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公开(公告)号：US20210222103A1
公开(公告)日：2021-07-22
申请号：US16095799
申请日：2017-05-11
Applicant: Corning Incorporated
Inventor： Gregory Roger Martin , Allison Jean Tanner
Abstract: A structured bag for cell culture is provided herein. The structured bag includes a top portion, a bottom portion having a shape, and a sidewall extending between the top portion and the bottom portion and at least partially defining an interior compartment for receiving fluid. The bottom portion is configured to maintain the shape to support the structured bag such that the structured bag is free standing when placed on a surface.
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公开(公告)号：US20210189314A1
公开(公告)日：2021-06-24
申请号：US16758066
申请日：2018-11-05
Applicant: CORNING INCORPORATED
Inventor： Gregory Roger Martin , Allison Jean Tanner
Abstract: A cell culture apparatus includes a cell culture module including multiple cell culture chambers. A manifold connects the multiple cell culture chambers together along a side of the cell culture module. The manifold includes a side wall base structure connected to the side of the cell culture module and a column structure that is formed as a monolithic part of the side wall base structure. The column structure defines a fluid flow pathway through the manifold and to inlets to the cell culture chambers to allow filling and emptying of the cell culture chambers of liquid medium.
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公开(公告)号：US20200179923A1
公开(公告)日：2020-06-11
申请号：US16628474
申请日：2018-07-13
Applicant: CORNING INCORPORATED
Inventor： William Joseph Lacey , Gregory Roger Martin , Ana Maria del Pilar Pardo , Allison Jean Tanner
Abstract: A cell culture vessel has a wall and cell culture surface having a plurality of microcavities for culturing cells in three-dimensional conformation, referred to as “spheroids”. The inner surface of the wall and the cell culture surface define a cell culture chamber of the vessel. The wall is attached to the cell culture surface in a way that does not provide flat surfaces on or around the cell culture surface so that the vessel provides an environment suitable for the production of a homogeneous population of three-dimensional cell clusters, or spheroids.
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公开(公告)号：US20190322969A1
公开(公告)日：2019-10-24
申请号：US16447453
申请日：2019-06-20
Applicant: Corning Incorporated
Inventor： Ye Fang , Ann MeeJin Ferrie , Vasiliy Nikolaevich Goral , Gregory Roger Martin , Kaitlyn Mary Matias , Michael Kurt Schaefer , Allison Jean Tanner
Abstract: The present disclosure relates to apparatuses, systems and methods for culturing cells. In particular, devices and methods are provided for generation and culture of 3d cell aggregates.
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公开(公告)号：US20180051242A1
公开(公告)日：2018-02-22
申请号：US15691102
申请日：2017-08-30
Applicant: CORNING INCORPORATED
CPC classification number: C12M23/08 , C12M23/34 , C12M23/40 , C12M23/44 , Y10T29/49826
Abstract: A cell culture apparatus includes cell culture units having cell culture chambers, each with at least one manifold. The manifold connects the cell culture unit to a fluid flow channel. The manifold has a dam which allows liquid to pool in the manifold and allows for the creation of an airspace in the manifold, which reduces hydrostatic pressure inside the apparatus and enables the stacking of multiple cell culture units. Embodiments include cascading manifolds, manifolds having reservoirs, and manifolds having valves.
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Patent Agency Ranking
公开(公告)号：US20170135337A1
公开(公告)日：2017-05-18
申请号：US15419678
申请日：2017-01-30
Applicant: CORNING INCORPORATED
Inventor： Jessica Monique Brown , Nicholas Michael Illsley , Gregory Roger Martin , Ana Marie del Pilar Pardo , Allison Jean Tanner
IPC: A01N1/02
CPC classification number: A01N1/0284 , A01N1/0242 , A01N1/0263 , A01N1/0268 , A01N1/0273 , A61J1/05 , A61J1/1412 , A61J1/16 , A61M5/145 , A61M5/2425 , C12M23/48 , C12M33/04 , C12M45/22
Abstract: An article including, either: a frame having an interior cavity, and a flexible liner situated within the interior cavity; or a deformable frame having an interior cavity, as defined herein. Either frame can receive a sample, such as liquid having suspended live cells, and cooling freezes the sample to a solid sample. The solid sample can be readily ejected from the article having either a frame with the flexible liner, or the deformable frame, without extensive thawing. The solid sample can be rapidly displaced from the article by the methods and apparatus disclosed herein.
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公开(公告)号：US20140106444A1
公开(公告)日：2014-04-17
申请号：US14132749
申请日：2013-12-18
Applicant: CORNING INCORPORATED
Inventor： Gregory Roger Martin , Allison Jean Tanner
IPC: C12N5/071
CPC classification number: C12M23/08 , C12M23/04 , C12M23/24 , C12M23/34 , C12M23/38 , C12M23/58 , C12M25/02 , C12M25/04 , C12M25/06 , C12M29/04 , C12N5/0602
Abstract: A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s). The body of the apparatus has imparted therein gas permeable membranes in combination with tracheal spaces that will allow the free flow of gases between the cell culture chambers and the external environment. The flask body also includes an aperture that will allow access to the cell growth chambers by means of a needle or cannula. The size of the apparatus, and location of an optional neck and cap section, allows for its manipulation by standard automated assay equipment, further making the apparatus ideal for high throughput applications.
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公开(公告)号：US20130260454A1
公开(公告)日：2013-10-03
申请号：US13904171
申请日：2013-05-29
Applicant: Corning Incorporated
Inventor： Gregory Roger Martin , Allison Jean Tanner
IPC: C12M1/12
CPC classification number: C12M23/08 , C12M23/04 , C12M23/24 , C12M23/34 , C12M23/38 , C12M23/58 , C12M25/02 , C12M25/04 , C12M25/06 , C12M29/04 , C12N5/0602
Abstract: A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s). The body of the apparatus has imparted therein gas permeable membranes in combination with tracheal spaces that will allow the free flow of gases between the cell culture chambers and the external environment. The flask body also includes an aperture that will allow access to the cell growth chambers by means of a needle or cannula. The size of the apparatus, and location of an optional neck and cap section, allows for its manipulation by standard automated assay equipment, further making the apparatus ideal for high throughput applications.
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公开(公告)号：US12146154B2
公开(公告)日：2024-11-19
申请号：US17005801
申请日：2020-08-28
Applicant: CORNING INCORPORATED
Inventor： Scott Matthew Bennett , Brian Robb Douglass , Paul Ernest Gagnon, Jr. , Gregory Roger Martin , Paul Michael Szlosek , Allison Jean Tanner
Abstract: A spheroid cell culture article including: a chamber including: an opaque side wall surface; a top aperture; and a gas-permeable, liquid impermeable bottom including at least one concave surface, wherein at least a portion of the bottom is transparent, wherein at least a portion of the bottom includes a low-adhesion or no-adhesion material in or on the at least one concave surface, and wherein the gas permeable, liquid impermeable bottom includes polystyrene.
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公开(公告)号：US20240263121A1
公开(公告)日：2024-08-08
申请号：US18635480
申请日：2024-04-15
Applicant: CORNING INCORPORATED
Inventor： Gregory Roger Martin , Allison Jean Tanner
Abstract: A cell culture insert for use in culturing cells to promote the formation of spheroids and methods of using these spheroid-promoting cell culture inserts. The cell culture insert includes a porous membrane and one or more sidewalls that are non-adherent to cells and cause the cells in the insert to associate with each other and form spheroids.
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