公开(公告)号：US20220411434A1

公开(公告)日：2022-12-29

申请号：US17748853

申请日：2022-05-19

Applicant: Gilead Sciences, Inc.

Inventor： Elbert Chin ,  John O. Link ,  James G. Taylor ,  Zheng-Yu Yang

IPC: C07D491/052 ,  A61P31/14

Abstract: Provided herein are compounds of Formula (I): the formula(I): wherein the various substituents are defined herein,

公开(公告)号：US20220402931A1

公开(公告)日：2022-12-22

申请号：US17748470

申请日：2022-05-19

Applicant: Gilead Sciences, Inc.

Inventor： Elbert Chin ,  John O. Link ,  Ezra Roberts ,  James G. Taylor ,  Zheng-Yu Yang

IPC: C07D493/06

Abstract: Provided herein are compounds and methods for the treatment or prevention of Zika virus infection. For example, a compound of the formula(I): Wherein the variable substituents are described herein.

公开(公告)号：US20220298148A1

公开(公告)日：2022-09-22

申请号：US17690889

申请日：2022-03-09

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas J. Brizgys ,  Chienhung Chou ,  Jeromy J. Cottell ,  Chao-I Hung ,  Michael L. Mitchell ,  James G. Taylor ,  Rhiannon Thomas-Tran ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Sheila M. Zipfel

IPC: C07D409/14 ,  A61P1/16 ,  A61K45/06 ,  A61K31/4545 ,  C07D417/14 ,  C07D405/14

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

公开(公告)号：US20220177449A1

公开(公告)日：2022-06-09

申请号：US17530300

申请日：2021-11-18

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas J. Brizgys ,  James S. Cassidy ,  Chienhung Chou ,  Jeromy J. Cottell ,  Chao-I Hung ,  Kavoos Kolahdouzan ,  James G. Taylor ,  Nathan E. Wright ,  Zheng-Yu Yang

IPC: C07D401/14 ,  C07D405/14 ,  A61K45/06

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

公开(公告)号：US11352371B2

公开(公告)日：2022-06-07

申请号：US16986909

申请日：2020-08-06

Applicant: Gilead Sciences, Inc.

Inventor： Jamie G. Bates ,  Ana Z. Gonzalez Buenrostro ,  Hongyan Guo ,  Xiaochun Han ,  Brian J. Kirby ,  Yurong Lai ,  Michael L. Mitchell ,  Gregg M. Schwarzwalder ,  James G. Taylor ,  Ting Wang

IPC: C07D519/00

Abstract: The present disclosure relates generally to thienopyrimidine compounds that bind to Acetyl-CoA Carboxylase (ACC) and act as inhibitors of ACC. The disclosure further relates to the use of the thienopyrimidine compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of ACC, including liver diseases such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

公开(公告)号：US20220098187A1

公开(公告)日：2022-03-31

申请号：US17268245

申请日：2019-08-13

Applicant: Gilead Sciences, Inc.

Inventor： Stephen Ammann ,  Elizabeth M. Bacon ,  Gediminas Brizgys ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  Marilyn Ndukwe ,  Marina Shatskikh ,  James G. Taylor ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Sheila M. Zipfel

IPC: C07D471/04 ,  C07D519/00

Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.

公开(公告)号：US20200017510A1

公开(公告)日：2020-01-16

申请号：US16508979

申请日：2019-07-11

Applicant: Gilead Sciences, Inc.

Inventor： Stephen Ammann ,  Elizabeth M. Bacon ,  Gediminas Brizgys ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  Marilyn Ndukwe ,  James G. Taylor ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Sheila M. Zipfel

IPC: C07D487/04

Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof, wherein the variable substituents are disclosed herein.

公开(公告)号：US10336762B2

公开(公告)日：2019-07-02

申请号：US15898095

申请日：2018-02-15

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Gediminas Brizgys ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  John O. Link ,  James G. Taylor ,  Winston C. Tse ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Jennifer R. Zhang ,  Sheila M. Zipfel

IPC: C07D401/04 ,  C07D413/04 ,  C07D487/04 ,  C07D453/00 ,  C07D519/00 ,  A61P29/00

Abstract: Provided is a compound of Formula (I) wherein the variable groups are defined herein.

公开(公告)号：US20190092787A1

公开(公告)日：2019-03-28

申请号：US16017371

申请日：2018-06-25

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Zhenhong R. Cai ,  Xiaowu Chen ,  Jeromy J. Cottell ,  Manoj C. Desai ,  Mingzhe Ji ,  Haolun Jin ,  Scott E. Lazerwith ,  Michael R. Mish ,  Philip Anthony Morganelli ,  Hyung-Jung Pyun ,  James G. Taylor ,  Teresa Alejandra Trejo Martin

IPC: C07D498/14 ,  A61K45/06 ,  C07D498/18 ,  A61K31/498 ,  A61K31/551 ,  A61K31/537 ,  C07D471/18 ,  C07D471/22 ,  A61K31/4985 ,  A61K31/529 ,  C07D487/14 ,  A61K31/553

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US10059695B2

公开(公告)日：2018-08-28

申请号：US15634314

申请日：2017-06-27

Applicant: Gilead Sciences, Inc.

Inventor： Gayatri Balan ,  Chien-Hung Chou ,  Musong Kim ,  Thorsten A. Kirschberg ,  John O. Link ,  Gary Phillips ,  Roland D. Saito ,  Neil H. Squires ,  James G. Taylor ,  William J. Watkins ,  Nathan E. Wright

IPC: C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14

CPC classification number: C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.