公开(公告)号：US4812585A

公开(公告)日：1989-03-14

申请号：US108467

申请日：1987-10-15

申请人： Michitada Kondo ,  Masayoshi Minai ,  Seiichi Kai ,  Takayuki Higashii ,  Yuji Ueda

发明人： Michitada Kondo ,  Masayoshi Minai ,  Seiichi Kai ,  Takayuki Higashii ,  Yuji Ueda

IPC分类号： C07D307/46 ,  C07D307/54

CPC分类号： C07D307/46 ,  C07D307/54

摘要： 2-Acylfuran derivatives ##STR1## (R: alkyl, phenyl, etc.; R.sub.1 : H, alkyl) are prepared in high yield by reaction, in the presence of a boron trifluoride complex catalyst, of a furan compound ##STR2## (X: H, Cl, Br; Y: Cl, Br) or with RCOOH in the presence of (XYCHCO).sub.2 O.

摘要翻译： 2-呋喃基衍生物通过在三氟化硼配合物催化剂的存在下，通过在呋喃化合物（X）（X）中的反应制备高收率的（R：烷基，苯基等; R 1：H，烷基） ：H，Cl，Br; Y：Cl，Br）或与RCOOH在（XYCHCO）2 O存在下反应。

公开(公告)号：US5235068A

公开(公告)日：1993-08-10

申请号：US915747

申请日：1992-07-21

申请人： Masayoshi Minai ,  Michitada Kondo ,  Yuji Ueda ,  Seiichi Kai ,  Takayuki Higashii

发明人： Masayoshi Minai ,  Michitada Kondo ,  Yuji Ueda ,  Seiichi Kai ,  Takayuki Higashii

IPC分类号： C07C45/46 ,  C07D207/32 ,  C07D207/333 ,  C07D307/46 ,  C07D307/54 ,  C07D307/80 ,  C07D333/22 ,  C07D333/24 ,  C07D333/28 ,  C07D333/56 ,  C07D409/06

CPC分类号： C07D207/333 ,  C07C45/46 ,  C07D307/46 ,  C07D307/54 ,  C07D307/80 ,  C07D333/22 ,  C07D333/24 ,  C07D333/28 ,  C07D333/56 ,  C07D409/06

摘要： Acylaromatic compounds ##STR1## (Q: aromatic compound residue; R: straight, branched or cyclic aliphatic group, aromatic group or araliphatic group) are prepared in high yield by a reaction, in the presence of a boron trifluoride complex catalyst, of an aromatic compound with ##STR2## (X: H, Cl, Br; Y: Cl, Br) or with RCOOH in the presence of (XYCHCO).sub.2 O.

摘要翻译： 酰化芳族化合物通过在三氟化硼配合物催化剂存在下，通过芳族化合物的芳香族化合物（Q：芳族化合物残基; R：直链，支链或环状脂族基团，芳族基团或芳脂族基团） 在（XYCHCO）2 O存在下与（X：H，Cl，Br; Y：Cl，Br）或与RCOOH化合。

公开(公告)号：US4957867A

公开(公告)日：1990-09-18

申请号：US055362

申请日：1987-05-29

申请人： Masayoshi Minai ,  Yuji Ueda ,  Takayuki Higashii ,  Michitada; Kondo ,  Seiichi Kai

发明人： Masayoshi Minai ,  Yuji Ueda ,  Takayuki Higashii ,  Michitada; Kondo ,  Seiichi Kai

IPC分类号： C12P7/42 ,  C12P7/62

CPC分类号： C12P7/42 ,  C12P7/62

摘要： A process for preparing an optically active cyclopentenone of the formula: ##STR1## wherein R is a hydrogen atom or a lower alkyl group and n is an integer of 4 to 8, which comprises contacting a dl-cyclopentenone ester of the formula: ##STR2## wherein R and n are each as defined above and R' is a lower alkyl group optionally substituted with halogen on an enzyme having a capability of hydrolyzing selectively either one of the d- or l-form isomer in the dl-cyclopentenone ester (II) in an aqueous medium for asymmetric hydrolysis.

