公开(公告)号：US20240398330A1

公开(公告)日：2024-12-05

申请号：US18695851

申请日：2022-09-29

Applicant: A.Y.Y.T. - TECHNOLOGICAL APPLICATIONS AND DATA UPDATE LTD ,  Mor Research Applications Ltd.

Inventor： Michal Balberg ,  Jonathan Rubin ,  Avihai Aharon ,  Heftsi Ragones ,  Yael Avni ,  Daniil Umansky ,  Hagit Shoffel Havakuk ,  Saja Assi

IPC: A61B5/00 ,  A61B5/053 ,  A61B5/389 ,  A61B7/00

Abstract: Disclosed herein is a multi-modal sensor system, including a wearable device configured to receive signals relating to a swallowing process of a subject, the wearable device including one or more surface Electromyograph sensors configured to receive signals relating to electrical potential in muscles of the throat, one or more bio-impedance sensors, one or more memories, one or more processors configured to operate one or more sensors of the wearable device, synchronize the signals to one or more predetermined events to generate a synchronization feature, receive the signals as a first diagnostic data set, analyze the first diagnostic data set, assess, based on the analysis, the swallowing process of the subject to yield an assessment output, and present the assessment output and determine a bio-impedance signal.

公开(公告)号：US12006357B2

公开(公告)日：2024-06-11

申请号：US17255796

申请日：2019-06-26

Applicant: Mor Research Applications Ltd.

Inventor： Michael Fassler ,  Jacob George

IPC: C07K16/18 ,  A61K49/00 ,  A61P9/00 ,  G01N33/68

CPC classification number: C07K16/18 ,  A61K49/0008 ,  A61P9/00 ,  G01N33/6893 ,  C07K2317/14 ,  C07K2317/76

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human transthyretin (TTR). The anti-TTR antibodies or antigen-binding fragments thereof are useful, for example, in detecting TTR and in treating TTR amyloidosis in a subject.

公开(公告)号：US11925643B2

公开(公告)日：2024-03-12

申请号：US17057845

申请日：2019-05-23

Applicant: MOR RESEARCH APPLICATIONS LTD. ,  BAR ILAN UNIVERSITY

Inventor： Edith Hochhauser ,  Arie-Lev Gruzman ,  Elena Trifonov

IPC: A61K31/513 ,  A61K38/06 ,  A61K38/07 ,  A61P9/10 ,  C07D239/47 ,  C07K5/083 ,  C07K5/087 ,  C07K5/103 ,  C07K5/107 ,  C07K5/113

CPC classification number: A61K31/513 ,  A61K38/06 ,  A61K38/07 ,  A61P9/10 ,  C07D239/47 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/1008 ,  C07K5/101 ,  C07K5/1016 ,  C07K5/1021

Abstract: Peptides, peptidomimetics and small molecules, collectively referred to as “decoy peptides”, are provided, which interfere with binding to a TIR domain of a toll-like receptor 4 (TLR4), and inhibit a TLR4-induced signaling pathway. These decoy peptides may be useful for treating diseases associated with induction of TLR4 signaling pathway such as a disease or disorder secondary to a cardiovascular disease, sepsis or an inflammatory disease.

公开(公告)号：US20230237848A1

公开(公告)日：2023-07-27

申请号：US18009798

申请日：2021-06-21

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Menahem CHOURAQUI

IPC: G06V40/18 ,  G06V40/16 ,  G06V10/70 ,  G06Q40/08

CPC classification number: G06V40/197 ,  G06V40/171 ,  G06V10/70 ,  G06Q40/08

Abstract: Embodiments pertain to a method for characterizing a droopy upper eyelid performed on a computer having a processor, memory, and one or more code sets stored in the memory and executed in the processor. The method may comprise capturing an image of a patient's facial features comprising an eye and a droopy upper eyelid; identifying at least one geometric feature of a pupil of the eye within the image; and determining, based on the at least one geometric feature, whether the droopy upper eyelid is vision impairing or not, or whether the droopy upper eyelid is more likely vision impairing than not vision-impairing.

公开(公告)号：US20230165521A1

公开(公告)日：2023-06-01

申请号：US17919267

申请日：2021-04-14

Applicant: Yeda Research and Development Co. Ltd. ,  Mor Research Applications Ltd.

