公开(公告)号：US5013750A

公开(公告)日：1991-05-07

申请号：US551375

申请日：1990-07-11

申请人： Ko Nakamura ,  Kazuharu Ienaga

发明人： Ko Nakamura ,  Kazuharu Ienaga

IPC分类号： C07D233/88

CPC分类号： C07D233/88

摘要： The glycocyamidine derivatives of the present invention are represented by the following formula (I): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, is hydrogen or a lower alkyl group, preferably a straight or branched alkyl group having 1 to 3 carbon atoms, such as methyl, ethyl, propyl or isopropyl, and R represents hydrogen or an acetyl group,which are useful as test reagents for diagnosis of renal failure.

摘要翻译： 本发明的甘氨酰胺衍生物由下式（I）表示：其中R 1，R 2和R 3可以相同或不同，为氢或低级烷基，优选直链或 甲基，乙基，丙基，异丙基等碳原子数1〜3的支链烷基，R表示氢或乙酰基，可用作肾功能衰竭的诊断试剂。

公开(公告)号：US4708961A

公开(公告)日：1987-11-24

申请号：US919746

申请日：1986-10-16

申请人： Kazuharu Ienaga ,  Ko Nakamura

发明人： Kazuharu Ienaga ,  Ko Nakamura

IPC分类号： C07D209/12 ,  A61K31/40

CPC分类号： C07D209/12

摘要： The present invention is concerned with novel acylindole derivatives of the formula (I) and platelet-aggregation inhibiting agents containing them as an active ingredient. ##STR1## In the formula (I), either R.sub.1 and R.sub.2 is hydrogen, an alkyl group having 1 to 5 carbon atoms, an alkyl group substituted by at least one hydroxy group and having 1 to 5 carbon atoms, or a group of the formula ##STR2## in which R.sub.3 is an alkyl group having 1 to 5 carbon atoms, and --OR.sub.2 is a substituent at the ortho or para position.The compounds of the invention are useful as preventive medicine or remedy for various diseases or symptoms caused by platelet-aggregation, as well as inhibitors of platelet-aggregation on vascular walls during or after an operation.

摘要翻译： 本发明涉及式（I）的新型丙烯酰基吲哚衍生物和含有它们作为活性成分的血小板聚集抑制剂。 （I）在式（I）中，R 1和R 2是氢，具有1至5个碳原子的烷基，被至少一个羟基取代且具有1至5个碳原子的烷基，或 其中R 3是具有1至5个碳原子的烷基的式“IMAGE”的基团，-OR 2是邻位或对位的取代基。 本发明的化合物可用作预防药物或由血小板聚集引起的各种疾病或症状的补救剂，以及在手术期间或手术后在血管壁上血小板聚集的抑制剂。

公开(公告)号：US5686251A

公开(公告)日：1997-11-11

申请号：US510316

申请日：1995-08-02

申请人： Seikoh Horiuchi ,  Kazuharu Ienaga ,  Ko Nakamura

发明人： Seikoh Horiuchi ,  Kazuharu Ienaga ,  Ko Nakamura

IPC分类号： G01N33/531 ,  C07D471/04 ,  C07K14/76 ,  C07K16/00 ,  C07K16/44 ,  G01N33/53 ,  G01N33/532 ,  G01N33/68

CPC分类号： G01N33/6842 ,  C07D471/04 ,  C07K16/44 ,  G01N33/5308 ,  G01N33/68 ,  Y02P20/55

摘要： The present invention provides naphthyridinium derivatives which are effective, for example, in diagnosis of diabetes, diabetic complications, dialysis-related complications, aging, diseases accompanied by aging, etc. and also provides an antibody prepared from said derivative as a hapten. The naphthyridinium derivatives of the present invention are compounds represented by the general formula (I): ##STR1## wherein R and R' may be the same or different and are alkyl groups optionally substituted with at least one amino group, at least one protected amino group, at least one carboxyl group, or combinations thereof, and their pharmaceutically accepted salts. It is possible to conduct the diagnosis of diabetes, diabetic complications, dialysis-related complications, aging, diseases accompanied by aging, etc. using a compound of the present invention as an indicator. Moreover, it is possible to utilize a compound of the present invention for the evaluation of the pharmaceutical effect of pharmaceuticals effective for treating diabetes-related diseases, dialysis-related complications, aging and diseases accompanied by aging.

摘要翻译： 本发明提供了例如糖尿病诊断，糖尿病并发症，透析相关并发症，衰老，老化等疾病等有效的萘啶鎓衍生物，并且还提供由所述衍生物制备的抗体作为半抗原。 本发明的萘啶鎓衍生物是由通式（I）表示的化合物：其中R和R'可以相同或不同，并且是任选被至少一个氨基取代的烷基，至少 一个保护的氨基，至少一个羧基或其组合，以及它们的药学上可接受的盐。 使用本发明化合物作为指标，可以进行糖尿病，糖尿病并发症，透析相关并发症，老化，老化等疾病的诊断。 此外，可以利用本发明的化合物来评价有效治疗糖尿病相关疾病，透析相关并发症，老化和伴随衰老的疾病的药物的药效。