摘要翻译： 一种制备下式的光学活性环戊烯酮的方法：其中R是氢原子或低级烷基，n是4至8的整数，其包括使下式的dl-环戊烯酮与式 （II）其中R和n各自如上所定义，R'是任选被卤素取代的低级烷基，该酶具有选择性地水解d-或l-型异构体中的任一种的能力 dl-环戊烯酮酯（II）在不溶性水解的水性介质中。

公开(公告)号：US5268501A

公开(公告)日：1993-12-07

申请号：US988432

申请日：1992-12-09

申请人： Takaharu Ikeda ,  Seiichi Kai ,  Masayoshi Minai

发明人： Takaharu Ikeda ,  Seiichi Kai ,  Masayoshi Minai

IPC分类号： C07C67/313 ,  C07C67/343 ,  C07C69/716 ,  C07C251/38 ,  C07C229/06

CPC分类号： C07C251/38 ,  C07C67/313 ,  C07C67/343 ,  C07C69/716

摘要： Process for preparing haloketo acid derivatives [I]: ##STR1## wherein R is H or C.sub.1-6 alkyl, and X is chlorine or bromine, which comprises reacting .beta.-oxo-acid ester [II]: ##STR2## wherein R.sup.1 is H or C.sub.1-6 alkyl, R.sup.2 is C.sub.1-5 alkyl or OR.sup.3 (R.sup.3 is C.sub.1-6 alkyl), and X is the same as above, with nitrosating agent [IV]:ONOR.sup.4 [IV]wherein R.sup.4 is H, alkyl, halogen or SO.sub.3 H to give 7-halo-2-hydroxyminoheptanoic acid ester [III]: ##STR3## wherein R.sup.1 and X are the same as above, following by reacting the product with aldehyde or ketone; and intermediates therefor, and process for preparing said intermediates. Said haloketo acid derivatives are useful as intermediate for synthesis of cilastatin, which is useful as medicament, especially as dehydropeptidase inhibitor.

摘要翻译： 制备卤代羧酸衍生物的方法[I]：其中R是H或C 1-6烷基，X是氯或溴，其包括使β-氧代酸酯[II]： II]其中R 1是H或C 1-6烷基，R 2是C 1-5烷基或OR 3（R 3是C 1-6烷基），X与上述相同，与亚硝化剂[Ⅳ]：ONOR4 [Ⅳ]其中R4 是H，烷基，卤素或SO 3 H，得到7-卤代-2-羟基乙酸庚酯。[III]：其中R1和X与上述相同，然后使产物与醛或酮反应; 及其中间体，以及制备所述中间体的方法。 所述卤代酸衍生物可用作合成西司他丁的中间体，其可用作药物，特别是作为脱氢肽酶抑制剂。

公开(公告)号：US5202467A

公开(公告)日：1993-04-13

申请号：US651971

申请日：1991-02-07

申请人： Takaharu Ikeda ,  Seiichi Kai ,  Masayoshi Minai

发明人： Takaharu Ikeda ,  Seiichi Kai ,  Masayoshi Minai

IPC分类号： C07C67/313 ,  C07C67/343 ,  C07C69/716 ,  C07C251/38

CPC分类号： C07C69/716 ,  C07C251/38 ,  C07C67/313 ,  C07C67/343

摘要： Process for preparing haloketo acid derivatives [I]: ##STR1## wherein R is H or C.sub.1-6 alkyl, and X is chlorine or bromine, which comprises reacting .beta.-oxo-acid ester [II]: ##STR2## wherein R.sup.1 is C.sub.1-6 alkyl, R.sup.2 is C.sub.1-5 alkyl or OR.sup.3 (R.sup.3 is C.sub.1-6 alkyl), and X is the same as above, with nitrosating agent [IV]:ONOR.sup.4 [IV]wherein R.sup.4 is H, alkyl, halogen or SO.sub.3 H to give 7-halo-2-hydroxyiminoheptanoic acid ester [III]: ##STR3## wherein R.sup.1 and X are the same as above, followed by reacting the product with aldehyde or ketone; and intermediates therefor, and process for preparing said intermediates. Said haloketo acid derivatives are useful as intermediate for synthesis of cilastatin, which is useful as medicament, especially as dehydropeptidase inhibitor.

