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公开(公告)号：US08750982B2
公开(公告)日：2014-06-10
申请号：US13725675
申请日：2012-12-21
Applicant: Cardiac Pacemakers, Inc.
Inventor： Pramodsingh Hirasingh Thakur , John D. Hatlestad , Ramesh Wariar , Viktoria A. Averina , Lynne E. Swanson
IPC: A61B5/053
Abstract: A processor circuit can be configured to obtain a first multidimensional vector. The first multidimensional vector can include dimensions corresponding to respective first conductivity characteristics obtained from different implantable electrode configurations associated with a subject. The processor circuit can also be configured to obtain a second multidimensional vector or vector space. The second multidimensional vector or vector space can include dimensions corresponding to respective second conductivity characteristics obtained from such different electrode configurations associated with the same or a different subject. The processor circuit can also provide a physiological status indicator that can be obtained at least in part by performing a vector comparison of the first multidimensional vector to the second multidimensional vector space or vector.
Abstract translation: 处理器电路可以被配置为获得第一多维向量。 第一多维向量可以包括对应于从与对象相关联的不同可植入电极配置获得的各自的第一导电特性的尺寸。 处理器电路还可以被配置为获得第二多维向量或向量空间。 第二多维向量或向量空间可以包括对应于从与相同或不同对象相关联的这种不同电极配置获得的各自的第二导电特性的尺寸。 处理器电路还可以提供至少部分地通过执行第一多维向量与第二多维向量空间或向量的向量比较来获得的生理状态指示符。
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62.发明申请公开(公告)号：US20130178786A1
公开(公告)日：2013-07-11
申请号：US13781258
申请日：2013-02-28
Applicant: Cardiac Pacemakers, Inc.
Inventor： Ramesh Wariar , Barun Maskara , Qi An , Pramodsingh Hirasingh Thakur , Julie A. Thompson
CPC classification number: A61N1/36585 , A61M5/1723 , A61M2005/1726 , A61M2205/054 , A61M2205/3303 , A61M2230/20 , A61M2230/30 , A61M2230/42 , A61N1/3627 , A61N1/36564 , A61N1/36578 , A61N1/36592 , A61N1/3702 , A61N1/375
Abstract: An apparatus comprises one or more physiological sensing circuits that generate a sensed physiological signal and at least one of the physiological sensing circuits is implantable, a measurement circuit configured to recurrently measure one or more physiological parameters that indicate a status of heart failure of the subject, a comparison circuit configured to compare the one or more physiological parameter measurements to one or more physiological parameter target values, a therapy circuit configured to control delivery of one or more drugs to treat heart failure, and a control circuit in electrical communication with the comparison circuit and the therapy circuit and configured to recurrently adjust delivery of drug therapy according to the comparison of the measured physiological parameters to the physiological parameter targets.
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公开(公告)号：US20250025097A1
公开(公告)日：2025-01-23
申请号：US18775575
申请日：2024-07-17
Applicant: Cardiac Pacemakers, Inc.
Inventor： John D. Hatlestad , Pramodsingh Hirasingh Thakur , Bin Mi , Jonathan Bennett Shute
Abstract: An ambulatory medical device includes a multi-axis posture sensor and processing circuitry. The multi-axis posture sensor is configured to provide an electrical posture sensor output representative of alignment of respective first, second, and third non-parallel axes of the ambulatory medical device with the gravitational field of the earth. The processing circuitry is configured to determine that the subject avoids lying on their left side using the posture sensor output, and compute a metric predictive of one or both of orthopnea and trepopnea in response to determining that the subject avoids lying on their left side.
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公开(公告)号：US20240341677A1
公开(公告)日：2024-10-17
申请号：US18631421
申请日：2024-04-10
Applicant: Cardiac Pacemakers, Inc.
Inventor： Jonathan Bennett Shute , Bin Mi , Pramodsingh Hirasingh Thakur
IPC: A61B5/00 , A61B5/0205 , A61B5/11 , A61B5/349
CPC classification number: A61B5/4836 , A61B5/0022 , A61B5/0205 , A61B5/349 , A61B5/6801 , A61B5/686 , A61B5/7275 , A61B5/742 , A61B5/1116 , A61B5/1118 , A61B2560/0443 , A61B2560/0462 , A61B2562/0219
Abstract: Systems and methods for detecting and managing heart failure are discussed. A medical-device system receives heart sound information sensed from the patient, generates a heart sound metric using the received heart sound information, and generate a heart failure indicator indicating whether the patient has a heart failure with preserved ejection fraction (HFpEF) or a heart failure with reduced ejection fraction (HFrEF) based at least in part on the heart sound metric. The medical-device system can detect a transition from HFpEF to HFrEF. A therapy circuit can deliver or adjust a heart failure therapy in response to the detected transition from HFpEF to HFrEF.
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公开(公告)号：US20240226576A1
公开(公告)日：2024-07-11
申请号：US18391355
申请日：2023-12-20
Applicant: Cardiac Pacemakers, Inc.
Inventor： Pramodsingh Hirasingh Thakur , Kevin Chu , Viktoria A. Averina
CPC classification number: A61N1/368 , A61N1/36578 , A61N1/36585 , A61N1/37247 , A61N1/371
Abstract: Systems and methods for electrically stimulating a patient's cardiac conduction system at selected locations based on heart sounds are disclosed. A medical-device system includes a data receiver to receive heart sound information sensed from a patient, an electrostimulation circuit to deliver electrostimulation to the cardiac conduction system, and a controller circuit to generate, from the heart sound information sensed in response to the electrostimulation being delivered respectively to two or more candidate locations at or near the cardiac conduction system, heart sound metrics respectively for the two or more candidate locations. Based on the heart sound metrics, the controller circuit selects at least one of the candidate locations as a pacing location for subsequent electrostimulation. Electrostimulation can be delivered to the selected pacing location to restore cardiac synchrony.
