公开(公告)号：US20230133069A1

公开(公告)日：2023-05-04

申请号：US17517919

申请日：2021-11-03

Applicant: Clemson University Research Foundation

Inventor： Riley Rapert ,  Robert A. Latour ,  George Chumanov ,  Tyler George Harvey ,  Guzeliya Korneva

IPC: A61B5/08 ,  A61B5/097

Abstract: Provided is an apparatus for measuring the ammonia concentration in exhaled breath and a method for measuring the ammonia concentration in exhaled breath. The apparatus comprises a sample collection portion, capable of capturing exhaled breath to control the volume of exhaled breath, a pressure gauge for the control of the flow rate of exhaled breath, a small diameter inner tube oriented in a perpendicular direction to the colorimetric sensor to focus the exhaled breath stream onto the central region of the sensor, and an analysis portion capable of receiving said exhaled breath from said sample collection portion. The analysis portion comprises a colorimetric sensor comprising an active component on a substrate. The colorimetric sensor changes color proportional to the ammonia concentration in said exhaled breath.

公开(公告)号：US11596876B2

公开(公告)日：2023-03-07

申请号：US16267579

申请日：2019-02-05

Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION

Inventor： R. Kenneth Marcus ,  Terri F. Bruce ,  Lei Wang ,  Sisi Huang ,  Tyler Y. Slonecki ,  Rhonda Reigers Powell

IPC: B01D15/32 ,  G01N30/00 ,  C07K14/47 ,  C12N9/00 ,  C12N15/10 ,  G01N1/40 ,  G01N33/50 ,  A61K35/68 ,  B01J20/26 ,  B01J20/28 ,  B01J20/285 ,  B01J20/286

Abstract: A relatively fast, inexpensive, and non-destructive method for separation and isolation of biologically active nanoparticles is described. Methods include the use of solid phase separation medis such as channeled fibers in a hydrophobic interaction chromatography (HIC) protocol to isolate biologically active nanoparticles from other components of a mixture. Biologically active nanoparticles can include natural nanoparticles (e.g., exosomes, lysosomes, virus particles) as well as synthetic nanoparticles (liposomes, genetically modified virus particles, etc.)

公开(公告)号：US20230017076A1

公开(公告)日：2023-01-19

申请号：US17877167

申请日：2022-07-29

Applicant: SAVANNAH RIVER NUCLEAR SOLUTIONS, LLC ,  CLEMSON UNIVERSITY RESEARCH FOUNDATION ,  GEORGIA TECH RESEARCH CORPORATION

Inventor： DALE A. HITCHCOCK ,  STEVEN M. SERKIZ ,  TIMOTHY M. KRENTZ ,  JOSEF A. VELTEN ,  KYLE S. BRINKMAN ,  ERIC M. VOLGEL ,  KATHERINE T. YOUNG

IPC: B01D59/42 ,  B01D59/14 ,  B01D71/02 ,  C01B4/00

Abstract: Methods and systems for the separation of hydrogen isotopes from one another are described. Methods include utilization of a hydrogen isotope selective separation membrane that includes a hydrogen isotope selective layer (e.g., graphene) and a hydrogen ion conductive supporting layer. An electronic driving force encourages passage of isotopes selectively across the membrane at an elevated separation temperature to enrich the product in a selected hydrogen isotope.

公开(公告)号：US20220252607A1

公开(公告)日：2022-08-11

申请号：US17672586

申请日：2022-02-15

Applicant: University of Washington ,  Clemson University Research Foundation

Inventor： Daniel T. Chiu ,  Changfeng Wu ,  Jason McNeill ,  Jiangbo Yu

IPC: G01N33/58 ,  C09K11/06

Abstract: The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.

公开(公告)号：US11357281B2

公开(公告)日：2022-06-14

申请号：US16657209

申请日：2019-10-18

Applicant: Clemson University Research Foundation

Inventor： John DesJardins ,  Gregory S. Batt ,  Alexander Bina

IPC: G01M5/00 ,  A42B3/20

Abstract: A force generator applying a force load against a facemask. A first load cell carrying a first portion of the facemask at an attachment point of the facemask where the facemask is attachable to a helmet. A second load cell carrying a second portion of the facemask at another attachment point of the facemask where the facemask is attachable to a helmet. A first attachment platform carrying the first load cell, wherein the first attachment platform is laterally movable in at least two degrees of freedom. A second attachment platform carrying the second load cell, wherein the second attachment platform is laterally movable in at least two degrees of freedom. The force generator directs the contact plate against the facemask to cause a horizontal deformation of the facemask and a lateral movement of the attachment platforms to allow for repeatable force load testing on a single facemask.

