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    Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor
    61.
    发明申请
    Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor 有权
    光栅传感器结合无标签结合检测和荧光放大和传感器读出系统

    公开(公告)号：US20100003743A1

    公开(公告)日：2010-01-07

    申请号：US12387391

    申请日：2009-04-30

    Applicant: Stephen C. Schulz ,  Brian T. Cunningham ,  Lance G. Laing ,  Peter Y. Li ,  Brant Binder ,  Gangadhar Jogikalmath ,  Alex Borsody

    Inventor： Stephen C. Schulz ,  Brian T. Cunningham ,  Lance G. Laing ,  Peter Y. Li ,  Brant Binder ,  Gangadhar Jogikalmath ,  Alex Borsody

    IPC: C12M1/34

    CPC classification number: G01N21/648 ,  G01N21/552 ,  G01N21/6428 ,  G01N21/7743 ,  Y10S435/808 ,  Y10S436/805 ,  Y10T436/143333

    Abstract: A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode, in which the sample is dry. Other embodiments are optimized for ER detection in liquid mode, in which the sample is suspended in liquid medium such as water. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. One embodiment includes a first light source optimized for collecting label-free detection data, a second light source optimized for collecting ER fluorescence amplification data, and at least one detector. In one embodiment, the detector is an imaging system and includes a CCD camera for collecting both ER and label-free data. In other embodiments, the at least one detector takes the form of a spectrometer for collection of label-free data and a photomultiplier for collecting ER data. In other embodiments, a single light source such as a tunable laser or broad band light source is used.

    Abstract translation: 公开了一种光栅传感器，其具有构造和设计用于ev逝共振（ER）荧光检测和无标签检测应用的光栅结构。 公开了一些实施例，其被优化用于空气模式中的ER检测，其中样品是干的。 其他实施方案针对液体模式中的ER检测进行了优化，其中将样品悬浮在诸如水的液体介质中。 还公开了一维和二维光栅，包括以具有中心柱，中心孔和两层二维光栅的单元电池为特征的光栅。 还公开了一种用于这种传感器的读出系统。 一个实施例包括优化用于收集无标记检测数据的第一光源，为采集ER荧光放大数据而优化的第二光源和至少一个检测器。 在一个实施例中，检测器是成像系统，并且包括用于收集ER和无标签数据的CCD照相机。 在其他实施例中，至少一个检测器采用用于收集无标签数据的光谱仪的形式和用于收集ER数据的光电倍增管。 在其他实施例中，使用诸如可调激光器或宽带光源的单个光源。

    Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor
    62.
    发明申请
    Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor 失效
    光栅传感器结合无标签结合检测和荧光放大和传感器读出系统

    公开(公告)号：US20090226950A1

    公开(公告)日：2009-09-10

    申请号：US11818742

    申请日：2007-06-15

    Applicant: Brian T. Cunningham ,  Peter Y. Li ,  Lance G. Laing ,  Gangadhar Jogikalmath

    Inventor： Brian T. Cunningham ,  Peter Y. Li ,  Lance G. Laing ,  Gangadhar Jogikalmath

    IPC: C12Q1/02 ,  C12M1/34

    CPC classification number: G01N21/6452 ,  G01N21/648 ,  G01N21/76 ,  G01N21/7743 ,  G01N33/54373 ,  G01N33/6872 ,  Y10S436/805

    Abstract: A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. Various applications for the biosensors are described, including cell-based assays for assessing the effect of drug compounds on cell function. A biosensor embodiment optimized for a luminescent response at two different wavelengths is also described. Such luminescent response could be produced by fluorescence (either native or from an attached fluorophore), phosphorescence, chemi-luminescence, or other luminescence technology. Two different luminescence technologies could be combined on the same biosensor chip.

    Abstract translation: 公开了一种光栅传感器，其具有构造和设计用于ev逝共振（ER）荧光检测和无标签检测应用的光栅结构。 还公开了一维和二维光栅，包括以具有中心柱，中心孔和两层二维光栅的单元电池为特征的光栅。 还公开了一种用于这种传感器的读出系统。 描述了用于生物传感器的各种应用，包括用于评估药物化合物对细胞功能的影响的基于细胞的测定。 还描述了针对两个不同波长的发光响应进行了优化的生物传感器实施例。 这种发光反应可以通过荧光（天然的或来自附着的荧光团），磷光，化学发光或其他发光技术产生。 两种不同的发光技术可以组合在相同的生物传感器芯片上。

    Photonic crystal sensors with integrated fluid containment structure
    64.
    发明申请
    Photonic crystal sensors with integrated fluid containment structure 有权
    光电晶体传感器具有集成的流体容纳结构

    公开(公告)号：US20080265137A1

    公开(公告)日：2008-10-30

    申请号：US11983108

    申请日：2007-11-06

    Applicant: Brian T. Cunningham ,  Charles Choi

    Inventor： Brian T. Cunningham ,  Charles Choi

    IPC: H01L27/00

    CPC classification number: B01L3/5085 ,  B01L3/5027 ,  B01L2300/0636 ,  B01L2300/0654 ,  B82Y20/00 ,  G01N21/253 ,  G02B2006/1213

    Abstract: Photonic crystal (PC) sensors, and sensor arrays and sensing systems incorporating PC sensors are described which have integrated fluid containment and/or fluid handling structures. Sensors and sensing systems of the present disclosure are capable of high throughput sensing of analytes in fluid samples, bulk refractive index detection, and label-free detection of a range of molecules, including biomolecules and therapeutic candidates. The present disclosure also provides a commercially attractive fabrication platform for making photonic crystal sensors and systems wherein an integrated fluid containment structure and a photonic crystal structure are fabricated in a single molding or imprinting processing step amendable to high throughput processing.

