公开(公告)号：US20130145727A1

公开(公告)日：2013-06-13

申请号：US13808452

申请日：2011-06-10

申请人： Sebastian Vogt ,  Hubert Buechner ,  Tim Schnieber

发明人： Sebastian Vogt ,  Hubert Buechner ,  Tim Schnieber

IPC分类号： B65B69/00

CPC分类号： B65B69/00 ,  A61B17/8833 ,  A61F2002/30561 ,  A61F2002/4685 ,  B01F11/0082 ,  B01F13/0023 ,  B01F15/0206 ,  B01F15/0258 ,  B65B69/0008

摘要： A vacuum cementing system has at least one cement powder cartridge and a container-opening system. The container-opening system has at least one container for at least one liquid and/or at least one powder, an opening device, and an outlet opening for applying a negative pressure. When a negative pressure is being applied, the opening device is mobile relative to at least a part of the at least one container. The vacuum cementing system has a means for connecting the cement powder cartridge to the at least one container and utilizes necessary vacuum for automatically opening the at least one container.

摘要翻译： 真空固井系统具有至少一个水泥粉末盒和容器开启系统。 容器开启系统具有用于至少一种液体和/或至少一种粉末，开启装置和用于施加负压的出口开口的至少一个容器。 当施加负压时，打开装置相对于至少一个容器的至少一部分是可移动的。 真空固井系统具有用于将水泥粉末筒连接到至少一个容器并利用必要的真空来自动打开至少一个容器的装置。

公开(公告)号：US20120006874A1

公开(公告)日：2012-01-12

申请号：US13176364

申请日：2011-07-05

申请人： Sebastian Vogt ,  Hubert Büchner

发明人： Sebastian Vogt ,  Hubert Büchner

IPC分类号： B67B7/92

CPC分类号： B67B7/92 ,  Y10T225/371

摘要： The invention relates to a device for vial opening comprising an external container, in which a closed vial having a vial body and a vial head is arranged, and comprising a hollow space in the region of the vial head, whereby the hollow space comprises at least one opening and a connection to the vial, whereby the vial head, at least regions thereof, is arranged in the connection of the hollow space to the vial, and the walls of the external container comprise at least one deformable region or are altogether made of a deformable material, whereby tilting of the vial with respect to the connection is made feasible, and the diameter of the connection is adapted to the dimensions of the vial head in such a manner that the vial head can be fractured or broken off the vial body when the vial is being tilted with respect to the connection.

摘要翻译： 本发明涉及一种用于小瓶开口的装置，其包括外部容器，其中布置有具有小瓶主体和小瓶头的封闭小瓶，并且在小瓶头的区域中包括中空空间，由此中空空间至少包括 一个开口和与小瓶的连接，其中，小瓶头至少其区域布置在中空空间与小瓶的连接中，并且外部容器的壁包括至少一个可变形区域或者由 一种可变形的材料，由此可使瓶子相对于连接件的倾斜变得可行，并且连接件的直径适合于小瓶头的尺寸，使得小瓶头可以从瓶体断裂或断裂 当小瓶相对于连接件倾斜时。

公开(公告)号：US20110272438A1

公开(公告)日：2011-11-10

申请号：US13096105

申请日：2011-04-28

申请人： Sebastian Vogt ,  Hubert Büchner

发明人： Sebastian Vogt ,  Hubert Büchner

IPC分类号： G01F11/00

CPC分类号： B05C17/015 ,  A61B17/8822 ,  A61B17/8825 ,  A61B17/8827 ,  A61B2017/0023 ,  F16N11/10

摘要： A dispensing device for cartridges having a trigger grip for operating a valve of the dispensing device, a connection for supplying a pressurised gas, a cartridge connector for connecting a cartridge, and a base body, in which at least one passage extends through such that pressurised gas can be guided to the cartridge connector. The cartridge connector comprises an opening towards the passage such that the content can be expelled from the cartridge upon application of the pressurised gas to the floor of a cartridge when the cartridge is arranged in the cartridge connector, and wherein the passage can be closed and opened through the operated valve. The valve has a valve body that is arranged in the base body in a rotatable manner, wherein a motion of the trigger grip leads to a rotation of the valve body in the base body. The passage is arranged in or on the valve body such that the passage is closed in a first position of the valve body and the passage in or on the valve body guides the pressurised gas to the cartridge connector in a second position of the valve body.