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Patent Agency Ranking
公开(公告)号：US11890116B2
公开(公告)日：2024-02-06
申请号：US17994934
申请日：2022-11-28
Applicant: Cardiac Pacemakers, Inc.
Inventor： Pramodsingh Hirasingh Thakur , Yi Zhang , Qi An , Viktoria A. Averina
IPC: A61B5/00 , A61B5/091 , G16H40/63 , G16H50/30 , G16H50/20 , G16H40/67 , A61B5/0205 , A61N1/362 , A61N1/365 , A61B5/08 , A61B7/04
CPC classification number: A61B5/7275 , A61B5/0205 , A61B5/091 , A61B5/4836 , A61B5/686 , A61B5/7264 , A61B5/7282 , A61B5/746 , A61N1/3627 , A61N1/36585 , G16H40/63 , G16H40/67 , G16H50/20 , G16H50/30 , A61B5/0816 , A61B7/04
Abstract: Systems and methods for detecting worsening cardiac conditions such as worsening heart failure events are described. A system may include sensor circuits to sense physiological signals and signal processors to generate from the physiological signals first and second signal metrics. The system may include a risk stratifier circuit to produce a cardiac risk indication. The system may use at least the first signal metric to generate a primary detection indication, and use at least the second signal metric and the risk indication to generate a secondary detection indication. The risk indication may be used to modulate the second signal metric. A detector circuit may detect the worsening cardiac event using the primary and secondary detection indications.
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公开(公告)号：US11615891B2
公开(公告)日：2023-03-28
申请号：US15961209
申请日：2018-04-24
Applicant: Cardiac Pacemakers, Inc.
Inventor： Yi Zhang , Qi An , Pramodsingh Hirasingh Thakur
Abstract: This document discusses, among other things, systems and methods to determine an alert state for each of a plurality of patients using received physiologic information, determine an event rate for the plurality of patients for a specific alert state, and adjust a composite HF risk determination for the plurality of patients using the determined event rate.
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公开(公告)号：US11612359B2
公开(公告)日：2023-03-28
申请号：US15478433
申请日：2017-04-04
Applicant: Cardiac Pacemakers, Inc.
Inventor： Qi An , Yi Zhang , Viktoria A. Averina , Jeffrey E. Stahmann , Pramodsingh Hirasingh Thakur
IPC: A61B5/00 , A61B5/053 , A61B5/08 , A61B5/11 , A61B7/00 , A61B5/20 , G16H50/30 , G16H50/20 , G16H40/63
Abstract: Systems and methods for assessing a patient's risk of renal dysfunction are described. A system may include sensor circuits to sense physiological signals and processors to generate signal metrics from the physiological signals. The system may generate a primary renal risk indication using a first signal metric, and a secondary renal risk indication using at least a second signal metric. The system may generate a composite renal risk indication and estimate a glomerular filtration rate or a chronic kidney disease stage using at least the primary and secondary risk indications. The composite renal risk indication, which indicative of a degree of renal dysfunction, may be presented to a clinician, or provided to a detector for detecting worsening heart failure.
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公开(公告)号：US11602298B2
公开(公告)日：2023-03-14
申请号：US16821332
申请日：2020-03-17
Applicant: Cardiac Pacemakers, Inc.
Inventor： Pramodsingh Hirasingh Thakur , Rezwan Ahmed , Stephen B. Ruble
Abstract: Systems and methods for assessing a cardiac arrhythmia risk of a patient, such as a risk for developing atrial fibrillation, are disclosed. An exemplary medical-device system includes an arrhythmia predictor circuit configured to receive physiologic information of a patient, and in an absence of atrial tachyarrhythmia in the patient, determine a risk of the patient developing future atrial tachyarrhythmia using the physiologic information. In accordance with the arrhythmia risk indication, the system can generate an alert, or initiate more aggressive monitoring of a patient identified as having a high atrial tachyarrhythmia risk.
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公开(公告)号：US11534113B2
公开(公告)日：2022-12-27
申请号：US16653011
申请日：2019-10-15
Applicant: Cardiac Pacemakers, Inc.
Inventor： Qi An , Viktoria A. Averina , Julie A. Thompson , Pramodsingh Hirasingh Thakur
IPC: A61B5/00 , A61B5/0205 , G16H50/30 , G16H20/10 , G16H40/20 , A61B7/04 , A61B5/024 , A61B5/0538 , A61B5/08 , A61B5/021 , A61B5/145 , A61B5/11 , G16H20/30
Abstract: Systems and methods for monitoring patients with a chronic disease are described. A patient management system may sense physiological signals from a patient using one or more implantable or other ambulatory sensors, and generate from the physiological signals a chronobiological rhythm indicator (CRI) such as indicating a circadian rhythm. A reference CRI associated with a prior hospital admission event of the patient may be provided to the patient management system, which compares the CRI to the reference CRI and generates a readmission risk score indicating the patient's risk of subsequent hospital readmission due to a worsened condition of the chronic disease. The readmission risk score may be provided to a user or a process, or used to initiate or adjust a therapy delivered to the patient.
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