公开(公告)号：US20060185178A1

公开(公告)日：2006-08-24

申请号：US11305949

申请日：2005-12-19

申请人： Craig Smith ,  Joseph Donaldson

发明人： Craig Smith ,  Joseph Donaldson

IPC分类号： B43L23/00

CPC分类号： B43L23/08

摘要： A carpenter's pencil sharpener is designed for cutting a point on a carpenter's pencil that defines a longitudinal axis and has a maximum width or dimension (MD) perpendicular to the longitudinal axis. The sharpener has a contouring portion defining a rotational axis, a pencil point contour surface and a blade. The sharpener also has a centering portion at least rotationally fixed to the contouring portion. The centering portion has a non-rotating, cylindrical, inner surface and an outer end defining an aperture for receiving the carpenter's pencil. The cylindrical surface has an inner diameter (ID) dimensioned to fit the maximum dimension (MD) of the carpenter's pencil, and is large enough to permit rotation of the carpenter's pencil within the cylindrical surface. The centering portion also has a length (L) generally parallel to the rotational axis and measured from the contouring portion to the outer end for maintaining the carpenter's pencil parallel to the axis. With this configuration, radial motion of the carpenter's pencil relative to the rotational axis is limited when the carpenter's pencil is rotated within the inner surface.

公开(公告)号：US20060127985A1

公开(公告)日：2006-06-15

申请号：US11128422

申请日：2005-05-13

申请人： Raymond Goodwin ,  Craig Smith ,  Mark Alderson

发明人： Raymond Goodwin ,  Craig Smith ,  Mark Alderson

IPC分类号： C07K14/52 ,  C07H21/04 ,  C12P21/02

CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/30 ,  G01N33/6863

摘要： Novel 4-1BB ligand (4-1BB-L) polypeptides and a human cell surface receptor designated 4-1BB that binds 4-1BB-L are provided. Isolated 4-1BB-L-encoding and human 4-1BB-encoding DNA sequences, recombinant expression vectors comprising the isolated DNA sequences, and host cells transformed with the recombinant expression vectors are disclosed, along with methods for producing the novel polypeptides by cultivating such transformed host cells. Soluble forms of the 4-1BB-L or 4-1BB polypeptides are derived from the extracellular domains thereof.

公开(公告)号：US20060025452A1

公开(公告)日：2006-02-02

申请号：US11236145

申请日：2005-09-27

申请人： Craig Smith ,  Michel Rathbone ,  Margaret Petty ,  David Rampe

发明人： Craig Smith ,  Michel Rathbone ,  Margaret Petty ,  David Rampe

IPC分类号： A61K31/4439

CPC分类号： A61K31/4439 ,  Y10S514/903

摘要： N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of Demyelinating Diseases and Conditions such as Multiple Sclerosis, Spinal Cord Injury, Traumatic Brain Injury and Stroke. The compounds are also useful for Stroke Rehabilitation, the treatment of Bladder Irritation and Dysfunction, and the treatment of Neuropathic Pain and Chemokine-Induced Pain.

公开(公告)号：US20050287583A1

公开(公告)日：2005-12-29

申请号：US11200955

申请日：2005-08-10

申请人： Craig Smith ,  Charles York

发明人： Craig Smith ,  Charles York

IPC分类号： C12Q1/68 ,  G01N33/543 ,  G01N33/551

CPC分类号： G01N33/54326 ,  C12Q1/6806 ,  G01N2446/80 ,  C12Q2563/143 ,  C12Q2527/125

摘要： The present invention provides methods for isolating biological target materials, particularly nucleic acids, such as DNA or RNA or hybrid molecules of DNA and RNA, from other substances in a medium using silica magnetic particles. The methods of the present invention involve forming a complex of the silica magnetic particles and the biological target material in a mixture of the medium and particles, separating the complex from the mixture using external magnetic force, and eluting the biological target material from the complex. The preferred embodiments of magnetic silica particles used in the methods and kits of the present invention are capable of forming a complex with at least 2 μg of biological target material per milligram of particle, and of releasing at least 60% of the material from the complex in the elution step of the method. The methods of the present invention produce isolated biological target material which is substantially free of contaminants, such as metals or macromolecular substances, which can interfere with further processing or analysis, if present.

摘要翻译： 本发明提供了使用二氧化硅磁性颗粒从介质中的其他物质分离生物靶材料，特别是DNA或RNA或DNA和RNA的混合分子的方法。 本发明的方法包括在介质和颗粒的混合物中形成二氧化硅磁性颗粒和生物目标材料的复合物，使用外部磁力从混合物中分离复合物，并从复合物中洗脱生物目标物质。 在本发明的方法和试剂盒中使用的磁性二氧化硅颗粒的优选实施方案能够与每毫克颗粒至少2个生物靶材料形成复合物，并且从复合物中释放至少60％的材料 在该方法的洗脱步骤中。 本发明的方法产生基本上不含污染物（例如金属或大分子物质）的分离的生物靶材料，如果存在可能会干扰进一步的加工或分析。

