公开(公告)号：US06472534B2

公开(公告)日：2002-10-29

申请号：US09986146

申请日：2001-11-07

Applicant: Bennett C. Borer ,  Scott E. Zook ,  Juliette K. Busse

Inventor： Bennett C. Borer ,  Scott E. Zook ,  Juliette K. Busse

IPC: C07D26308

CPC classification number: C07D263/14 ,  C07D307/22 ,  C07D413/06 ,  Y02P20/55

Abstract: Methods for the preparation of chemical intermediates in the synthesis of HIV-protease inhibitors related to and including nelfinavir mesylate are disclosed. The method of this invention comprises converting tetrohydran derivatives into oxazolines to provide key reaction intermediates for the preparation of nelfinavir. Also disclosed is a method for the preparation of a chiral amino alcohol from an epoxy-tetrahydrofuran.

Abstract translation: 公开了在与奈非那韦甲磺酸盐相关的HIV-蛋白酶抑制剂的合成中制备化学中间体的方法。 本发明的方法包括将四氢化茚衍生物转化为恶唑啉以提供制备奈非那韦的关键反应中间体。 还公开了一种由环氧 - 四氢呋喃制备手性氨基醇的方法。

公开(公告)号：US06465661B1

公开(公告)日：2002-10-15

申请号：US10101858

申请日：2002-03-21

Applicant: Srinivasan Babu ,  Bennett C. Borer ,  Travis P. Remarchuk ,  Robert J. Szendroi ,  Kathleen R. Whitten ,  Juliette K. Busse ,  Kim F. Albizati

Inventor： Srinivasan Babu ,  Bennett C. Borer ,  Travis P. Remarchuk ,  Robert J. Szendroi ,  Kathleen R. Whitten ,  Juliette K. Busse ,  Kim F. Albizati

IPC: C07D20902

CPC classification number: C07D209/48 ,  C07D217/26 ,  C07D263/14 ,  C07D317/24 ,  C07D327/10 ,  C07D401/04 ,  C07D413/04 ,  C07D413/06

Abstract: HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive intermediates.

公开(公告)号：US06316625B1

公开(公告)日：2001-11-13

申请号：US09621681

申请日：2000-07-21

Applicant: Srinivasan Babu ,  Bennett C. Borer ,  Travis P. Remarchuk ,  Robert J. Szendroi ,  Kathleen R. Whitten ,  Juliette K. Busse ,  Kim F. Albizati

Inventor： Srinivasan Babu ,  Bennett C. Borer ,  Travis P. Remarchuk ,  Robert J. Szendroi ,  Kathleen R. Whitten ,  Juliette K. Busse ,  Kim F. Albizati

IPC: C07D21706

CPC classification number: C07D209/48 ,  C07D217/26 ,  C07D263/14 ,  C07D317/24 ,  C07D327/10 ,  C07D401/04 ,  C07D413/04 ,  C07D413/06

Abstract: HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive intermediates.

Abstract translation: HIV蛋白酶抑制剂抑制或阻断HIV蛋白酶的生物学活性，导致HIV病毒的复制终止。 这些化合物可以通过使用本发明新颖的中间体的本发明的新方法来制备。

公开(公告)号：US06117999A

公开(公告)日：2000-09-12

申请号：US252802

申请日：1999-02-19

Applicant: Srinivasan Babu ,  Bennett C. Borer ,  Travis P. Remarchuk ,  Robert J. Szendroi ,  Kathleen R. Whitten ,  Juliette K. Busse ,  Kim F. Albizati

Inventor： Srinivasan Babu ,  Bennett C. Borer ,  Travis P. Remarchuk ,  Robert J. Szendroi ,  Kathleen R. Whitten ,  Juliette K. Busse ,  Kim F. Albizati

IPC: C07D209/48 ,  C07D217/26 ,  C07D263/14 ,  C07D317/24 ,  C07D327/10 ,  C07D401/04 ,  C07D413/04 ,  C07D413/06 ,  C07D217/16

CPC classification number: C07D209/48 ,  C07D217/26 ,  C07D263/14 ,  C07D317/24 ,  C07D327/10 ,  C07D401/04 ,  C07D413/04 ,  C07D413/06

Abstract: HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive intermediates.

公开(公告)号：US5621586A

公开(公告)日：1997-04-15

申请号：US610482

申请日：1996-03-04

Applicant: Bennett C. Hinnen ,  Hai T. Ho ,  Eric A. Rinard ,  Gregory S. Rinard ,  Brian A. Ruff ,  Nathan C. Thompson ,  Hossein Zia-Shakeri

Inventor： Bennett C. Hinnen ,  Hai T. Ho ,  Eric A. Rinard ,  Gregory S. Rinard ,  Brian A. Ruff ,  Nathan C. Thompson ,  Hossein Zia-Shakeri

IPC: G11B15/68 ,  G11B17/24

CPC classification number: G11B15/686 ,  G11B17/24

Abstract: A storage system (10) is disclosed that provides random access storage/retrieval of data on data cartridges within the storage system (10). In one embodiment, the storage system (10) includes a storage array (20), a player/recorder device (22), a guard device (80) and a cartridge transport device (40). The player/recorder device (22) and the transport device (40) are positioned on substantially opposite sides of the storage array. The transport device (40) moves cartridges between the storage array (20) and the player/recorder device (22). The guard device (80) pushes a prolapsed data cartridge back into the storage array (20) and/or limits the distance a data cartridge will prolapse from the storage array (20).