公开(公告)号：US4708954A

公开(公告)日：1987-11-24

申请号：US826997

申请日：1986-02-07

申请人： Kazuharu Ienaga ,  Ko Nakamura ,  Akira Ishii

发明人： Kazuharu Ienaga ,  Ko Nakamura ,  Akira Ishii

IPC分类号： C07D295/20 ,  A61K31/445 ,  A61P3/08 ,  A61P3/10 ,  C07C67/00 ,  C07C239/00 ,  C07C275/50 ,  C07D295/10 ,  C07D295/215 ,  A61K31/535

CPC分类号： C07D295/215 ,  C07C275/50 ,  C07C2101/08 ,  C07C2101/14

摘要： Pharmaceutical compositions containing an oxaluric acid derivative of the formula: ##STR1## wherein each of R.sub.1 and R.sub.2, which may be the same or different, is hydrogen; an alkyl group or a cycloalkyl group; or R.sub.1 and R.sub.2 are joined to form a heterocyclic ring with the nitrogen atom to which they are both attached; and R.sub.3 is hydrogen or an alkyl group. These compounds have excellent hypoglycemic effects with low toxcicity and safety.

摘要翻译： 含有下式的草酸衍生物的药物组合物：其中R1和R2可以相同或不同，为氢; 烷基或环烷基; 或者R 1和R 2连接形成与它们相连的氮原子的杂环; 并且R 3是氢或烷基。 这些化合物具有优异的低血糖作用，具有低毒性和安全性。

公开(公告)号：US4647574A

公开(公告)日：1987-03-03

申请号：US709861

申请日：1985-03-08

申请人： Kazuharu Ienaga ,  Ko Nakamura

发明人： Kazuharu Ienaga ,  Ko Nakamura

IPC分类号： C07D233/66 ,  C07D233/72 ,  C07D233/74 ,  A61K31/415

CPC分类号： C07D233/72

摘要： The present invention relates to novel hydantoin derivatives represented by the general formula (I) and pharmaceutical compositions containing them as an active ingredient. ##STR1## In the formula (I), X is hydrogen or a group having the formula --OR.sub.4, and each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, is hydrogen, an alkyl group or a cycloalkyl group.Hydantoin derivatives and pharmaceutically acceptable salts thereof of the present invention have excellent hypoglycemic, hypolipidemic and diuretic effects, as well as low toxicity and great safety. Therefore, the compounds of the present invention are not only useful as antidiabetics but also as drugs for hyperlipidemia.

摘要翻译： 本发明涉及由通式（I）表示的新型乙内酰脲衍生物和含有它们作为有效成分的药物组合物。 （I）在式（I）中，X是氢或具有式-OR 4的基团，R 1，R 2，R 3和R 4可以相同或不同，为氢，烷基 或环烷基。 本发明的乙内酰脲衍生物及其药学上可接受的盐具有优异的降血糖，降血脂和利尿作用，并且毒性低，安全性高。 因此，本发明的化合物不仅可用作抗糖尿病药，还可用作高脂血症药物。

公开(公告)号：US4957936A

公开(公告)日：1990-09-18

申请号：US472494

申请日：1990-01-30

申请人： Ko Nakamura ,  Kazuharu Ienaga

发明人： Ko Nakamura ,  Kazuharu Ienaga

IPC分类号： G01N33/50 ,  A61K31/415 ,  A61K49/00 ,  A61P9/08 ,  A61P9/10 ,  C07D233/88

CPC分类号： C07D233/88 ,  Y02P20/55

摘要： The glycocyamidine derivatives of the present invention are represented by the following formula (I): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, is hydrogen or a lower alkyl group, preferably a straight or branched alkyl group having 1 to 3 carbon atoms, such as methyl, ethyl, propyl or isopropyl, and R represents hydrogen or an acetyl group.which are useful as test reagents for diagnosis of renal failure.

摘要翻译： 本发明的糖胞苷衍生物由下式（I）表示：其中R 1，R 2和R 3可以相同或不同，为氢或低级烷基，优选直链或支链 具有1至3个碳原子的烷基，例如甲基，乙基，丙基或异丙​​基，R代表氢或乙酰基。 其用作诊断肾衰竭的测试试剂。

公开(公告)号：US5446021A

公开(公告)日：1995-08-29

申请号：US240534

申请日：1994-05-10

申请人： Masaharu Kurohashi ,  Ko Nakamura ,  Kazuharu Ienaga

发明人： Masaharu Kurohashi ,  Ko Nakamura ,  Kazuharu Ienaga

IPC分类号： A01N43/90 ,  C07K5/12 ,  A61K38/12

CPC分类号： A01N43/90 ,  C07K5/12

摘要： The present invention relates to an agricultural and horticultural composition inducing resistance in plants against salt- and water-stresses which comprises as an active ingredient an effective amount of at least one cyclic dipeptide of the following formula (I) or an agriculturally or horticulturally acceptable salt thereof; ##STR1## wherein each of R.sub.1 and R.sub.2, which may be the same or different, is a hydrogen atom or lower alkyl group, or R.sub.1 and R.sub.2 are joined to form pyrrolidine ring which may optionally have hydroxy group, and R.sub.3 is a hydrogen atom or hydroxy group.