摘要翻译： 一种用于墨盒的分配装置，具有用于操作分配装置的阀的触发器手柄，用于供应加压气体的连接件，用于连接墨盒的卡座连接器和基体，其中至少一个通道延伸穿过，使得加压 气体可以被引导到盒式连接器。 盒式连接器包括朝向通道的开口，使得当盒被布置在盒连接器中时，当将加压气体施加到盒的底部时，内容物可以从盒中排出，并且其中通道可以被关闭和打开 通过操作阀。 阀具有以可旋转的方式布置在基体中的阀体，其中触发器手柄的运动导致阀体在基体中的旋转。 通道布置在阀体中或阀体上，使得通道在阀体的第一位置关闭，并且阀体中或阀体上的通道将加压气体引导到阀体的第二位置。

公开(公告)号：US20110272436A1

公开(公告)日：2011-11-10

申请号：US13096260

申请日：2011-04-28

申请人： Sebastian Vogt ,  Hubert Büchner

发明人： Sebastian Vogt ,  Hubert Büchner

IPC分类号： B67D7/78

CPC分类号： B05C17/00553 ,  B01F5/061 ,  B01F13/0023 ,  B01F15/0087 ,  B01F15/0237 ,  B01F2215/0029 ,  B05C17/00506 ,  B05C17/00513 ,  B05C17/00516 ,  B65D81/325

摘要： A cartridge system mixes and applies a mixing ware, such as, for example, a medical cement. The cartridge system has two cartridges that are arranged parallel to each other, and a mixing space having an outlet opening, wherein the cartridges each comprise at least one opening in the cartridge walls that connects the cartridges to the mixing space. The cartridges each comprise a feed plunger for expelling starting components of the mixing ware out of the cartridges through the openings, wherein a closure that can be shifted in the mixing space is arranged in the mixing space in a manner such that it closes the openings of the cartridges in a starting position and in that the openings to the mixing space are opened, at least in part, in a final position of the shiftable closure, wherein the shiftable closure can be shifted from a starting position to a final position. A dispensing tube for the cartridge system has, opposite from a dispensing tube tip of the dispensing tube, an extension with a diameter is smaller than an internal diameter of the mixing space, and which is designed to shift the shiftable closure during the insertion of the dispensing tube into the cartridge system head of the cartridge system such that the openings of the cartridges are open, at least in part.

摘要翻译： 盒式系统混合并施加混合器，例如医用水泥。 盒系统具有彼此平行布置的两个盒，以及具有出口开口的混合空间，其中盒每个包括将盒连接到混合空间的盒壁中的至少一个开口。 每个盒都包括一个进料柱塞，用于通过这些开口排出混合物料的起始组分，其中可以在混合空间中移动的封闭件以这样的方式设置在混合空间中： 所述盒处于起始位置，并且至少到所述混合空间的开口至少部分地打开在所述可移动封闭件的最终位置，其中所述可移动闭合件可以从起始位置移动到最终位置。 用于盒系统的分配管具有与分配管的分配管末端相反的直径小于混合空间的内径的延伸部，其被设计成在插入期间移动可移动的封闭件 将药筒分配到药筒系统的药筒系统头部，使得药筒的开口至少部分地打开。

公开(公告)号：US08012173B2

公开(公告)日：2011-09-06

申请号：US12889550

申请日：2010-09-24

申请人： Sebastian Vogt ,  Klaus-Dieter Kuhn ,  Hubert Büchner

发明人： Sebastian Vogt ,  Klaus-Dieter Kuhn ,  Hubert Büchner

IPC分类号： A61B17/04

CPC分类号： A61B17/06166 ,  A61B2017/00889 ,  A61B2017/00893 ,  A61L17/005 ,  A61L17/145 ,  A61L2300/208 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2300/802 ,  B05D1/18 ,  B05D2256/00

摘要： A surgical suture material with an antimicrobial surface is described, the surface exhibiting a coating containing a) at least one fatty acid, b) octenidine dichloride and/or dequalinium chloride and c) optionally oligomeric lactic acid esters. In addition, a process for coating surgical suture material is described which is characterized by the fact that the thread material is wetted with a homogeneous methanolic solution of octenidine dichloride and/or dequalinium chloride and subsequently the methanol is evaporated, a coating forming on the thread surface.

