公开(公告)号：US20150038488A1

公开(公告)日：2015-02-05

申请号：US14448160

申请日：2014-07-31

Applicant: Gilead Sciences, Inc.

Inventor： Kevin S. Currie ,  Zhimin Du ,  Julie Farand ,  Juan A. Guerrero ,  Ashley A. Katana ,  Darryl Kato ,  Scott E. Lazerwith ,  Jiayao Li ,  John O. Link ,  Nicholas Mai ,  Gregory Notte ,  Hyung-Jung Pyun ,  Michael Sangi ,  Aaron C. Schmitt ,  Adam J. Schrier ,  Kirk L. Stevens ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Zheng-Yu Yang ,  Jeff Zablocki ,  Sheila Zipfel

IPC: C07D487/04 ,  C07D417/04 ,  C07D417/12 ,  C07D403/12 ,  C07D471/04 ,  C07D401/14

CPC classification number: C07D471/04 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D487/04 ,  C07D491/08 ,  C07D498/04 ,  C07D519/00

Abstract: The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I wherein X1, X2, X3, R2, R3, R4, R5, and Y are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.

Abstract translation: 本公开涉及作为Syk抑制剂的化合物及其在治疗各种疾病状态（包括癌症和炎性病症）中的用途。 在具体实施方案中，化合物的结构由式I给出，其中X 1，X 2，X 3，R 2，R 3，R 4，R 5和Y如本文所述。 本公开进一步提供包含式I化合物或其药学上可接受的盐的药物组合物，以及使用这些化合物和组合物治疗由Syk介导的病症的方法。

公开(公告)号：US20140316144A1

公开(公告)日：2014-10-23

申请号：US14316573

申请日：2014-06-26

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Jeromy J. Cottell ,  John O. Link ,  Teresa Alejandra Trejo Martin

IPC: C07D491/052

CPC classification number: C07D491/052 ,  A61K31/4188 ,  A61K31/7056 ,  A61K31/7068 ,  A61K31/7072 ,  A61K38/21 ,  A61K45/06 ,  C07D491/04 ,  A61K2300/00

Abstract: The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US08809267B2

公开(公告)日：2014-08-19

申请号：US13932945

申请日：2013-07-01

Applicant: Gilead Sciences, Inc.

Inventor： Jeromy J. Cottell ,  John O. Link ,  Scott D. Schroeder ,  James Taylor ,  Winston C. Tse ,  Randall W. Vivian ,  Zheng-Yu Yang

IPC: A61K38/00

CPC classification number: C07K5/0808 ,  A61K38/00 ,  C07D207/16 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D495/04 ,  C07K5/0804 ,  C07K5/0812 ,  C07K5/0821

Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明涉及抗病毒化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US20140051656A1

公开(公告)日：2014-02-20

申请号：US13956195

申请日：2013-07-31

Applicant: Gilead Sciences, Inc.

Inventor： Hongyan Guo ,  Darryl Kato ,  Thorsten A. Kirschberg ,  Hongtao Liu ,  John O. Link ,  Michael L. Mitchell ,  Jay P. Parrish ,  Jianyu Sun ,  James Taylor ,  Elizabeth M. Bacon ,  Eda Canales ,  Aesop Cho ,  Choung U. Kim ,  Jeromy J. Cottell ,  Manoj C. Desai ,  Randall L. Halcomb ,  Michael Graupe ,  Evan S. Krygowski ,  Scott E. Lazerwith ,  Qi Liu ,  Richard L. Mackman ,  Hyung-Jung Pyun ,  Joseph H. Saugier ,  James D. Trenkle ,  Winston C. Tse ,  Randall W. Vivian ,  Scott D. Schroeder ,  William J. Watkins ,  Lianhong Xu

IPC: C07D403/14 ,  A61K45/06 ,  A61K31/4184

CPC classification number: C07D403/14 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/427 ,  A61K31/435 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5415 ,  A61K31/55 ,  A61K45/06 ,  A61P31/12 ,  C07D207/16 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D491/113 ,  C07D495/04 ,  C07F5/025

Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US20130309196A1

公开(公告)日：2013-11-21

申请号：US13831116

申请日：2013-03-14

Applicant: Gilead Sciences, Inc.

