公开(公告)号：US5151542A

公开(公告)日：1992-09-29

申请号：US731007

申请日：1991-07-16

申请人： Isao Kurimoto ,  Masayoshi Minai

发明人： Isao Kurimoto ,  Masayoshi Minai

IPC分类号： C07C68/06

CPC分类号： C07C68/06

摘要： Di-tert.-butyl dicarbonate having a high purity is prepared by reacting alkali metal tert.-butyl carbonate with methanesulfonyl chloride optionally in the presence of a phase transfer catalyst or an aromatic amine.

公开(公告)号：US5041620A

公开(公告)日：1991-08-20

申请号：US892103

申请日：1986-08-04

申请人： Fumio Toda ,  Masayoshi Minai

发明人： Fumio Toda ,  Masayoshi Minai

IPC分类号： C07C33/48 ,  C07C69/013 ,  C07C69/24 ,  C07C69/63 ,  C07C69/708

CPC分类号： C07C69/63 ,  C07C33/48 ,  C07C69/013 ,  C07C69/24 ,  C07C69/708

摘要： A method for producing an optically active 2-cyclopenten-4-one-1-ol ester useful as an intermediate for medicines, agricultural chemicals and represented by the general formula (I), ##STR1## wherein R represents a saturated or unsaturated aliphatic hydrocarbon residue which may or may not be substituted with a halogen atom, and a mark * represents an asymmetric carbon,which comprises bringing a 2-cyclopenten-4-one-1-ol ester represented by the general formula ##STR2## wherein R represents a saturated or unsaturated aliphatic hydrocarbon residue which may or may not be substituted with a halogen atom, into contact with an optically active 1,6-diphenyl-2,4-hexadiyne-1,6-diol derivative represented by the general formula (II), ##STR3## wherein R' represents a halogenated phenyl, lower alkylphenyl, naphthyl or tertiary lower alkyl group, and a mark * represents an asymmetric carbon,in an organic solvent to obtain an optically active cyclopentenone ester complex which is a bound product of the optically active 2-cyclopenten-4-one-1-ol ester represented by the foregoing general formula (I) with the optically active 1,6-diphenyl-2,4-hexadiyne-1,6-diol derivative represented by the foregoing general formula (II), and then decomposing the resulting optically active cyclopentenone ester complex.

摘要翻译： 可用作药物，农药中间体的光学活性2-环戊烯-4-酮-1-醇酯的方法，由通式（I）表示，其中R表示饱和或 不饱和脂肪族烃残基，其可以被卤素原子取代，也可以不被卤原子取代，标记*表示不对称碳，该方法包括使由通式表示的2-环戊烯-4-酮-1-醇酯 R表示可以或可以不被卤素原子取代的饱和或不饱和脂肪族烃残基，与通式（1）表示的光学活性1,6-二苯基-2,4-己二炔-1,6-二醇衍生物接触， （II），其中R'表示卤代苯基，低级烷基苯基，萘基或叔低级烷基，标记*表示不对称碳，在有机溶剂中得到光学活性环戊烯酮酯络合物，其中 是一个有限的亲 由上述通式（I）表示的光学活性2-环戊烯-4-酮-1-醇酯与光学活性1,6-二苯基-2,4-己二炔-1,6-二醇衍生物的管道，由 前述通式（II），然后分解得到的光学活性环戊烯酮酯络合物。

公开(公告)号：US4985590A

公开(公告)日：1991-01-15

申请号：US182461

申请日：1988-04-18

申请人： Masayoshi Minai ,  Takayuki Higashi

发明人： Masayoshi Minai ,  Takayuki Higashi

IPC分类号： C07C43/178 ,  C12P7/22 ,  C12P41/00

CPC分类号： C12P41/00 ,  C07C43/1783 ,  C07C43/1785 ,  C07C43/1786 ,  C12P7/22

摘要： Disclosed are novel optically active benzene derivatives represented by the formula (I): ##STR1## wherein R represents an alkyl or alkoxyalkyl group having 1 to 20 carbon atoms, which group may contain a halogen; Z represents a hydrogen atom or a halogen atom; l and n each represents a number of 0 or 1; and * indicates asymmetric carbon atom, anda process for preparing the above optically active benzene derivative which comprises debenzylating an optically active benzyl derivative represented by the formula (II): ##STR2## wherein, R, Z, l, n and * have the same meanings as defined above, and A represents a hydrogen atom, a lower alkyl group, a lower alkoxyl group or a halogen atom.

