Abstract:
Disclosed are methods and devices useful for imaging blood-containing tissue, for example for angiography, especially retinal angiography, whereby an image is generated by dividing pixels of an image acquired at some wavelength range by corresponding pixels of an image acquired at a different wavelength range. In some embodiments, a first wavelength range includes predominantly light having wavelengths between about 400 nm and about 620 nm and a second wavelength range includes predominantly light having wavelengths between about 620 nm and about 800 nm.
Abstract:
A pupillometer system includes a computer, a camera, and a testing compartment provided in the form of a substantially hemispheric bowl, where the substantially hemispheric bowl includes a plurality of chromatic beam emitters arranged about a visual field forming a plurality of visual field testing points. The plurality of chromatic beam emitters generate a first chromatic stimulus that stimulates a first anatomical structure of an eye and a second chromatic stimulus that stimulates a second anatomical structure of the eye where the first anatomical structure is different than the second anatomical structure. The camera records a pupil response of one or more eyes. The computer generates quantitative pupillary light reflex (PLR) measurements of the PLR in response to the stimuli, determines at least one PLR response ratio, and determines a state of health of the one or more eyes utilizing the at least one PLR response ratio.
Abstract:
The present invention relates to methods of treating, preventing, reducing the severity of, reducing the incidence of, delaying the onset of, or reducing pathogenesis of an inflammatory skin disease, condition or lesion in a human subject, which include the step of administering to the subject a therapeutically effective amount of mi RNA compositions. In addition, methods of this invention may be used to treat symptoms of inflammatory skin diseases and reduce and/or inhibit keratinocyte proliferation.
Abstract:
The present invention is directed to a peptide conjugate comprising an alpha-amino protecting moiety, a peptide comprising the amino acid sequence at least 3 amino-acid long derived from the C′-terminus of PAR-1, or an active variant thereof and a protease-disabling moiety. The present invention is further directed to pharmaceutical compositions comprising the peptide conjugate and use thereof for treating diseases and disorder associated with excessive PAR-1 activity.
Abstract:
Provided are compositions and methods for treating cancer, particularly solid tumors, and cancer metastasis, using micro-RNAs mi R-96 and/or mi R-182.
Abstract:
A hybridoma cell which has been deposited under ATCC Accession Number PTA-9974 is disclosed. Also provided are Antibodies and methods of using same.
Abstract:
Provided are novel compounds which are capable of inhibiting an activity of RNA polymerase I, and uses thereof in treating diseases or disorders modulated by RNA polymerase I, preferably autoimmune diseases such as multiple sclerosis and proliferative diseases.
Abstract:
The present invention provides antibodies, as well as molecules having at least the antigen-binding portion of an antibody, recognizing a specific epitope of the protein CEACAM1 and optionally binds also other subtypes of the CEACAM protein family. Disclosed antibodies and antibody fragments are characterized by specific CDR sequences. Methods of production and use in therapy and diagnosis, of such antibodies and antibody fragments are also provided.
Abstract:
A method of providing an intraoperative magnetic resonance image of a target site of a patient body at which a medical procedure is performed, the method comprising: acquiring a high resolution preoperative magnetic resonance image (MRI), MRI0, of a first region of the patient comprising the target site, the MRI0 image comprising a plurality of slices MRI0 n having voxels; acquiring a preoperative, iMRI0 image of a second region of the patient comprising the target site, using an iMRI scanner having a field of view (FOV), the iMRI0 image comprising plurality of slices iMRI0 m having voxels; registering the MRI0 image to the iMRI0 image to provide a rigid body transform (RT0) that transforms the MRI0 to the iMRI0 image; acquiring an IMRI1 image of the target site during performance of the procedure; registering the image iMRI0 to the iMRIj image to obtain a non-rigid body transform (NRT); and applying RT0 and NRT to MRI0 to provide a high resolution (hiQ-iMRIj) image.
Abstract translation:一种提供执行医疗程序的患者身体的目标部位的术中磁共振图像的方法,所述方法包括:获取患者的第一区域的高分辨率术前磁共振图像(MRI)MRI0 所述MRI0图像包括具有体素的多个切片MRI0 n; 使用具有视场(FOV)的iMRI扫描仪获取包括所述目标部位的所述患者的第二区域的术前iMRI0图像,所述iMRI0图像包括具有体素的多个切片iMRI0 m; 将MRI0图像注册到iMRI0图像以提供将MRI0转换为iMRI0图像的刚体变换(RT0); 在执行程序期间获取目标站点的IMRI1图像; 将图像iMRI0注册到iMRIj图像以获得非刚体变换(NRT); 并将RT0和NRT应用于MRI0以提供高分辨率(hiQ-iMRIj)图像。
Abstract:
A method of tracking a region in a video image having a plurality of video frames is disclosed. The method comprises: generating one or more candidate contours in a video frame; and, for each candidate contour, analyzing the candidate contour based on intensity values of picture-elements along the candidate contour, and analyzing an area at least partially enclosed by the candidate contour based on texture features in the area. The method further comprises selecting a winner contour from the candidate contour(s) based on the analyses, and associating the region with the winner contour.