预防由雌激素减少引起的骨质疏松症是非常有用的，雌激素通常由妇女更年期或卵巢切除引起。 接种痘苗病毒的炎性兔皮的提取物即使长期施用，也具有高安全性。

公开(公告)号：US5891848A

公开(公告)日：1999-04-06

申请号：US637418

申请日：1996-04-25

申请人： Yutaka Oomura

发明人： Yutaka Oomura

IPC分类号： A61K38/00 ,  C07K14/50

CPC分类号： C07K14/501 ,  A61K38/00

摘要： Peptide fragments and their pharmaceutically acceptable salts, and therapeutic agents containing one or more of them as an effective component possess excellent therapeutic activity for improving cerebral function and protecting cerebral neurons and are useful as pharmaceutical agents. The peptide fragments of the present invention are amino acid residue peptide fragments of acid fibroblast growth factor (aFGF) of mammalian animals or humans which do not contain cysteine at the 16-position. The compounds include a 1-29 amino acid residue peptide fragment of acid fibroblast growth factor in which cysteine, an amino acid at the 16-position, is substituted with another amino acid, such as alanine, serine, or glutamic acid, and pharmaceutically acceptable salts thereof. The compounds also include a 1-15 amino acid residue fragment of acid fibroblast growth factor of mammalian animals or humans and pharmaceutically acceptable salts thereof. The protein fragments may have an N-terminal group which is in amide form or free form. In a passive avoidance learning test and in a maze-learning test in water, the peptides of the present invention exhibit an excellent action of improving the learning and the remembering ability of senility-accelerated mice in which remembering and learning abilities were reduced. The peptide fragments also exhibit a protective effect against the death of cerebral neurons caused by ischemia. As such, the compounds of the present invention show excellent improvement of brain functions and protection of cerebral neurons. The compounds are useful as a pharmaceutical agent for dementia and other diseases caused by reduction of various brain functions.

摘要翻译： 肽片段及其药学上可接受的盐和含有一种或多种作为有效成分的治疗剂对于改善脑功能和保护脑神经元具有优异的治疗活性，并且可用作药剂。 本发明的肽片段是在16位不含有半胱氨酸的哺乳动物或人类的酸性成纤维细胞生长因子（aFGF）的氨基酸残基肽片段。 化合物包括酸性成纤维细胞生长因子的1-29个氨基酸残基肽片段，其中16位氨基酸的半胱氨酸被另一个氨基酸如丙氨酸，丝氨酸或谷氨酸取代，并且药学上可接受的 的盐。 所述化合物还包括哺乳动物或人的酸成纤维细胞生长因子的1-15个氨基酸残基片段及其药学上可接受的盐。 蛋白质片段可以具有酰胺形式或游离形式的N-末端基团。 在被动回避学习测试和水中的迷宫学习测试中，本发明的肽表现出改善衰老加速小鼠的学习和记忆能力的优异作用，其中记忆和学习能力降低。 肽片段也表现出对缺血引起的脑神经元死亡的保护作用。 因此，本发明的化合物显示脑功能的极好改善和对脑神经元的保护。 该化合物可用作由各种脑功能降低引起的痴呆症和其它疾病的药剂。

公开(公告)号：US5658896A

公开(公告)日：1997-08-19

申请号：US590509

申请日：1996-01-24

申请人： Jin-emon Konishi ,  Giichi Hamada

发明人： Jin-emon Konishi ,  Giichi Hamada

IPC分类号： A61K31/695 ,  A61K33/00 ,  A61K33/06 ,  A61K33/12 ,  A61P9/08 ,  A61P25/02 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  C01B33/193

CPC分类号： A61K33/12 ,  A61K33/00 ,  A61K33/06

摘要： The present invention provides silicate polymers which regulate the function of a living body by restoring and normalizing the lowered cell functions due to diseases. The silicate polymers are preferably water soluble. The molecular weight of the polymers is in the range of 4,800 to 2,000,000, preferably 20,000 to 1,000,000, and they have a degree of polymerization in the range of 75 to 33,000, preferably 490 to 16,500. The monomer unit is (SiO.sub.2). The polymers may be produced by dissolving a water-soluble silicate or a silicic acid containing material such as water glass in water to obtain an aqueous solution. The solution may be admixed with an acid to adjust the pH to 2-10, preferably 4-9.5. A saccharide or sugar alcohol or pharmaceutically acceptable salt may also be admixed with the solution. The aqueous solution is preferably dried to obtain a powder by heating at 150.degree. C. to 250.degree. C. or by lyophilization. The pharmaceutical composition may be used to treat or prevent various diseases, ailments or symptoms associated with allergies, inflammation, or pain.