公开(公告)号：US5191109A

公开(公告)日：1993-03-02

申请号：US648893

申请日：1991-01-31

申请人： Masayoshi Minai ,  Sachiko Imazu ,  Seiichi Kai ,  Takaharu Ikeda ,  Hideyuki Ikehira

发明人： Masayoshi Minai ,  Sachiko Imazu ,  Seiichi Kai ,  Takaharu Ikeda ,  Hideyuki Ikehira

IPC分类号： C07C69/593 ,  C07C69/606 ,  C07C69/738 ,  C07D307/54 ,  C12P7/62 ,  C12P41/00

CPC分类号： C07C69/593 ,  C07C69/606 ,  C07C69/738 ,  C07D307/54 ,  C12P41/004 ,  C12P7/62

摘要： An improved process for preparing an optically active 4-hydroxycyclopentenone of the formula: ##STR1## wherein R is a lower alkyl, the symbol means double bond or triple bond, and the * marked carbon is an asymmetric carbon, and the corresponding racemic 4-hydroxycyclopentenone, which are useful as an intermediate for preparing medicinal or agricultural products, particularly pharmaceutically active prostaglandins, and intermediates for preparing the optically active and/or racemic 4-hydroxycyclopentenone.

摘要翻译： 制备下式的光学活性4-羟基环戊烯酮的改进方法：其中R是低级烷基，符号是指双键或三键，并且*标记的碳是不对称碳，相应的 可用作制备药用或农产品的中间体，特别是药学上可接受的前列腺素的外消旋4-羟基环戊烯酮和用于制备光学活性和/或外消旋4-羟基环戊烯酮的中间体。

公开(公告)号：US4336109A

公开(公告)日：1982-06-22

申请号：US151530

申请日：1980-05-19

申请人： Hirokazu Hosaka ,  Kenji Tanimoto ,  Kunihiko Tanaka ,  Toshiharu Morita ,  Katsuyuki Shiota ,  Yuji Ueda ,  Seiichi Kai

发明人： Hirokazu Hosaka ,  Kenji Tanimoto ,  Kunihiko Tanaka ,  Toshiharu Morita ,  Katsuyuki Shiota ,  Yuji Ueda ,  Seiichi Kai

IPC分类号： C07C49/08 ,  C07C45/00 ,  C07C45/78 ,  C07C45/82 ,  C07C45/85 ,  C07C67/00 ,  B01D3/34

CPC分类号： C07C45/82 ,  C07C45/85

摘要： Acetone having a markedly low content of aldehydes is recovered from an aqueous rectification residue brought about by rectification of crude acetone carried out after one crude acetone having been alkali-treated or while an alkali or an aqueous solution thereof being added to the crude acetone, by mixing the aqueous rectification residue with an alkali, neutralizing the mixture to a pH of 4 to 9, and then subjecting the resulting mixture to distillation to obtain acetone as a distillate.

摘要翻译： 具有显着低的醛含量的丙酮从经过碱处理的一种粗制丙酮之后进行的粗丙酮的精馏所产生的水性精馏残渣或将碱或其水溶液加入粗丙酮中的丙酮中回收。 将水精制残渣与碱混合，将混合物中和至pH4至9，然后将所得混合物进行蒸馏，得到作为馏出物的丙酮。

公开(公告)号：US20120265423A1

公开(公告)日：2012-10-18

申请号：US13449236

申请日：2012-04-17

申请人： Seiichi Kai ,  Osamu Tani ,  Masakazu Noro ,  Tetsuya Masuda

发明人： Seiichi Kai ,  Osamu Tani ,  Masakazu Noro ,  Tetsuya Masuda

IPC分类号： F02D41/30

CPC分类号： F02D41/30 ,  F02D41/3094

摘要： A fuel injection control system is provided. The fuel injection control system comprises a first injector and a second injector positioned upstream of the first injector; a memory section which contains a map for defining a correspondence between a running state of an engine and first and second fuel injection ratios; a fuel injection ratio setting section for setting the first fuel injection ratio as a first set value and the second fuel injection ratio as a second set value; and a fuel injection ratio compensation section for making compensation such that the first set value is greater than a value of the first fuel injection ratio derived from the map, when a condition in which the second fuel injection ratio read out from the map is greater in magnitude than a predetermined determination criterion is met.