摘要翻译： 描述了具有抗微生物表面的外科缝合材料，所述表面显示包含a）至少一种脂肪酸，b）二氯化奥立芬和/或氯化脱氯化物的涂层，以及c）任选的低聚乳酸酯。 另外，描述了用于涂覆外科缝合材料的方法，其特征在于螺纹材料被二氯化二苯胺和/或氯化金合金的均匀甲醇溶液润湿，随后甲醇蒸发，在螺纹上形成涂层 表面。

公开(公告)号：US08009887B2

公开(公告)日：2011-08-30

申请号：US12288215

申请日：2008-10-17

申请人： Razvan Ionasec ,  Bogdan Georgescu ,  Helene C. Houle ,  Sebastian Vogt ,  Michael Scheuering ,  Estelle Camus ,  Dorin Comaniciu

发明人： Razvan Ionasec ,  Bogdan Georgescu ,  Helene C. Houle ,  Sebastian Vogt ,  Michael Scheuering ,  Estelle Camus ,  Dorin Comaniciu

IPC分类号： G06K9/00

CPC分类号： G06K9/00 ,  G06K2209/051 ,  G06T7/0016 ,  G06T7/251 ,  G06T17/20 ,  G06T2207/10076 ,  G06T2207/10136 ,  G06T2207/20076 ,  G06T2207/20081 ,  G06T2207/30048

摘要： A method and system for modeling the aortic valve in 4D image data, such as 4D CT and echocardiography, is disclosed. An initial estimate of a physiological aortic valve model is determined for at least one reference frame of a 4D image sequence based on anatomic features in the reference frame. The initial estimate is refined to generate a final estimate in the reference frame. A dynamic model of the aortic valve is then generated by estimating the physiological aortic valve model for each remaining frame of the 4D image sequence based on the final estimate in the reference frame. The aortic valve can be quantitatively evaluated using the dynamic model.

摘要翻译： 公开了用于4D图像数据建模主动脉瓣的方法和系统，如4D CT和超声心动图。 基于参考系中的解剖特征，为4D图像序列的至少一个参考帧确定生理主动脉瓣模型的初始估计。 改进初始估计以在参考系中产生最终估计。 然后通过基于参考框架中的最终估计估计4D图像序列的每个剩余帧的生理主动脉瓣模型来生成主动脉瓣的动态模型。 主动脉瓣可以使用动态模型进行定量评估。

公开(公告)号：US20110184083A1

公开(公告)日：2011-07-28

申请号：US13012349

申请日：2011-01-24

申请人： Sebastian Vogt ,  Hubert Büchner

发明人： Sebastian Vogt ,  Hubert Büchner

IPC分类号： A61L24/06 ,  B01J19/28

CPC分类号： B01F7/00291 ,  B01F7/00391 ,  B01F15/0289 ,  B01F2215/0029

摘要： A device is provided with which it is possible to produce poly(methyl methacrylate) bone-cement paste, which is degassed to the greatest extent possible, while avoiding large-volume mixing containers and large cement volumes contained therein. The device includes a tubular hollow body (10) having a first opening (30) on the input side and a second opening (20) on the output side, at least one rotatably-mounted shaft (40) arranged in the axial direction in the tubular hollow body (10), thread turns (50) arranged axially along the outer side of the shaft (40), wherein the shaft (40) has at least one section with thread turns (50) whose pitch decreases in the direction of the second opening (20), at least one stirring blade (60) arranged on the shaft (40), and rigid mixing elements (70) arranged on the inner side of the tubular hollow body (10).

摘要翻译： 提供了一种可以生产聚甲基丙烯酸甲酯骨水泥浆的装置，其在最大程度上脱气，同时避免了大体积的混合容器和其中所含的大的水泥体积。 该装置包括管状中空体（10），其具有在输入侧上的第一开口（30）和在输出侧的第二开口（20），至少一个可旋转地安装的轴（40）沿轴向布置在 管状中空体（10），沿着轴（40）的外侧轴向布置的螺纹（50），其中轴（40）具有至少一个具有螺纹匝（50）的部分，螺纹匝（50）的螺距在 第二开口（20），设置在所述轴（40）上的至少一个搅拌叶片（60）和布置在所述管状中空体（10）的内侧上的刚性混合元件（70）。

公开(公告)号：US20090280189A1

公开(公告)日：2009-11-12

申请号：US12506388

申请日：2009-07-21

申请人： Klaus-Dieter Kühn ,  Sebastian Vogt

发明人： Klaus-Dieter Kühn ,  Sebastian Vogt

IPC分类号： A61K33/24 ,  A61K31/7036

CPC分类号： A61K9/1611 ,  A61K9/1635 ,  A61K31/7036 ,  A61L27/16 ,  A61L27/446 ,  A61L27/54 ,  A61L2300/418 ,  C08L33/12

摘要： A local system for the liberation of an active principle is described which consists of spherical bodies which are composed of polymethyl methacrylate or polymethyl methacrylate co-methyl acrylate and, if necessary, zirconium dioxide and/or barium sulphate and a pharmaceutical active principle, which contains at least one hemostyptically effective compound stable at least up to 120° C., preferably a calcium salt. The local system for the liberation of an active principle is provided as medical product or drug.