摘要翻译： 本发明提供了通过恢复和归一化由于疾病引起的降低的细胞功能来调节活体功能的硅酸盐聚合物。 硅酸盐聚合物优选是水溶性的。 聚合物的分子量为4,800至2,000,000，优选为20,000至1,000,000，聚合度为75至33,000，优选为490至16,500。 单体单元为（SiO 2）。 可以通过将水溶性硅酸盐或含硅酸的材料如水玻璃溶解在水中来获得水溶液来制备聚合物。 该溶液可以与酸混合以将pH调节至2-10，优选4-9.5。 糖或糖醇或药学上可接受的盐也可以与溶液混合。 优选将水溶液干燥，通过在150℃至250℃下加热或通过冻干获得粉末。 药物组合物可用于治疗或预防与过敏，炎症或疼痛相关的各种疾病，疾病或症状。

公开(公告)号：US5648228A

公开(公告)日：1997-07-15

申请号：US284972

申请日：1994-08-04

申请人： Katsumi Nishikawa ,  Hitoshi Kawakubo

发明人： Katsumi Nishikawa ,  Hitoshi Kawakubo

IPC分类号： C12Q1/56 ,  G01N33/86

CPC分类号： C12Q1/56 ,  C12Q2337/12 ,  G01N2333/96455 ,  G01N2333/96458

摘要： The present invention provides a method for measuring the activity of tested substances utilizing a reconstituted plasma kallikrein-kinin system. A series of enzymatic reactions is started wherein an activation of a blood coagulation factor XII is an initiating reaction. The series of reactions is started in the presence of the tested substance in the reconstituted plasma kallikrein-kinin system. Then, the series of reactions is stopped and the physiologically active substance produced in the reaction series is quantitatively determined. In the activity measuring method of the present invention, the real activity (a promoting or inhibiting ability) of the tested substance against the production of the produced physiologically active substance can be easily, simply, quickly and precisely measured. In the reconstituted plasma kallikrein-kinin reaction system the contaminating other factors are substantially removed. Accordingly, the method of measuring the activity in accordance with the present invention is a very advantageous means for ascertaining action which is useful for adjusting the bioregulations in, for example, the plasma kallikrein-kinin system, the blood clotting system, the fibrinolysis system, etc. It may also be used for developing or screening drugs which are related to the systems.

摘要翻译： 本发明提供了利用重构的血浆激肽释放酶 - 激肽系统测量被测物质的活性的方法。 开始一系列酶促反应，其中凝血因子XII的活化是起始反应。 在重构的血浆激肽释放酶 - 激肽系统中测试物质的存在下开始一系列反应。 然后，停止一系列反应，并定量测定反应系列产生的生理活性物质。 在本发明的活性测定方法中，可以容易地简单，快速，精确地测定被测物质对生成的生理活性物质的生成的实际活性（促进抑制能力）。 在重建的血浆激肽释放酶 - 激肽反应系统中，污染的其他因子基本上被除去。 因此，根据本发明的测定活性的方法是用于确定可用于调节例如血浆激肽释放酶 - 激肽系统，血液凝固系统，纤维蛋白溶解系统中的生物调节的作用的非常有利的手段， 它也可用于开发或筛选与系统有关的药物。

公开(公告)号：US5602302A

公开(公告)日：1997-02-11

申请号：US175740

申请日：1993-12-30

申请人： Hiroki Mikami ,  Ryoji Nishibata

发明人： Hiroki Mikami ,  Ryoji Nishibata

IPC分类号： A01K67/027 ,  C12N15/00 ,  A61K49/00

CPC分类号： A01K67/027

摘要： The present invention relates to a method of preparing bronchial hypersensitive or hyposensitive guinea pigs by selective breeding on the basis of bronchial sensitivity to inhalant chemicals inducing bronchoconstriction. The hypersensitive guinea pigs of the present invention are extremely useful as model animals for the study of bronchial asthma and allergic rhinitis and for the evaluation of efficacy of-antiasthmatics and antiallergic substances.

摘要翻译： 本发明涉及一种通过选择性繁殖来制备支气管超敏感或低敏感性豚鼠的方法，其基于支气管对吸入性药物诱发支气管收缩的敏感性。 本发明的过敏性豚鼠作为用于研究支气管哮喘和过敏性鼻炎的模型动物以及用于评估抗哮喘和抗过敏物质的功效的非常有用。

公开(公告)号：US5081955A

公开(公告)日：1992-01-21

申请号：US619676

申请日：1990-11-29

申请人： Ryozo Yoneda ,  Hiroyuki Ohara ,  Shinji Ohtsuka

发明人： Ryozo Yoneda ,  Hiroyuki Ohara ,  Shinji Ohtsuka

IPC分类号： A01K1/00 ,  A01K1/03

CPC分类号： A01K1/031

摘要： An animal experiment apparatus is disclosed. Heated air or cooled air introduced into an air fan chamber provided in a housing is circulated in the housing by an air fan. The housing is vertically divided into a plurality of chambers by reticulate partition shelves and a cage containing a small animal is put into and out of each chamber. The housing is provided with a commutator plate for controlling the circulating air and/or a temperature detector, a humidity detector, a control unit for controlling the housing in accordance with signals from the detectors, and a brightness-controlling device.