摘要翻译： 本发明涉及一种诱导植物对抗盐胁迫和水分胁迫的抗性的农业和园艺组合物，其包含作为活性成分的有效量的至少一种下式（I）的环状二肽或农业上或园艺上可接受的盐 的; （I）其中R 1和R 2可以相同或不同，其中R 1和R 2各自为氢原子或低级烷基，或R 1和R 2连接形成可任选具有羟基的吡咯烷环，R 3为 氢原子或羟基。

公开(公告)号：US4683240A

公开(公告)日：1987-07-28

申请号：US826607

申请日：1986-02-06

申请人： Kazuharu Ienaga ,  Ko Nakamura ,  Akira Ishii

发明人： Kazuharu Ienaga ,  Ko Nakamura ,  Akira Ishii

IPC分类号： A61K31/415 ,  C07D233/96

CPC分类号： C07D233/96 ,  A61K31/415 ,  Y10S514/824 ,  Y10S514/866

摘要： Pharmaceutical compositions containing imidazolidinetrione derivatives or pharmaceutically acceptable salts thereof having hypoglycemic and hypolipidemic effects. The compositions comprise as an active ingredient at least one imidazolidinetrione derivative of the formula: ##STR1## wherein each of R.sub.1 and R.sub.2, which may be the same or different, is hydrogen, an alkyl group, a cycloalkyl group or ##STR2## and each of R.sub.3 and R.sub.4, which may be the same or different, is hydrogen, halogen, a nitro group, a lower alkyl group or a lower alkoxy group.

摘要翻译： 含有具有低血糖和降血脂作用的咪唑烷四酮衍生物或其药学上可接受的盐的药物组合物。 所述组合物包含至少一种下式的咪唑烷四酮衍生物作为活性成分：其中R 1和R 2可以相同或不同，分别为氢，烷基，环烷基或者每个 可以相同或不同的R 3和R 4是氢，卤素，硝基，低级烷基或低级烷氧基。

公开(公告)号：US08497537B2

公开(公告)日：2013-07-30

申请号：US12128088

申请日：2008-05-28

申请人： Wensheng Wang ,  Ko Nakamura

发明人： Wensheng Wang ,  Ko Nakamura

IPC分类号： H01L21/02

CPC分类号： H01L21/02107 ,  H01L27/11507 ,  H01L28/57 ,  H01L28/65

摘要： A semiconductor device has a ferro-electric capacitor with small leak current and less process deterioration even upon miniaturization. The semiconductor device includes: a semiconductor element formed in a semiconductor substrate; lamination of an interlayer insulating film and a lower insulating shielding film having a hydrogen/moisture shielding function, the lamination being formed covering the semiconductor element; a conductive adhesion enhancing film formed above the lower insulating shielding film; and a ferro-electric capacitor including a lower electrode formed above the conductive adhesion enhancing film, a ferro-electric film formed on the lower electrode and being disposed within the lower electrode as viewed in plan, and an upper electrode formed on the ferro-electric film and being disposed within the ferro-electric film as viewed in plan, wherein the conductive adhesion enhancing film has a function of improving adhesion of the lower electrode and reducing leak current of the ferro-electric capacitor.

摘要翻译： 半导体器件具有漏电流小的铁电电容，即使在小型化时也具有较少的工艺劣化。 半导体器件包括：形成在半导体衬底中的半导体元件; 夹层绝缘膜和具有氢/水分屏蔽功能的下绝缘屏蔽膜，形成覆盖半导体元件的叠层; 形成在下绝缘屏蔽膜上方的导电粘附增强膜; 以及包含形成在导电性粘合增强膜上的下电极的铁电电容器，形成在下电极上的铁电膜，并且设置在俯视图中的下电极内;以及上电极，形成在铁电 膜，并且设置在平面图所示的铁电膜内，其中，导电性粘附增强膜具有提高下部电极的附着力和降低铁电体的漏电流的功能。

公开(公告)号：US07816150B2

公开(公告)日：2010-10-19

申请号：US11933684

申请日：2007-11-01

申请人： Ko Nakamura

发明人： Ko Nakamura

IPC分类号： H01L21/8242

CPC分类号： H01L27/11507 ,  H01L27/11502

摘要： A method for fabricating a semiconductor device includes the steps of forming a first ferroelectric film over a lower electrode, crystallizing the first ferroelectric film, forming a second ferroelectric film in an amorphous state over the first ferroelectric film so as to fill voids existing on a surface of the first ferroelectric film, and forming an upper electrode over the second ferroelectric film of the amorphous state, wherein the crystallizing step of the first ferroelectric film is conducted by a thermal annealing process at a temperature of 585° C. or higher.

摘要翻译： 一种制造半导体器件的方法包括以下步骤：在下电极上形成第一铁电体膜，使第一铁电体膜结晶，在第一铁电体膜上形成非晶状态的第二铁电体膜，以填充存在于表面上的空隙 并且在非晶状态的第二铁电体膜上形成上电极，其中第一强电介质膜的结晶步骤通过热退火工艺在585℃或更高的温度下进行。