公开(公告)号：US4957867A

公开(公告)日：1990-09-18

申请号：US055362

申请日：1987-05-29

申请人： Masayoshi Minai ,  Yuji Ueda ,  Takayuki Higashii ,  Michitada; Kondo ,  Seiichi Kai

发明人： Masayoshi Minai ,  Yuji Ueda ,  Takayuki Higashii ,  Michitada; Kondo ,  Seiichi Kai

IPC分类号： C12P7/42 ,  C12P7/62

CPC分类号： C12P7/42 ,  C12P7/62

摘要： A process for preparing an optically active cyclopentenone of the formula: ##STR1## wherein R is a hydrogen atom or a lower alkyl group and n is an integer of 4 to 8, which comprises contacting a dl-cyclopentenone ester of the formula: ##STR2## wherein R and n are each as defined above and R' is a lower alkyl group optionally substituted with halogen on an enzyme having a capability of hydrolyzing selectively either one of the d- or l-form isomer in the dl-cyclopentenone ester (II) in an aqueous medium for asymmetric hydrolysis.

摘要翻译： 一种制备下式的光学活性环戊烯酮的方法：其中R是氢原子或低级烷基，n是4至8的整数，其包括使下式的dl-环戊烯酮与式 （II）其中R和n各自如上所定义，R'是任选被卤素取代的低级烷基，该酶具有选择性地水解d-或l-型异构体中的任一种的能力 dl-环戊烯酮酯（II）在不溶性水解的水性介质中。

公开(公告)号：US4714782A

公开(公告)日：1987-12-22

申请号：US700890

申请日：1985-02-12

申请人： Masayoshi Minai ,  Yuji Ueda

发明人： Masayoshi Minai ,  Yuji Ueda

IPC分类号： C07C45/67 ,  C07C45/78 ,  C07C45/79 ,  C07C45/81 ,  C07D307/93

CPC分类号： C07D307/93 ,  C07C45/673 ,  C07C45/78 ,  C07C45/79 ,  C07C45/81

摘要： A process for preparing an optically active 2-substituted or unsubstituted-4-hydroxy-2-cyclopentenone of the formula: ##STR1## wherein R is a hydrogen atom, an allyl group or a propargyl group, which comprises reacting the corresponding 2-substituted or unsubstituted-4-hydroxy-2-cyclopentenone of the formula: ##STR2## wherein R is defined above with a lactone chosen from (1R,5S)-6,6-dimethyl-4-hydroxy-3-oxabicyc lo[3.1.0]hexan-2-one or (1S,5R)-6,6-dimethyl-4-hydroxy-3-oxabicyclo[3.1.0]hexan-2-one in a molar ratio of 1.5 - 2:1 in the presence of p-toluenesulfonic acid or benzenesulfonic acid in the coexistence of an organic solvent under elimination of water as an azeotropic mixture with the organic solvent to obtain a reaction mixture comprising (1R,5S)-6,6-dimethyl-3-oxa-4(R)-[1(R)-4-oxo-2-substituted or unsubstituted-2-cyclopentenyloxy]bicyclo[3.1.0]hexan-2-one or (1S,5R)-6,6-dimethyl-3-oxa-4(S)-[1(S)-4-oxo-2-substituted or unsubstituted-2-cyclopentenyloxy]bicyclo[3.1.0]hexan-2-one of the formula: ##STR3## wherein R is as defined above, of which either one isomer is contained in a considerably larger amount than the other isomer, separating the isom er having the larger content from the reaction mix ture and hydrolyzing the separated isomer to give the optically active 2-substituted or unsubstituted-4-hydrox y-2-cyclopentenone.

摘要翻译： 制备下式的光学活性2-取代或未取代的4-羟基-2-环戊烯酮的方法：其中R是氢原子，烯丙基或炔丙基，其包括使相应的2-取代的 或下式所示的未取代的4-羟基-2-环戊烯酮：其中R定义如上，其中内酯选自（1R，5S）-6,6-二甲基-4-羟基-3-氧杂双环[3.1。 0]己-2-酮或（1S，5R）-6,6-二甲基-4-羟基-3-氧杂双环[3.1.0]己烷-2-酮，其摩尔比为1.5-2:1 的对甲苯磺酸或苯磺酸在与有机溶剂的共沸混合物中除去水作为有机溶剂共存，得到包含（1R，5S）-6,6-二甲基-3-氧杂-4 （R） - [1（R）-4-氧代-2-取代或未取代的-2-环戊烯氧基]双环[3.1.0]己-2-酮或（1S，5R）-6,6-二甲基-3- 氧杂-4（S） - [1（S）-4-氧代-2-取代或未取代的-2-环戊烯氧基]双环[3.1.0]己-2-酮 其中R如上所定义，其中一种异构体的含量比其他异构体大得多，从反应混合物中分离具有较大含量的等分子并水解分离的异构体，得到 光学活性的2-取代或未取代的-4-羟基-2-环戊烯酮。