公开(公告)号：US20220089706A1

公开(公告)日：2022-03-24

申请号：US17423999

申请日：2019-01-22

Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION

Inventor： NARENDRA R. VYAVAHARE ,  CHARLES D. RICE ,  NASIM NOSOUDI ,  SAKETH KARAMCHED ,  VAIDEESH PARASARAM

IPC: C07K16/18 ,  A61K47/68 ,  A61K49/00

Abstract: Antibodies and antigen binding fragments thereof that specifically recognize and bind an epitope of elastin that is exposed and accessible in degraded elastic fiber are described. The antibodies and/or antigen binding fragments can be operably linked to a secondary component, including biologically active agents such as therapeutics and/or imaging agents. Optionally, the antibodies and/or antigen binding fragments thereof can be attached to a surface of a carrier, such as a particle, for specific binding and delivery of the carried agents to degraded elastic fiber.

公开(公告)号：US11253167B2

公开(公告)日：2022-02-22

申请号：US16328430

申请日：2017-08-28

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT ,  CLEMSON UNIVERSITY RESEARCH FOUNDATION

Inventor： Nancy DeMore ,  Delphine Dean ,  Scott R. Slaney ,  Melissa McCullough ,  Cody Jordan ,  Joseph R. Wilson, III

IPC: A61B5/06 ,  A61B90/00 ,  A61B5/05

Abstract: Systems and methods for detecting metal clips inserted within a portion of a body of a patient are disclosed herein. In one embodiment, a clip detector assembly includes a detector having a ferrous member, a transmitting coil around the ferrous member and configured to induce a current in the metal clip, and a receiving coil around the ferrous member and configured to receive a magnetic field generated by the current induced in the metal clip. The assembly can further include a control circuit having a band-pass filter configured to pass electrical signals induced by the magnetic field from the receiving coil that are within at most 35 kHz of a resonance frequency of the metal clip. The assembly still further includes a user notification component configured to alert a user to a location of the metal clip.

公开(公告)号：US11192297B2

公开(公告)日：2021-12-07

申请号：US15602360

申请日：2017-05-23

Applicant: UNIVERSITY OF SOUTH CAROLINA ,  CLEMSON UNIVERSITY RESEARCH FOUNDATION ,  TIGHITCO, Inc.

Inventor： Michael Johannes Leonardus Van Tooren ,  Igor Luzinov ,  Nikolay Borodinov ,  Wout De Backer ,  Arturs Peteris Bergs

IPC: B29C64/165 ,  B29C64/209 ,  B29C64/314 ,  B29C70/30 ,  B29B15/12 ,  B29C64/118 ,  B33Y10/00 ,  B33Y70/00 ,  B29C64/106 ,  B29C70/20 ,  B29K105/10 ,  B29K307/04

Abstract: A composite filament for use in additive manufacturing such as fused filament fabrication is described along with methods of its construction and use. The composite filament includes a single continuous filament (e.g., a continuous carbon roving) and a polymer (e.g., a high glass transition polymer) in intimate contact. The composite filament is formed through immersion of the continuous filament in a solution of the polymer. The composite filament can be combined with an additional formation material in an additive manufacturing process.

公开(公告)号：US10998711B2

公开(公告)日：2021-05-04

申请号：US16274941

申请日：2019-02-13

Applicant: Clemson University Research Foundation (CURF)

Inventor： Keith A. Corzine

IPC: H02H3/16 ,  H03K17/687

Abstract: An improved DC circuit breaker is provided for automatically detecting and isolating a fault between a source and a ground. The DC circuit breaker comprises at least one switch, in electrical series with a first inductor between the source and a load, and a second inductor magnetically coupled to the first inductor wherein a first side of the second inductor is electrically connected to the load and a second side of the second inductor is grounded through a capacitor.

公开(公告)号：US20210005339A1

公开(公告)日：2021-01-07

申请号：US16933641

申请日：2020-07-20

Applicant: Clemson University Research Foundation

Inventor： Xiao Ran ZHENG ,  Endre TAKACS ,  Mark LEISING

IPC: G21K1/02 ,  A61N5/10 ,  G21K5/04

Abstract: Radiation delivery devices are described herein having compact and lightweight design in comparison to existing architectures. A radiation delivery device comprises a source body including a plurality of radiation sources and a collimator component for directing radiation from the radiation sources to a common focal area, wherein the radiation sources are arranged within the collimator component. In some embodiments, for example, the source body is positioned within an interior cavity of the collimator component.