    Abstract translation: 描述了具有集成流体容纳和/或流体处理结构的光子晶体（PC）传感器以及包含PC传感器的传感器阵列和感测系统。 本公开的传感器和感测系统能够高流量感测流体样品中的分析物，体积折射率检测和一系列分子（包括生物分子和治疗候选物）的无标记检测。 本公开还提供了用于制造光子晶体传感器和系统的商业上有吸引力的制造平台，其中集成流体容纳结构和光子晶体结构在可修改为高通量处理的单个模制或压印处理步骤中制造。

    Photonic crystal sensors with intergrated fluid containment structure
    65.
    发明申请
    Photonic crystal sensors with intergrated fluid containment structure 有权
    光子晶体传感器具有集成的流体封闭结构

    公开(公告)号：US20080219615A1

    公开(公告)日：2008-09-11

    申请号：US11983109

    申请日：2007-11-06

    Applicant: Brian T. Cunningham

    Inventor： Brian T. Cunningham

    IPC: G02B6/00

    CPC classification number: B01L3/5085 ,  B01L3/5027 ,  B01L2300/0636 ,  B01L2300/0654 ,  B82Y20/00 ,  G01N21/253 ,  G02B2006/1213

    Abstract: Photonic crystal (PC) sensors, and sensor arrays and sensing systems incorporating PC sensors are described which have integrated fluid containment and/or fluid handling structures. Sensors and sensing systems of the present disclosure are capable of high throughput sensing of analytes in fluid samples, bulk refractive index detection, and label-free detection of a range of molecules, including biomolecules and therapeutic candidates. The present disclosure also provides a commercially attractive fabrication platform for making photonic crystal sensors and systems wherein an integrated fluid containment structure and a photonic crystal structure are fabricated in a single molding or imprinting processing step amendable to high throughput processing.

    Abstract translation: 描述了具有集成流体容纳和/或流体处理结构的光子晶体（PC）传感器以及包含PC传感器的传感器阵列和感测系统。 本公开的传感器和感测系统能够高流量感测流体样品中的分析物，体积折射率检测和一系列分子（包括生物分子和治疗候选物）的无标记检测。 本公开还提供了用于制造光子晶体传感器和系统的商业上有吸引力的制造平台，其中集成流体容纳结构和光子晶体结构在可修改为高通量处理的单个模制或压印处理步骤中制造。

    Biosensor substrate structure for reducing the effects of optical interference
    66.
    发明授权
    Biosensor substrate structure for reducing the effects of optical interference 失效
    用于降低光学干涉影响的生物传感器基板结构

    公开(公告)号：US07197198B2

    公开(公告)日：2007-03-27

    申请号：US11207491

    申请日：2005-08-18

    Applicant: Stephen C. Schulz ,  Brian T. Cunningham

    Inventor： Stephen C. Schulz ,  Brian T. Cunningham

    IPC: G02B6/00

    CPC classification number: G01N21/7743

    Abstract: A biosensor substrate structure is provided that eliminates the effects of optical interference of light reflected from a substrate/air interface with light reflected by the biosensor's active surface by incorporating a roughened or “non-specular” surface on the lower surface of the substrate opposite the grating. One can generate a useful non-specular or “anti-interference” surface in a number of ways in accordance with this disclosure, including (1) by adding a coating of optically diffuse material, such as UV cured acrylate, to the sensor substrate, (2) etching or otherwise roughening the surface of the sensor substrate, or (3) applying a grating structure to the surface.

    Abstract translation: 提供一种生物传感器基板结构，其通过在与基板/空气界面相反的基板的下表面上并入粗糙或“非镜面”表面，从而消除由基板/空气界面反射的光与生物传感器的活性表面反射的光的光学干涉的影响 光栅。 根据本公开，可以以多种方式产生有用的非镜面或“抗干扰”表面，包括（1）通过将光学漫射材料如UV固化的丙烯酸酯涂层添加到传感器基底， （2）蚀刻或以其它方式粗糙化传感器基板的表面，或（3）将光栅结构施加到表面。

    Method and instrument for detecting biomolecular interactions
    67.
    发明授权
    Method and instrument for detecting biomolecular interactions 失效
    用于检测生物分子相互作用的方法和仪器

    公开(公告)号：US07170599B2

    公开(公告)日：2007-01-30

    申请号：US11288878

    申请日：2005-11-28

    Applicant: Brian T. Cunningham ,  Peter Li

    Inventor： Brian T. Cunningham ,  Peter Li

    IPC: G01J3/28

    CPC classification number: G01N21/253 ,  B01L3/5085 ,  C12Q1/68 ,  G01J3/42 ,  G01N21/31 ,  G01N21/4788 ,  G01N21/55 ,  G01N21/75 ,  G01N21/7743 ,  G01N33/54373 ,  G01N2021/7773 ,  G01N2021/7776 ,  G02B5/1809

    Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An instrument system for detecting a biochemical interaction on a biosensor. The system includes an array of detection locations comprises a light source for generating collimated white light. A beam splitter directs the collimated white light towards a surface of a sensor corresponding to the detector locations. A detection system includes an imaging spectrometer receiving the reflected light and generating an image of the reflected light.

    Abstract translation: 用于检测生物分子相互作用的方法和装置。 不需要使用标签，并且可以以高通量的方式执行方法。 用于检测生物传感器上的生物化学相互作用的仪器系统。 该系统包括一组检测位置，包括用于产生准直白光的光源。 分束器将准直的白光引导到对应于检测器位置的传感器的表面。 检测系统包括接收反射光并产生反射光的图像的成像光谱仪。

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