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公开(公告)号：US11835526B2
公开(公告)日：2023-12-05
申请号：US17672586
申请日：2022-02-15
发明人： Daniel T. Chiu , Changfeng Wu , Jason McNeill , Jiangbo Yu
CPC分类号： G01N33/587 , C09K11/06 , G01N33/582
摘要： The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.
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公开(公告)号：US20220252607A1
公开(公告)日：2022-08-11
申请号：US17672586
申请日：2022-02-15
发明人： Daniel T. Chiu , Changfeng Wu , Jason McNeill , Jiangbo Yu
摘要： The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.
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公开(公告)号：US20240069032A1
公开(公告)日：2024-02-29
申请号：US18492120
申请日：2023-10-23
发明人： Daniel T. Chiu , Changfeng Wu , Jason McNeil , Jiangbo Yu
CPC分类号： G01N33/587 , C09K11/06 , G01N33/582
摘要： The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.
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公开(公告)号：US11249086B2
公开(公告)日：2022-02-15
申请号：US16209729
申请日：2018-12-04
发明人： Daniel T. Chiu , Changfeng Wu , Jason McNeill , Jiangbo Yu
摘要： The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.
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公开(公告)号：US11823809B2
公开(公告)日：2023-11-21
申请号：US17368078
申请日：2021-07-06
发明人： Daniel T. Chiu , Jiangbo Yu , Yu Rong , Changfeng Wu
CPC分类号： H01B1/18 , C07K14/00 , C07K16/00 , C08K3/36 , C08L83/04 , G02F1/015 , C08K2201/001 , C08L2203/20
摘要： The present disclosure provides organic-inorganic hybrid polymer particles, which have desirable surface chemistry and optical properties that make them particularly suitable for biological and optical applications. The present disclosure also provides methods of making organic-inorganic hybrid polymer particles. The present disclosure also provides methods of using the organic-inorganic hybrid polymer particles for biological and optical applications.
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公开(公告)号：US10770197B2
公开(公告)日：2020-09-08
申请号：US16309795
申请日：2017-06-13
发明人： Daniel T. Chiu , Jiangbo Yu , Yu Rong , Changfeng Wu
摘要： The present disclosure provides organic-inorganic hybrid polymer particles, which have desirable surface chemistry and optical properties that make them particularly suitable for biological and optical applications. The present disclosure also provides methods of making organic-inorganic hybrid polymer particles. The present disclosure also provides methods of using the organic-inorganic hybrid polymer particles for biological and optical applications.
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公开(公告)号：US10514381B2
公开(公告)日：2019-12-24
申请号：US14774971
申请日：2014-03-14
发明人： Daniel T. Chiu , Wei Sun , Jiangbo Yu , Changfeng Wu , Fangmao Ye
IPC分类号： G01N33/58 , C09K11/02 , G01N33/543 , C08G61/02 , C08G73/00 , C08G75/32 , G01N33/533
摘要： Lyophilized chromophoric polymer dot compositions are provided. Also disclosed are methods of making and using the lyophilized compositions, methods of dispersing the lyophilized compositions in aqueous solutions and kits supplying the compositions.
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公开(公告)号：US09810693B2
公开(公告)日：2017-11-07
申请号：US13865942
申请日：2013-04-18
发明人： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
IPC分类号： G01N33/58 , C09K11/06 , B82Y30/00 , B82Y40/00 , H01L51/00 , B82Y15/00 , C08G61/12 , C08J3/11 , C09K11/02
CPC分类号： G01N33/588 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C08G61/126 , C08G2261/12 , C08G2261/1426 , C08G2261/228 , C08G2261/3142 , C08G2261/3246 , C08G2261/522 , C08G2261/54 , C08G2261/72 , C08G2261/94 , C08J3/11 , C08J2327/22 , C09K11/025 , C09K11/06 , C09K2211/1425 , H01L51/0039
摘要： The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
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公开(公告)号：US20160341737A1
公开(公告)日：2016-11-24
申请号：US15167513
申请日：2016-05-27
发明人： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
摘要： The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
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公开(公告)号：US20230408526A1
公开(公告)日：2023-12-21
申请号：US18058458
申请日：2022-11-23
发明人： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
IPC分类号： G01N33/58 , B82Y30/00 , B82Y40/00 , B82Y15/00 , H10K85/10 , C09K11/06 , C08G61/12 , C08J3/11 , C09K11/02
CPC分类号： G01N33/588 , C09K2211/1425 , B82Y40/00 , B82Y15/00 , H10K85/115 , C09K11/06 , C08G61/126 , C08J3/11 , C09K11/025 , C08G2261/12 , C08G2261/1426 , C08G2261/228 , C08G2261/3142 , C08G2261/3246 , C08G2261/522 , C08G2261/54 , C08G2261/72 , C08G2261/94 , C08J2327/22 , B82Y30/00
摘要： The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
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