Inventor： Noam SOBEL ,  Anat ARZI ,  Liron ROZENKRANTZ ,  Lior GORODISKY ,  Yael HOLTZMAN ,  Yaron SACHER ,  Danit ROZENKRANTZ

IPC: A61B5/00 ,  A61B5/08 ,  A61B5/091

CPC classification number: A61B5/4842 ,  A61B5/091 ,  A61B5/0816 ,  A61B5/4011

Abstract: A method of assessing a subject including: measuring a plurality of respirations of the subject; determining one or more respiration parameter from the plurality of respirations; and determining, using the one or more respiration parameter, one or more of: a state of consciousness of the subject; and a prognosis of the subject.

公开(公告)号：US11638642B2

公开(公告)日：2023-05-02

申请号：US16483752

申请日：2018-03-01

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Gonen Omer ,  Ori Mahler

IPC: A61F2/16 ,  G02C7/04 ,  A61F2/14

Abstract: Embodiments concern an intraocular implantable device operable comprising a disk-shaped body having a symmetry axis and which further comprises a light-transmissive portion and an opaque portion wherein the light-transmissive portion is decentered with respect to the symmetry axis.

公开(公告)号：US20230125981A1

公开(公告)日：2023-04-27

申请号：US17906243

申请日：2021-03-18

Applicant: Mor Research Applications Ltd. ,  Yeda Research and Development Co. Ltd.

Inventor： Yaniv SHILO ,  Brian BERKOWITZ

IPC: A61M27/00 ,  A61F2/04

Abstract: Embodiments pertain to ureteral stents for treatment of partial or full ureteral occlusion by bridging one or more ureteral occlusions, where each stent includes a tubular portion, a first spout portion and a second spout portion. The stent may have one or more tapered edges by having the smallest diameter of the first and/or the second spout portion smaller than the largest diameter of the tubular portion, and/or be of an overall length allowing the ureteral stent to be completely located within a patient's ureter once deployed therein.

公开(公告)号：US20230023026A1

公开(公告)日：2023-01-26

申请号：US17758422

申请日：2021-01-06

Applicant: Mor Research Applications Ltd.

Inventor： Orith Waisbourd-Zinman

IPC: A61K31/198 ,  A61K31/385 ,  A61K31/593 ,  A61K31/26 ,  A61K31/7076 ,  A61P1/16

Abstract: Methods of treating damaged bile ducts by way of elevating glutathione (GSH) levels, restoring normal GSH levels, and/or maintaining normal GSH levels in the biliary ducts are disclosed. A disclosed method comprises local treatment of damaged biliary ducts, e.g., by directly delivering to the bile ducts lumen of at least one active agent that promotes increasing of GSH production or inhibiting of GSH degradation in the biliary epithelial cells.

公开(公告)号：US11519914B2

公开(公告)日：2022-12-06

申请号：US16480342

申请日：2018-01-25

Applicant: MOR RESEARCH APPLICATIONS LTD. ,  RAMOT AT TEL AVIV UNIVERSITY LTD.

Inventor： Esther Rabizadeh

IPC: G01N33/86 ,  G01N33/574

Abstract: A method for diagnosing a malignant proliferative disease or disorder in a subject, and/or for following up, monitoring or prognosticating the therapy of a malignant proliferative disease or disorder in a subject is disclosed. The method is based on measurement of platelet-mediated fibrinogen-like protein 2 (FGL2) activity in a sample essentially comprising platelets obtained from the subject. In accordance with the disclosed method, platelet-mediated FGL2 activity level higher than control is indicative of the presence of a malignant proliferative disease or disorder in a subject.

公开(公告)号：US11241244B2

公开(公告)日：2022-02-08

申请号：US15962285

申请日：2018-04-25

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Ronen Jaffe ,  Eytan Jaffe

IPC: A61B17/221 ,  A61B17/22 ,  A61M25/10

Abstract: A catheter for removable insertion into a body vasculature has at least one inflatable member. The catheter has at least in part an expandable body that forms an internal axially extending lumen in at least the expanded state of the body. The inflatable member is adjacent a distal axial end of the body and is configured to at least partially obstruct the lumen.