公开(公告)号：US20050274347A1

公开(公告)日：2005-12-15

申请号：US10868308

申请日：2004-06-14

申请人： Thomas Cusumano ,  Craig Smith

发明人： Thomas Cusumano ,  Craig Smith

IPC分类号： B01D45/00 ,  B60K13/02 ,  F02M35/00 ,  F02M35/02 ,  F02M35/022 ,  F02M35/10 ,  F02M35/16 ,  H01M8/04

CPC分类号： F02M35/10013 ,  F02M35/022 ,  F02M35/10144 ,  F02M35/10262 ,  F02M35/161 ,  Y02T10/146

摘要： A novel air intake system which is suitable for at least substantially reducing the inadvertent intake of water with ambient air into an air compressor or other operational component of a fuel cell or internal combustion engine is disclosed. The air intake system typically includes an elongated air flow conduit having a downwardly-angled air inlet arm that is typically fitted with multiple louver elements and a splash shield to deflect entering water downwardly into a drain or gullet chamber. The air intake system typically further includes a mechanism for gravity-mediated draining of water from the air flow conduit to prevent entering water from being drawn into the air compressor or other component.

摘要翻译： 公开了一种新颖的进气系统，其适于至少基本上将环境空气中的水的无意吸入量减少到空气压缩机或燃料电池或内燃机的其它操作部件中。 进气系统通常包括细长的空气流动管道，其具有向下倾斜的空气入口臂，其通常装配有多个百叶窗元件和防溅罩以将进入的水向下偏转到排水口或齿槽室中。 进气系统通常还包括用于重力介导从空气流动导管排出水的机构，以防止进入水被吸入空气压缩机或其它部件。

公开(公告)号：US20050253353A1

公开(公告)日：2005-11-17

申请号：US11127523

申请日：2005-05-12

申请人： Takashi Yamamura ,  Katsuhisa Shimizu ,  Minoru Seto ,  Tomoaki Ooishi ,  Craig Smith

发明人： Takashi Yamamura ,  Katsuhisa Shimizu ,  Minoru Seto ,  Tomoaki Ooishi ,  Craig Smith

IPC分类号： B60G3/18

CPC分类号： B60G3/20 ,  B60G7/00 ,  B60G2200/144 ,  B60G2200/422 ,  B60G2204/143 ,  B60G2204/15 ,  B60G2204/19 ,  B60G2206/60 ,  B60G2300/124

摘要： A vehicle includes a wheel suspension device on a right side and a wheel suspension device on a left side, with the right and left side wheel suspension devices being connected to each other through a rear frame mounted on a body frame. The right and left side wheel suspension devices include a lower arm supported at an inner end of the rear frame so as to extend outward and so as to be pivotally movable in a vertical direction. The right and left side wheel suspension devices also include an upper arm connected to the outer end of the lower arm through a wheel-supporting knuckle and so as to extend outward from the knuckle. The wheel suspension devices are provided with a rear cushion unit connected at one end to the swinging side end of one of the lower and upper arm members. At least one of the inner end of the upper arm and the other end of the rear cushion unit is supported on the rear frame so as to be pivotally movable.

摘要翻译： 车辆包括右侧的车轮悬挂装置和左侧的车轮悬挂装置，左右侧轮悬挂装置通过安装在车体框架上的后架彼此连接。 右侧和左侧悬架装置包括支撑在后框架的内端处的下臂，以便向外延伸并且能够在垂直方向上枢转地运动。 右侧和左侧车轮悬挂装置还包括通过轮支撑转向节连接到下臂的外端并且从转向节向外延伸的上臂。 车轮悬挂装置设置有后缓冲单元，其一端连接到下臂构件和上臂构件之一的摆动侧端部。 上臂的内端和后缓冲单元的另一端中的至少一个被支撑在后框架上以便可枢转地移动。

公开(公告)号：US06504668B1

公开(公告)日：2003-01-07

申请号：US09307989

申请日：1999-05-10

申请人： Kenji Takeuchi ,  Craig Smith

发明人： Kenji Takeuchi ,  Craig Smith

IPC分类号： G11B5596

CPC分类号： G11B5/59627

摘要： A disk drive has a servo controller that compensates for repeatable runout between the drive's data-transducing head and a data-storage disk disposed within the drive. The drive incorporates an improved runout-compensation technique by which a runout-error correction is applied to a plurality of locations on the disk without a need to store position-error data corresponding to each location. The drive also incorporates an improved runout-compensation technique by which the runout-error correction is optimally matched to the response characteristics of the drive's actuator mechanism. This optimal matching is accomplished by setting the anticipation interval for the correction in non-whole-sector increments, and calculating a to-be applied runout-error correction. Alternatively, the drive is equipped with a digital filter that calculates a runout-error correction based on a model of the actuator mechanism incorporated into the filter.