摘要翻译： 描述了用于释放有效原理的局部系统，其由聚甲基丙烯酸甲酯或聚甲基丙烯酸甲酯共​​聚甲基丙烯酸酯和如果需要的二氧化锆和/或硫酸钡和药物活性成分组成的球形体组成，其包含 至少一种具有至少120摄氏度稳定的止血药剂，优选钙盐。 解放积极原则的地方制度是作为医疗产品或药物提供的。

公开(公告)号：US07569621B2

公开(公告)日：2009-08-04

申请号：US11483339

申请日：2006-07-07

申请人： Klaus-Dieter Kühn ,  Sebastian Vogt

发明人： Klaus-Dieter Kühn ,  Sebastian Vogt

IPC分类号： A61F2/28

CPC分类号： A61L24/001 ,  A61L24/06 ,  A61L27/16 ,  A61L27/50 ,  A61L2430/02 ,  C08L33/12

摘要： A dyed polymethyl methacrylate bone cement is described which is characterized by at least the surface of the polymer particles of the powder component being coated partially or completely with a mixture of one or several dyes and a hydrophobic, low molecular or oligomeric organic coupling agent, such a quantity of coupling agent being present that the polymer particles can be visually recognized as not having swollen.

摘要翻译： 描述了染色的聚甲基丙烯酸甲酯骨粘固剂，其特征在于粉末组分的聚合物颗粒的至少表面部分或完全被一种或多种染料和疏水性，低分子或低聚有机偶联剂的混合物部分或完全涂覆， 存在一定量的偶联剂，使得聚合物颗粒可以在视觉上被认为不具有溶胀。

公开(公告)号：US07345024B2

公开(公告)日：2008-03-18

申请号：US10600556

申请日：2003-06-20

申请人： Sebastian Vogt ,  Matthias Schnabelrauch ,  Klaus-Dieter Kühn

发明人： Sebastian Vogt ,  Matthias Schnabelrauch ,  Klaus-Dieter Kühn

IPC分类号： A61K31/65 ,  A61K31/70

CPC分类号： A61K9/0024 ,  A61K31/192 ,  A61K31/405 ,  A61K31/573 ,  A61K31/65 ,  A61K31/655 ,  A61K31/7036 ,  A61K45/06 ,  A61K2300/00

摘要： The invention relates to hardly soluble antiphlogistic salts and antiphlogistic-antibiotic pharmaceutical preparations and their use. The hardly water soluble antiphlogistic antibiotics salts have as their cationic component one of the antibiotics gentamicin, clindamycin, neomycin, streptomycin, tetracycline, doxicyline, oxytetracycline and rolitetracycline and as their anionic component one of the antiphlogistics ibuprofen, naproxen, indomethacin, dexamethasone-21-phosphate, dexamethasone-21-sulfate, triamcinolone-21-phosphate and triamcinolone-21-sulfate. The antiphlogistic antibiotics salts are used in pharmaceutical preparations as controlled-release antibiotic/antibiotics drugs. The invention describes antiphlogistic-antibiotic pharmaceutical preparations for which mixtures in the solid state of aggregation are used, which are composed of an easily water soluble salt of gentamicin, clindamycin, neomycin, streptomycin, tetracycline, doxicycline, oxytetracycline and/or rolitetracycline and at least one easily water soluble salt of ibuprofen, naproxen, indomethacin, dexamethasone-21-phosphate, dexamethasone-21-sulfate, triamcinolone-21-phosphate and/or triamcinolone-21-sulfate and at least one inorganic and/or organic pharmaceutical adjuvant and which are used as permanent or temporary implants in the form of tablets and/or molded bodies.

摘要翻译： 本发明涉及难溶性消炎盐和消炎抗生素药物制剂及其应用。 难溶水性消炎抗生素盐作为其阳离子成分，其中一种抗生素是庆大霉素，克林霉素，新霉素，链霉素，四环素，多西环素，土霉素和四环素，作为其阴离子组分之一布洛芬，萘普生，吲哚美辛，地塞米松21- 磷酸盐，地塞米松21-硫酸盐，曲安西龙21-磷酸盐和曲安奈德21-硫酸盐。 消炎抗生素盐用作药物制剂作为控释抗生素/抗生素药物。 本发明描述了使用固体状态的混合物的消炎抗生素药物制剂，其由庆大霉素，克林霉素，新霉素，链霉素，四环素，多西环素，土霉素和/或四环素的易水溶性盐组成，至少 布洛芬，萘普生，吲哚美辛，地塞米松21-磷酸盐，地塞米松21-硫酸盐，曲安西龙21-磷酸盐和/或曲安奈德21-硫酸盐和至少一种无机和/或有机药物佐剂的一种易溶于水的盐， 用作片剂和/或成型体形式的永久或临时植入物。