公开(公告)号：US4665174A

公开(公告)日：1987-05-12

申请号：US377050

申请日：1982-05-11

申请人： Masayoshi Minai ,  Tadashi Katsura

发明人： Masayoshi Minai ,  Tadashi Katsura

IPC分类号： C07C45/71 ,  C07C49/753 ,  C07C69/708 ,  C07C225/00 ,  C07C225/20 ,  C07C327/22 ,  C07D213/36 ,  C07D213/38 ,  C07D295/116 ,  C07D295/30 ,  C07D307/00 ,  C07D307/32 ,  C07D307/33 ,  C07D307/42 ,  C07D317/64 ,  C07D333/14 ,  C07D333/20 ,  C07D333/34 ,  C07D493/04 ,  C07D493/06 ,  C07H15/203 ,  C07D279/10 ,  C07C85/02 ,  C07C87/50 ,  C07D265/30

CPC分类号： C07D295/30 ,  C07C321/00 ,  C07C323/00 ,  C07C327/00 ,  C07C45/71 ,  C07D213/38 ,  C07D295/116 ,  C07D307/33 ,  C07D307/42 ,  C07D317/64 ,  C07D333/20 ,  C07D333/34 ,  C07H15/203

摘要： A process for preparing cyclopentenone derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl or lower alkenyl, R.sup.2 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted ar(lower)alkyl and A is the residue of a nucleophilic agent from which a hydrogen atom is excluded, which comprises reacting a 3-hydroxy-4-cyclopentenone compound of the formula: ##STR2## wherein R.sup.1 and R.sup.2 are each as defined above with a nucleophilic agent of the formulaA--H (III)wherein A is as defined above.The cyclopentenone derivatives of the formula (I) are useful as pharmaceuticals, agricultural chemicals, perfumes and as intermediates for the preparation of agricultural chemicals, pharmaceuticals and perfumes.

摘要翻译： 制备下式的环戊烯酮衍生物的方法：其中R 1是氢，低级烷基或低级链烯基，R 2是氢，低级烷基，低级烯基，低级炔基，环烷基，取代或未取代的芳基或取代或未取代的芳基 Ar（低级）烷基，A是除去氢原子的亲核剂的残基，其包括使下式的3-羟基-4-环戊烯酮化合物：其中R 1和R 2各自为 如上定义的具有式AH（III）的亲核剂，其中A如上所定义。 式（I）的环戊烯酮衍生物可用作药物，农药，香料以及用于制备农药，药物和香料的中间体。

公开(公告)号：US4608442A

公开(公告)日：1986-08-26

申请号：US629488

申请日：1984-07-10

申请人： Masayoshi Minai ,  Tadashi Katsura

发明人： Masayoshi Minai ,  Tadashi Katsura

IPC分类号： C07C49/703 ,  C07B55/00 ,  C07C45/00 ,  C07C45/64 ,  C07C45/67 ,  C07C49/707 ,  C07C49/743 ,  C07C67/00 ,  C07C45/65

CPC分类号： C07C45/673

摘要： A process for producing a compound of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom, an alkyl group or an alkenyl group and R.sub.2 is an alkyl group, an alkenyl group or an alkynyl group, which comprises treating a compound of the formula: ##STR2## wherein R.sub.1 and R.sub.2 are each as defined above and R is a hydrogen atom or a lower alkyl group in the presence of an acidic substance and water.

摘要翻译： 一种制备下式的化合物的方法：其中R1是氢原子，烷基或烯基，R2是烷基，烯基或炔基，其包括处理化合物 其中R1和R2各自如上所定义，R是氢原子或低级烷基，其在酸性物质和水的存在下进行。

公开(公告)号：US4542235A

公开(公告)日：1985-09-17

申请号：US482259

申请日：1983-04-05

申请人： Masayoshi Minai ,  Tadashi Katsura ,  Kazuhiko Hamada ,  Gohfu Suzukamo

发明人： Masayoshi Minai ,  Tadashi Katsura ,  Kazuhiko Hamada ,  Gohfu Suzukamo

IPC分类号： C07C51/487 ,  C07C61/04

CPC分类号： C07C51/487

摘要： A method for producing an optically active 2,2-dimethylcyclopropanecarboxylic acid useful as an intermediate for dehydropeptidase I inhibitors, medicines and agricultural chemicals, which comprises reacting an optically active diphenylethylamine represented by the formula, ##STR1## wherein R.sub.1 and R.sub.2 are each a hydrogen atom or a lower alkyl group, with 2,2-dimethylcyclopropanecarboxylic acid in a solvent to achieve the optical purification of said acid.