摘要翻译： 磁盘驱动器具有伺服控制器，其补偿驱动器的数据传输头与设置在驱动器内的数据存储盘之间的可重复的跳动。 该驱动器包含改进的跳动补偿技术，通过该技术，对盘上的多个位置应用偏移纠错，而不需要存储对应于每个位置的位置误差数据。 该驱动器还集成了改进的跳动补偿技术，通过该技术，跳动 - 误差校正与驱动器执行器机构的响应特性最佳匹配。 通过以非全扇区增量设置校正的预期间隔，并计算要应用的跳动 - 误差校正来实现该最佳匹配。 或者，驱动器配备有数字滤波器，其基于结合到滤波器中的致动器机构的模型来计算跳动误差校正。

公开(公告)号：US5840059A

公开(公告)日：1998-11-24

申请号：US483512

申请日：1995-06-07

申请人： Keith L. March ,  Michael Aita ,  Randy Kesten ,  Craig Smith

发明人： Keith L. March ,  Michael Aita ,  Randy Kesten ,  Craig Smith

IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B18/24 ,  A61M37/00 ,  A61M31/00

CPC分类号： A61M37/00 ,  A61B18/24 ,  A61B2017/00247 ,  A61B2017/22082 ,  A61B2018/00392 ,  A61M2210/125

摘要： A system for treating a patient's heart which comprises a means to form channels in the heart wall and a means to deliver a therapeutic or diagnostic agent into the channels. Additionally, the system may comprise a way to retain the agent within the channels for a useful period of time. The system may be configured to be introduced percutaneously or intraoperatively. The system generally comprises an elongated, flexible lasing transmission catheter that emits laser radiation and has delivery lumen opening at the distal end. Practice of the invention comprises forming channels in the heart wall and delivering a therapeutic or diagnostic agent into the channel. Gene therapy agents of this invention comprise vectors for transferring genetic information to the heart tissue in vivo or harvested cells which have been genetically engineered in vitro. Additionally, the invention may comprise retaining the agent within the channels, for example, by incorporating the agent in a viscous carrier.

摘要翻译： 一种用于治疗患者心脏的系统，其包括在心脏壁中形成通道的装置以及将治疗剂或诊断剂输送到通道中的手段。 另外，该系统可以包括将代理在该通道内保持一段有用的时间段的方式。 该系统可以被配置为经皮或手术引入。 该系统通常包括细长的，柔性的激光传输导管，其发射激光辐射并且在远端具有传送腔开口。 本发明的实践包括在心脏壁中形成通道并将治疗剂或诊断剂递送到通道中。 本发明的基因治疗剂包括用于将遗传信息转移到体外心脏组织的载体或已在体外进行遗传工程化的收获的细胞。 另外，本发明可以包括将试剂保持在通道内，例如通过将试剂掺入粘性载体中。

公开(公告)号：US5761597A

公开(公告)日：1998-06-02

申请号：US713637

申请日：1996-09-12

申请人： Craig Smith ,  H. Erwin Grellmann ,  Leonard Guan ,  David D. Martenson

发明人： Craig Smith ,  H. Erwin Grellmann ,  Leonard Guan ,  David D. Martenson

IPC分类号： G03G15/20 ,  G03G15/00 ,  G03G21/00

CPC分类号： G03G15/2092

摘要： An improved fusing apparatus for fixing or fusing images on print media is disclosed wherein a relatively small pressure applying surface, such as the surface of a rotatable pressure wheel, is lubricated with a lubricating medium such as silicone oil, and engages the printed image to apply pressure and fuse the image to the image receiving substrate. The fusing apparatus is mounted for reciprocal back and forth movement across the printed image on the image receiving substrate or medium to fuse the image into the substrate and flatten or smooth the upper exposed surface of the ink image. The pressure wheel is passed in multiple overlapping passes over the printed image to uniformly fuse the image into the media.

摘要翻译： 公开了一种用于在打印介质上固定或定影图像的改进的定影装置，其中相对小的压力施加表面（诸如可旋转的压力轮的表面）用诸如硅油的润滑介质润滑，并且与印刷图像接合以施加 压力并将图像融合到图像接收基板。 该定影装置安装成用于在图像接收基板或介质上横穿印刷图像往复运动，以将图像融合到基板中并使油墨图像的上部暴露表面变平或平滑。 压力轮在打印图像上以多重重叠的通过方式通过，以均匀地将图像融合到介质中。

公开(公告)号：US20160044203A1

公开(公告)日：2016-02-11

申请号：US14749988

申请日：2015-06-25

申请人： Brooke Paul ,  Craig Smith ,  Eric Kerr ,  Tanisha Robinson

发明人： Brooke Paul ,  Craig Smith ,  Eric Kerr ,  Tanisha Robinson

IPC分类号： H04N1/04 ,  H04N1/00 ,  G06Q10/02

CPC分类号： H04N1/04 ,  G06Q10/02 ,  H04N1/001 ,  H04N1/00331

摘要： A method to electronically capture, digitize, mobilize and transfer a paper ticket for use as an entry to a venue over a computer network.

摘要翻译： 一种电子捕获，数字化，动员和传送纸张票据作为通过计算机网络进入场地的方法。