Inventor： John O. Link ,  Jeromy J. Cottell ,  Teresa Alejandra Trejo Martin

IPC: C07D491/052 ,  A61K31/7072 ,  A61K38/21 ,  A61K31/4188 ,  A61K31/7056

CPC classification number: C07D491/052 ,  A61K31/4188 ,  A61K31/7056 ,  A61K31/7068 ,  A61K31/7072 ,  A61K38/21 ,  A61K45/06 ,  C07D491/04 ,  A61K2300/00

Abstract: The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US20130164260A1

公开(公告)日：2013-06-27

申请号：US13679862

申请日：2012-11-16

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Jeromy J. Cottell ,  Ashley Anne Kanata ,  Darryl Kato ,  Evan S. Krygowski ,  John O. Link ,  James Taylor ,  Chinh Viet Tran ,  Teresa Alejandra Trejo Martin ,  Zheng-Yu Yang ,  Sheila Zipfel

IPC: A61K31/4188 ,  A61K45/06

CPC classification number: C07D491/052 ,  A61K31/4188 ,  A61K31/7056 ,  A61K31/7064 ,  A61K31/7072 ,  A61K38/06 ,  A61K38/07 ,  A61K38/21 ,  A61K45/06 ,  A61K47/60 ,  C07D405/12 ,  C07F5/025 ,  Y10S514/894 ,  A61K2300/00

Abstract: The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US20130156732A1

公开(公告)日：2013-06-20

申请号：US13679874

申请日：2012-11-16

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Jeromy J. Cottell ,  Ashley Anne Katana ,  Darryl Kato ,  Evan S. Krygowski ,  John O. Link ,  James Taylor ,  Chinh Viet Tran ,  Teresa Alejandra Trejo Martin ,  Zheng-Yu Yang ,  Sheila Zipfel

IPC: A61K45/06 ,  A61K31/4188 ,  C07D491/052

CPC classification number: C07D491/052 ,  A61K31/4188 ,  A61K31/7056 ,  A61K31/7064 ,  A61K31/7072 ,  A61K38/06 ,  A61K38/07 ,  A61K38/21 ,  A61K45/06 ,  A61K47/60 ,  C07D405/12 ,  C07F5/025 ,  Y10S514/894 ,  A61K2300/00

Abstract: The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US12084467B2

公开(公告)日：2024-09-10

申请号：US18061127

申请日：2022-12-02

Applicant: Gilead Sciences, Inc.

Inventor： Zhimin Du ,  Julie Farand ,  Tezcan Guney ,  Darryl Kato ,  John O. Link ,  James B. C. Mack ,  Dong Min Mun ,  William J. Watkins ,  Jennifer R. Zhang

IPC: C07F9/6503 ,  A61K45/06 ,  C07D401/14

CPC classification number: C07F9/65038 ,  A61K45/06 ,  C07D401/14

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of a Retroviridae infection, including an HIV infection.

公开(公告)号：US20240132527A1

公开(公告)日：2024-04-25

申请号：US18236532

申请日：2023-08-22

Applicant: Gilead Sciences, Inc.

Inventor： Julie Farand ,  Michael Graupe ,  Tezcan Guney ,  Darryl Kato ,  Jiayao Li ,  John O. Link ,  James B. C. Mack ,  Dong Min Mun ,  Roland D. Saito ,  William J. Watkins ,  Jennifer R. Zhang

IPC: C07F9/09

CPC classification number: C07F9/095

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of a Retroviridae infection, including an HIV infection.

公开(公告)号：US20230203069A1

公开(公告)日：2023-06-29

申请号：US18061375

申请日：2022-12-02

Applicant: Gilead Sciences, Inc.

Inventor： Julie Farand ,  Michael Graupe ,  Tezcan Guney ,  Darryl Kato ,  Jiayao Li ,  John O. Link ,  James B. C. Mack ,  Dong Min Mun ,  Roland D. Saito ,  William J. Watkins ,  Jennifer R. Zhang

IPC: C07F9/09

CPC classification number: C07F9/095

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of a Retroviridae infection, including an HIV infection.