摘要翻译： 一种用作脱水肽酶I抑制剂，药物和农药的中间体的光学活性2,2-二甲基环丙烷羧酸的制备方法，其包括使下式表示的光学活性二苯乙胺，其中R1和R2各自为氢 原子或低级烷基，与2,2-二甲基环丙烷羧酸在溶剂中实现所述酸的光学纯化。

公开(公告)号：US4535182A

公开(公告)日：1985-08-13

申请号：US523602

申请日：1983-08-16

申请人： Masayoshi Minai ,  Tadashi Katsura

发明人： Masayoshi Minai ,  Tadashi Katsura

IPC分类号： C07C67/00 ,  C07C69/02 ,  C07C69/03 ,  C07C69/145 ,  C07C69/24

CPC分类号： C07C67/10 ,  C07C67/08 ,  C07C67/293 ,  C07C2101/10 ,  C07C2101/14

摘要： 2-Cyclopentenone esters of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl or lower alkenyl, R.sup.2 is lower alkyl, lower alkenyl, lower alkynyl, or cycloalkyl, cycloalkenyl or substituted or unsubstituted aryl and R.sup.3 is hydrogen or lower alkyl are prepared in high yields by reacting the corresponding racemic or optically active 4-cyclopentenone of the formula: ##STR2## wherein R.sup.1 and R.sup.2 are each as defined above and R.sup.3 is hydrogen or acyl with at least one lower aliphatic carboxylic acid and/or metal or amine salts thereof.

摘要翻译： 2-环戊烯酮，其分子式如下：其中R1是氢，低级烷基或低级烯基，R2是低级烷基，低级烯基，低级炔基或环烷基，环烯基或取代或未取代的芳基，R3是氢或 通过使下式的相应的外消旋或光学活性的4-环戊烯酮与其中R 1和R 2各自如上定义并且R 3是氢或酰基与至少一个低级脂族羧酸（II）反应制得低级烷基， 酸和/或其金属盐或胺盐。

公开(公告)号：US4092324A

公开(公告)日：1978-05-30

申请号：US716666

申请日：1976-08-23

申请人： Yoshio Suzuki ,  Masayoshi Minai ,  Noritaka Hamma ,  Eiichi Murayama ,  Shunji Aono

发明人： Yoshio Suzuki ,  Masayoshi Minai ,  Noritaka Hamma ,  Eiichi Murayama ,  Shunji Aono

IPC分类号： C07D211/46 ,  C07D213/30 ,  C07D213/75 ,  C07D213/55

CPC分类号： C07D213/30 ,  C07D211/46 ,  C07D213/75

摘要： Bisphenoxy carboxylic acid derivatives useful as an antiarteriosclerosis agent with good absorbability and low toxicity, which are novel compounds represented by the general formula, ##STR1## wherein R.sub.1 and R.sub.2 represent hydrogen atoms or lower alkyl groups and A preresents ##STR2## (wherein in case R.sub.3 is a hydrogen atom, R.sub.4 represents an amino-lower-alkyl group, an N-lower-alkylaminoalkyl group, a heterocyclic group, or a heterocyclic group-substituted alkyl group; or R.sub.3 and R.sub.4 may join through an intermediary hetero atom to form a heterocyclic group and if said hetero atom is a nitrogen atom, this nitrogen atom can bear a lower alkyl group as a substituent) or ##STR3## (wherein R.sub.5 represents a hydrogen atom, a hydroxyalkyl group or a derivative thereof, and R.sub.6 represents a hydroxyalkyl group or a heterocyclic group; or R.sub.5 and R.sub.6 may join to form a cyclic group, or may join through another intermediary hetero atom to form a heterocyclic group and if said hetero atom is a nitrogen atom, this nitrogen atom can bear a lower alkyl group as a substituent).

摘要翻译： 作为具有良好吸收性和低毒性的抗动脉硬化剂的双苯氧基羧酸衍生物，它们是由通式表示的新化合物，其中R 1和R 2表示氢原子或低级烷基，并且A表示（ 其中，在R 3为氢原子的情况下，R 4表示氨基 - 低级烷基，N-低级烷基氨基烷基，杂环基或杂环基取代的烷基;或者，R 3和R 4可以通过中间杂原子 原子形成杂环基，如果所述杂原子是氮原子，则该氮原子可以具有作为取代基的低级烷基）或者其中R5表示氢原子，羟烷基或其衍生物，和 R6表示羟基烷基或杂环基;或者R5和R6可以连接形成环状基团，或者可以通过另一个中间杂原子连接形成杂环基，如果所述杂原子是氮原子 ，该氮原子可以具有低级烷基作为取代基）。