摘要翻译： 提供燃料喷射控制系统。 燃料喷射控制系统包括位于第一喷射器上游的第一喷射器和第二喷射器; 存储部分，其包含用于定义发动机的运行状态与第一和第二燃料喷射比之间的对应关系的映射; 燃料喷射比设定部，其将第一燃料喷射率设定为第一设定值，第二燃料喷射比设定为第二设定值; 以及燃料喷射比补偿部，其用于进行补偿，使得当从所述地图读出的所述第二燃料喷射比较大时，所述第一设定值大于从所述地图导出的所述第一燃料喷射比的值 大于预定的确定标准。

公开(公告)号：US20090012676A1

公开(公告)日：2009-01-08

申请号：US12108376

申请日：2008-04-23

申请人： Naoki Kawamura ,  Junji Tamura ,  Takahiro Ogino ,  Seiichi Kai ,  Shinta Kawasetsu

发明人： Naoki Kawamura ,  Junji Tamura ,  Takahiro Ogino ,  Seiichi Kai ,  Shinta Kawasetsu

IPC分类号： B60G17/016

CPC分类号： F02D17/04 ,  B60K28/14 ,  B60W2520/16 ,  B60Y2200/12 ,  F02D41/042 ,  F02D2200/701

摘要： A vehicle including an engine, a tilting sensor configured to detect that a vehicle body of the vehicle has been tilted a predetermined angle or larger, a driving state sensor configured to detect a driving state of the vehicle using a component other than the tilting sensor, and a determiner configured to determine whether or not to stop the engine, based on a signal received from the tilting sensor, and a signal received from the driving state sensor.

摘要翻译： 一种包括发动机的车辆，被配置为检测车辆的车体已经倾斜了预定角度或更大的倾斜传感器;驱动状态传感器，被配置为使用除了倾斜传感器之外的部件来检测车辆的行驶状态， 以及确定器，其被配置为基于从倾斜传感器接收的信号和从所述驱动状态传感器接收的信号来确定是否停止所述发动机。

公开(公告)号：US09188076B2

公开(公告)日：2015-11-17

申请号：US13449236

申请日：2012-04-17

申请人： Seiichi Kai ,  Osamu Tani ,  Masakazu Noro ,  Tetsuya Masuda

发明人： Seiichi Kai ,  Osamu Tani ,  Masakazu Noro ,  Tetsuya Masuda

IPC分类号： F02D41/30

CPC分类号： F02D41/30 ,  F02D41/3094

摘要： A fuel injection control system is provided. The fuel injection control system comprises a first injector and a second injector positioned upstream of the first injector; a memory section which contains a map for defining a correspondence between a running state of an engine and first and second fuel injection ratios; a fuel injection ratio setting section for setting the first fuel injection ratio as a first set value and the second fuel injection ratio as a second set value; and a fuel injection ratio compensation section for making compensation such that the first set value is greater than a value of the first fuel injection ratio derived from the map, when a condition in which the second fuel injection ratio read out from the map is greater in magnitude than a predetermined determination criterion is met.

摘要翻译： 提供燃料喷射控制系统。 燃料喷射控制系统包括位于第一喷射器上游的第一喷射器和第二喷射器; 存储部分，其包含用于定义发动机的运行状态与第一和第二燃料喷射比之间的对应关系的映射; 燃料喷射比设定部，其将第一燃料喷射率设定为第一设定值，第二燃料喷射比设定为第二设定值; 以及燃料喷射比补偿部，其用于进行补偿，使得当从所述地图读出的所述第二燃料喷射比较大时，所述第一设定值大于从所述地图导出的所述第一燃料喷射比的值 大于预定的确定标准。