Abstract translation: 公开了一种存储系统（10），其提供在存储系统（10）内的数据盒上的数据的随机访问存储/检索。 在一个实施例中，存储系统（10）包括存储阵列（20），播放器/记录器装置（22），保护装置（80）和盒输送装置（40）。 播放器/记录器装置（22）和输送装置（40）位于存储阵列的基本相对的两侧。 运送装置（40）在存储阵列（20）和播放器/记录装置（22）之间移动盒。 防护装置（80）将脱垂的数据盒推回到存储阵列（20）中，和/或限制数据盒从存储阵列（20）脱落的距离。

公开(公告)号：US5577033A

公开(公告)日：1996-11-19

申请号：US253753

申请日：1994-06-03

Applicant: Eugene Y. Chang ,  David B. Richardson ,  Bennett C. Baker

Inventor： Eugene Y. Chang ,  David B. Richardson ,  Bennett C. Baker

IPC: H04L12/18 ,  H04L12/28

CPC classification number: H04L12/18 ,  H04L12/28 ,  H04L12/1886 ,  Y10S370/904

Abstract: A method and apparatus for using switched telecommunications services to emulate a local area network (LAN) medium. The method and apparatus convert a public switched network or an equivalent private network into a LAN cabling method for connecting distant devices using the same communications software as used in traditionally wired LANs.

Abstract translation: 一种使用交换电信业务来模拟局域网（LAN）介质的方法和装置。 该方法和装置将公共交换网络或等效专用网络转换成LAN布线方法，用于使用与传统有线LAN中使用的相同的通信软件连接远程设备。

公开(公告)号：US5028697A

公开(公告)日：1991-07-02

申请号：US229941

申请日：1988-08-08

Applicant: David A. Johnson ,  Bennett C. Laguzza ,  William L. Scott

Inventor： David A. Johnson ,  Bennett C. Laguzza ,  William L. Scott

IPC: C12P21/08 ,  A61K39/395 ,  A61K47/48 ,  A61P35/00 ,  C07D475/08 ,  C07K1/113 ,  C07K14/00 ,  C07K14/705 ,  C07K16/00 ,  C07K19/00 ,  C12R1/91

CPC classification number: A61K47/48692

Abstract: Conjugates of antibodies and cytotoxic methotrexate drugs make use of linkers between the drug and antibody which are simple organic groups, wherein the link to the antibody is an acyl group and the link to the drug is an alkylidene hydrazide.

公开(公告)号：US4912176A

公开(公告)日：1990-03-27

申请号：US340367

申请日：1989-04-13

Applicant: Edwardo Alvarez ,  Lorenzo P. DiSano ,  Bennett C. Ward

Inventor： Edwardo Alvarez ,  Lorenzo P. DiSano ,  Bennett C. Ward

IPC: B29C43/02 ,  B29K71/00 ,  B29K79/00 ,  C08G73/18 ,  C08J5/00 ,  C08L65/00 ,  C08L71/08 ,  C08L71/10 ,  C08L79/04

CPC classification number: C08L65/00 ,  C08G73/18 ,  C08L79/04 ,  Y10S521/919

Abstract: Sinterd molded article having improved thermal resistance and strength formed from a homogeneous mixture comprising from about 5 to 75 percent by weight polybenzimidazole and from about 95 to 25 percent by weight of a polyaryleneketone.

Abstract translation: 具有由包含约5-75重量％聚苯并咪唑和约95-25重量％聚亚芳基酮的均匀混合物形成的具有改进的耐热性和强度的烧结模塑制品。

公开(公告)号：US4814530A

公开(公告)日：1989-03-21

申请号：US92493

申请日：1987-09-03

Applicant: Bennett C. Ward ,  Edwardo Alvarez ,  Ralph S. Blake

Inventor： Bennett C. Ward ,  Edwardo Alvarez ,  Ralph S. Blake

IPC: B29C43/02 ,  B29C43/52 ,  B29C67/04 ,  B29K79/00 ,  B29K105/16 ,  C08G73/18 ,  C08J9/24 ,  C08G33/02

CPC classification number: C08G73/18

Abstract: Sintered polybenzimidazole articles are obtained by compacting a particulate, dried polybenzimidazole resin under a pressure of 2,000 to 10,000 psi in a mold, heating the formed article to a temperature in the range of 825.degree. to 950.degree. F. for at least four hours, cooling the polybenzimidazole article to below 800.degree. F. while maintaining the article under a pressure of 2,000 to 10,000 psi, and thereafter heating the constrained formed polybenzimidazole article to a temperature in the range of 825.degree. to 950.degree. F. for at least one hour.

Abstract translation: 烧结聚苯并咪唑制品通过在模具中在2,000至10,000psi的压力下压实颗粒状干燥的聚苯并咪唑树脂获得，将成型制品加热至825-950°F的温度至少4小时，冷却 聚苯并咪唑制品低于800°F，同时在2,000至10,000psi的压力下保持制品，然后将约束形成的聚苯并咪唑制品加热至825℃至950℃的温度至少1小时。

公开(公告)号：US4801712A

公开(公告)日：1989-01-31

申请号：US60588

申请日：1987-06-11

Applicant: Bennett C. Laguzza ,  Cynthia L. Nichols ,  Nicholas J. Bach

Inventor： Bennett C. Laguzza ,  Cynthia L. Nichols ,  Nicholas J. Bach

IPC: C07D209/90 ,  C07D457/02 ,  A61K31/48

CPC classification number: C07D209/90 ,  C07D457/02

Abstract: D-2-Alkyl(or phenyl)thio-6-n-alkylergolines or .+-.-2-alkyl(or phenyl)thio-4-dialkylaminotetrahydrobenz[c,d]indoles, dopamine D-1 antagonists.

Abstract translation: D-2-烷基（或苯基）硫代-6-正烷基高甘油或+ / - 2-烷基（或苯基）硫代-4-二烷基氨基四氢苯并[c，d]吲哚，多巴胺D-1拮抗剂。