公开(公告)号：US4957936A

公开(公告)日：1990-09-18

申请号：US472494

申请日：1990-01-30

申请人： Ko Nakamura ,  Kazuharu Ienaga

发明人： Ko Nakamura ,  Kazuharu Ienaga

IPC分类号： G01N33/50 ,  A61K31/415 ,  A61K49/00 ,  A61P9/08 ,  A61P9/10 ,  C07D233/88

CPC分类号： C07D233/88 ,  Y02P20/55

摘要： The glycocyamidine derivatives of the present invention are represented by the following formula (I): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, is hydrogen or a lower alkyl group, preferably a straight or branched alkyl group having 1 to 3 carbon atoms, such as methyl, ethyl, propyl or isopropyl, and R represents hydrogen or an acetyl group.which are useful as test reagents for diagnosis of renal failure.

摘要翻译： 本发明的糖胞苷衍生物由下式（I）表示：其中R 1，R 2和R 3可以相同或不同，为氢或低级烷基，优选直链或支链 具有1至3个碳原子的烷基，例如甲基，乙基，丙基或异丙​​基，R代表氢或乙酰基。 其用作诊断肾衰竭的测试试剂。

公开(公告)号：US4908353A

公开(公告)日：1990-03-13

申请号：US257605

申请日：1988-10-14

申请人： Atsushi Yamamoto ,  Kazuharu Ienaga ,  Kunihiko Higashiura ,  Masaharu Kurohashi

发明人： Atsushi Yamamoto ,  Kazuharu Ienaga ,  Kunihiko Higashiura ,  Masaharu Kurohashi

IPC分类号： A01N37/46 ,  A01N47/12

CPC分类号： A01N37/46 ,  A01N47/12

摘要： The present invention relates to a novel dipeptide having the formula (I): ##STR1## wherein R represents hydrogen atom or an amino-protecting group, Y represents hydrogen atom or hydroxy group which may optionally have protecting group, and X represents an acidic amino acid residue which may optionally have at least one protecting group; and pharmaceutical acceptable salt thereof. These dipeptides are useful as plant growth regulator.

公开(公告)号：US4858604A

公开(公告)日：1989-08-22

申请号：US775836

申请日：1985-09-13

申请人： Ryusaku Konishi

发明人： Ryusaku Konishi

IPC分类号： A61F13/02 ,  A61L15/44 ,  A61L15/58 ,  A61L15/00

CPC分类号： A61F13/0203 ,  A61L15/44 ,  A61L15/58 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/418 ,  A61L2300/62

摘要： An adhesive bandage comprising a pad for absorbing a medicine which is separately stored from the pad by means of a medicine covering film interposed between the medicine and the adhesive tape or by means of a capsule enclosing the medicine in it until the bandage is applied to a local site of body such as wound, an adhesive tape carrying the pad thereon, a release sheet provided with a blister portion adapted to placing the medicine in it and attached to the adhesive tape in such a manner that the open side of the blister may face the adhesive tape.

摘要翻译： 一种胶粘绷带，其包括用于吸收药物的垫，其通过介于药物和胶带之间的药物覆盖膜或通过将药物包裹在其中的胶囊分别储存在垫中，直到将绷带施加到 身体的局部部位如伤口，在其上带有垫的胶带，具有适于将药物放置在其中并附着到粘合带上的泡罩部分的释放片，使得泡罩的开口侧可以面对 胶带。

公开(公告)号：US4545993A

公开(公告)日：1985-10-08

申请号：US400029

申请日：1982-07-20

申请人： Kaoru Okamoto ,  Masaki Hamada ,  Teikichi Kurosaki

发明人： Kaoru Okamoto ,  Masaki Hamada ,  Teikichi Kurosaki

IPC分类号： A61K31/35 ,  A61K31/352 ,  A61P25/04 ,  A61P29/00 ,  C07D311/58 ,  C07D311/64 ,  C07D409/06 ,  C07D311/70

CPC分类号： C07D409/06 ,  C07D311/58 ,  C07D311/64

摘要： Heterocyclic compounds comprising the formula (I): ##STR1## wherein: R.sub.1, R.sub.2, R.sub.4 and R.sub.5 each are hydrogen or a lower alkyl group;R.sub.3 is hydrogen, a halogen, an alkyl group, a haloalkyl group, an alkoxy group, an alkenyl group, an alkenyloxy group, an aryl group, an aryloxy group, an acyl group or a nitro group;and the broken line connotes a single or double bond at the C.sub.3 -C.sub.4 position, provided that when the broken line connotes a single bond, R.sub.3 is other than hydrogen; and pharmaceutically acceptable salts thereof,exhibiting antiinflammatory, antipyretic and analgesic action.

摘要翻译： 包含式（I）的杂环化合物：其中：R 1，R 2，R 4和R 5各自为氢或低级烷基; R3是氢，卤素，烷基，卤代烷基，烷氧基，烯基，烯氧基，芳基，芳氧基，酰基或硝基; 且虚线表示在C3-C4位置的单键或双键，条件是当虚线表示单键时，R 3不是氢; 和其药学上可接受的盐，具有抗炎，解热和镇痛作用。